Boletraaz 5mg Tablet 10'S

Auto Immune Disease Rx required
OUT OF STOCK

Best Price*  ₹ 15,840.00
MRP ₹19,800.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Alkem Laboratories Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

BOLETRAAZ 5MG contains Everolimus is an antineoplastic chemotherapy drug. This medication is classified as an mTOR kinase inhibitor. It reduces the blood supply to the tumour and slows down the growth and spread of cancer cells. This medicine is used to treat people with advanced kidney cancer and subependymal giant cell astrocytoma (SEGA) by slowing the growth and spread of tumour cells. It is also used as Prophylaxis of organ rejection in kidney and liver transplant.

Everolimus is a targeted therapy which works by targeting specific to the cancer cells, thereby decreasing side effects caused by unwanted damage to the healthy cells. It is a kinase inhibitor that inhibits mTor kinase. mTor kinase is an enzyme required for cell growth and survival and by blocking this enzyme, the medication prevents cell division and, in turn, tumor growth. The medication can also interrupt the development of blood vessels (angiogenesis) that supply with nutrients, which tumor need to grow.

Always take this medicine as instructed by your doctor.Avoid grapefruit juice while taking this medicine. Swallow this medicine whole and do not chew or crush it. BOLETRAAZ 5MG can develop mouth ulcers and sores. Your doctor might prescribe with a mouthwash, gel or other products. Before taking this medicine, consult your doctor if you have any ongoing medication for any underlying disease. Do not drive or handle any machines while taking this medicine may cause tiredness. It is not to be used in children or adolescents below 18 years of age. The most common side effects are chills (signs of infection), fever, coughing and wheezing, excessive thirst, high or low urine output, increased appetite with weight loss, tiredness and bleeding.

USES OF BOLETRAAZ 5MG

  • Breast cancer
  • Neuroendocrine tumors (NET)
  • Renal cell carcinoma (RCC)

HOW BOLETRAAZ 5MG WORKS

BOLETRAAZ 5MG works by inhibiting mTor kinase, an enzyme required for cell growth and survival. By blocking this enzyme, it prevents cell division and, in turn, tumor growth. This medicine can also interrupt the development of blood vessels (angiogenesis) that supply with nutrients, which tumor need to grow.

DIRECTIONS FOR USE

Always take BOLETRAAZ 5MG exactly as your doctor has directed you. Avoid grapefruit juice while taking this medicine. Swallow this medicine whole and do not chew or crush it.

SIDE EFFECTS OF BOLETRAAZ 5MG

SERIOUS

  • difficulty breathing or swallowing
  • swelling of the face, lips, tongue or throat
  • severe itching of the skin

COMMON

  • increased temperature
  • chills (signs of infection)
  • fever, coughing and wheezing
  • excessive thirst
  • high or low urine output
  • increased appetite with weight loss
  • tiredness
  • bleeding

RARE

  • Shortness of breath or rapid breath

HOW TO MANAGE SIDE EFFECTS

Cough:

Drink sufficient quantity of fluids which helps to thin the mucus in your throat. Suck on cough drops or hard candies.

WARNING & PRECAUTIONS

PREGNANCY

BOLETRAAZ 5MG should be used with caution in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

BOLETRAAZ 5MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or handle any machines while taking this medicine may cause tiredness.

KIDNEY

BOLETRAAZ 5MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.

LIVER

BOLETRAAZ 5MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Do not take if you are allergic (hypersensitive) to Everolimus or any of the other ingredients in this medicine.

OTHERS

Inform your doctor if you have:

  • diabetes (high level of sugar in your blood)
  • high cholesterol
  • had recent major surgery, or if you still have an unhealed wound following surgery
  • an infection
  • previously had hepatitis B

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

  • ketoconazole, itraconazole, voriconazole or fluconazole (used to treat fungal infections)
  • clarithromycin, telithromycin and erythromycin (used to treat bacterial infections)
  • ritonavir, efavirenz and nevirapine (used to treat HIV infection/AIDS)
  • verapamil or diltiazem (used to treat heart conditions or high blood pressure)
  • dronedarone (used to regulate heartbeat)
  • ciclosporin
  • imatinib (inhibits the growth of abnormal cells)
  • ramipril
  • rifampicin (used to treat tuberculosis)
  • dexamethasone
  • phenytoin, carbamazepine or phenobarbital

SYNOPSIS

Drug :   Everolimus
Pharmacological Category :   Antineoplastic Agent, Immunosuppressant Agent
Therapeutic Indication :   Breast cancer, Neuroendocrine tumors (Carcinoid tumors), Renal cell carcinoma, Renal and Liver transplantation
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT BOLETRAAZ 5MG

What should I avoid while taking BOLETRAAZ 5MG?

Avoid grapefruit or grapefruit juice while taking this medicine. 

How long can you take BOLETRAAZ 5MG?

There is no definite duration of treatment with this medicine. It is continued till clinical benefit is seen or unacceptable toxicity or side effects occur.

How is BOLETRAAZ 5MG administered?

It is taken once or twice daily. The medicine should always either be taken with food or always be taken without food. It should be swallowed whole with water and should not be crushed or chewed.

REFERENCES

1. KD Tripathi MD. Miscellaneous drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 882.

2. Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page - 1013.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 526.

4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC); [Revised Feb 2020] [Accessed Oct 7, 2020] https://www.medicines.org.uk/emc/files/pil.7732.pdf

5. Novartis Pharmaceuticals Corporation. 2009; U.S. Food & Drug Administration; [Revised Oct 2010] [Accessed Oct 7, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022334s6lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Breast Cancer (CA 15.3/ ER/ PR)
  • Carcino Embryonic Antigen
  • Complete Blood Count

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    17.5
    Ingredient
    EVEROLIMUS 5MG
    Hsn Code
    30049099
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