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Carbokem 600mg Injection 60ml
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INTRODUCTION
CARBOKEM 600MG INJECTION contains Carboplatin, which belongs to the group of medicines called Anti-cancer agents. It is used to manage advanced ovarian cancer and small-cell lung cancer. It is generally used in combination with other anti-cancer medicines to achieve better results.
Advanced ovarian cancer is a cancer that originates in the ovary and spreads to other parts of the body and small cell lung cancer is a cancer that occurs in the tissues of the lungs. It is caused mainly by smoking and is characterized by symptoms such as chest pain, coughing with blood, shortness of breath, tiredness, and weight loss.
Before receiving CARBOKEM 600MG INJECTION, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have a fever or low blood counts before receiving CARBOKEM 600MG INJECTION. CARBOKEM 600MG INJECTION should not be used by pregnant or breastfeeding women.
Men receiving CARBOKEM 600MG INJECTION must not father a child during management with CARBOKEM 600MG INJECTION and up to six months after stopping the therapy. Both men and women receiving CARBOKEM 600MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with CARBOKEM 600MG INJECTION.
The use of CARBOKEM 600MG INJECTION may cause an abnormal decrease in total blood counts. It may also cause nausea, vomiting, mouth sores, hearing loss, loss of taste, tingling or numbness of body parts, increased serum creatinine levels, difficulty passing urine, increased bilirubin levels in the blood, and changes in vision.
To avoid this, your doctor will closely monitor your blood count, liver functions, kidney functions, nerve functions, and ear functions. However, consult your doctor if they trouble you.
USES OF CARBOKEM 600MG INJECTION
It is used either alone or in combination with other anticancer medicines to manage:
- advanced ovarian cancer (cancer that originated in the ovary and spread to other parts of the body)
- small cell lung carcinoma (lung cancer)
HOW CARBOKEM 600MG INJECTION WORKS
CARBOKEM 600MG INJECTION is an anticancer medicine. It acts by damaging the genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from growing and multiplying within the body.
DIRECTIONS FOR USE
CARBOKEM 600MG INJECTION will be given to you only by a doctor or a nurse into the vein as an intravenous infusion. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
SIDE EFFECTS OF CARBOKEM 600MG INJECTION
COMMON
- low blood counts (WBC, RBC, and platelets)
- nausea and vomiting
- stomach pain and cramps
- increased urea levels in the blood
- low magnesium, sodium, and potassium levels in the blood
- kidney damage, liver damage
- tingling, burning, pricking sensation, or numbness of body parts
- loss of taste
- changes in vision
- decreased bone movements
- ringing in the ears, loss of hearing
- chest tightness or wheezing
- diarrhea or constipation
- sore lips or mouth ulcers
- hair loss
- skin rash or itching
- back pain, joint pain, and muscle pain
- difficulty in urination
- extreme tiredness or weakness (asthenia)
RARE
- temporary loss in eyesight
Contact your doctor immediately if you experience any of the following side effects after receiving CARBOKEM 600MG INJECTION:
- signs of low platelet and WBC counts (such as infections, fever, sore throat, abnormal bleeding, and bruising)
- severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat, itching, and chest tightness, which can lead to difficulty breathing or swallowing)
- signs of tumour lysis syndrome (such as an irregular heartbeat, kidney problems, or an abnormal blood cell count)
- signs of hemolytic-uremic syndrome (such as kidney damage, bloody urine, difficulty in urination, and extreme tiredness and shortness of breath with low RBC, WBC, or platelet counts)
- signs of hemolytic anemia (such as extreme tiredness and shortness of breath with a low RBC count)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink plenty of fluids, such as water, fruit juices, or electrolytes, to avoid dehydration in your body. Consult your doctor if your symptoms worsen.
Mouth Ulcers
Use a soft toothbrush to brush your teeth. Avoid eating spicy and acidic foods such as beverages, sodas, and processed foods. Also, you may use over-the-counter pain-relieving oral gel to get some relief.
