Tell your healthcare provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements or any other medicines such as 

• hormone-based birth control, such as pills, shots, patches, and implants
• rifampin used for tuberculosis
• ketoconazole, fluconazole, itraconazole, or voriconazole used for fungal infections
• warfarin sodium used to prevent blood clots
• ritonavir used to treat HIV
• cyclosporine used to treat psoriasis and rheumatoid arthritis, and to prevent rejection of heart, liver, and kidney transplants
• glyburide used to treat diabetes

• Take BOSENTAS 125MG exactly as prescribed
• Your healthcare provider will tell you how much BOSENTAS 125MG to take and when to take it
• In most cases, you will take 1 tablet in the morning and 1 in the evening
• You can take BOSENTAS 125MG orally with or without food
• Each 32mg dispersible tablet, or tablet part, can be dispersed in a minimal amount of water to make a liquid medicine immediately before administration. When the tablet has fully dispersed, the liquid should be administered to the patient

If you take more BOSENTAS 125MG

• If you take more than the prescribed dose of BOSENTAS 125MG, call your healthcare provider right away

If you forget to take BOSENTAS 125MG

• If you miss a dose of Bosentan, take your tablet as soon as you remember. Do not take 2 doses at the same time
• If it is almost time for your next dose, skip the missed dose. Just take the next dose at your regular time

If you stop taking BOSENTAS 125MG

• Do not stop taking BOSENTAS 125MG unless your healthcare provider tells you to do so