INTRODUCTION

CILACAR C 6.25MG TABLET is a combination of Chlorthalidone and Cilnidipine which belongs to the group of medicines called Antihypertensive agents. It is used to treat essential hypertension.

Hypertension also known as high or raised blood pressure, is a condition in which the blood vessels have persistently raised pressure. Blood is carried from the heart to all parts of the body in the vessels. Each time the heart beats, it pumps blood into the vessels. Blood pressure is created by the force of blood pushing against the walls of blood vessels (arteries) as it is pumped by the heart. The higher the pressure, the harder the heart has to pump.

During the course of treatment your doctor might regularly monitor your blood pressure, kidney function and electrolyte balance at regular intervals to avoid any untoward side effects.

CILACAR C 6.25MG TABLET is not recommended for use in patients with liver, kidney, and heart disease and it should be used in caution with patient having diabetes.

CILACAR C 6.25MG TABLET is not intended for use in the pregnant and breast-feeding woman. Consult your doctor before taking the medicine.

As safety and efficacy in children has not been established, consult your doctor about the risk and benefits before taking CILACAR C 6.25MG TABLET.

It should be used with caution in elderly patients. The most common side effects of taking CILACAR C 6.25MG TABLET are dizziness, nausea, headache, constipation, fever and chills. Consult your doctor if the above-mentioned side effects are not improving.

USES OF CILACAR C 6.25MG TABLET

• Used to treat essential hypertension (high blood pressure)

HOW CILACAR C 6.25MG TABLET WORKS

CILACAR C 6.25MG TABLET effectively reduces the blood pressure where Chlorthalidone acts by enhancing excretion of sodium (which is necessary for constriction of blood vessels) and water from the body causing blood vessels to relax and Cilnidipine makes the blood vessels to relax and thus lowers the blood pressure by blocking the calcium entry in blood vessels which is necessary for the smooth muscle contraction.

DIRECTIONS FOR USE

Take CILACAR C 6.25MG TABLET as advised by your physician. Swallow this medicine with a glass of water and do not crush or chew the medicine. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.

SIDE EFFECTS OF CILACAR C 6.25MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea or Vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks, and drinks. Try to avoid drinking too much liquid along with your meals, drink slowly in between meals. Consult your doctor for advice.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly.

Dizziness:

Lie, or sit down immediately when you feel dizzy. If you're feeling a severe episode of dizziness, lie in a dark and quite place with eyes closed. Discuss with your doctor.

Headache:

Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage the scalp or head with mild pressure. Consult your doctor for advice.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking CILACAR C 6.25MG TABLET inform your doctor if you are taking any of the following medicine:

• other antihypertensive medicines (Ex. telmisartan, losartan, captopril)
• digoxin (medicine used to treat heart failure and abnormal heart rhythm)
• cimetidine (medicine used for stomach ulcer)
• rifampicin (medicine used to treat tuberculosis)
• itraconazole, miconazole (medicines used to treat fungal infections)

B.  Drug - Food interaction:

Avoid drinking grapefruit juice while taking CILACAR C 6.25MG TABLET as it may increase the levels of this medicine in body.

Overdosage:

If you or anyone else accidentally takes too much of CILACAR C 6.25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage includes low blood pressure, dizziness, nausea, sleepiness, and electrolyte disturbances associated with cardiac arrhythmias (irregular heartbeat) and muscle stiffness.

SYNOPSIS

MORE INFORMATION

• Keep CILACAR C 6.25MG TABLET out of reach of children
• Store at a temperature not exceeding 30°C

FAQs ABOUT CILACAR C 6.25MG TABLET

Q: What is CILACAR C 6.25MG TABLET used for?

A: CILACAR C 6.25MG TABLET is a combination of Chlorthalidone and Cilnidipine. It is used in the treatment of essential hypertension in adults.

Q: Is CILACAR C 6.25MG TABLET safe in pregnant and breast-feeding women?

A: CILACAR C 6.25MG TABLET is not intended for use in pregnant and breast-feeding woman as it may pass through the breastmilk to the baby. Consult your doctor about the risk and benefits before taking it.

Q: Is CILACAR C 6.25MG TABLET safe for use in elder patients?

A: CILACAR C 6.25MG TABLET should be used with caution in elder patients of 65 years and above. Your doctor will decide the correct dose and duration of the treatment with CILACAR C 6.25MG TABLET for you along with regular monitoring.

Q: Does CILACAR C 6.25MG TABLET can be taken by patients with kidney and liver disease?

A: CILACAR C 6.25MG TABLET is not recommended for use in patients with kidney and liver failure. It should be used with caution in patients having progressive liver disease. Consult your doctor before taking CILACAR C 6.25MG TABLET.

Q: Does CILACAR C 6.25MG TABLET cause dizziness?

A: Yes, it may cause dizziness. Lie, or sit down immediately when you feel dizzy. If you're feeling a severe episode of vertigo, lie in a dark and quite place with eyes closed. Talk to your doctor if the symptom does not improve.

REFERENCES

1. KD. Tripathi. Diuretics. Essentials of medical pharmacology. Eighth edition. 2019. Page – 630-632.

2. Connor C. Kerndt; Jayesh B. Patel. Chlorthalidone. National Library of Medicine, National center for biotechnology information. Revised in May 2022. [Accessed 8th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK553174/#:~:text=Mechanism%20of%20Action,-Chlorthalidone%20exerts%20its&text=Chlorthalidone%20inhibits%20sodium%20reabsorption%20at,retains%20a%20higher%20sodium%20content.

3. Paul Muntner, PhD,  Emily B. Levitan, PhD,  Amy I. Lynch, PhD,  Lara M. Simpson, PhD, Jeffrey Whittle, MD,  Barry R. Davis, MD, PhD,  John B. Kostis, MD,  Paul K. Whelton, MD, and Suzanne Oparil, MD . Effect of Chlorthalidone, Amlodipine, and Lisinopril on Visit-to-Visit Variability of Blood Pressure: Results From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. National Library of Medicine, National center for biotechnology information. PubMed Central. Revised in May 2014. [Accessed 8th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141643/

4. J. B. Chemicals & Pharmaceuticals Ltd.  [Revised in November 2021] [Accessed 8th May 2022] https://jbpharma.com/wp-content/uploads/2021/11/CILACAR-C-12.5_PI_India_November-2021.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney function test