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INTRODUCTION
CAL 123 FEM TABLET is a combination of Calcitriol, Calcium Carbonate, Calcium Orotate, Calcium Citrate, Calcium Aspartate, Soya Isoflavones, and Vitamin K2-7 which belongs to the group of medicines called Vitamin D derivatives, Calcium compounds, Phytoestrogens, and Vitamin K derivatives. It is used to prevent, treat, or manage postmenopausal osteoporosis and fractures.
Menopause is the time that marks the natural end of reproductive age for a woman, along with the cessation of the menstrual cycle and a decline in reproductive hormone levels in the body, causing bone loss (postmenopausal osteoporosis) and fractures.
Osteoporosis is a condition that causes thinning and weakening of bones because of excessive absorption of calcium from the bones. It is characterized by symptoms such as bleeding gums, weak grip strength, brittle fingernails, loss of height, frequent fractures, and neck and back pain.
CAL 123 FEM TABLET is also not recommended for use in patients with hypercalcemia (high calcium levels in the blood) and/or metastatic calcification (extra deposits of calcium in your body).
Before taking [GBNKEWYORD], inform your doctor if you are immobilized (due to an operation or any other reason) and/or have liver problems (such as non-alcoholic fatty liver disease).
CAL 123 FEM TABLET should be used with caution in pregnant and breastfeeding women only clearly necessary. CAL 123 FEM TABLET should be used with caution in children and adolescents (aged below 18 years).
The most common side effects associated with the use of CAL 123 FEM TABLET are hypercalcemia (high calcium levels in the blood), headache, skin rash, excess thirst, and nausea. abdominal pain and/or urinary tract infection. Consult your doctor if any of these symptoms worsen.
USES OF CAL 123 FEM TABLET
- Prevent, treat and manage postmenopausal osteoporosis and fractures
HOW CAL 123 FEM TABLET WORKS
CAL 123 FEM TABLET helps in promoting bone health in postmenopausal women, where calcitriol works by aiding the body to absorb more calcium from food or supplements, which also regulates the production of parathyroid hormone (the chemical responsible for maintaining the balance between calcium and phosphorus in the body).
Calcium carbonate, calcium orotate, calcium citrate, and calcium aspartate work by facilitating calcium retention and bone accrual, which leads to consolidation and maintenance of bone mass, thus preventing bone fracture and reducing the risk of osteoporosis.
Soy isoflavones mimic the actions of oestrogen, which is a hormone that is needed for calcium deposition in the bones, thereby reversing bone loss in postmenopausal women.
Vitamin K2-7 works by increasing collagen production through osteoblastic cells and preventing calcium deposits in the arteries, thus increasing healthy bone deposits and thereby treating osteoporosis in affected individuals.
DIRECTIONS FOR USE
Take CAL 123 FEM TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CAL 123 FEM TABLET
COMMON
- signs of hypercalcemia (increased calcium levels in the blood) such as tiredness, weakness, vomiting, excessive urination, high blood pressure
- headache
- skin rash
- excess thirst
- nausea
- abdominal pain
- urinary tract infection
UNCOMMON
- high blood pressure
- drowsiness
- high fever
- anorexia (eating disorder)
- ophthalmic conditions such as conjunctivitis, photophobia
RARE
- signs of hypercalcemia (increased calcium levels in the blood) such as loss of appetite, weight loss, nausea, vomiting, headache, sluggishness, drowsiness, weakness
- signs of extreme hypercalcemia (very high calcium levels in the blood) such as high fever, thirsty, dehydration, passing more urine, wetting the bed, constipation, stomach pain, blockage of the bowel, irregular heartbeat, urinary bladder infection, restricted growth, and/or mental problems
- signs of allergic reactions such as itchy skin, skin rashes, and/or reddening of the skin
Stop taking CAL 123 FEM TABLET and contact your doctor if you experience any of the following side effects:
- signs of severe allergic reactions such as itchy skin, skin rashes, and reddening of the skin
HOW TO MANAGE SIDE EFFECTS
Nausea And Vomiting
Try to take CAL 123 FEM TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Thirst
Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice daily and use mouthwash. Consult and inform your doctor if the symptom gets worse.
