INTRODUCTION

CETJOINT SG CAPSULE is a combination of Calcitriol, Calcium carbonate and Zinc sulphate which belongs to the group of medicines called Nutritional supplements. It is used in adults for the management of low blood calcium levels in conditions including chronic renal failure, osteodystrophy (bone pain, joint pain, bone deformation and fractures due to kidney disease or disturbances in calcium and phosphorus levels), osteoporosis (bones become weak and brittle as we age).

CETJOINT SG CAPSULE is also used to treat hypoparathyroidism (changes to parathyroid glands that may decrease the blood calcium too low, rickets or osteomalacia (softening and weakening of bones in children and adults respectively due to lack of adequate vitamin D), after small bowel resection and psoriasis (a disease in which skin becomes dry with itchy, scaly patches, most commonly on the knees, elbows, trunk and scalp).

Avoid taking CETJOINT SG CAPSULE within 2 hours of eating foods rich in oxalic acid (Ex. spinach and rhubarb), phosphate (Ex. brain) or phytic acid (Ex. whole cereals). CETJOINT SG CAPSULE is not recommended for patients having diseases and/or conditions resulting in hypercalcaemia and/or hypercalciuria (ex. myeloma, bone metastases, primary hyperparathyroidism) and hypervitaminosis D.

CETJOINT SG CAPSULE should be used with caution in patients with impaired liver function and kidney problems such as nephrolithiasis, nephrocalcinosis and renal failure. CETJOINT SG CAPSULE is generally not recommended for use in pregnant women, children and adolescents unless considered necessary. CETJOINT SG CAPSULE should be avoided in breastfeeding women. CETJOINT SG CAPSULE should be used with caution in elderly patients.

The common side effects of CETJOINT SG CAPSULE are muscle pain, weakness, headache, excessive sleepiness, nausea and vomiting and dry mouth. If any of these become worsen, contact your doctor.

USES OF CETJOINT SG CAPSULE

Treats the following conditions in adults:

• Chronic renal failure
• Renal osteodystrophy
• Osteoporosis
• Hypoparathyroidism
• Parathyroidectomy
• Vitamin d-dependent rickets
• Osteocalcaemia
• Hypocalcaemia and hypomagnesaemia after small bowel resection
• Psoriasis

HOW CETJOINT SG CAPSULE WORKS

CETJOINT SG CAPSULE is a combination of Calcitriol that acts as an active form of vitamin D3 (cholecalciferol) for the absorption of calcium from the stomach and the functioning of calcium in the body. Calcium carbonate works as a nutritional supplement to directly increase the calcium stores within the body and zinc sulphate counteracts the diminished calcitriol response to arrest bone loss. All these actions together will increase the levels of calcium, which is useful in treating bone disorders and disturbances in the parathyroid glands.

DIRECTIONS FOR USE

Take CETJOINT SG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. The correct dose and duration for you will be decided by your doctor, depending on your age, body weigh and disease condition.

SIDE EFFECTS OF CETJOINT SG CAPSULE

HOW TO MANAGE SIDE EFFECTS

Constipation:

Consume more fiber-rich foods, such as fresh fruits, vegetables and cereals, in your diet and drink plenty of water. Exercise more regularly. In the event of no improvement, consult your doctor.

Diarrhoea:

Drink more fluids, such as water, fruit juice or coconut water, to keep yourself hydrated. In the event of no improvement, consult your doctor.

Stomach pain:

Take a break to relax. Try to eat and drink slowly or have smaller, more frequent meals. Place a heating pad on your stomach. In case of no improvement, consult your doctor.

Flatulence:

Eat smaller and more frequent meals. Eat and drink slowly and exercise regularly. If you still see no improvement, contact your doctor.

Nausea or vomiting:

Take this medicine with meals or just after meals. Stick to simple meals and avoid oil-rich or spicy foods. In case of no improvement, consult your doctor.

Headache:

Try to relax and rest yourself. Apply pain balm to the head to ease the pain. Sip on some hot water or ginger tea. In case of no improvement, contact your doctor for advice.

WARNING & PRECAUTIONS

PREGNANCY

CETJOINT SG CAPSULE is generally not recommended for use in pregnant women unless considered necessary. Consult your doctor for advice.

BREASTFEEDING

CETJOINT SG CAPSULE is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor for advice.

