INTRODUCTION

BLUVIT D3 DROPS contains Cholecalciferol (Vitamin D3) which belongs to the group of medicines called Vitamin D analogs. It is used in children for the treatment of vitamin D deficiency in hypophosphataemic rickets (disorder of bone mineralization due to defects in renal handling of phosphorus) and osteomalacia (softening of the bones), postgastrectomy (gastric surgery) and intestinal malabsorption osteomalacia.

Also used in osteomalacia associated with prolonged use of anticonvulsants and other hepatic microsomal enzyme-inducing drugs and hepatobiliary disorders.

Along with this treatment, your child’s doctor might advise your child to eat and drink foods that are rich in calcium. Your child’s doctor might want your child to take certain blood tests prior to the treatment to understand the existing condition.

BLUVIT D3 DROPS is not recommended for use in children with high levels of calcium or vitamin D3 in the blood, malabsorption syndrome, renal osteodystrophy (kidney disease weakening the bones) with hyperphosphataemia.

Before giving BLUVIT D3 DROPS to your child, inform your child’s doctor if your child have impaired kidney or heart function, heart or liver disease, sarcoidosis (a multisystem chronic inflammatory condition which can affect your lungs, heart and kidneys), hyperlipidemia (high lipid levels) and high levels of phosphorous in the blood.

BLUVIT D3 DROPS is not recommended for use in pregnant or breast-feeding women and elderly individuals as it is used only in children. Consult your child’s doctor immediately if your child experiences any unusual effects during treatment with this medicine.

USES OF BLUVIT D3 DROPS

Treats vitamin D deficiency in:

• hypophosphataemic rickets and osteomalacia
• postgastrectomy and intestinal malabsorption osteomalacia
• osteomalacia associated with prolonged use of anticonvulsants and other hepatic microsomal enzyme-inducing drugs and hepatobiliary disorders
• chronic disease states (such as infectious disease, tuberculosis, chronic obstructive pulmonary disease, cancer and cardiovascular disease)

HOW BLUVIT D3 DROPS WORKS

BLUVIT D3 DROPS helps the body to absorb calcium and phosphorus by increasing their absorption from the gut and reducing the amount removed by the kidneys and is a fat-soluble vitamin.

DIRECTIONS FOR USE

Give BLUVIT D3 DROPS to your child as advised by the physician. Shake well before use. Use a medicine dropper to properly measure the dose.  Your child’s doctor will decide the correct dose and duration of BLUVIT D3 DROPS for your child depending upon the age, body weight and disease condition.

SIDE EFFECTS OF BLUVIT D3 DROPS

WARNING & PRECAUTIONS

PREGNANCY

BLUVIT D3 DROPS is not recommended for use in pregnant women as it is used only in children.

BREASTFEEDING

BLUVIT D3 DROPS is not recommended for use in breast-feeding women as it is used only in children.

KIDNEY

BLUVIT D3 DROPS is not recommended for use in children with renal osteodystrophy (kidney disease weakening the bones) with hyperphosphataemia. It should be used with caution in children with renal impairment or calculi. Consult your child’s doctor for advice before administration of BLUVIT D3 DROPS.

LIVER

BLUVIT D3 DROPS should be used with caution in children with liver disease. Consult your child’s doctor for advice before administration of BLUVIT D3 DROPS.

ALLERGY

Do not give BLUVIT D3 DROPS to your child if they are allergic to Cholecalciferol or any other ingredients of this medicine.

HEART DISEASE

BLUVIT D3 DROPS should be used with caution in children with heart disease, cardiac function impairment or arteriosclerosis (buildup of fats, cholesterol and other substances in and on the artery walls). Consult your child’s doctor for advice before administration of BLUVIT D3 DROPS.

