INTRODUCTION

CHANNEL 30MG contains Diltiazem which belongs to a group of medicines called calcium-channel blockers. It is used to treat high blood pressure and angina. It works by making your blood vessels wider. This helps to lower your blood pressure and also makes it easier for your heart to pump blood around the body. It also helps to prevent the chest pain caused by angina. Angina pectoris is a type of chest pain caused due to an inadequate supply of oxygen to the heart muscle.

The most common side effect of taking this medicine are nausea, vomiting, stomach pain, constipation, feeling dizzy or headache. This medicine is strictly not recommended for use in children. Consult your doctor before taking. It is advisable to limit the amount of grapefruit juice you drink while taking this medicine, as it can increase the blood levels of diltiazem and increases toxicity. Do not take this medicine if you are a pregnant or breastfeeding woman. Consult your doctor for advice before taking any medicine.

USES OF CHANNEL 30MG

• treat (long-term) and prevent angina pectoris
• treat mild to moderate high blood pressure

HOW CHANNEL 30MG WORKS

Diltiazem is a slow calcium channel blocker that binds to the extracellular site of the alpha-1C subunit of the channel. It inhibits the entry of extracellular calcium across the myocardial and vascular smooth muscle cell membranes. The reduced intracellular calcium concentrations will increase smooth muscle relaxation, resulting in arterial vasodilation and therefore, decrease blood pressure. It also increases the supply of blood and oxygen to the heart.

DIRECTIONS FOR USE

Always take CHANNEL 30MG as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the dose and duration depending upon your condition.  Limit the amount of grapefruit juice you drink while taking this medicine, as it can increase the blood levels of diltiazem and may increase your chance of getting side effects.

SIDE EFFECTS OF CHANNEL 30MG

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after, a meal and stick to simple meals and do not eat rich or spicy food.

Constipation:

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Skin redness:

Avoid hot showers or baths because hot water can irritate the skin. Moisturizers can be used regularly to soothe and hydrate the affected area.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• dantrolene or cilostazol (used for severe muscle spasms)
• ivabradine (used to treat certain heart diseases)
• other medicines used to treat high blood pressure such as doxazosin, tamsulosin, atenolol, propranolol or acebutolol
• medicines used to treat arrhythmia (uneven heartbeat) such as amiodarone and digoxin
• other medicines used for angina (such as glyceryl trinitrate or isosorbide trinitrate)
• medicines used to treat high levels of cholesterol (simvastatin, fluvastatin and atorvastatin)
• ciclosporin (used to stop graft rejection)
• medicine used to treat epilepsy (e.g. phenytoin and carbamazepine)
• medicines used to stop blood clotting (aspirin or clopidogrel)
• theophylline (used to treat breathing problems)
• lithium (used to treat depression)
• medicines used for anxiety (triazolam or midazolam)
• methylprednisolone (used to treat inflammation)
• rifampicin used to treat tuberculosis

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT CHANNEL 30MG

Can CHANNEL 30MG cause dizziness?

Yes. This medicine may cause dizziness in some individuals, although not everybody gets them. Do not drive or operate any tools or machines if this medicine may make you feel dizzy.

What CHANNEL 30MG is used for?

It is used to treat high blood pressure and angina.

Can CHANNEL 30MG be used during pregnancy?

No. This medicine is strictly not recommended for use in pregnant women. Consult your doctor before taking.

REFERENCES

1. KD. Tripathi. Antiarrhythmic Drugs. Antianginal and Other Anti-ischemic Drugs. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 536, 548-549, 562-563

2. Thomas Michel and Brian B. Hoffman. Treatment of myocardial ischemia and hypertension. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 755 – 760 and 776-777.

3. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1184-1186.

4. Hospital de la Mujer. Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on January 2020] [Accessed 19th November 2020] https://clinicaltrials.gov/ct2/show/NCT04222855

5. Luis Rodríguez Padial, Gonzalo Barón-Esquivias, Antonio Hernández Madrid, Domingo Marzal Martín, Vicente Pallarés-Carratalá, and Alejandro de la Sierra. Clinical Experience with Diltiazem in the Treatment of Cardiovascular Diseases. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2016. [Accessed 19th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906086/

6. Sanofi Winthrop Industrie. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 19th November 2020] https://www.medicines.org.uk/emc/files/pil.4969.pdf

7. Bard Pharmaceuticals Limited. Electronic Medicines Compendium (EMC); [Revised on October 2020] [Accessed 19th November 2020] https://www.medicines.org.uk/emc/files/pil.1012.pdf

8. Sanofi Winthrop Industrie. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 19th November 2020] https://www.medicines.org.uk/emc/files/pil.1465.pdf

9. Accord. Electronic Medicines Compendium (EMC); [Revised on October 2019] [Accessed 19th November 2020] https://www.medicines.org.uk/emc/files/pil.5774.pdf