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INTRODUCTION
CARVIL 6.25MG TABLET contains Carvedilol which belongs to a group of medicines called Beta-blockers. It is used to treat high blood pressure (hypertension), chest pain or angina and also used to treat heart failure. Hypertension is defined as persistently elevated arterial blood pressure. Angina pectoris can be defined as a sudden, sharp and severe chest pain that originates from the apex of the heart and radiates to the left shoulder and it can be characterized by the presence of severe and crushing pain along with a feeling of pressure and suffocation, especially behind the breastbone. Heart failure is an inability of the heart to pump sufficient blood to meet the body’s needs.
CARVIL 6.25MG TABLET is not recommended for use in patients with severe heart failure (fluid retention and breathlessness), a history of wheezing due to asthma or other lung diseases, severe hardening of arteries affecting the circulation in legs or feet, liver disease, conduction defect of the heart or heart block, AV heart block grade II or III, sick sinus syndrome (sino- atrial block), slow heartbeat, cardiogenic shock, very low blood pressure, unstable heart failure, Prinzmetal’s angina (chest pain at rest), untreated pheochromocytoma (a tumour of the adrenal gland), metabolic acidosis (disturbance in body’s acid-base balance), glucose or galactose intolerance.
Before taking CARVIL 6.25MG TABLET inform your doctor, if you have diabetes, kidney, liver problems, severe hardening of arteries affecting the circulation in your legs or feet, arms, low blood pressure or elderly, first-degree heart block or other heart problems, severe heart failure, low salt and blood levels, Raynaud’s syndrome or peripheral vascular disease (cold hands and feet), thyroid problems, pheochromocytoma, previous history of serious allergic reaction or desensitisation therapy, psoriasis, Prinzmetal’s angina (chest pain at rest), dry eyes, lung disease (Asthma, COPD), pain, numbness or weakness of muscles due to low blood flow, surgery.
Avoid consumption of alcohol while taking CARVIL 6.25MG TABLET. CARVIL 6.25MG TABLET is generally not recommended for use by pregnant and breastfeeding women. CARVIL 6.25MG TABLET is not recommended for use in children and adolescents under 18 years of age. CARVIL 6.25MG TABLET should be used with caution in elderly patients (aged above 65 years). The most common side effects of taking CARVIL 6.25MG TABLET are dizziness, headache, weakness, tiredness and low blood pressure causing lightheaded or fainting.
USES OF CARVIL 6.25MG TABLET
- Treats high blood pressure (Hypertension)
- Treats angina pectoris (Chest pain)
HOW CARVIL 6.25MG TABLET WORKS
CARVIL 6.25MG TABLET works by blocking Beta receptors (Beta-1 and Beta- 2) and alpha1 receptors causing relaxation of blood vessels. This makes it easier for the heart to pump blood around the body and reduces blood pressure and strain on your heart. It has also a calcium channel blockade effect in high doses, antioxidant/ free radical scavenging properties.
DIRECTIONS FOR USE
Take CARVIL 6.25MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF CARVIL 6.25MG TABLET
COMMON
- lack of muscle strength, weakness, dizziness or feeling unwell, tiredness, headache
- heart failure or heart problems
- low blood pressure
- infections of the airway Ex. bronchitis, pneumonia, asthma, nose and throat (upper respiratory tract) causing wheezing, shortness of breath, chest tightness and sore throat
- decreased red blood cells (causing pale skin, tiredness, heart palpitations and shortness of breath)
- weight gain
- increased cholesterol levels in the blood
- change in blood sugar levels
- depression or depressed mood
- dry eyes
- vision problems
- eye irritation
- slow heartbeat
- drop in blood pressure when standing (feeling dizzy, lightheaded or fainting)
- problems with blood circulation in arms and legs (cold hands and feet)
- oedema (accumulation of fluid in the body causing swelling of ankles, feet, fingers and legs)
- decreased volume of circulating blood
- fluid accumulation in the lungs
- generalised pain
- pain in hands and feet
- stomach acidity, indigestion, stomach pain, nausea, vomiting, loose stools
- kidney problems
- urinary tract infections which can use difficulty in passing urine
- hardening of the arteries (atherosclerosis) results in worsening of symptoms in patients with Raynaud’s disease (cold hands and feet or pain in the legs which worsens when walking)
UNCOMMON
- heart disease
- feeling faint, tiredness
- confusion
- certain skin reactions (Ex. skin rash, hives, lesions, dry, flaky, itchy skin, abnormal sensation in the skin, allergic dermatitis, psoriatic or lichen planus-like skin lesions).
