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Caprin 25000IU Injection 5ml
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INTRODUCTION
CAPRIN 25000IU INJECTIONcontains Heparin which belongs to the group of medicines called Anticoagulants. It is used to treat blood clots in leg veins (deep vein thrombosis), blood clots in the lung (pulmonary embolism), chest pains resulting from disease of the heart arteries (unstable angina pectoris), severe blockages affecting arteries in the legs (acute peripheral arterial occlusion).
CAPRIN 25000IU INJECTION is also used during heart, lung operations, during kidney dialysis and prevention of blood clots in the heart following a heart attack (mural thrombosis). A blood clot or thrombus is a gel-like collection of blood that form in arteries or veins when blood changes from liquid to partially solid form.
CAPRIN 25000IU INJECTION is not recommended for use if you have liver disease, serious bleeding problems, haemophilia, bruise easily, high blood pressure, tuberculosis, major trauma, have had severe skin problems resulting from previous heparin treatment, surgery of the brain, spine or eye, a lumbar puncture or receiving anesthetic, had an operation, thrombocytopenia, bleeding into the brain, drink a lot of alcohol.
Before receiving CAPRIN 25000IU INJECTIONinform your doctor if you have kidney disease, diabetes, a condition that makes you bleed easily, or suffer from excess acid or high levels of potassium in your blood. Do not consume alcohol, tobacco, or smoke during this treatment.
CAPRIN 25000IU INJECTION should be used with caution in pregnant and breastfeeding women. CAPRIN 25000IU INJECTION is not recommended for use in premature and newborn babies (up to 4 weeks old). Ask for your doctor’s advice.
CAPRIN 25000IU INJECTION should be used with caution in elderly patients above 60 years of age. The most common side effects of receiving CAPRIN 25000IU INJECTION are red lumps or red, itchy patches like eczema at injection site. Consult your doctor if symptoms do not show improvement.
USES OF CAPRIN 25000IU INJECTION
To treat,
- deep vein thrombosis
- pulmonary embolism
- acute peripheral arterial occlusion
- unstable angina pectoris
- prevent clots during heart, lung operations, kidney dialysis
- mural thrombosis
HOW CAPRIN 25000IU INJECTION WORKS
CAPRIN 25000IU INJECTION binds to the antithrombin (an enzyme present in the clotting system) which in turn inhibits several clotting factors such as factor Xa, factor IIa. This inactivation of thrombin prevents the formation of clots and prolongs the clotting time of blood.
DIRECTIONS FOR USE
CAPRIN 25000IU INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. It should not be given into a muscle. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
SIDE EFFECTS OF CAPRIN 25000IU INJECTION
COMMON
- red lumps or red, itchy patches like eczema at the injection site
RARE
- raised levels of potassium in the blood, particularly in patients with kidney failure or diabetes (feel tired and weak)
- irritation or sloughing of skin at the injection site
Stop receiving CAPRIN 25000IU INJECTION and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (itchy skin rash, eye irritation, runny nose, wheezing, rapid breathing, blue tinge to the lips, fever, chills, swelling of the eyes and lips, and shock)
- thrombocytopenia may result in the formation of dangerous blood clots causing chest pains, shortness of breath, coughing, dizziness or loss of consciousness
- signs of developing paralysis (after having an epidural or spinal anesthetic, tingling, weakness or numbness in legs or lower body, back pain, incontinence of urine or back passage)
- unusual bruising or purple spots on skin, unusual bleeding from gums, nose, urine, stool, or injury
HOW TO MANAGE SIDE EFFECTS
Itchy skin:
Hot water makes your skin irritated, so avoid taking hot showers. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. To soothe and hydrate irritated skin, apply moisturizers. Contact your doctor if the itching worsens.
WARNING & PRECAUTIONS
PREGNANCY
CAPRIN 25000IU INJECTION should be used with caution in pregnant women. Inform your doctor or nurse know prior to receiving CAPRIN 25000IU INJECTION if you are pregnant, wish to become pregnant or have a history of, or known risk to miscarriage. If CAPRIN 25000IU INJECTION is given, bleeding may be a problem during pregnancy or after delivery. Your bones may get thinner if you receive CAPRIN 25000IU INJECTION for a long-time during pregnancy. If you are pregnant and are going to have an epidural anesthetic, you should stop having the medicine. Consult your doctor before receiving it.