KIDNEY

CETJOINT SG CAPSULE should be used cautiously in patients having kidney problems such as nephrolithiasis, nephrocalcinosis and renal failure. Consult your doctor for advice.

LIVER

CETJOINT SG CAPSULE should be used with caution in patients with impaired liver function. Consult your doctor for advice.

ALLERGY

Do not take CETJOINT SG CAPSULE if you are allergic to Calcitriol, Calcium Carbonate or Zinc Sulphate.

INTERACTIONS

A. Drug-Drug interactions:  

Before taking CETJOINT SG CAPSULE, inform your doctor if you are taking any of the following medicine:

• medicines used to clear fluid from the body [Ex. chlorothiazide, chlorthalidone, hydrochlorothiazide, indapamide and metolazone]
• medicines used to suppress the immune system [Ex. cortisone, prednisone and prednisolone]
• digoxin (used in the treatment of heart problems)
• cholestyramine (used to lower high cholesterol levels in blood
• paraffin oil (used to treat constipation)
• levothyroxine (used to treat an underactive thyroid gland)
• medicines used in the treatment of bacterial infections [Ex. tetracycline, sparfloxacin, ofloxacin, penicillamine, norfloxacin]
• medicines used to treat epilepsy [Ex. carbamazepine, phenobarbital, phenytoin, primidone]
• ketoconazole (used to treat fungal infections)

B. Drug-Food interaction:

Avoid taking CETJOINT SG CAPSULE within 2 hours of eating foods rich in oxalic acid (Ex. spinach and rhubarb), phosphate (Ex. bran) or phytic acid (Ex. whole cereals).

Overdosage:

If you or anyone else accidentally take too much of CETJOINT SG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, severe vomiting, dehydration and restlessness.

SYNOPSIS

MORE INFORMATION

• Keep CETJOINT SG CAPSULE out of reach from children
• Store at room temperature

FAQs ABOUT CETJOINT SG CAPSULE

Q: What is the use of CETJOINT SG CAPSULE?

A: CETJOINT SG CAPSULE is used in the treatment of hypocalcaemia, rickets or osteomalacia, hypophosphatemia, hypoparathyroidism, osteodystrophy and osteoporosis to increase blood calcium. It also maintains the balance of calcium and phosphate metabolism in the body.

Q: Does CETJOINT SG CAPSULE have vitamin D?

A: Yes, CETJOINT SG CAPSULE contains calcitriol, which acts as an active form of fat-soluble vitamin D. It helps increase intestinal absorption of calcium and acts as a regulator of calcium and phosphate metabolism.

Q: What are the side effects of CETJOINT SG CAPSULE?

A: CETJOINT SG CAPSULE may cause constipation, nausea, loss of appetite, feeling thirsty, bone pain, stomach pain, frequent urination and muscle weakness due to its effect on the blood calcium level. If any of these symptoms bother you, consult your doctor immediately.

Q: Is CETJOINT SG CAPSULE good for health?

A: CETJOINT SG CAPSULE contains vitamin D and calcium, which help strengthen bones and improve the overall quality of bones. Calcium is also required for the optimal functioning of muscles, the nervous system and the heart. Hence, taking this medicine is good for your overall health.

Q: How do I take CETJOINT SG CAPSULE?

A: Always take CETJOINT SG CAPSULE as instructed by your doctor and continue to follow any advice about diet recommended by your doctor. Do not stop taking the medicine suddenly because the symptoms may return.

REFERENCES

1. KD Tripathi. Drugs affecting calcium balance. Essentials of medical pharmacology. Eighth edition. 2019. Page – 361, 362, 368.

2. Lung BE, Mowery ML, Komatsu DEE. Calcitriol. National Library of Medicine. [Revised in November 2021] [Accessed on 24th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK526025/

3. Ciplamed. Calzem capsules. [Revised in November 2013] [Accessed on 24th June 2022] https://www.ciplamed.com/content/calzem-capsules

4. DM pharma. Caldific CZ. [Accessed on 24th June 2022] https://www.dmpharma.co.in/Calcium%20carbonate,%20Zinc%20&%20Calcitriol%20Soft%20Gelatin%20Capsule.html

USEFUL DIAGNOSTIC TESTS

• Serum calcium
• Serum alkaline phosphatase
• Serum creatinine

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 23 Jan 2023 | 05:44 PM(IST)