Bosenat 125mg Tablet 10'S

Hypertension Rx required

Best Price*  ₹ 1,055.75
MRP ₹1,319.69
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mfr: Natco Pharma Ltd * Country of Origin: India
TOTAL AMOUNT ₹ 1,319.69

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INTRODUCTION

BOSENAT 125MG contains Bosentan which belongs to the class of medicines called endothelin receptor antagonists. It is used to treat primary pulmonary arterial hypertension (PAH) and PAH caused by scleroderma (abnormal growth of the connective tissue) or congenital heart defects with shunts. PAH is a type of high blood pressure that affects the blood vessels of the lungs. It is characterized by severe narrowing of the blood vessels, resulting in high blood pressure in blood vessels (pulmonary arteries) that carry blood from heart to lungs. This increased pressure reduces the amount of oxygen that can get into the blood in the lungs, making physical activity more difficult.

Bosentan blocks a hormone called endothelin-1 (ET-1), which causes blood vessels to narrow. It causes vasodilatation of pulmonary arteries, making it easier for the heart to pump blood through them. This lowers the increased blood pressure and relieves the associated symptoms. BOSENAT 125MG can also be used to treat digital ulcers (sores on toes and fingers) in adult patients with scleroderma. Your doctor would suggest frequent blood test for you before and during the treatment, to access your liver function and to check for anemia. If the results are abnormal, your doctor will reduce your dose or stop bosentan treatment.

The most common side effects of taking this medicine are headache, edema, diarrhea, fainting and low blood pressure. Before taking this medicine, inform your doctor if you are pregnant or think you may be pregnant. Bosentan can cause harm to the unborn babies conceived before starting or during the treatment. Your doctor will advise you a suitable contraceptive method. It should be used in children only with PAH. Consult your doctor for advice before taking. It is not recommended for use in pediatric patients with systemic sclerosis and ongoing digital ulcer disease.

USES OF BOSENAT 125MG

  • Treats Pulmonary arterial hypertension (PAH)
  • Treats digital ulcers (sores on toes and fingers)

HOW BOSENAT 125MG WORKS

Bosentan is an endothelin receptor antagonist that effectively blocks a naturally occurring hormone called endothelin-1 (ET-1), which is responsible to cause narrowing of blood vessels. Through this action, bosentan induces vasodilatation of blood vessels (pulmonary arteries) that carry blood from heart to lungs, making it easier for the heart to pump blood through them. This lowers the increased blood pressure and relieves its associated symptoms.

DIRECTIONS FOR USE

Take this medicine as directed by your physician. It can be taken in the morning or evening with or without meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF BOSENAT 125MG

SERIOUS

  • signs of liver damage (such as nausea, vomiting, fever, stomach pain, jaundice (yellowing of skin or whites of eyes), dark-colored urine, itching, unusual tiredness, joint and muscle pain)
  • allergic reactions (such as skin rash, itching, swelling of hands, feet, ankles, face, lips or throat, difficulty in swallowing or breathing)
  • anemia (pale skin and weakness or breathlessness)
  • unexplained bruising or bleeding

COMMON

  • headache
  • edema (swelling of legs and ankles or other signs of fluid retention)
  • flushed appearance or redness of skin
  • gastroesophageal reflux disease (acid reflux)
  • diarrhea
  • syncope (fainting)
  • fast or irregular heartbeats
  • low blood pressure
  • nasal congestion

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

PREGNANCY

BOSENAT 125MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

BOSENAT 125MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Consumption of alcohol is not recommended during treatment with this medicine.

LIVER

Do not take BOSENAT 125MG if you have liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic to bosentan.

INTERACTIONS

Talk to your doctor, if you are taking,

  • cyclosporine A (used to prevent graft rejection and to treat psoriasis)
  • other medicines used to treat graft rejection (e.g. sirolimus or tacrolimus)
  • other medications used to treat pulmonary hypertension (e.g. sildenafil and tadalafil)
  • medicines used to treat fungal infection (e.g. fluconazole and ketoconazole)
  • medicines used to treat HIV infection (e.g. nevirapine, lopinavir and ritonavir)
  • glibenclamide (used to treat diabetes)
  • rifampicin (used to treat tuberculosis)
  • hormonal contraceptives (birth control pills)
  • warfarin (used to thin blood)
  • simvastatin (used to treat high blood cholesterol levels)

SYNOPSIS

Drug :   Bosentan
Pharmacological Category :   Vasodilator, Endothelin receptor antagonists
Therapeutic Indication :   Pulmonary arterial hypertension, digital ulcers
Dosage Forms :   Tablet

MORE INFORMATION

Store at room temperature and keep out of reach of children.

FAQs ABOUT BOSENAT 125MG

Can you take BOSENAT 125MG with sildenafil?

No. Avoid concomitant use of sildenafil and bosentan, because it can increase the risks of side effects.

Can BOSENAT 125MG be taken during pregnancy?

It is strictly not recommended for use in pregnant women, because it can cause harm to the unborn babies conceived before starting or during the treatment. Your doctor will advise you a suitable contraceptive method.

Can BOSENAT 125MG be taken during breastfeeding?

No. This medicine is strictly not recommended for use in breastfeeding mothers, because it is not known whether this medicine passes into breast milk.

REFERENCES

1. Peter J. Barnes. Pulmonary Pharmacology. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York Mc Graw Hill Medical 2011. Page – 1059.

2. John R. Teerlink, Karen Sliwa, Lionel H. Opie. Heart Failure. Drugs for the heart. 8th Edition. 2013. Page – 229.

3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 462- 464.

4. Actelion. A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of Bosentan in Patients with Mildly Symptomatic Pulmonary Arterial Hypertension (PAH). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on August 2011] [Accessed 4th November 2020] https://clinicaltrials.gov/ct2/show/NCT00091715

5. Eli Gabbay, John Fraser and Keith McNeil. Review of bosentan in the management of pulmonary arterial hypertension. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2007. [Accessed 4th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350123/

6. Zentiva. Electronic Medicines Compendium (EMC); [Revised on June 2020] [Accessed 4th November 2020] https://www.medicines.org.uk/emc/files/pil.8909.pdf

7. Pharmadox Healthcare Ltd. Electronic Medicines Compendium (EMC); [Revised on June 2018] [Accessed 4th November 2020] https://www.medicines.org.uk/emc/files/pil.9821.pdf

USEFUL DIAGNOSTIC TESTS

  • Transesophageal echocardiogram
  • Pulmonary function test

Manufacturer/Marketer Details

    Net Qty
    1
    Shelf Life
    NA
    Item Weight
    17.5
    No. of Units in a Kit
    NA
ALTERNATE SALTS
Bosentas 125mg Tablet 10'S
Prescription Hypertension Rx required
Rs.1,359.28
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Bosenat 125mg Tablet 10'S

Bosenat 125mg Tablet 10'S Mfr: Natco Pharma Ltd

M.R.P.: Rs.1,319.69
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