BREASTFEEDING
CAPRIN 25000IU INJECTION should be used with caution in breastfeeding women as it will be given to you after evaluating the risk and benefit ratio. Consult your doctor before receiving it.
DRIVING AND USING MACHINES
CAPRIN 25000IU INJECTION does not affect your ability to drive or use machines.
ALCOHOL
Do not consume alcohol while receiving CAPRIN 25000IU INJECTION.
KIDNEY
CAPRIN 25000IU INJECTION should be used with caution patients having kidney disease, dose will be adjusted by your doctor. Consult your doctor before receiving it.
LIVER
CAPRIN 25000IU INJECTIONis not recommended for use in patients who suffer from severe liver problems which can lead to bleeding into the esophagus. CAPRIN 25000IU INJECTION should be used with caution in mild to moderate liver disease, dose will be adjusted by your doctor. Consult with your doctor before receiving CAPRIN 25000IU INJECTION.
ALLERGY
Do not receive CAPRIN 25000IU INJECTION if you are allergic to Heparin or any other ingredients of this medicine.
OTHERS
CAPRIN 25000IU INJECTION is not recommended for use if you:
- drink large amounts of alcohol
- have high blood pressure
- are bleeding from anywhere in the body (apart from your normal periods)
- have hemophilia (a genetic disorder) or any other bleeding problem
- have or have ever had thrombocytopenia (prevents blood from clotting properly)
- bruise easily or have lots of purple spots that look like bruises (purpura)
- are suffering from tuberculosis (TB)
- have had severe skin problems resulting from previous treatment with heparin
- are about to have surgery of the spine or eye, brain, or a lumbar puncture
- have recently had an operation
- have bleeding into the brain
Before receiving CAPRIN 25000IU INJECTION, inform your doctor if you:
- are having an epidural or spinal anesthetic
- have any condition which makes you likely to bleed more easily (stomach ulcer, hiatus hernia, inflammation of the heart, problems in the back of your eye, piles, a stroke, cancer or threatened miscarriage)
- suffer from diabetes
- suffer from excess acid or high levels of potassium in your blood
- smoke
Use in pediatrics:
CAPRIN 25000IU INJECTION is not recommended for use in premature and newborn babies (up to 4 weeks old). Consult with your child’s doctor.
Use in geriatrics:
CAPRIN 25000IU INJECTIONshould be used with caution in elderly patients above 60 years of age. Dose will be adjusted by your doctor. Consult your doctor before receiving it.
INTERACTIONS
A. Drug - Drug interactions:
Before receiving CAPRIN 25000IU INJECTION, inform your doctor if you are taking any of the following medicine:
- medicines used to treat pain and inflammation (Ex. diclofenac (especially intravenous), ibuprofen, aspirin)
- medicines used to treat shock (Ex. dextran solutions)
- medicines which may interfere with clotting of the blood (Ex. dipyridamole, epoprostenol, clopidogrel or streptokinase)
- medicines used to treat infections (Ex. cephalosporins, gentamicin, amikacin, neomycin or tobramycin)
- medicines used to treat high blood pressure or heart problems (Ex. captopril enalapril, lisinopril, ramipril, losartan or valsartan, aliskiren)
- medicines that may increase the potassium level in blood (Ex. amiloride, triamterene, eplerenone or spironolactone)
- glyceryl trinitrate given into a vein (used for coronary heart disease)
- medicines used to treat gout (Ex. probenecid)
Overdosage:
CAPRIN 25000IU INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like severe bleeding.
SYNOPSIS
| Drug | : | Heparin |
| Pharmacological Category | : | Anticoagulant |
| Therapeutic Indication | : | Blood clots |
| Dosage Forms | : | Gel, Injection, Solution, Topical solution |
MORE INFORMATION
- Keep CAPRIN 25000IU INJECTION out of reach of children
- Store CAPRIN 25000IU INJECTION at room temperature below 25°C
FAQs ABOUT CAPRIN 25000IU INJECTION
Can CAPRIN 25000IU INJECTION be received by children?
