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INTRODUCTION
CARNISURE 500MG contains levocarnitine which belongs to the group of medicines called amino acid derivatives. It is used to treat levocarnitine amnio acid deficiency in the body. Deficiency of levocarnitine can occur either due to systemic deficiency at birth or can occur as an effect of various metabolic disorders or when patient is diagnosed with end stage kidney disorder and is on hemodialysis.
This reduced levels of levocarnitine results in decreased energy leading to muscle weakness (muscles of hips, shoulders, neck, jaw and even heart muscles) and in severe cases can lead to fatigue, low blood sugar, stomach pain, growth retardation and brain function defects. CARNISURE 500MG helps to treat these symptoms by treating the deficiency.
Levocarnitine is a naturally occurring substance in the body that is essential for the energy metabolism. It is utilized in the process of energy production in the energy building bodies of our cells (mitochondria). This helps in sustaining the muscular activity of heart and other muscles.
Before taking CARNISURE 500MG, your doctor may want you take blood tests to check for the existing amount of Levocarnitine in circulation to determine the correct dosage for you. CARNISURE 500MG is not recommended for use in patients suffering from history of fits or severely compromised renal function.
Before taking this medicine, inform your doctor if you have diabetes and are taking medications of it (Ex. insulin, metformin etc.) or taking medications for anti-clotting disorders (Ex. Warfarin, Heparin, Aspirin, Clopidogrel).
CARNISURE 500MG should be used with caution among pregnant or breastfeeding women, therefore consult your doctor before taking. The most common side effects of taking CARNISURE 500MG are vomiting, nausea, stomach pain, diarrhea, headache, abnormal taste or body odour (fish like smell). Contact doctor if any of the symptoms get worse.
USES OF CARNISURE 500MG
CARNISURE 500MG is used to treat:
- primary systemic carnitine deficiency by birth
- secondary carnitine deficiency due to certain metabolic disorders that result in accumulation of abnormal and toxic metabolites (Ex. methyl malonic aciduria, propionic acidemia, glutaric aciduria and medium chain fatty acetyl dehydrogenase deficiency
- secondary carnitine deficiency due to hemodialysis
HOW CARNISURE 500MG WORKS
CARNISURE 500MG helps to treat levocarnitine deficiency which is a naturally occurring substance in the body. It is utilized in the process of energy production. This helps in sustaining the muscular activity of heart and other muscles.
DIRECTIONS FOR USE
CARNISURE 500MG is to be taken as advised by the doctor. Take the medicine preferably after meals. Use water to swallow it. Do not crush or chew CARNISURE 500MG. Your Doctor will decide the correct dose and duration for you, depending upon your age, body weight and disease conditions.
SIDE EFFECTS OF CARNISURE 500MG
COMMON
- vomiting
- nausea
- upset stomach
- diarrhoea
- stomach pain
- abnormal taste
- body odour (fish like smell)
- headache
RARE
Stop taking CARNISURE 500MG and consult your doctor immediately if you experience any of the following:
- signs of allergic reaction such as difficulty swallowing or breathing, hives, swelling of the face, lips, tongue or throat, rash
- unexplainable muscle pain, muscle tenderness or weakness, dark brown urine (Rhabdomyolysis)
- signs of increased levels of calcium such as increased thirst, frequent urination, nausea, vomiting, constipation, pain in bones, confusion and fatigue
- signs of high blood pressure such as headache, dizziness, vision problems, shortness of breath
- palpitations
- signs of decreased blood platelet count such as bleeding or bruising, fatigue and weakness
- signs of anemia such as fatigue, loss of energy, weakness, shortness of breath
- signs of bronchitis such as coughing and difficulty breathing
- low blood sugar
- fits (seizures)
- signs of dermatitis exfoliative such as rashes, redness, widespread blistering or peeling of the skin and mucosa (mouth)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if it persists for long or worsens with time.
Difficulty in breathing (Dyspnea):
Take slow deep breaths. Perform breathing exercises. Try to seek medical help immediately.
Headache:
Stay hydrated and take rest as much possible. Stay away from harsh lights and loud sounds. Apply a pain-relieving balm on forehead.
Tiredness:
Drink plenty of fluids and electrolytes and eat balanced diet with increased frequency of meals. Try to do regular minimal exercise and follow proper sleep schedule. If the symptom does not improve consult your doctor for the same.
WARNING & PRECAUTIONS
PREGNANCY
CARNISURE 500MG must be used with caution in pregnant women and those who are planning to get pregnant due to lack of safety data. Consult your doctor before taking CARNISURE 500MG.
BREASTFEEDING
CARNISURE 500MG must be used in caution in nursing women due to lack of safety data. Consult your doctor before taking CARNISURE 500MG.
DRIVING AND USING MACHINES
CARNISURE 500MG is considered safe for driving or while using machinery. However, consult the doctor before you take it.
KIDNEY
CARNISURE 500MG is not recommended in patients having severely compromised renal function as it may lead to toxic metabolites being accumulated in kidney. This medicine must be used in caution in patients suffering from kidney disorders and are undergoing hemodialysis. Consult your doctor before taking CARNISURE 500MG.
