INTRODUCTION

CILIDIN O 20MG TABLET is a combination of Cilnidipine and Olmesartan which belongs to the group of medicines called Antihypertensive agents. It is used to treat hypertension (high blood pressure) when treatment with single agents is not effective.

Hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels supplying several vital organs, such as heart, kidney, or brain. If left untreated, it may cause serious complications such as heart attack, heart failure, stroke or even blindness.

Before taking CILIDIN O 20MG TABLET inform your doctor if you have any heart, liver, or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure or are severely dehydrated due to excessive vomiting or diarrhea.

CILIDIN O 20MG TABLET is not recommended for use in patients with severe hypotension. It is also not suitable for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby. Stop taking CILIDIN O 20MG TABLET and inform your doctor immediately if you become pregnant while undergoing therapy with CILIDIN O 20MG TABLET.

During treatment with CILIDIN O 20MG TABLET your doctor will constantly monitor your kidney functions, blood pressure and blood sugar levels to avoid the risk of unwanted side effects.

The most common side effects of taking CILIDIN O 20MG TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles, and flushing. Contact your doctor if any of these side effect worsens.

USES OF CILIDIN O 20MG TABLET

• Treats Hypertension (high blood pressure)

HOW CILIDIN O 20MG TABLET WORKS

CILIDIN O 20MG TABLET effectively controls blood pressure in patients with hypertension. It contains two medicines namely, Cilnidipine and Olmesartan. Olmesartan blocks the actions of certain hormones (angiotensin-II) in the body that causes narrowing of blood vessels and increase in blood pressure.

Cilnidipine is a vasodilator. It relaxes the blood vessels by blocking the entry of certain ions (calcium ions) within them that causes narrowing. This allows blood to flow more smoothly across the blood vessels. Collectively, they reduce the strain on the heart and helps the heart to pump blood more smoothly with less pressure.

DIRECTIONS FOR USE

Take CILIDIN O 20MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Try to take CILIDIN O 20MG TABLET at the same time each day. CILIDIN O 20MG TABLET can be taken with or without food.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Continue to take CILIDIN O 20MG TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.

SIDE EFFECTS OF CILIDIN O 20MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Take CILIDIN O 20MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

WARNING & PRECAUTIONS

PREGNANCY

CILIDIN O 20MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking CILIDIN O 20MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with this medicine, stop taking it and consult your doctor immediately.

BREASTFEEDING

CILIDIN O 20MG TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking CILIDIN O 20MG TABLET.

ALCOHOL

Avoid consumption of alcohol while taking CILIDIN O 20MG TABLET as it might make you feel dizzier and drowsier.

KIDNEY

CILIDIN O 20MG TABLET should be used with caution in patients with kidney problems (such as kidney transplant, narrowing of renal arteries). Therefore, consult your doctor before taking it.

LIVER

CILIDIN O 20MG TABLET is not recommended for use in patients with severe liver impairment (such as cholestasis, jaundice, biliary obstruction). It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take CILIDIN O 20MG TABLET if you are allergic to Cilnidipine or Olmesartan.

HEART DISEASE

CILIDIN O 20MG TABLET should be used with caution in patients with heart problems (such as irregular heart rhythm, heart failure, recent heart attack, and problems with heart muscle or valves). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking CILIDIN O 20MG TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to treat elevated blood pressure (such as aliskiren, captopril, enalapril, lisinopril, verapamil, diltiazem, losartan, valsartan)
• lithium, St. John’s wort (medicines used to treat depression)
• potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
• non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
• colesevelam (a medicine used to treat high blood cholesterol levels)
• antacids (medicines used to neutralize stomach acid) Ex. aluminium hydroxide, magaldrate
• medicines used to treat mental disorders such as depression, psychosis, or anxiety (Ex. pimozide, amisulpride, haloperidol)
• aldesleukin (a medicine used to treat kidney cancer)
• quinidine (a medicine used to treat abnormal heart rhythm)
• phenytoin (a medicine used to treat epilepsy)
• rifampicin (a medicine used to treat tuberculosis)
• erythromycin (a medicine used to treat bacterial infection)

Overdosage:

If you or anyone else accidentally took more CILIDIN O 20MG TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, and dizziness.

SYNOPSIS

MORE INFORMATION

• Keep CILIDIN O 20MG TABLET out of reach of children
• Store CILIDIN O 20MG TABLET at room temperature

FAQs ABOUT CILIDIN O 20MG TABLET

What are the uses of CILIDIN O 20MG TABLET?

CILIDIN O 20MG TABLET is used to treat hypertension in adults.

What type of a medicine is CILIDIN O 20MG TABLET?

