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BYPOL 250MG TABLET contains Sodium Valproate which belongs to the group of medicines called Mood stabilizers. It is used to manage or control mania (feeling very excited, enthusiastic, over-active and easily irritated or distracted) caused by bipolar disorder. Bipolar disorder is when the mood fluctuates between feeling very high (mania) and very low (depression).
BYPOL 250MG TABLET can be used when lithium cannot be used. BYPOL 250MG TABLET is also used to treat complex partial seizures (in adults and children 10 years of age and older) and simple and complex absence seizures, with or without other types of seizures.
A seizure results from an excessive discharge of specific nerve cells and is characterized by changes in electrical activity. BYPOL 250MG TABLET can also be used to prevent migraine headaches (episodes of moderate to severe headache, mostly unilateral, generally associated with nausea and hypersensitivity to light and sound).
Before taking BYPOL 250MG TABLET, inform your doctor if you have fits, porphyria, liver, kidney, or pancreatic problems, diabetes, systemic lupus erythematosus, or any genetic diseases. Patients should be monitored for signs of suicidal ideation and behaviour and advised to seek medical advice if any such signs occur.
Avoid consumption of alcohol while taking BYPOL 250MG TABLET. BYPOL 250MG TABLET is not recommended for use in pregnant or breastfeeding women or children (younger than 2 years) who are at a considerably increased risk of developing liver toxicity.
The most common side effects of taking BYPOL 250MG TABLET are nausea, vomiting, headache, sleepiness, blurry or double vision, weight gain, hair loss, problems with walking, etc. Consult your doctor if any of the symptoms get worse.
BYPOL 250MG TABLET is used:
BYPOL 250MG TABLET works by acting on GABA (γ aminobutyric acid) levels in the CNS, whose inhibitory activity is impaired in seizures and also in migraine headaches. It may also exert antiepileptic effects by reducing the high-frequency firing (excessive discharge) of nerve cells. BYPOL 250MG TABLET stabilizes mood by stabilizing the levels of chemicals in your brain that are responsible to affect your mood.
Take BYPOL 250MG TABLET as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of BYPOL 250MG TABLET for you based upon your age, body weight and disease condition. Do not stop taking BYPOL 250MG TABLET unless your doctor advises you to stop.
Stop taking BYPOL 250MG TABLET and contact your doctor immediately if you experience any of the following side effects:
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If your appetite does not improve, contact your doctor.
Drink lots of fluids, like water or fruit juice, to keep yourself hydrated. Check with your doctor before taking any medicine for diarrhoea. If the diarrhoea does not get better, contact your doctor.
Lie down until the dizziness is resolved, then get up slowly. Do not hurry and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. If dizziness does not get better, consult your doctor.
Take BYPOL 250MG TABLET with, or just after, meals. Stick to simple meals. Avoid eating oily or spicy foods. If you still feel nauseous, contact your doctor. Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating; you don't have to eat or avoid any specific foods. Do not take any medicine for vomiting without your doctor's consultation. If vomiting does not get better, contact your doctor.
Try to rest and relax. Eat and drink slowly, or try to eat smaller meals more frequently. Keep a heating pad on your stomach. If your stomach still aches, contact your doctor.
Drink plenty of water and get adequate rest. Try to be relaxed and stress-free. Check with your doctor before taking any medicine for a headache. If your headache does not get better, consult your doctor.
Avoid driving or going outside on your own if you have blurred eyesight. Close your eyes for some time until your eyesight gets clear. Contact your doctor if your vision remains blurred for a long period.
BYPOL 250MG TABLET is not recommended for use in pregnant women, especially if you are taking it to prevent migraine headaches. Females of child-bearing capability must use effective contraception. Consult your doctor before taking it.
BYPOL 250MG TABLET should be used with caution in breastfeeding women as a little amount may pass through the breast milk. Consult your doctor before taking it.
Do not drive or operate any machines if you feel sleepy, confused or dizzy after taking BYPOL 250MG TABLET.
Alcohol consumption is not recommended while taking BYPOL 250MG TABLET as it may cause sleepiness or dizziness or make these worse.
BYPOL 250MG TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking it.
BYPOL 250MG TABLET is not recommended in patients with liver problems or a family history of liver problems caused by taking medicine. Consult your doctor before taking it.
Do not take BYPOL 250MG TABLET if you are allergic to Valproic acid, divalproex sodium, sodium valproate, aspirin or any of the other ingredients of this medicine.
BYPOL 250MG TABLET is not recommended for use in children (younger than two years) who are at a considerably increased risk of developing liver toxicity. Consult your doctor before taking it.
BYPOL 250MG TABLET should be used with caution in elderly patients as they may experience drowsiness or sleepiness. Consult your doctor before taking it.
