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INTRODUCTION
BRIMONIX EYE DROPS contains Brimonidine which belongs to the group of medicines called Ophthalmic anti-glaucoma agents. It is used to treat ocular hypertension and glaucoma. Ocular hypertension refers to increased pressure within the eye without any significant damage to the optic nerve. Whereas glaucoma is a group of eye condition that causes significant damage to the optic nerve due to elevated pressure within the eye followed by vision loss if left untreated.
Both ocular hypertension and glaucoma are caused due to impaired secretion or drainage of fluids (aqueous humour) within the eyes. Brimonidine reduces the pressure within the eyes by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. This reduces strain on the eyes and therefore decreases the elevated pressure within the eye.
Before using BRIMONIX EYE DROPS inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have depression or other types of mental illnesses.
Consult your doctor before using BRIMONIX EYE DROPS if you are pregnant or think you may be pregnant or breastfeeding. It is not recommended for use in children aged below 12 years due to lack of safety data.
If you wear soft contact lenses, remove the lens before applying BRIMONIX EYE DROPS and wait for at least 15 minutes before reinsertion. BRIMONIX EYE DROPS may make your vision blur, therefore be cautious while you drive or operate heavy tools.
The most common side-effect of using BRIMONIX EYE DROPS are eye redness, burning sensation, eye inflammation and itching, watery eyes, dry mouth, and blurred vision. Consult your doctor if any of these side effect worsens.
USES OF BRIMONIX EYE DROPS
- Treats ocular hypertension and glaucoma
HOW BRIMONIX EYE DROPS WORKS
BRIMONIX EYE DROPS effectively reduces the elevated pressure within the eye, where brimonidine acts by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. This reduces strain on the eyes and therefore decreases the elevated pressure within the eye.
DIRECTIONS FOR USE
Use BRIMONIX EYE DROPS as advised by your doctor. It is for ophthalmic use only. Wash your hands before use. Instil few drops of BRIMONIX EYE DROPS into the affected eye. Close your eyes and press the corner of your eye with your finger for a minute.
Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. Apply applying BRIMONIX EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying BRIMONIX EYE DROPS and wait for at least 15 minutes before reinsertion.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop using BRIMONIX EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again.
SIDE EFFECTS OF BRIMONIX EYE DROPS
COMMON
- eye redness, itching, burning or stinging sensation
- white spots on the whites of the eye
- blurred vision
- feeling of something in the eye
- headache
- tiredness, weakness
- drowsiness
- dry mouth
- erosion on eye surface, staining
- swollen or red eyelid, abnormal vision, sticky, watery eyes, sensitivity to light
- pain, irritation, whitening of the membrane covering the inside of the eyelid
- inflammation of the cornea (outer layer of the eye)
- nausea, vomiting
- stomach and digestion problems
- cold-like symptoms
- abnormal taste
UNCOMMON
- depression
- palpitations or changes in heart rate
- dry nose
- general allergic reactions
RARE
- shortness of breath
Stop using BRIMONIX EYE DROPS and contact your doctor immediately if you experience any of the following symptoms:
- severe allergic reaction symptoms of which are difficulty in breathing, swelling of tongue, lips, face, or throat
HOW TO MANAGE SIDE EFFECTS
Eye Irritation Or Itching
Wash your eyes with plain cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops, or television. Wear protective eyeglasses while going outdoors.
Eye Pain Or Sensitivity
Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
WARNING & PRECAUTIONS
PREGNANCY
Use with CautionBRIMONIX EYE DROPS should be used with caution in pregnant women. Therefore, consult your doctor before using it.
BREASTFEEDING
ContraindicatedBRIMONIX EYE DROPS is not recommended for use in breastfeeding women. Therefore, consult your doctor before using it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any heavy tools or machines if you experience blurred vision, drowsiness or tiredness after using BRIMONIX EYE DROPS.
ALCOHOL
Consult your doctorAvoid the consumption of alcohol while using BRIMONIX EYE DROPS as it may increase the risk of side effects.
KIDNEY
Use with CautionBRIMONIX EYE DROPS should be used with caution in patients having kidney diseases. Therefore, consult your doctor before using it.
LIVER
Use with CautionBRIMONIX EYE DROPS should be used with caution in patients having liver diseases. Therefore, consult your doctor before using it.
ALLERGY
ContraindicatedDo not use BRIMONIX EYE DROPS if you are allergic to Brimonidine.
HEART DISEASE
Use with CautionBRIMONIX EYE DROPS should be used with caution in patients with heart diseases. Therefore, consult your doctor before using it.
USE IN PEDIATRICS
Consult your doctorBRIMONIX EYE DROPS can be used in children and adolescents aged between 2-12 years if prescribed by a physician. It is not recommended for use in infants and children aged below 12 years due to lack of safety data. Therefore, consult your doctor before using it.
USE IN GERIATRICS
Use with CautionBRIMONIX EYE DROPS should be used with caution in elderly patients. Therefore, consult your doctor before using it.