ALLERGY
Do not take CARNISURE 500MG if you are allergic to Levocarnitine.
OTHERS
CARNISURE 500MG is not recommended for use if you:
- have a history of fits (seizure activity) as it may lead to a rise in the frequency, duration and severity of the seizures
Before taking CARNISURE 500MG inform your doctor if you:
- have diabetes
- are on a reduced calorie diet
- have a disorder of kidney
- are intolerant to some sugars
Use in Pediatrics:
CARNISURE 500MG must be used with caution in pediatric patients and should be taken based on their age, body weight and disease condition. Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking CARNISURE 500MG, inform your doctor if you are taking any of the following medicine:
- medicines used to treat blood clots (Ex. Warfarin, Heparin, Aspirin, Clopidogrel)
- medicines to treat elevated blood sugar levels Ex. Insulin, Metformin etc.)
Overdosage:
If you or anyone else accidentally take too much of CARNISURE 500MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are upset stomach and/or diarrhoea.
SYNOPSIS
| Drug | : | Levocarnitine |
| Pharmacological Category | : | Amino acid derivatives |
| Therapeutic Indication | : | Carnitine deficiency |
| Dosage Forms | : | Tablet, Capsule, Syrup, Injection
|
MORE INFORMATION
- Keep CARNISURE 500MG out of reach of children
- Store at controlled room temperature of 25°C
- Do not refrigerate or freeze CARNISURE 500MG
- Keep it away from moisture and sunlight
FAQs ABOUT CARNISURE 500MG
What is CARNISURE 500MG used for?
CARNISURE 500MG is used to treat carnitine deficiency present at birth or occurred due to certain metabolic disorders or carnitine deficiency acquired as a result of some medical procedure such as hemodialysis. This reduced levels of levocarnitine results in decreased energy leading to muscle weakness. CARNISURE 500MG helps to treat these symptoms by treating the deficiency.
How should CARNISURE 500MG be stored?
CARNISURE 500MG should be stored at controlled room temperature of 25° C. It is recommended to not store in refrigerator. Keep it away from humidity and sunlight. It is recommended to not store CARNISURE 500MG after removal from the foil package.
What medications should I not take before/after taking CARNISURE 500MG?
Anti-diabetic medications (Ex. Insulin, Metformin), blood thinning medications (Ex. Aspirin) and medications to treat blood clots (Ex. Heparin, Warfarin) are not recommended to be taken along with CARNISURE 500MG as they may lead to unwanted side-effects. Inform your doctor about all the medicinal and/or surgical treatments that you were/are/would be undergoing before taking CARNISURE 500MG.
Can I drive to my way back home after taking CARNISURE 500MG?
Yes, you can drive after taking CARNISURE 500MG since CARNISURE 500MG has not reported to cause disturbance while driving or while using machinery. However, consult your doctor before taking CARNISURE 500MG.
Is it normal to experience body odour after taking CARNISURE 500MG?
Yes, body odour is a common side effect usually seen after taking CARNISURE 500MG. Apply mild deodorant/ perfume on the skin to manage it. However, it should be brought to the notice of your doctor if it worsens with time.
Can I take CARNISURE 500MG if I am pregnant?
It is recommended to consult your doctor and bring to his notice if you are pregnant or are planning pregnancy before taking CARNISURE 500MG as its effects have not been studied in pregnant women.
REFERENCES
1. KD. Tripathi. Miscellaneous drugs. Vitamins. Essentials of Medical Pharmacology. Seventh edition. 2013. Page 912.
2. Sakurauchi, Y., Matsumoto, Y., Shinzato, T., Takai, I., Nakamura, Y., Sato, M., Nakai, S., Miwa, M., Morita, H., Miwa, T. and Amano, I., 1998. Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. American journal of kidney diseases [Available on 1st August 1998] [Accessed on 19th July 2022] https://www.ajkd.org/article/S0272-6386(98)00208-X/fulltext#relatedArticles
3. Matsumoto, Y., Sato, M., Ohashi, H., Araki, H., Tadokoro, M., Osumi, Y., Ito, H., Morita, H. and Amano, I., 2000. Effects of L-carnitine supplementation on cardiac morbidity in hemodialyzed patients. American journal of nephrology [Published on 30th June 2000] [Accessed on 19th July 2022] https://www.karger.com/Article/Abstract/13584
4. sigma-tau Pharmaceuticals, Inc. Gaithersburg [Available on 15th April 2002] [Accessed on 19th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/18948S22lbl.pdf
5. Sigma-Tau Pharmaceuticals, Inc. [Available in June 2006] [Accessed on 19th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/018948s024,019257s011lbl.pdf
6. Leadiant Biosciences, Inc. Levocarnitine. [Revised in November 2017] [Accessed on 19th July 2022] https://pdf.hres.ca/dpd_pm/00041980.PDF .
USEFUL DIAGNOSTIC TESTS
- Carnitine test – Blood test
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