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Drug Information

What is Everolimus used for?

Everolimus is used to prevent the rejection of transplanted organ in patients who have undergone a kidney, liver or heart transplant. Transplant rejection occurs when the organ recipient’s immune system attacks the transplanted organ.

Everolimus helps prevent transplant rejection by suppressing the immune system. Everolimus belongs to the group of drugs called anti-rejection medications. Everolimus is used in combination with other medicines to prevent transplant rejection in organ transplant patients. Everolimus may also be used to treat other conditions as determined by your doctor.

How to take Everolimus?

The dosage of Everolimus may vary based on the patient’s age, gender, body weight, medical condition and response to treatment. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Swallow the Everolimus tablets whole with a full glass of water. Do not crush or chew the Everolimus tablets.

Always take Everolimus tablets in the same way everyday, either with or without food.

To note:Do not take Everolimus with grapefruit juice.

If your physician has instructed or directed you to take Everolimus medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose.

Any medication taken in excess can have serious consequences. If you suspect an overdose of Everolimus, seek medical attention immediately.

What are the drugs that interact with Everolimus?

  • Amprenavir
  • Carbamazepine
  • Clarithromycin
  • Dexamethasone
  • Diltiazem
  • Efavirenz
  • Erythromycin
  • Fluconazole
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Midazolam
  • Nelfinavir
  • Rifabutin
  • Rifampicin
  • St John’s Wort
  • Verapamil

It may be noted that drugs other than those listed above may also interact with Everolimus.

Everolimus can interact with the following types of medicines: antibiotics, antifungal medicines, high blood pressure medicines, heart medicines, epilepsy medicines, HIV/AIDS medicines and cholesterol-lowering medications. Avoid eating grapefruit or drinking grapefruit juice as well.

Make sure to inform your doctor if you are taking any of the above-mentioned medicines.

Usually drug interactions may occur when certain drugs are taken together. Before you take a medication for a particular ailment, you should inform the health expert about intake of any prescription medications, over-the-counter products (non-prescription medications) and dietary supplements like vitamins, minerals and herbals, which may increase the effect of Everolimus. This information can help your doctor to warn you of any possible drug interactions.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. It is also important to tell your healthcare professional if you have any medical conditions or a family history of any medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Everolimus?

Like other medicines, Everolimus can cause some side effects. If they do occur, the side effects of Everolimus are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Everolimus cannot be anticipated. If any side effects of Everolimus develop or change in intensity, the doctor should be informed as soon as possible.

Everolimus can cause side effects such as :

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Acne
  • Impotence
  • Difficulty sleeping
  • Dizziness
  • Headache
  • Joint pain
  • Hypertension
  • Diabetes and cough

This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Everolimus.

What are the questions to ask your doctor before taking Everolimus?

Is it possible for me to take Everolimus with other drugs?
Should certain beverages, foods and other products be avoided when I take Everolimus?
What are the possible drug interactions of Everolimus?
How will Everolimus work in my body?
How should Everolimus be taken?
How to reduce the risk of Everolimus drug interactions and side effects?

What other important information should you know about Everolimus?

Before taking Everolimus tablets, make sure to tell your doctor if you have

  • high blood sugar
  • liver problems
  • high cholesterol
  • skin cancer or a family history of skin cancer
  • galactose intolerance
  • Lapp lactase deficiency.

- Also inform your doctor if you are taking any other medicines that suppress your immune system, or if you have recently received a live vaccine.
- While taking Everolimus, avoid receiving any live vaccines.
- Be sure to tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.
- Avoid becoming pregnant when taking Everolimus.
- Also, let your doctor know if you are allergic to Everolimus, or if you have ever had an allergic reaction to any other medicines.
- Avoid prolonged exposure to sunlight while on treatment with Everolimus.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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