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INTRODUCTION
BUDEZ CR contains Budesonide which belongs to a group of medicines called corticosteroids which reduces inflammation. It is an anti-inflammatory medicine works by decreasing the body's natural defense response (immune response). This medicine is used in the treatment of ulcerative colitis (inflammation of the large intestine colon and the rectum) and inflammation of the small bowel and the first part of the large bowel (Crohn’s disease) and also microscopic colitis (disease with chronic inflammation of the large bowel with chronic watery diarrhoea). IBD is a chronic relapsing inflammatory disease of the ileum, colon, or both associated with systemic manifestations. The two important types of IBD are ulcerative colitis (UC) and Crohn’s disease (CrD).
Take this medicine as prescribed by your doctor. The dose you take will depend on your age, other medications you are taking and whether you have any kidney or liver problems. It is not recommended for use in children. The common side effects are nausea, vomiting, headache and dizziness. Before taking this BUDEZ CR, tell your doctor if you have tuberculosis, infections, pregnant or breastfeeding. It is not recommended for use in children. Avoid grapefruit juice while you are taking this medicine. The common side effects are headache, heartburn and palpitations.
USES OF BUDEZ CR
- Treats Ulcerative colitis, Crohn’s disease and Microscopic colitis
HOW BUDEZ CR WORKS
BUDEZ CR is a corticosteroid that exhibits an anti-inflammatory action. It works by preventing the cells in the lungs and breathing passages from releasing chemical messengers that cause inflammation of the airways. This widens the airways and makes breathing easier.
DIRECTIONS FOR USE
Take this medicine according to the dose and frequency as advised by your doctor. Swallow as a whole, do not crush or chew. It can be taken with or without food.
SIDE EFFECTS OF BUDEZ CR
SERIOUS
- raised lumps on skin (weals)
- swelling of face, lips, mouth, tongue or throat
COMMON
- heartburn
- muscle cramps
- palpitations
- rash or itchy skin
- heavy or irregular periods (women)
- low levels of potassium
- rounded face, acne, weight gain and bruising more easily (Cushingoid feature)
- nervousness, difficulty sleeping, mood swings and depression
RARE
- aggression
- clouding of the eye's natural lens
- skin discoloration
- glaucoma
- blurred vision
HOW TO MANAGE SIDE EFFECTS
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Heartburn:
Eat smaller and more frequent meals. Avoid eating before bedtime.
WARNING & PRECAUTIONS
PREGNANCY
BUDEZ CR should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
BUDEZ CR should be used with caution during breastfeeding. Consult your doctor before taking this medicine.
DRIVING AND USING MACHINES
This medicine has no or negligible influence on the ability to driving or using machines.
LIVER
BUDEZ CR should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Budesonide.
OTHERS
Inform your doctor if you have,
- infection
- tuberculosis
- high blood pressure
- diabetes
- ever had brittle bones
- stomach ulcers
- glaucoma or cataracts
- mental health problems
INTERACTIONS
Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,
- prednisolone or dexamethasone
- cholestyramine (used to reduce cholesterol levels or reduce itching)
- ketoconazole or itraconazole (used to treat infection)
- oestrogen such as hormone replacement therapy (HRT)
- oral contraceptives
- ritonavir, cobicistat and nelfinivir
- carbamazepine (used to treat epilepsy and fits)
SYNOPSIS
| Drug | : | Budesonide |
| Pharmacological Category | : | Corticosteroid, Systemic |
| Therapeutic Indication | : | Crohn disease, mild to moderate ulcerative colitis |
| Dosage Forms | : | Tablet, Capsule, Inhaler, Nasal spray |
MORE INFORMATION
Do not store above 30°C and keep out of reach of children.
FAQs ABOUT BUDEZ CR
Can BUDEZ CR be given in children?
It is not recommended for use in children.
Is BUDEZ CR effective?
Yes, it is effective if used in the correct dose and duration as advised by your doctor.
REFERENCES
1. KD Tripathi MD. Histamine and Antihistaminics. Drugs for constipation and diarrhoea. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 683.
2. John L. Wallace & Keith A. Sharkey. Drugs affecting Gastrointestinal function. Pharmacotherapy of inflammatory Bowel disease. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics.12th ed. New York, McGraw-Hill Medical 2011; Page -1356.
3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page -162-64.
4. Lichtenstein, Gary R. M.D, Bengtsson, Bengt M.D &Danilewitz, Mervyn M.D. Safety of Budesonide Capsules for the Treatment of Crohn's Disease. American Journal of Gastroenterology, Sep 2005, Vol – 100. [Accessed Nov 5 2020] https://journals.lww.com/ajg/Fulltext/2005/09001/Safety_of_Budesonide_Capsules_for_the_Treatment_of.861.aspx.
5. Ferring Pharmaceuticals Ltd, Cosmo S.P.A, (Italy); Electronic Medicines Compendium (EMC); [Revised Feb 2018] [Accessed Nov 30, 2020] https://www.medicines.org.uk/emc/files/pil.1895.pdf
6. AstraZeneca AB, (Sweden); Electronic Medicines Compendium (EMC); [Revised Oct 2019] [Accessed Nov 30, 2020] https://www.medicines.org.uk/emc/files/pil.872.pdf
7. Mihir K Raval, Riddhi V Ramani, Navin R Sheth. Formulation and evaluation of sustained release enteric-coated pellets of budesonide for intestinal delivery: International Journal of Pharmaceutical; Dec 2013 [Accessed Nov 30 2020] https://www.researchgate.net/publication/259355910_Formulation_and_evaluation_of_sustained_release_enteric-coated_pellets_of_budesonide_for_intestinal_delivery
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
Manufacturer DETAILS
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