Headache
If CAL 123 FEM TABLET causes a headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking CAL 123 FEM TABLET. If it lasts more than a week or is severe, inform your doctor.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredCAL 123 FEM TABLET should be used with caution during pregnancy and in women planning for pregnancy only if it is necessary. Consult your doctor before taking it.
BREASTFEEDING
Monitoring requiredCAL 123 FEM TABLET should be used with caution in breastfeeding women only if it is necessary. Consult your doctor before taking it.
DRIVING AND USING MACHINES
SafeCAL 123 FEM TABLET is unlikely to affect your ability to drive or operate machines. Consult your doctor before taking it.
KIDNEY
Use with CautionCAL 123 FEM TABLET should be used with caution in patients with kidney problems such as renal osteodystrophy. Consult your doctor before taking it.
LIVER
Use with CautionCAL 123 FEM TABLET should be used with caution in patients with liver problems such as non-alcoholic fatty liver disease. Consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take CAL 123 FEM TABLET if you are allergic to Calcitriol, other vitamin D metabolites (such as alfacalcidol, cholecalciferol), and/or any other ingredients of this medicine. Consult your doctor before taking it.
USE IN PEDIATRICS
Use with CautionCAL 123 FEM TABLET should be used with caution in children and adolescents (below 18 years). Consult your doctor before taking it.
USE IN GERIATRICS
Use with CautionCAL 123 FEM TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking it.
OTHERS
CAL 123 FEM TABLET is not recommended for use if you:
- have hypercalcemia (high calcium levels in the blood)
- have metastatic calcification (extra deposits of calcium in your body)
- are unwell due to high levels of vitamin D in your body
Before taking CAL 123 FEM TABLET, inform your doctor if you:
- are immobilized due to operation or any other reason
INTERACTIONS
A. Drug-Drug Interactions:
Before taking CAL 123 FEM TABLET, inform your doctor, if you are taking any of the following medicine:
- other medicines containing vitamin D
- diuretics (a medicine used to treat high blood pressure) Ex. bendroflumethiazide, chlortalidone, indapamide
- digoxin, digitoxin (medicines used to treat heart diseases)
- medicines containing magnesium such as antacids (medicines used to treat indigestion) Ex. magnesium hydroxide
- medicines used to treat pain and inflammation such as corticosteroids (Ex. hydrocortisone, prednisolone, dexamethasone)
- medicine used to treat high levels of blood cholesterol such as ion-exchange resins Ex. cholestyramine
- phosphate (a medicine used to treat certain urinary tract infections)
B. Drug-Food Interactions:
Avoid having vitamin D-rich foods (such as dairy products like milk, and cheese) or fortified foods (eatables to which vitamin D is added) while taking CAL 123 FEM TABLET since it may increase the risk of side effects. Consult your doctor before taking it.
Overdosage:
If you or anyone else accidentally takes too much of CAL 123 FEM TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include signs of hypercalcemia such as loss of appetite, weight loss, nausea, vomiting, constipation, headache, sluggishness, drowsiness, and/or weakness.
SYNOPSIS
| Drug | : | Calcitriol, Calcium Carbonate, Calcium Orotate, Calcium Citrate, Calcium Aspartate, Soya Isoflavones, and Vitamin K2-7 |
| Pharmacological Category | : | Vitamin D derivatives, Calcium compounds,Phytoestrogens, and Vitamin K derivatives |
| Therapeutic Indication | : | Postmenopausal osteoporosis and fractures |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep the medicine out of reach of children
- Store below 25°C
FAQs ABOUT CAL 123 FEM TABLET
Q: What is CAL 123 FEM TABLET used for?
A: CAL 123 FEM TABLET is used to prevent, treat, or manage postmenopausal osteoporosis and fractures. Menopause is the time that marks the natural end of reproductive age for a woman, along with the cessation of the menstrual cycle and a decline in reproductive hormone levels in the body, causing bone loss (postmenopausal osteoporosis) and fractures.
Q: What happens if you take more CAL 123 FEM TABLET than your required dose?
