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CAFIRATE 20mg Injection 2ml
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INTRODUCTION
CAFIRATE 20MG INJECTION contains Caffeine which belongs to the group of medicines called CNS stimulants. It is used to treat primary apnea (episodes of interrupted breathing) in premature babies. Primary apnea in premature babies happens due to immature development of baby’s breathing centers.
CAFIRATE 20MG INJECTION has been shown to reduce the number of episodes of interrupted breathing in premature newborns babies. It can also be used to treat and prevent bronchopulmonary dysplasia (airway damage) among premature babies.
Before CAFIRATE 20MG INJECTION is administered, inform your doctor if you child has any liver, kidney or heart problems. You must also inform your doctor if your child suffers from seizure disorders, slow weight gain or frequent regurgitation (spitting up of milk or food) as a precaution.
If you are the mother of the premature infant who receives the treatment, you must not drink coffee or take foods which has high caffeine content. This is because the caffeine taken by the breastfeeding mother may pass through the breast milk to the nursing premature infant who is already receiving caffeine therapy and may lead to an overdosage. The most common side effect of CAFIRATE 20MG INJECTION is fast or irregular heart rate. Consult your doctor if it worsens.
USES OF CAFIRATE 20MG INJECTION
- Treats primary apnea (episodes of interrupted breathing) in premature babies
- Treats and prevents bronchopulmonary dysplasia (airway damage) in premature babies
HOW CAFIRATE 20MG INJECTION WORKS
CAFIRATE 20MG INJECTION is a CNS stimulant. It works by stimulating a part of the brain that controls breathing. As a result, the brain transfers a lot of breathing signals to the lungs which makes the lungs breathe more deeper and faster. It also increases the number of breathing cycles, prevents the airway damage and reduces the need for mechanical ventilation.
DIRECTIONS FOR USE
CAFIRATE 20MG INJECTION will be administered by a doctor or a nurse into the vein of the child (intravenous drips). Your doctor will decide the correct dose and duration of therapy for your child based on their gestational age, body weight and health condition.
SIDE EFFECTS OF CAFIRATE 20MG INJECTION
COMMON
- Fast or irregular heart rate
- Increased blood sugar levels
Contact your doctor immediately if you notice any of the following side effects in your child after CAFIRATE 20MG INJECTION is administered:
- Severe bloody stools
- Fits
- Blood infections (sepsis)
- Allergic reactions (such as skin rash, itching, redness, swelling of the face, lips, tongue or threating and breathing difficulties)
WARNING & PRECAUTIONS
BREASTFEEDING
ContraindicatedIf you are the mother of the premature infant who receives the treatment, you must not drink coffee or take foods which has high caffeine content. This is because the caffeine taken by the breastfeeding mother may pass through the breast milk to the nursing premature infant who is already receiving caffeine therapy and may lead to an overdosage.
KIDNEY
Use with CautionCAFIRATE 20MG INJECTION should be used with caution in babies with kidney problems. Therefore, inform your doctor as a precaution.
LIVER
Use with CautionCAFIRATE 20MG INJECTION should be used with caution in babies with liver problems. Therefore, inform your doctor as a precaution.
ALLERGY
ContraindicatedIf your child is allergic to caffeine, kindly inform your doctor before CAFIRATE 20MG INJECTION is administered to the child.
HEART DISEASE
Use with CautionCAFIRATE 20MG INJECTION should be used with caution in babies with heart problems (such as irregular heart rate). Therefore, inform your doctor as a precaution.
USE IN PEDIATRICS
SafeCAFIRATE 20MG INJECTION can be used in premature infants born between 28-33 gestation weeks (7-8 months of pregnancy) under careful medical supervision.
OTHERS
Before CAFIRATE 20MG INJECTION is administered to the baby, kindly inform the doctor if your baby suffers from any of the following conditions:
- fits
- frequent regurgitation (spitting up of milk or food)
- increased urination
- slow or reduced weight gain or food intake
- increased caffeine intake by the mother before the baby is delivered
- use of antiepileptic medicines by the mother during her pregnancy
INTERACTIONS
A. Drug-Drug interactions:
Before CAFIRATE 20MG INJECTION is administered to the child, kindly inform the doctor if your child is given any of the following medicines as a precaution:
- other medicines that help in breathing (Ex. theophylline, doxapram)
- medicines used to control fits (such as phenobarbitone or phenytoin) taken by the mother during pregnancy before delivering the baby
- ketoconazole (a medicine used to treat fungal infections)
- medicines used to treat stomach ulcers (such as omeprazole, pantoprazole, rabeprazole, ranitidine, famotidine, cimetidine, etc.)
Overdosage:
CAFIRATE 20MG INJECTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you notice fits or any other side effects in your child.
SYNOPSIS
| Drug | : | Caffeine |
| Pharmacological Category | : | Methylxanthines |
| Therapeutic Indication | : | Apnea of prematurity in infants |
| Dosage Forms | : | Tablet, Injection, Oral solution, Suspension |
MORE INFORMATION
- Keep CAFIRATE 20MG INJECTION out of reach of children
- Store CAFIRATE 20MG INJECTION at room temperature
FAQs ABOUT CAFIRATE 20MG INJECTION
Q: What is the use of CAFIRATE 20MG INJECTION?
A: CAFIRATE 20MG INJECTION is used to treat primary apnea (episodes of interrupted breathing) in premature babies. It can also be used to treat and prevent bronchopulmonary dysplasia (airway damage) among premature babies.
Q: How CAFIRATE 20MG INJECTION helps in breathing problems?
A: CAFIRATE 20MG INJECTION is a CNS stimulant. It works by stimulating a part of the brain that controls breathing. As a result, the brain transfers a lot of breathing signals to the lungs which makes the lungs breathe more deeper and faster. It also increases the number of breathing cycles, prevents the airway damage and reduces the need for mechanical ventilation.
Q: Is CAFIRATE 20MG INJECTION safe for use in children?
A: CAFIRATE 20MG INJECTION can be used in premature infants born between 28-33 gestation weeks (7-8 months of pregnancy) under careful medical supervision.
Q: Why newborn babies suffer from apnea?
A: Primary apnea in premature babies happens due to immature development of baby’s breathing centers.
Q: What are the side effects of CAFIRATE 20MG INJECTION?
A: The most common side effect of CAFIRATE 20MG INJECTION is fast or irregular heart rate. Consult your doctor if it worsens.
Q: Is CAFIRATE 20MG INJECTION effective?
A: CAFIRATE 20MG INJECTION effectively improves breathing among infants suffering from apnea of prematurity. It works by stimulating a part of the brain that controls breathing. It also increases the number of breathing cycles, prevents the airway damage and reduces the need for mechanical ventilation.
REFERENCES
1. KD. Tripathi. Drugs for Cough and Bronchial asthma. CNS Stimulants and Cognition Enhancers. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 224, 227& 488.
2. Justin Evans; John R. Richards; Amanda S. Battisti. Caffeine. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2022. [Accessed on 25th March 2023] https://www.ncbi.nlm.nih.gov/books/NBK519490/
3. Martindale Pharma. Caffeine Citrate 10mg/ml Solution for Injection. Electronic Medicines Compendium (EMC). [Revised in February 2020]. [Accessed on 25th March 2023] https://www.medicines.org.uk/emc/files/pil.5146.pdf
4. American Regent, Inc. Caffeine Citrate Injection, Solution. Dailymed.com. [Revised in September 2020]. [Accessed on 25th March 2023] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d17e3be5-514f-454a-8347-d804cd5ec37f
PRODUCT DETAILS
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