CAPRIN 25000IU INJECTION is not recommended for use in premature and newborn babies (up to 4 weeks old). Dose will be adjusted by your doctor depending on your age, body weight and disease condition. Consult your doctor before receiving
Can CAPRIN 25000IU INJECTION be received by pregnant women?
CAPRIN 25000IU INJECTION should be used with caution in pregnant women. Inform your doctor or nurse know prior to receiving CAPRIN 25000IU INJECTION if you are pregnant, wish to become pregnant or have a history of, or known risk to miscarriage. If CAPRIN 25000IU INJECTION is given, bleeding may be a problem during pregnancy or after delivery. Your bones may get thinner if you receive CAPRIN 25000IU INJECTION for a long-time during pregnancy. If you are pregnant and are going to have an epidural anesthetic, you should stop having the medicine. Consult your doctor before receiving it.
Can I smoke while receiving CAPRIN 25000IU INJECTION?
Avoid smoking while receiving CAPRIN 25000IU INJECTION. Tobacco smoke can also interfere with the working of CAPRIN 25000IU INJECTION. Ask for your doctor’s advice and inform your doctor if you smoke.
Can I Keep receiving CAPRIN 25000IU INJECTION if I have a planned surgery?
You must remind your doctor that you are having CAPRIN 25000IU INJECTION before you receive any anesthetic. After you have the anesthetic your doctor or nurse might make regular checks to make sure you are not getting any major bleeding or bruising around your spine which may cause paralysis that could be permanent. After you have the anesthetic, your doctor will tell you when you can take CAPRIN 25000IU INJECTION again.
Do I need to undergo any diagnostic tests while receiving CAPRIN 25000IU INJECTION?
The presence of CAPRIN 25000IU INJECTION in the blood can affect the results of some blood tests such as thyroid tests and the levels of calcium or some antibiotics such as gentamicin in the blood. Your doctor might ask you to take several diagnostic tests.
Will I be given a test dose of CAPRIN 25000IU INJECTION?
If you suffer from allergies or have previously had an allergic reaction to heparin, a small test dose of CAPRIN 25000IU INJECTION may be given first to make sure that you are not allergic to it.
REFERENCES
1. KD Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of medical pharmacology. Eighth Edition. 2019. Page –663-664
2. Mandana Izadpanah, Hossein Khalili, Mostafa Mohammadi. Comparing safety of heparin as continuous intravenous infusion and multiple subcutaneous injections. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.gov. December 2015. [Accessed on 10th August 2022] https://pubmed.ncbi.nlm.nih.gov/26689885/
3. Eziafa, Oduah, Robert J. Linhardt, and Susan T. Sharfstein. Heparin: Past, Present, and Future. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. September 2016. [Accessed on 10th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039491/
4. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2018] [Accessed on 10th August 2022] https://www.medicines.org.uk/emc/files/pil.1678.pdf
5. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2018] [Accessed on 10th August 2022] https://www.medicines.org.uk/emc/files/pil.1680.pdf
6. Fresenius Kabi. U.S. Food & Drug Administration. [Revised in August 2017] [Accessed on 10th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017029s140lbl.pdf
7. Pfizer Laboratories Div Pfizer Inc. Heparin Sodium. Dailymed. [Revised in May 2020]. [Accessed on 10th August 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56dc3074-f1c5-45a3-b923-f1d14858e06d
8. Troikaa Pharmaceuticals. Cathflush (Heparin Sodium). [Accessed on 10th August 2022] https://www.troikaa.com/wp-content/uploads/2021/10/Common-Products-List-Novogen-Excluded.pdf
9. Drug bank. Heparin. [Accessed on 10th August 2022] https://go.drugbank.com/drugs/DB01109
USEFUL DIAGNOSTIC TESTS
- Blood tests
- Thyroid Test
- Serum Calcium
- Prothrombin Time
AUTHOR DETAILS
Written By Dr. Priyanka Goel, BDS
Last updated on 21 Nov 2022 | 10:19 AM(IST)
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.