- Lab Tests
- Health Corner
CALMNERVE P CAPSULE is a combination of Pregabalin and Methylcobalamin which belongs to the group of medicines called Anticonvulsants and Vitamin-B complex respectively. CALMNERVE P CAPSULE is indicated for the treatment of neuropathic pain in adults. Neuropathic pain is a chronic painful condition caused by damage or disease affecting the somatosensory (sense of touch) nervous system (such as lesion or disease of spinal cord and/or brain).
It can also be caused by prolonged diabetes mellitus, infectious diseases (such as HIV infection or leprosy), chemotherapy, auto-immune disease (Ex. Guillain-Barre syndrome) or by other metabolic dysfunctions. Symptoms include shooting, burning or stabbing pain, tingling and numbness, spontaneous pain (pain without stimulus) or pain caused by normal daily activities that are typically not painful (such as brushing your hair, being in cold temperatures or rubbing against something).
Do not stop taking CALMNERVE P CAPSULE without consulting your doctor as it could precipitate withdrawal symptoms such as headache, insomnia (lack of sleep), nausea, pain, diarrhea, flu syndrome, anxiety, nervousness, depression, convulsion, excessive sweating, dizziness and physical dependence.
CALMNERVE P CAPSULE has high potential to cause addiction and therefore caution should be exercised among patients who already has a history of substance abuse. CALMNERVE P CAPSULE can cause suicidal ideation in some individuals and therefore appropriate treatment should be considered as soon as the signs emerge.
CALMNERVE P CAPSULE is not recommended for use in pregnant or breastfeeding women unless advised by the doctor and in male patients who plan to father a child. Consult your doctor before taking CALMNERVE P CAPSULE.
The most common side effects of taking CALMNERVE P CAPSULE are dizziness, sleepiness, headache, dry mouth, mood changes, fluid retention and weight gain. Consult your doctor if any of the side effects worsen.
CALMNERVE P CAPSULE effectively alleviates the symptoms of various types of neuropathic pain, where methylcobalamin acts by rejuvenating the damaged neurons by improving the production of myelin (a substance that covers and protects the nerve fibers from damage) and pregabalin acts by interfering with various pain signals travelling through the damaged nerves and the brain, thus leading to a significant pain relief in various neuropathic pain states.
Take CALMNERVE P CAPSULE as advised by your physician. Swallow CALMNERVE P CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of CALMNERVE P CAPSULE for you depending upon your age, body weight and disease condition.
Stop taking CALMNERVE P CAPSULE and contact your doctor immediately if you experience any of the following side effects:
Nausea and vomiting:
Try to take CALMNERVE P CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.
Drink lots of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. Consult your doctor if the symptom did not improve.
Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.
There is no proper information on the use of CALMNERVE P CAPSULE during pregnancy and therefore should be used only if the benefit to the mother clearly outweighs the potential risk to the fetus. Consult your doctor before taking CALMNERVE P CAPSULE. Women of childbearing potential should use a suitable contraceptive method to avoid pregnancy while taking CALMNERVE P CAPSULE.
CALMNERVE P CAPSULE is not recommended for use in breastfeeding women unless it is considered clearly necessary. Consult your doctor whether to discontinue breast-feeding or to discontinue therapy with CALMNERVE P CAPSULE.
Do not drive or operate any heavy tools or machines if you experience dizziness or sleepiness after taking this medicine. Consult your doctor before taking CALMNERVE P CAPSULE.
Avoid consumption of alcohol while taking CALMNERVE P CAPSULE, as it may cause impairment of motor skills and sedating effects of alcohol. Consult your doctor before taking CALMNERVE P CAPSULE.
CALMNERVE P CAPSULE should be taken with caution in patients with impaired kidney function. Consult your doctor before taking CALMNERVE P CAPSULE.
CALMNERVE P CAPSULE should be taken with caution in patients with liver disease. Consult your doctor before taking CALMNERVE P CAPSULE.
Do not take CALMNERVE P CAPSULE if you are allergic to Pregabalin, Methylcobalamin or any other ingredients of CALMNERVE P CAPSULE.
CALMNERVE P CAPSULE should be taken with caution in patients with heart disease (such as congestive heart failure). Consult your doctor before taking CALMNERVE P CAPSULE.
CALMNERVE P CAPSULE is not recommended for use if you:
Before taking this medicine, inform your physician if you:
Use in Pediatrics:
CALMNERVE P CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Consult your child’s doctor for advice.