Skin Rash Or Itching
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult your doctor if the symptoms worsen.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedCARBOKEM 600MG INJECTION is not recommended for use by pregnant women. Women of childbearing age must use a suitable contraceptive before and during management with CARBOKEM 600MG INJECTION to avoid pregnancy and up to 6 months after management discontinuation. If you became pregnant while undergoing therapy with CARBOKEM 600MG INJECTION, stop taking the medicine and contact your doctor immediately.
BREASTFEEDING
ContraindicatedCARBOKEM 600MG INJECTION is not recommended for use in breast-feeding women due to a lack of proper safety data. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any heavy tools or machines if you experience any unpleasant symptoms (such as nausea, vomiting, worsening of eyesight, or changes in vision and sense of hearing) after receiving CARBOKEM 600MG INJECTION.
ALCOHOL
Consult your doctorConsumption of alcohol is not recommended during management with CARBOKEM 600MG INJECTION.
KIDNEY
Consult your doctorCARBOKEM 600MG INJECTION is not recommended for use in patients with severe kidney diseases. It should be used with caution in patients with mild kidney problems. Therefore, consult your doctor before receiving it.
LIVER
Use with CautionCARBOKEM 600MG INJECTION should be used with caution in patients with liver disease. Therefore, consult your doctor before receiving it.
ALLERGY
ContraindicatedDo not take CARBOKEM 600MG INJECTION if you are allergic to carboplatin or to other platinum-containing cancer drugs (such as cisplatin and oxaliplatin).
USE IN PEDIATRICS
ContraindicatedThe safety and effectiveness of CARBOKEM 600MG INJECTION in children have not been established. Therefore, CARBOKEM 600MG INJECTION should not be used in children and adolescents (aged below 18 years) unless prescribed by a physician.
USE IN GERIATRICS
Use with CautionCARBOKEM 600MG INJECTION should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.
OTHERS
CARBOKEM 600MG INJECTION is not recommended for use if you:
- have low blood cell counts (red blood cells, white blood cells, and platelets)
- have a tumour that bleeds
Before receiving CARBOKEM 600MG INJECTION, inform your doctor if you:
- have previously taken any cisplatin or any other similar anti-cancer medicines in the past
- have a headache, abnormal vision, altered mental functioning, and/or seizures.
- have a fever or chills (or any signs of infection)
INTERACTIONS
A. Drug-Drug interactions:
Before receiving CARBOKEM 600MG INJECTION, inform your doctor if you are taking any of the following medicines, such as:
- medicines used to manage bacterial infections, such as aminoglycosides (Ex. gentamicin, amikacin, capreomycin, or vancomycin)
- medicines that can lower the number of blood cells (azacitidine, bosentan, carbidopa-levodopa)
- phenytoin, fosphenytoin (used to manage seizures)
- warfarin (a medicine used to manage blood clots)
- live vaccines (yellow fever vaccine, typhoid vaccine, cholera vaccine)
- tacrolimus, sirolimus, and ciclosporin (used to suppress immune activity)
- diuretics (used to manage edema and high blood pressure) such as furosemide and torsemide
Overdosage:
CARBOKEM 600MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Carboplatin |
| Pharmacological Category | : | Alkylating agents |
| Therapeutic Indication | : | Cancer (small cell lung cancer, advanced ovarian cancer) |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep CARBOKEM 600MG INJECTION out of reach of children
- Store at room temperature (not above 25°C) or in the refrigerator (between 2 and 8°C), depending upon the instructions given on the product label.
FAQs ABOUT CARBOKEM 600MG INJECTION
Q: What is the use of CARBOKEM 600MG INJECTION?
A: CARBOKEM 600MG INJECTION is an anticancer medicine used to manage lung cancer and ovarian cancer.
Q: Is CARBOKEM 600MG INJECTION a strong chemotherapy?
A: Yes. CARBOKEM 600MG INJECTION is a strong chemotherapeutic agent. It damages the genetic material (DNA and RNA) of the cancer cells, which prevents them from growing and multiplying within the body.
Q: Will the use of CARBOKEM 600MG INJECTION cause nerve pain?
