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Drug Information

What is Cyproterone + Estradiol combination used for?

Cyproterone + Estradiol combination tablet is used to reduce the symptoms of menopause and in the prevention of osteoporosis in females. It is also recommended for the treatment of the following conditions:

  • Prostate cancer in males
  • Breast cancer in females
  • Ovarian failure
  • Hirsutism (unwanted facial hair growth in females)

Cyproterone + Estradiol combination may also be prescribed for other conditions as determined by the doctor.

How does Cyproterone + Estradiol combination work?

In Cyproterone + Estradiol combination, Cyproterone belongs to the class of drugs called anti-androgen drugs. The drug acts by reducing the amount of androgen produced in the body by blocking the action of male sex hormone.

Estradiol belongs to the class of drugs called steroidal hormones. The drug acts by mimicking the action of oestrogen by binding to the oestrogen receptors. 

How to take Cyproterone + Estradiol combination?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Cyproterone + Estradiol combination tablet as prescribed by your doctor.

  • Swallow the tablet Do not crush or chew the tablet. Take the drug with or without food.

If you miss a dose of Cyproterone + Estradiol combination, please take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with Cyproterone + Estradiol combination?

Drugs that interact with Cyproterone + Estradiol combination include the following:

  • Carfilzomib
  • Dantrolene
  • Fulvestrant
  • Lenalidomide
  • Tamoxifen
  • Thalidomide
  • Tranexamic acid

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Cyproterone + Estradiol combination?

The following are the most common side effects of Cyproterone + Estradiol combination:

  • Nausea
  • Vomiting
  • Bloating
  • Headache
  • Restlessness
  • Tiredness
  • Dizziness

The following are the severe side effects and you may require immediate medical attention:

  • Weight changes
  • Breast tenderness
  • Increased thirst
  • Increased urination

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Cyproterone + Estradiol combination?

  • Avoid taking the medicine if you are allergic to Cyproterone + Estradiol combination or similar drugs.
  • Avoid consumption of alcohol as it may alter the absorption of Cyproterone + Estradiol combination.
  • Do not drive or operate heavy machinery if Cyproterone + Estradiol combination causes dizziness or blurred vision.
  • Do not stop taking the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Do not exceed the dose prescribed by the doctor.

You are advised not to take Cyproterone + Estradiol combination if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Cyproterone + Estradiol combination?

  • Tell your doctor if you have any history of heart, liver or kidney diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Notify your doctor if you become pregnant while taking Cyproterone + Estradiol combination.

Frequently Asked Questions about Cyproterone + Estradiol combination

  1. Can Cyproterone + Estradiol combination be used in the treatment of Polycystic ovary syndrome?
  2. Yes, Cyproterone + Estradiol combination can be used in the treatment of polycystic ovary syndrome when prescribed by the doctor.

  3. Is it common to experience jaw pain while taking Cyproterone + Estradiol combination?
  4. No. Jaw pain is one of the severe and rare side effects of Cyproterone + Estradiol combination. Consult a doctor immediately on experiencing such symptoms.

  5. Is it safe to take Cyproterone + Estradiol combination in diabetes patients?
  6. No. It is advised not to take Cyproterone + Estradiol combination in diabetes patients. However, please consult your doctor.

  7. Can Cyproterone + Estradiol combination interfere with any laboratory test results?
  8. Yes, Cyproterone + Estradiol combination interferes with the thyroid function test results. Notify your doctor about the use of Cyproterone + Estradiol combination before undergoing thyroid function test.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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