Use in Geriatrics:
CALMNERVE P CAPSULE should be used with caution in elderly patients (aged 65 years and above), especially in patients with decreased renal function. Proper dose adjustments and careful monitoring of kidney function are required in such patients. Consult your doctor before taking CALMNERVE P CAPSULE.
A. Drug-Drug interactions:
Before taking CALMNERVE P CAPSULE, inform your doctor, if you are taking any of the following medicines:
If you or anyone else accidentally take too much of CALMNERVE P CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of CALMNERVE P CAPSULE might include sleepiness, confusion, agitation, restlessness, seizures and coma.
|Pharmacological Category||:||Anticonvulsants, Vitamin B complex|
|Therapeutic Indication||:||Neuropathic pain|
|Dosage Forms||:||Tablet, Capsule, Soft gels|
Q: Can CALMNERVE P CAPSULE affect fertility?
A: Fertility studies in men have shown that there were no effects on sperm motility. However, CALMNERVE P CAPSULE can be associated with an increased risk of male-mediated teratogenicity (abnormalities in fetus). Men being treated with CALMNERVE P CAPSULE who plan to father a child should be informed about the potential risk of male-mediated teratogenicity. There are not enough clinical data on the effects of this medicine on female fertility.
Q: Can CALMNERVE P CAPSULE cause weight gain?
A: Yes, CALMNERVE P CAPSULE can cause weight gain in some individuals mainly due to the formation of peripheral edema (fluid retention). Weight gain can be more prominent among diabetic patients who are treated with thiazolidinediones (Ex. pioglitazone, rosiglitazone) and so inform your doctor if you have diabetes prior to treatment with CALMNERVE P CAPSULE as a precaution.
Q: Can CALMNERVE P CAPSULE decrease libido?
A: Yes, CALMNERVE P CAPSULE may cause decrease in sex drive (libido) in some individuals, although not everybody gets them. Consult your doctor if this symptom troubles you.
Q: Is CALMNERVE P CAPSULE addictive?
A: Yes, CALMNERVE P CAPSULE has high potential to create substance abuse or dependence and therefore caution should be exercised among patients who already has a history of substance abuse. Careful monitoring of symptoms of abuse are required in such patients.
Q: Can I stop taking CALMNERVE P CAPSULE once my pain is relieved?
A: No. Do not stop taking CALMNERVE P CAPSULE without consulting your doctor as it could precipitate withdrawal symptoms such as headache, lack of sleep, nausea, pain, diarrhea, flu syndrome, anxiety, nervousness, depression, convulsion, hyperhidrosis and dizziness and dependence. If your condition improves, contact your doctor so that he might reduce the dose appropriately before discontinuation of the therapy with CALMNERVE P CAPSULE.
1. KD. Tripathi. Antiepileptic Drugs & Hematinics and Erythropoietin. Essentials of medical pharmacology. Seventh edition. 2013. Page – 420 & 608.
2. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 3223-3225.
3. Yasmin U Dongre and Onkar C Swami. Sustained release pregabalin with methylcobalamin in neuropathic pain: an Indian real-life experience. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2013. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674019/
4. Gupta JK and Qureshi Shaiba Sana. Potential Benefits of Methylcobalamin: A Review. Austin Potential benefits of Pharmacology and Therapeutics. 2015. [Accessed on 21st October 2022] https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v3-id1076.php
5. Ram Prabhoo, Atul Panghate, Raj Pavitra Dewda, Balaji More, Tanay Prabhoo and Rajiv Rana. Efficacy and Tolerability of a Fixed Dose Combination of Methylcobalamin and Pregabalin in the Management of Painful Neuropathy. NCBI; PMC US National Library of Medicine, National Institute of Health. November 2012. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503385/
6. Torrent Pharmaceuticals Ltd. Predgeb M OD (Pregabalin Sustained Release and Methylcobalamin Tablets). Torrentian.com. May 2017. [Accessed on 21st October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1836.pdf
7. Torrent Pharmaceuticals Ltd. Pregalin M (Pregabalin & Methylcobalamin Capsules). Torrentian.com. May 2017. [Accessed on 21st October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1428.pdf
8. Cipla Ltd. Nova M Capsules (Pregabalin + Methylcobalamin). Ciplamed.com. [Revised in May 2016]. [Accessed on 21st October 2022] https://www.ciplamed.com/content/nova-m-capsules
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 13 Jan 2023 | 05:12 PM(IST)
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.