BYPOL 250MG TABLET is not recommended for use if you:
Before taking BYPOL 250MG TABLET, inform your doctor if you:
A. Drug-Drug interactions:
Before taking BYPOL 250MG TABLET, inform your doctor if you are taking any of the following medicines:
If you or anyone else accidentally take too much of BYPOL 250MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of GBNKEYWORD] overdose are nausea, vomiting, headache, blurred eyesight, dizziness, poor reflexes, confusion, memory loss, tiredness, weak or ‘floppy’ muscles, fits, loss of consciousness, behavioural changes, fast breathing, shortness of breath or chest pain.
|Pharmacological Category||:||Aliphatic carboxylic acid|
|Therapeutic Indication||:||Mania, Seizures, Migraine headaches|
|Dosage Forms||:||Tablet, Oral solution|
Q: Can BYPOL 250MG TABLET be taken during pregnancy?
A: BYPOL 250MG TABLET is not recommended for use by pregnant women, especially if you are taking it to prevent migraine headaches. Females of childbearing capability must use effective contraception. Do not stop taking your contraception until your doctor advises you further.
If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking BYPOL 250MG TABLET. Inform your doctor immediately if you become pregnant during treatment with BYPOL 250MG TABLET.
Q: Can BYPOL 250MG TABLET make me feel suicidal?
A: Thoughts of harming or killing oneself are seen in a small number of patients being treated with BYPOL 250MG TABLET. Patients taking BYPOL 250MG TABLET should be monitored for signs of suicidal ideation and behaviours, especially sudden changes in mood, behaviours, thoughts, or feelings, and advised to seek medical advice if any such signs occur.
Q: Can BYPOL 250MG TABLET cause weight gain?
A: Yes. Taking BYPOL 250MG TABLET may make you put on weight. Discuss with your doctor for advice before taking BYPOL 250MG TABLET.
Q: Can I take other medicines with BYPOL 250MG TABLET?
A: Before taking BYPOL 250MG TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, over-the-counter or herbal medicine, as these might cause serious side effects by interacting with each other.
Q: Can BYPOL 250MG TABLET cause erectile dysfunction?
A: According to some studies, men on BYPOL 250MG TABLET therapy show irregularities in androgens blood levels, sperm motility, and erectile dysfunction. Consult your physician if you have trouble getting an erection or related symptoms during BYPOL 250MG TABLET treatment.
Q: Can BYPOL 250MG TABLET cause autism?
A: Autism and related disorders are more often diagnosed in children exposed to BYPOL 250MG TABLET during pregnancy. Consult your doctor for further doubts.
Q: Can BYPOL 250MG TABLET be given to children?
A: BYPOL 250MG TABLET is not recommended for use in children (younger than two years) who are at a considerably increased risk of developing liver toxicity. Your doctor will decide on the correct dose of BYPOL 250MG TABLET or select a suitable alternative treatment for your child.
Q: What if I forget to take a dose of BYPOL 250MG TABLET?
A: If you forget to take a dose of BYPOL 250MG TABLET, take it as soon as you remember. However, omit the missed dose if it's almost time for the next one. Do not take BYPOL 250MG TABLET twice to make up for the missed dose.
Q: Can BYPOL 250MG TABLET be stopped?
A: Continue taking BYPOL 250MG TABLET until your doctor tells you to stop unless you experience any unwanted effects, a worsening of your condition, or any new symptoms. Contact your doctor in such cases.
If you stop taking BYPOL 250MG TABLET without your doctor’s advice, your condition may get worse. When your doctor finds it okay to discontinue BYPOL 250MG TABLET treatment, your dose will be lowered gradually.
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Epilepsy. Pharmacotherapy Handbook. Ninth edition. Page-518, 530.
2. Rahman M, Nguyen H. Valproic Acid. NIH National Library of Medicine, National center for biotechnology information. StatPearls [Internet]. July 2022. [Accessed on 9th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK559112/
3. Cutrer FM, Limmroth V, Moskowitz MA. Possible mechanisms of valproate in migraine prophylaxis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 1997. [Accessed on 9th August 2022] https://pubmed.ncbi.nlm.nih.gov/9137844/#:~:text=Valproate%20increases%20brain%20GABA%20levels,and%20directly%20attenuates%20nociceptive%20neurotransmission.
4. Sanofi-aventis SA. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 9th August 2022] https://www.medicines.org.uk/emc/files/pil.6102.pdf
5. AbbVie Ltd. Valproic Avid. [Revised in October 2021] [Accessed on 9th August 2022] https://www.rxabbvie.com/pdf/depakote.pdf
Sodium Valproate Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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