A: If you or anyone else accidentally takes too much CAL 123 FEM TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include signs of hypercalcemia such as loss of appetite, weight loss, nausea, vomiting, constipation, headache, sluggishness, drowsiness, and/or weakness.
Q: What side effects are seen with CAL 123 FEM TABLET?
A: The most common side effects associated with the use of CAL 123 FEM TABLET are hypercalcemia (high calcium levels in the blood), headache, skin rash, excess thirst, and nausea. abdominal pain and/or urinary tract infection. Consult your doctor if any of these symptoms worsen.
Q: Who should avoid taking CAL 123 FEM TABLET?
A: CAL 123 FEM TABLET is not recommended for use in patients allergic to calcitriol, other vitamin D metabolites (such as alfacalcidol, cholecalciferol), and/or any other ingredients of this medicine. CAL 123 FEM TABLET is also not recommended for use in patients with hypercalcemia (high calcium levels in the blood) and/or metastatic calcification (extra deposits of calcium in your body). Consult your doctor before taking CAL 123 FEM TABLET.
Q: Is CAL 123 FEM TABLET safe to use in children or elderly patients?
A: Yes, CAL 123 FEM TABLET can be used, but with caution in children and adolescents (below 18 years) and in elders (aged above 65 years). Consult your doctor before taking it.
Q: Is CAL 123 FEM TABLET safe for use by pregnant and breastfeeding women?
A: Yes, CAL 123 FEM TABLET can be used, but with caution during pregnancy and in women planning for pregnancy only if it is necessary. It is also used with caution in breastfeeding women if deemed necessary by the consulting doctor. Consult your doctor before taking CAL 123 FEM TABLET.
Q: What if I forget to take my CAL 123 FEM TABLET dose?
A: If you forgot to take your CAL 123 FEM TABLET dose, take it as soon as possible when you remember. Do not double the dose to make up for the missed dosage. Consult your doctor if you have doubts about a missed dosage.
Q: How much CAL 123 FEM TABLET can be taken in a day?
A: Take CAL 123 FEM TABLET as advised by your physician, who shall decide the correct dose and duration for you depending on your age, body weight, and disease condition.
REFERENCES
1. Edward Giovannucci, Martin Hewison, Roger Bouillon, David Goltzman, David Feldman. The Vitamin D analogs, Eldecalcitol. Vitamin D: Volume 2: Health, Disease and Therapeutics. Fourth edition. 2018. Page 215.
2. Paul Insel, Elaine Turner, Don Ross. Calcium Supplements: Are they right for you? Discovering Nutrition. Third edition. 2010. Page 417.
3. Jan Gordeladze. Vitamin K2 and Bone Heath. Vitamin K2 is Vital for Health and Wellbeing. Edition. 2017. Page 110.
4. Brandon E. Lung; Myles L. Mowery; David E E. Komatsu. Calcitriol. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. July 2022. [Accessed on 4th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK526025/
5. Hamid Lorvand Amiri, Shahram Agah , Javad Tolouei Azar , Sharieh Hosseini , Farzad Shidfar , Seyedeh Neda Mousavi. Effect of daily calcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energy-restricted diet: Randomized, controlled, double-blind trial. NIH National Library of Medicine. National Centre for Biotechnology Information. PubMed.gov. September 2016. [Accessed on 4th October 2022] https://pubmed.ncbi.nlm.nih.gov/27720403/
6. Ji Yeon Lee, Tsz-Yin So, and Jennifer Thackray. A Review on Vitamin D Deficiency Treatment in Pediatric Patients. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. December 2013. [Accessed on 4th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979050/
7. Meghan Meehan, Sue Penckofer. The Role of Vitamin D in the Aging Adult. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. December 2014. [Accessed on 4th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399494/
8. Atnahs Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 4th October 2022] https://www.medicines.org.uk/emc/files/pil.11802.pdf
9. PHARMED LIMITED. Cal 123 fem. [Accessed on 4th October 2022] https://www.pharmedlimited.com/women-health/cal123-fem.html
USEFUL DIAGNOSTIC TESTS
- Dual X-ray absorptiometry
- Blood tests
PRODUCT DETAILS
ALTERNATE BRANDS
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