- increased sweating
- loss of hair
- disturbance in sleep
- tingling or numbness (decreased sensation of hands and feet)
- disturbed vision
- chest pain
- heart block or symptoms of heart failure
- disturbance in the heart conduction system, chest pain
- swelling of ankles, feet or fingers
- constipation
- being sick
- impotency
- erectile dysfunction
RARE
- decreased platelet count in blood (bruise easily and nose bleed)
- blocked nose, wheezing or flu-like symptoms (fever, muscle ache, chills, headache, fatigue)
- dry mouth
Stop taking CARVIL 6.25MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- an allergic reaction (swelling of the face, lips, throat and mouth, leading to breathing difficulty or swallowing; skin rash, hives
- flu-like symptoms (Ex. headache, fever, chills and body aches)
- serious skin reactions such as (erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis) can occur. Redness often associated with blisters may appear on the skin, mouth, genital areas or eyelids. These may lead to widespread peeling of the skin
- chest pain accompanied by shortness of breath, sweating and feeling sick
- decreased urination often with swelling of legs (indicates problems with kidneys)
- low blood sugar (hypoglycaemia) which may lead to seizures or unconsciousness
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if your symptom does not improve.
Nausea or vomiting:
Take the medicine with or just after a meal. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if your symptom does not improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if your symptom does not improve.
Stomach pain:
Rest and relax. Try to have smaller meals but take them frequently. Keep a heating pad on your stomach. Contact your doctor if your symptom does not improve.
Constipation:
Eat plenty of fiber-rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. Contact your doctor if your symptom does not improve.
Dizziness or drowsiness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if your symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
CARVIL 6.25MG TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking CARVIL 6.25MG TABLET.
BREASTFEEDING
CARVIL 6.25MG TABLET is generally not recommended for use in breastfeeding women as it is not known if this medicine passes into breast milk. Consult your doctor before taking CARVIL 6.25MG TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel drowsy after taking CARVIL 6.25MG TABLET.
ALCOHOL
Avoid consumption of alcohol while taking CARVIL 6.25MG TABLET because it might make you dizzier.
KIDNEY
CARVIL 6.25MG TABLET is not recommended for use in patients with kidney problems. Consult your doctor before taking CARVIL 6.25MG TABLET.
LIVER
CARVIL 6.25MG TABLET is not recommended for use in patients with liver problems. Consult your doctor before taking CARVIL 6.25MG TABLET.
ALLERGY
Do not take CARVIL 6.25MG TABLET if you are allergic to Carvedilol or any of the other ingredients of this medicine.
LUNGS
CARVIL 6.25MG TABLET is not recommended for use in patients with breathing problems such as asthma or other lung diseases. Consult your doctor before taking CARVIL 6.25MG TABLET.
HEART DISEASE
CARVIL 6.25MG TABLET is not recommended for use in patients having severe heart failure, conduction defect of the heart or heart block, AV heart block grade II or III, sick sinus syndrome (sino-atrial block), slow heartbeat, cardiogenic shock, very low blood pressure, unstable heart failure, Prinzmetal’s angina (chest pain at rest). Consult your doctor before taking CARVIL 6.25MG TABLET.
OTHERS
CARVIL 6.25MG TABLET is not recommended for use if you have:
- severe hardening of arteries affecting the circulation in legs or feet
- untreated pheochromocytoma
- metabolic acidosis
- glucose or galactose intolerance
- receiving diltiazem or verapamil injection or infusion
Before taking CARVIL 6.25MG TABLET, inform your doctor if you have:
- diabetes
- Raynaud’s syndrome (poor circulation affecting hands, feet or lower legs causing cold hands and feet or pain)
- Raynaud’s syndrome (cold feet and hands) or peripheral vascular disease causing cold hands and feet)
- thyroid problems
- previous history of a serious allergic reaction
- desensitisation therapy
- psoriasis
- wear contact lenses (as they may cause dry eyes)
- surgery
- taking other antihypertensives like debrisoquine
Use in pediatrics:
CARVIL 6.25MG TABLET is generally not recommended for use in children and adolescents under 18 years of age. Consult your doctor before taking CARVIL 6.25MG TABLET.
