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Celdaz 500Mg Injection 1's
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INTRODUCTION
CELDAZ 500MG INJECTION contains Dacarbazine which belongs to the group of medicines called Anticancer Agents. It is used to treat certain types of skin cancer (such as metastatic melanoma) and lymph cancer (such as Hodgkin’s disease). It can also be used in the treatment of soft tissue sarcoma (cancer of connective tissues).
Before receiving CELDAZ 500MG INJECTION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have low WBC and platelet counts in blood, or currently receiving radiotherapy as a precaution. Avoid consumption of alcohol while undergoing therapy with this medicine.
CELDAZ 500MG INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with this medicine and until 6 months after the last dose.
The common side effects associated with the use of CELDAZ 500MG INJECTION are nausea, vomiting, flu-like symptoms, nerve damage and low RBC, WBC and platelet counts causing tiredness, pale skin, increased infections, fever, sore throat, chills and increased bleeding or bruising. Consult your doctor if any of these side effects trouble you.
USES OF CELDAZ 500MG INJECTION
It is used to treat:
- Skin cancer (metastatic melanoma)
- Lymph cancer (Hodgkin’s disease)
- Soft tissue sarcoma (cancer of connective tissues passing between muscles, fat, blood vessels and supporting tissues)
HOW CELDAZ 500MG INJECTION WORKS
CELDAZ 500MG INJECTION is an anticancer medication. It works by damaging the cellular genetic material (DNA). This interferes with the functions of DNA and stops cancer cells from multiplying. Therefore, it prevents abnormal cell division within the body and decreases cancer progression.
DIRECTIONS FOR USE
CELDAZ 500MG INJECTION will be given to you only by a doctor specialized in oncology or haematology into the vein (intravenously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CELDAZ 500MG INJECTION
COMMON
- signs of anaemia (reduced red blood cell count) such as paleness, fatigue, shortness of breath, or mouth ulcers
- signs of leukopenia (low white blood cell count) such as fever, chills, sore throat, and mouth ulcers
- signs of thrombocytopenia (deficiency platelets in the blood) such as unusual bruising and bleeding
- anorexia (an eating disorder cause fear of weight gain)
- nausea
- vomiting
UNCOMMON
- increased rate of infections
- alopecia (abnormal hair loss)
- hyperpigmentation (skin darkening)
- sensitivity to light
RARE
- irritation at the site of injection
Consult your doctor immediately if you experience any of the following side effects after receiving CELDAZ 500MG INJECTION:
- signs of increased infections such as fever and sore throat
- increased bleeding tendency, bruising, extreme tiredness
- persistent or severe diarrhea or vomiting
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing, fainting)
- yellowing of the skin and whites of the eyes
- signs of brain problems (such as headache, vision impairment, tiredness, fits, confusion, tingling or numbness of the face)
- signs of a liver dysfunction such as abnormal urine/stool, nausea, vomiting, or yellowing of skin/eyes
HOW TO MANAGE SIDE EFFECTS
Nausea And Vomiting
Expose yourself to fresh air. Drink plenty of water or fruit juices and take lot of rest. Avoid listening to music or watching a screen. Keep regular fluid intake. Prefer taking ginger or peppermint tea. Eat small and frequent meals.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedCELDAZ 500MG INJECTION is not recommended for use in pregnant women as it may harm the growing baby. Therefore, inform your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with CELDAZ 500MG INJECTION and until 6 months after stopping the therapy. If you accidentally became pregnant while receiving CELDAZ 500MG INJECTION, inform your doctor immediately.
BREASTFEEDING
ContraindicatedCELDAZ 500MG INJECTION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any heavy tools or machines if you experience dizziness, nausea, or vomiting after receiving CELDAZ 500MG INJECTION.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while undergoing therapy with CELDAZ 500MG INJECTION.