CILIDIN O 20MG TABLET is an antihypertensive medicine. It is a combination of two medicines namely Cilnidipine and Olmesartan. Cilnidipine is a calcium channel blocker and Olmesartan is an angiotensin-II receptor blocker. They both reduces strain on the heart, relaxes blood vessels and makes the heart to pump more blood with lesser force.

What happens when I stop taking CILIDIN O 20MG TABLET?

Do not stop taking CILIDIN O 20MG TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take CILIDIN O 20MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results.

What is the best time to take CILIDIN O 20MG TABLET?

CILIDIN O 20MG TABLET can be taken with or without meals. Your doctor will decide the best time for you to take CILIDIN O 20MG TABLET based on your age, body weight and disease condition.

What to do if I forgot to take a dose of CILIDIN O 20MG TABLET?

If you forgot to take a dose of CILIDIN O 20MG TABLET, take it as soon as you remember. However, if it is time for the next dose of CILIDIN O 20MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of CILIDIN O 20MG TABLET to compensate the missed ones.

What precautions should be followed while taking CILIDIN O 20MG TABLET?

Before taking CILIDIN O 20MG TABLET, inform your doctor if you have any heart, liver or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure volume or are severely dehydrated. Stop taking CILIDIN O 20MG TABLET and consult your doctor immediately if you become pregnant. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.

Can I consume alcohol while taking CILIDIN O 20MG TABLET?

Avoid consumption of alcohol while taking CILIDIN O 20MG TABLET as it might make you feel dizzier and drowsier.

What happens if I accidentally take more CILIDIN O 20MG TABLET?

If you or anyone else accidentally took more CILIDIN O 20MG TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, fainting, drowsiness, nausea, vomiting or confusion.

Can I take CILIDIN O 20MG TABLET daily?

Take CILIDIN O 20MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take CILIDIN O 20MG TABLET every day or not.

Is CILIDIN O 20MG TABLET safe to use in diabetic patients?

CILIDIN O 20MG TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking CILIDIN O 20MG TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.

What are the side effects of CILIDIN O 20MG TABLET?

The most common side effects of taking CILIDIN O 20MG TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles, and flushing. Contact your doctor if any of these side effect worsens.

Can I stop taking CILIDIN O 20MG TABLET once my symptoms subside?

No. Do not stop taking CILIDIN O 20MG TABLET without consulting your doctor. As hypertension is a chronic condition, long term treatment may be necessary to control its symptoms. Therefore, take CILIDIN O 20MG TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.

Can CILIDIN O 20MG TABLET be taken during pregnancy?

CILIDIN O 20MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking CILIDIN O 20MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with CILIDIN O 20MG TABLET, stop taking it and consult your doctor immediately.

Is CILIDIN O 20MG TABLET safe to use in kidney disease?

CILIDIN O 20MG TABLET should be used with caution in patients with kidney diseases (such as those having renal artery stenosis, kidney transplant or in those undergoing haemodialysis). Your doctor will access your health condition and suggest a suitable dose for you. Therefore, it is important to inform your doctor if you have any kidney problems before taking CILIDIN O 20MG TABLET as a precaution.

Can the use of CILIDIN O 20MG TABLET affect the liver?

Yes. CILIDIN O 20MG TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.

REFERENCES

1. KD. Tripathi. Antihypertensive drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 561 &562.

2. Rabindra Nath Chakraborty, Deepak Langade, Shyam More, Vaibhav Revandkar, and Ashish Birla. Efficacy of Cilnidipine (L/N-type Calcium Channel Blocker) in Treatment of Hypertension: A Meta-Analysis of Randomized and Non-randomized Controlled Trials. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2021. [Accessed on 24th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695827/#:~:text=In%20this%20study%2C%20Cilnidipine%20caused,after%20six%20months%20%5B13%5D.

3. Xiaoshen Zhang, Han Zhang, Yuxia Ma, Wenliang Che, and Michael R. Hamblin. Management of Hypertension Using Olmesartan Alone or in Combination. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March 2017. [Accessed on 24th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446820/

4. Centaur Pharma. CENTAPRES® Tablets. [Accessed on 24th December 2022] https://www.centaurpharma.com/downloads/CENTAPRES.pdf

5. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 24th December 2022] https://www.medicines.org.uk/emc/files/pil.9886.pdf

6. Alkem Labs. Cilnikem OM. Cilnidipine and Olmesartan Medoxomil Tablet. [Revised in March 2017] [Accessed on 24th December 2022] https://www.alkemlabs.com/pdf/adverse/Cilnikem%20OM.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney Function Test

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 24 Dec 2022 | 05:47 PM(IST)