A: Yes. The use of CARBOKEM 600MG INJECTION may affect nerves and cause tingling, numbness, burning, or pricking sensations in body parts. To avoid this, your doctor will constantly monitor your nerve functions and adjust the dose accordingly. However, if it worsens, consult your doctor for advice.
Q: Can CARBOKEM 600MG INJECTION cause hearing problems?
A: Yes. The use of CARBOKEM 600MG INJECTION may affect the sense of hearing. To avoid this, your doctor will constantly monitor your ear functions and adjust the dose accordingly. However, if it worsens, consult your doctor for advice.
Q: Can CARBOKEM 600MG INJECTION cure cancer?
A: CARBOKEM 600MG INJECTION is an anticancer medicine used to manage lung cancer and ovarian cancer. However, consult your doctor regarding the cure of the disease, as the success rate depends on the intensity of the cancer.
Q: Is CARBOKEM 600MG INJECTION toxic to the kidneys?
A: CARBOKEM 600MG INJECTION may affect the way your kidney works. It may cause bloody urine, difficulty passing urine, or even kidney failure. Therefore, prior to management, inform your doctor if you have any kidney problems. Do not receive CARBOKEM 600MG INJECTION if you have severe kidney problems.
Q: Will the use of CARBOKEM 600MG INJECTION cause weight gain?
A: Yes. The use of CARBOKEM 600MG INJECTION may cause weight gain in some individuals. Consult your doctor if they trouble you.
Q: Can the use of CARBOKEM 600MG INJECTION cause hair loss?
A: Yes. Hair loss is one of the common side effects of taking a chemotherapy medicine like CARBOKEM 600MG INJECTION. Consult your doctor if it bothers you.
Q: Will the use of CARBOKEM 600MG INJECTION affect fertility?
A: Yes. The use of CARBOKEM 600MG INJECTION affects fertility in both men and women. It may cause a lack of periods, delayed puberty, early menopause in women, and decreased sperm production in men. Consult your doctor if they trouble you.
Q: How long will it take for CARBOKEM 600MG INJECTION to cure my disease?
A: The time taken for cure depends on the intensity of the disease. Contact your doctor regarding the duration of the therapy.
Q: What are the side effects of CARBOKEM 600MG INJECTION?
A: CARBOKEM 600MG INJECTION may cause an abnormal decrease in total blood counts, nausea, vomiting, mouth sores, hearing loss, loss of taste, tingling or numbness of body parts, increased serum creatinine levels, difficulty passing urine, increased bilirubin levels in the blood, and changes in vision. Consult your doctor for advice if they trouble you.
Q: How does CARBOKEM 600MG INJECTION work?
A: CARBOKEM 600MG INJECTION is an anticancer medicine. It acts by damaging the genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from growing and multiplying within the body.
Q: Will the use of CARBOKEM 600MG INJECTION cause constipation?
A: Yes. The use of CARBOKEM 600MG INJECTION may cause constipation in some individuals. Consult your doctor if they trouble you.
REFERENCES
1. KD. Tripathi. Chemotherapy of Neoplastic Diseases. Essentials of medical pharmacology. Seventh edition. 2013. Page – 862
2. Accord U Gatzemeier, M Heckmayr, R Neuhauss, D Hossfeld, W Achterrath, L Lenaz. Phase II studies with carboplatin in non-small cell lung cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2002. [Accessed on 5th September 2022] https://pubmed.ncbi.nlm.nih.gov/2154856/
3. Hospira UK Limited. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 5th September 2022] https://www.medicines.org.uk/emc/files/pil.3787.pdf
4. Bristol-Myers Squibb Company U.S. Food & Drug Administration. [Revised in July 2010] [Accessed on 5th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020452s005lbl.pdf
5. Cipla Ltd. Cytocarb Injection (Carboplatin). Cipla med. [Revised on May 2013]. [Accessed on 5th September 2022] https://www.ciplamed.com/content/cytocarb-injection
AUTHOR DETAILS
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 21 Nov 2023 | 05:35 PM(IST)
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