KIDNEY
Consult your doctorCELDAZ 500MG INJECTION is not recommended for use in patients with severe kidney diseases. It should be used with caution in patients with mild or moderate kidney problems. Therefore, inform your doctor before receiving it.
LIVER
Consult your doctorCELDAZ 500MG INJECTION is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with mild or moderate liver problems. Therefore, inform your doctor before receiving it.
ALLERGY
ContraindicatedTalk to your doctor before receiving CELDAZ 500MG INJECTION if you are allergic to dacarbazine.
USE IN PEDIATRICS
ContraindicatedCELDAZ 500MG INJECTION is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.
USE IN GERIATRICS
Use with CautionCELDAZ 500MG INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
OTHERS
CELDAZ 500MG INJECTION is not recommended for use if you:
- have leukopenia (low count of white blood cells)
- have thrombocytopenia (low blood platelet count)
- are scheduled for a live vaccine immunization
Before receiving CELDAZ 500MG INJECTION, inform your doctor if you:
- are currently undergoing radiation therapy
INTERACTIONS
A. Drug-Drug Interactions:
Before receiving CELDAZ 500MG INJECTION, inform your doctor, if you are taking any of the following medicine:
- cytostatic agents (medicine used to stop the cell growth in cancer patients) Ex. paclitaxel, cisplatin
- diazepam (a medicine used to treat anxiety and to induce sleep)
- imipramine (a medicine used to treat depression)
- ketoconazole (a medicine used to treat fungal infections)
- medicines used to treat fits (such as phenytoin and carbamazepine)
- methoxypsoralen (medicine used to treat severe psoriasis)
- oral anticoagulants (medicine used to delay blood clotting) Ex. dabigatran
- cyclosporine or tacrolimus (medicines used to prevent organ rejection post-transplant)
- fotemustine (another medicine used to treat metastatic melanoma)
- radiotherapy or live vaccines
Overdosage:
CELDAZ 500MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual side effects.
SYNOPSIS
| Drug | : | Dacarbazine |
| Pharmacological Category | : | Alkylating agents |
| Therapeutic Indication | : | malignant melanoma, Hodgkin’s disease, soft tissue sarcomas |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep CELDAZ 500MG INJECTION out of reach of children
- Before opening: Store CELDAZ 500MG INJECTION at room temperature
- After opening: Store CELDAZ 500MG INJECTION in a refrigerator between 2-8°C
FAQs ABOUT CELDAZ 500MG INJECTION
Q: What CELDAZ 500MG INJECTION is used for?
A: CELDAZ 500MG INJECTION is used to treat certain types of skin cancer (such as metastatic melanoma) and lymph cancer (such as Hodgkin’s disease). It can also be used in the treatment of soft tissue sarcoma (cancer of connective tissues).
Q: What side effects are seen with CELDAZ 500MG INJECTION?
A: The common side effects associated with the use of CELDAZ 500MG INJECTION are nausea, vomiting, flu-like symptoms, nerve damage and low RBC, WBC and platelet counts causing tiredness, pale skin, increased infections, fever, sore throat, chills and increased bleeding or bruising. Consult your doctor if any of these side effects trouble you.
Q: Who should avoid receiving CELDAZ 500MG INJECTION?
A: CELDAZ 500MG INJECTION is not recommended for use in pregnant and/or breastfeeding women. It is also not recommended for use in patients suffering from leukopenia (low white blood cell count), thrombocytopenia (low blood platelet count), severe liver disease, or severe kidney diseases. Therefore, consult your doctor before receiving it.
Q: Is CELDAZ 500MG INJECTION safe for use in children?
A: CELDAZ 500MG INJECTION is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.
Q: Can I consume alcohol while undergoing therapy with CELDAZ 500MG INJECTION?
A: Avoid consumption of alcohol while undergoing therapy with CELDAZ 500MG INJECTION as it could lead to unwanted side effects.
Q: Is it safe to drive or use machinery while receiving CELDAZ 500MG INJECTION?