Use in geriatrics:
CARVIL 6.25MG TABLET should be used with caution in elderly patients aged above 65 years. Consult your doctor before taking CARVIL 6.25MG TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking CARVIL 6.25MG TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to treat diabetes (Ex. insulin, metformin)
- medicines used to treat depression or other mental health conditions (Ex. moclobemide, reserpine, amitriptyline, fluoxetine, paroxetine, isocarboxide, phenelzine, phenothiazines, haloperidol)
- medicines used to treat high blood pressure or heart diseases (Ex. clonidine, doxazosin, terazosin, amiodarone, diltiazem, verapamil, amlodipine, nifedipine, indoramin, digoxin, chlorthalidone, cyclopenthiazide, isosorbide-mononitrate, glyceryl trinitrate, guanethidine, guanfacine, reserpine, methyldopa)
- atracurium besilate (medicines used to relax muscles and also used in anaesthesia)
- corticosteroids Ex. prednisolone (medicines used to treat inflammation, pain or allergic reactions)
- cimetidine (medicines used to treat ulcers)
- erythromycin (used to treat infections)
- medicines used to treat cough and cold (Ex. ephedrine or pseudoephedrine)
- medicines used for migraine (Ex. clonidine, ergotamine)
- ketoconazole (used for fungal infections)
- amylobarbitone (a medicine used to induce sleep)
- prochlorperazine (a medicine used to treat nausea and vomiting)
- cyclosporine (a medicine used after organ transplantation)
- non-steroidal anti-inflammatory drugs. Ex. ibuprofen, diclofenac (used to treat inflammation, painful bones, joints and muscle)
- medicines used for hormone replacement therapy (Ex. oestrogens) or contraceptive pills (used to prevent pregnancy)
- rifampicin (medicines used to treat infections like tuberculosis)
- beta-agonist bronchodilators (medicines used to treat asthma or other chest conditions)
Overdosage:
If you or anyone else accidentally take too much of CARVIL 6.25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, faintness, sick, breathlessness or wheezy, very drowsy or experience convulsions.
SYNOPSIS
| Drug | : | Carvedilol |
| Pharmacological Category | : | Beta-blockers |
| Therapeutic Indication | : | Hypertension, Angina, Heart failure |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep CARVIL 6.25MG TABLET out of the sight and reach from children
- Store CARVIL 6.25MG TABLET below 30°C
FAQs ABOUT CARVIL 6.25MG TABLET
What conditions does CARVIL 6.25MG TABLET treat?
CARVIL 6.25MG TABLET is used to treat high blood pressure, angina (chest pain) and heart failure. Consult your doctor before taking CARVIL 6.25MG TABLET.
Does CARVIL 6.25MG TABLET cause weight gain?
Yes. CARVIL 6.25MG TABLET may cause weight gain. Contact your doctor before taking CARVIL 6.25MG TABLET.
What are the side effects of taking CARVIL 6.25MG TABLET?
The most common side effects of taking CARVIL 6.25MG TABLET are dizziness, headache, weakness, tiredness, low blood pressure causing lightheaded or fainting. Contact your doctor before taking CARVIL 6.25MG TABLET.
Does CARVIL 6.25MG TABLET cause shortness of breath?
Yes. CARVIL 6.25MG TABLET may cause shortness of breath. If you experience any unusual symptoms like chest pain, shortness of breath, dizziness, headache, sweating etc. Stop taking CARVIL 6.25MG TABLET and Contact your doctor immediately.
Does CARVIL 6.25MG TABLET cause heart palpitations?
Yes. CARVIL 6.25MG TABLET cause heart palpitations. If you feel any unusual symptoms like pounding, fluttering or skipped heartbeats. Contact your doctor immediately if your symptom gets worse or persist.
Can I use CARVIL 6.25MG TABLET in pregnancy?
CARVIL 6.25MG TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking CARVIL 6.25MG TABLET.
REFERENCES
1. Barbara G. wells, Terry L. schwinghammer, Joseph T. dipiro, Cecily V. dipiro. Hypertension, Heart failure. Pharmacotherapy handbook. Tenth edition. 2017. Page – 120, 140.
2. KD. Tripathi. Antiadrenergic drugs and drugs for glaucoma, cardiovascular drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 151, 564.
3. KRKA, d.d. Health Products Regulatory Authority (HPRA). [Accessed on 5th May 2022] https://www.hpra.ie/img/uploaded/swedocuments/32b2f26d-734b-4405-b35b-be48ca671f91.pdf
4. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised on December 2019] [Accessed on 5th May 2022] https://www.medicines.org.uk/emc/files/pil.3106.pdf
5. GlaxoSmithKline. U.S. Food & Drug Administration. [Revised on February 2005] [Accessed on 5th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020297s013lbl.pdf
6. Teva UK limited. Carvedilol. [Revised on October 2021] [Accessed on 5th May 2022] https://products.tevauk.com/mediafile/id/51932.pdf
7. Sun Pharmaceutical Industries, Inc. Carvedilol. [Revised on September 2017] [Accessed on 5th May 2022] https://sunpharma.com/usa/wp-content/uploads/sites/2/2020/12/097-carvedilol-er-capsules-pil-090132.pdf
USEFUL DIAGNOSTIC TESTS
- Kidney function test
VIDEOS
Carvedilol TABLET - Drug Information
Carvedilol TABLET : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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