OTHERS
Before using BRIMONIX EYE DROPS, inform your doctor if you:
- have depression
- have light-headedness or dizziness while standing up
- have reduced blood supply to the brain or reduced mental capacity
- have poor blood circulation or problems in blood vessels supplying the limbs (Ex. deep vein thrombosis)
INTERACTIONS
A. Drug-Drug Interaction:
Before using BRIMONIX EYE DROPS, inform your doctor if you are taking any of the following medicines such as:
- Medicines used to treat depression such as (Ex. citalopram, escitalopram, fluoxetine, sertraline, amitriptyline, nortriptyline)
- medicines used to induce sleep (Ex. alprazolam, midazolam, phenobarbital)
- medicines used to treat mental illness (Ex. chlorpromazine, methylphenidate, reserpine)
- pain killers (Ex. paracetamol, ibuprofen)
- medicines used to lower blood pressure (Ex. enalapril, ramipril)
- medicines that work similar to brimonidine (Ex. prazosin, isoprenaline)
- anaesthetics (used to induce numbness) Ex. lidocaine
Overdosage:
It is unlikely to have an overdosage of BRIMONIX EYE DROPS in adults. However, if overdosage occurs in children receiving BRIMONIX EYE DROPS as a part of their treatment contact your doctor immediately. Symptoms of overdosage might include sleepiness, floppiness, low temperature or breathing difficulties.
SYNOPSIS
| Drug | : | Brimonidine |
| Pharmacological Category | : | Alpha adrenergic receptor agonists |
| Therapeutic Indication | : | Glaucoma |
| Dosage Forms | : | Eye Drops, Ophthalmic Solution, Gel |
MORE INFORMATION
- Keep BRIMONIX EYE DROPS out of reach of children
- Store BRIMONIX EYE DROPS at room temperature
FAQs ABOUT BRIMONIX EYE DROPS
Q: Are there any specific instructions I need to follow while using BRIMONIX EYE DROPS?
A: BRIMONIX EYE DROPS is only meant for ophthalmic use only. Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. Apply applying BRIMONIX EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying BRIMONIX EYE DROPS and wait for at least 15 minutes before reinsertion.
Q: What if I miss a dose of BRIMONIX EYE DROPS?
A: If you missed a dose of BRIMONIX EYE DROPS, apply it as soon as you remember. However, if it is time for next dose, skip the missed dose and use the regular dose. Do not use a double dose of BRIMONIX EYE DROPS to compensate the missed dose.
Q: Can BRIMONIX EYE DROPS cause blurred vision?
A: Yes. BRIMONIX EYE DROPS may cause blurred vision after application. If you experience blurred vision, close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if your condition did not improve.
Q: What is the use of BRIMONIX EYE DROPS?
A: BRIMONIX EYE DROPS is used to treat ocular hypertension and glaucoma. It decreases the elevated pressure within the eye and reduces the risk of optic nerve damage and subsequent vision loss.
Q: What type of drug is BRIMONIX EYE DROPS?
A: BRIMONIX EYE DROPS contains Brimonidine which is an alpha-adrenergic receptor agonist. treat ocular hypertension and glaucoma. It decreases the elevated pressure within the eye and reduces the risk of optic nerve damage and subsequent vision loss.
Q: Who should not take [GBNKEYWORD]?
A: Do not take BRIMONIX EYE DROPS if you are allergic to brimonidine. Inform your doctor if you are pregnant or breastfeeding before using BRIMONIX EYE DROPS. It is not suitable for use in children aged below 12 years. Patients taking antidepressants must consult their doctor before taking BRIMONIX EYE DROPS.
Q: How long do you take BRIMONIX EYE DROPS?
A: Take BRIMONIX EYE DROPS as advised by your doctor. BRIMONIX EYE DROPS is usually taken as long-term therapy along with other medicines to treat glaucoma. Therefore, take it as long as prescribed by your doctor. Do not stop taking BRIMONIX EYE DROPS without consulting your doctor.
Q: Can I stop using BRIMONIX EYE DROPS without consulting my doctor?
A: Do not stop using BRIMONIX EYE DROPS without consulting your doctor. If you think that you are feeling better or if you wish to stop using BRIMONIX EYE DROPS, contact your doctor for advice. Your doctor will check your condition and gradually withdraw the use of BRIMONIX EYE DROPS.
Q: Can I use other eye medicines while using BRIMONIX EYE DROPS?
A: Yes. You can use other eye medicines while undergoing therapy with BRIMONIX EYE DROPS. But make sure to leave a time gap of at least 5 minutes before applying other eye drops or ointment.
Q: Can I use BRIMONIX EYE DROPS while wearing contact lenses?
A: If you wear soft contact lenses, remove the lens before applying BRIMONIX EYE DROPS and wait for at least 15 minutes before reinsertion.
Q: Is BRIMONIX EYE DROPS a beta blocker?
A: No. BRIMONIX EYE DROPS is not a beta blocker. BRIMONIX EYE DROPS contains Brimonidine which belongs to the group of medicines called Alpha adrenergic receptor agonists. It is used to treat ocular hypertension and glaucoma.
Q: Can we drink alcohol while using BRIMONIX EYE DROPS?
A: No, you should not drink alcohol while using BRIMONIX EYE DROPS as it may increase the risk of side effects.
REFERENCES
1. KD. Tripathi. Anti-Adrenergic Drugs Acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 154.
2. Louis B Cantor. Brimonidine in the treatment of glaucoma and ocular hypertension. NIH. National Library of Medicine, National center for biotechnology information. Pubmed central. December 2006. [Accessed on 14th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936355/
3. FDC International Ltd. Electronic Medicines Compendium (EMC). [Revised in October 2020]. [Accessed on 13th May 2022] https://www.medicines.org.uk/emc/files/pil.3426.pdf
4. Allergan, Inc. US Food and Drug Administration (USFDA). [Revised in May 2010]. [Accessed on 13th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021262s020,021770s004lbl.pdf
5. Allergan New Zealand Ltd. [Revised in Feb 2013]. [Accessed on 13th May 2022] https://allergan-web-cdn-prod.azureedge.net/allergan/allergannewzealand/media/allergannewzealand/products/alphagan-p-nz-ds.pdf
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