INTERACTIONS

A. Drug-Drug Interactions:

Before giving BLUVIT D3 DROPS to your child, inform to child’s doctor if your child is taking or receiving any of the following medicines:   

• medicines used to treat epilepsy (Ex phenobarbital, phenytoin, primidone)
• other vitamin D containing medicines including multi-vitamins
• medicines used to control the rate of your heartbeat (Ex. digoxin, digitoxin)
• thiazide diuretics (water tablets) Ex. Bendroflumethiazide (used to treat fluid retention)
• calcium supplements
• antacids for indigestion (Ex. magnesium hydroxide)
• medicine used to treat fungal infections (Ex. ketoconazole)
• corticosteroids Ex. hydrocortisone or prednisolone (used to treat inflammatory condition)
• laxatives such as paraffin oil (used to treat constipation)
• cholestyramine used to treat high cholesterol
• phosphate binding agents Ex. sevelamer (used to control high levels of phosphorous in the blood)

Overdosage:

If your child or anyone else accidentally takes too much of BLUVIT D3 DROPS, consult your child’s doctor immediately or visit the nearby hospital. Symptoms of overdose includes hypervitaminosis, hypercalciuria and hypercalcaemia (signs include loss of appetite, thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, mental disturbances, excess thirst or urination, bone pain, nephrocalcinosis, renal calculi and in severe cases it may cause cardiac arrhythmias).

SYNOPSIS

MORE INFORMATION

• Keep the medicine out of reach of children
• Store BLUVIT D3 DROPS at room temperature

FAQs ABOUT BLUVIT D3 DROPS

What is BLUVIT D3 DROPS used for?

BLUVIT D3 DROPS is used in children for the treatment of vitamin D deficiency in hypophosphataemic rickets (disorder of bone mineralization due to defects in renal handling of phosphorus) and osteomalacia (softening of the bones), postgastrectomy (gastric surgery) and intestinal malabsorption osteomalacia. Also used in osteomalacia associated with prolonged use of anticonvulsants and other hepatic microsomal enzyme-inducing drugs and hepatobiliary disorders.

What happens if you give more BLUVIT D3 DROPS to your child than the required dose?

If your child or anyone else accidentally takes too much of BLUVIT D3 DROPS, consult your child’s doctor immediately or visit the nearby hospital. Symptoms of overdose includes hypervitaminosis, hypercalciuria and hypercalcaemia (signs include loss of appetite, thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, mental disturbances, excess thirst or urination, bone pain, nephrocalcinosis, renal calculi and in severe cases it may cause cardiac arrhythmias).

How does BLUVIT D3 DROPS work?

BLUVIT D3 DROPS helps the body to absorb calcium and phosphorus and is a fat-soluble vitamin. It is produced naturally by your skin after exposure to the sun and is also found in some foods. BLUVIT D3 DROPS is prescribed as a dietary supplement when there is a deficiency of Vitamin D.

Can BLUVIT D3 DROPS be used in children with heart problems?

BLUVIT D3 DROPS is not recommended for use in children with renal osteodystrophy (kidney disease weakening the bones) with hyperphosphataemia. It should be used with caution in children with renal impairment or calculi. Consult your child’s doctor for advice before administration of BLUVIT D3 DROPS.

Is BLUVIT D3 DROPS safe to use in children with heart problems?

BLUVIT D3 DROPS should be used with caution in children with heart disease, cardiac function impairment or arteriosclerosis (buildup of fats, cholesterol and other substances in and on the artery walls). Consult your child’s doctor for advice before administration of BLUVIT D3 DROPS.

REFERENCES

1. KD. Tripathi. Section 11, Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 909.

2. Jose-Luis Perez-Castrillon, Ricardo Usategui-Martin and Pawel Pludowski Treatment of Vitamin D Deficiency with Calcifediol: Efficacy and Safety Profile and Predictability of Efficacy. May 2022. [Accessed on 21st June 2022] https://www.mdpi.com/2072-6643/14/9/1943/html

3. J Christopher Gallagher, Daniel D Bikle. Vitamin D: Mechanisms of Action and Clinical Applications. National library of Medicine, National center for Biotechnology information. Pubmed.gov 2017. [Accessed on 21st June 2022] https://pubmed.ncbi.nlm.nih.gov/29080648/

4. Ciplamed. D-sol Drops. (Cholecalciferol 400 IU). [Revised in May 2016] [ Accessed on 21st June 2022] https://www.ciplamed.com/content/d-sol-granules-chewable-tablets-drops

5. Torrent pharmaceuticals Ltd. D 360 (Cholecalciferol (Vitamin D3) Oral Drops). [ Accessed on 21st June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2633.pdf

USEFUL DIAGNOSTIC TESTS

• Vitamin D3 test
• Kidney function test

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 20 Oct 2022 | 03:32 PM(IST)