A: Do not drive or operate any heavy tools or machines if you experience dizziness, nausea, or vomiting after receiving CELDAZ 500MG INJECTION.
Q: How CELDAZ 500MG INJECTION works?
A: CELDAZ 500MG INJECTION is an anticancer medication. It works by damaging the cellular genetic material (DNA). This interferes with the functions of DNA and stops cancer cells from multiplying. Therefore, it prevents abnormal cell division within the body and decreases cancer progression.
Q: How CELDAZ 500MG INJECTION is administered?
A: CELDAZ 500MG INJECTION will be given to you only by a doctor specialized in oncology or haematology into the vein (intravenously).
Q: Can CELDAZ 500MG INJECTION increase the risk of infections?
A: CELDAZ 500MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving CELDAZ 500MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.
Q: Can CELDAZ 500MG INJECTION cure cancer?
A: The cure rate of cancer depends upon the severity of the disease. However, CELDAZ 500MG INJECTION acts by preventing the abnormal growth and multiplication of cancer cells in the body, which may help in curing cancer completely.
Q: Can the use of CELDAZ 500MG INJECTION cause hair loss?
A: Hair loss is one of the uncommon side effects of receiving CELDAZ 500MG INJECTION. This side effect is usually temporary and disappears once after therapy with this medicine stops completely. If it bothers you, consult your doctor for advice.
Q: Is CELDAZ 500MG INJECTION a chemo drug?
A: Yes. CELDAZ 500MG INJECTION contains a medicine called Dacarbazine which is a chemotherapeutic agent. It stops abnormal growth and multiplication of cancer cells in the body.
Q: What happens if I stop undergoing therapy with CELDAZ 500MG INJECTION?
A: No. Do not stop therapy with CELDAZ 500MG INJECTION without consulting your doctor as it may make your symptoms reappear. Therefore, take CELDAZ 500MG INJECTION as advised by your doctor for the stipulated duration.
Q: Can the use of CELDAZ 500MG INJECTION make me feel tired?
A: Yes. CELDAZ 500MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after taking CELDAZ 500MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.
Q: How to control nausea caused due to CELDAZ 500MG INJECTION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with CELDAZ 500MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.
REFERENCES
1. KD. Tripathi. Anticancer Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 861.
2. Jun Ho Yi, Seong Yoon Yi, Hye Ran Lee, Soon Il Lee, Do Hyoung Lim, Jung Han Kim, Keon Woo Park, Jeeyun Lee. Dacarbazine-based chemotherapy as first-line treatment in noncutaneous metastatic melanoma: multicenter, retrospective analysis in Asia. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. June 2011. [Accessed on 30th March 2023] https://pubmed.ncbi.nlm.nih.gov/21471822/
3. Medac GmbH. Dacarbazine Citrate. Electronic Medicines Compendium. [Revised in July 2020]. [Accessed on 1st April 2023] https://www.medicines.org.uk/emc/product/999/smpc#gref
4. Dacarbazine medac 200 mg powder for solution for injection/infusion. Health Products Regulatory Agency. [Revised in July 2020]. [Accessed on 1st April 2023] https://www.hpra.ie/img/uploaded/swedocuments/1d9264f6-b924-4af9-9b27-af9c9593d4a3.pdf
5. Dacarbazine medac 500mg and 1000g powder for solution for injection/infusion. Health Products Regulatory Agency. [Revised in July 2020]. [Accessed on 1st April 2023] https://www.hpra.ie/img/uploaded/swedocuments/17bfc53a-9962-4f05-9653-08a1848e0a13.pdf
6. medac GmbH. Dacarbazine. [Revised in July 2020] [Accessed on 30th March 2023] https://www.medac.eu/fileadmin/user_upload/medac-eu/SPCs/United_Kingdom/Dacarbazine_medac-spc-gb.pdf
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 03 Apr 2023 | 11:01 AM(IST)
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