INTRODUCTION

CANDID contains a medicine called clotrimazole which belongs to the group of medicines called azole antifungal agents. It is indicated for the local treatment and prevention of oropharyngeal candidiasis. Oropharyngeal candidiasis (also known as oral thrush) is a fungal infection caused by the overgrowth of the fungus Candida albicans in your mouth and throat. It often occurs in babies, toddlers and infants and is characterized by the presence of slightly raised, creamy white, sore patches in the mouth or tongue.

Clotrimazole acts by blocking the biosynthesis of fungal ergosterol which leads to the disruption of fungal cell membrane and inhibition of fungal growth in the mouth and throat. This medicine is meant for local treatment in the oral cavity. Do not swallow the medicine. Do not stop using this medicine abruptly without consulting your doctor as it may leads to recurrence of the infection.

CANDID is generally safe and well tolerated. However, it may cause nausea, vomiting and mild irritation in your mouth after taking. These side effects are usually temporary and disappears with time. If you are pregnant or think you may be pregnant or breastfeeding, consult your doctor for advice before taking. Your doctor will decide whether you should use this medicine or not. This medicine should be used with caution in children (below 18 years). Consult your doctor before using.

USES OF CANDID

• Oropharyngeal candidiasis (oral thrush)

HOW CANDID WORKS

Clotrimazole exerts its antifungal activity by inhibiting the biosynthesis of ergosterol, an essential constituent of fungal cell membrane which helps to keep the fungal cell intact and directly promotes its growth. Inhibition of ergosterol biosynthesis damages the fungal cell integrity and leads to the inhibition of fungal growth.

DIRECTIONS FOR USE

Apply this medicine as directed by your physician. Shake well before use. It is meant for local use in the oral cavity. Do not swallow the medicine. Apply the required amount of the medicine on the affected areas of the oral cavity. Avoid contact of this medicine with your eyes. If contact happens, rinse it thoroughly with water. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the infection. Continue to apply this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF CANDID

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor about all the medicines you use, including non-prescription and prescription medicines and herbal supplements.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Do not store above 25°C

FAQs ABOUT CANDID

Can I stop taking CANDID suddenly?

No. Do not stop using this medicine abruptly without consulting your doctor as it may leads to recurrence of the infection.

How long can I use CANDID?

Try to take this medicine as long as your doctor tells you to do so. Usually it is taken for 7-14 days depending upon the severity of infection. Consult your doctor regarding the duration of therapy before taking this medicine.

Can [GBNKYWORD] be used in babies?

No. Before using any medicine in babies, please consult your doctor. It is suitable for use in infants and toddlers only under medical supervision.

REFERENCES

1. KD. Tripathi. Antifungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 792.

2. John E. Bennett. Antifungal agents. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1587.

3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 895-897.

4. Pfizer. A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on June 2005] [Accessed 20th January 2021] https://clinicaltrials.gov/ct2/show/NCT00002282

5. Carla Garcia-Cuesta, Maria-Gracia Sarrion-Pérez and Jose V. Bagán. Current treatment of oral candidiasis: A literature review. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2014. [Accessed 20th January 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312689/

6. Nulife Pharmaceuticals Pvt Ltd. Clotrin Mouth Paint (Clotrimazole Mouth Paint). [Accessed 21st January 2021] http://www.nulifepharma.com/p-products/clotrin-mouth-paint