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BISONEXT AM 2.5 Tablet 15's
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INTRODUCTION
BISONEXT AM 2.5 TABLET is a combination of Amlodipine and Bisoprolol, which belong to the group of medicines called Calcium-channel blockers and Beta-blockers, respectively. It is used in the treatment of mild to moderate hypertension (high blood pressure). Hypertension is a condition in which the force of the blood is consistently high against the walls of the arteries, which can increase the risk of heart disease, kidney disease, and stroke.
Before taking BISONEXT AM 2.5 TABLET, inform your doctor if you are pregnant or breastfeeding. Inform your doctor if you have any problems related to the kidney, liver, lungs, or heart, or if you have other conditions such as diabetes, thyroid problems, psoriasis, or peripheral artery disease. BISONEXT AM 2.5 TABLET is not recommended for children and adolescents younger than 18 years of age.
If you are taking any other medicines for other conditions or if you have a history of drug allergies, inform your doctor as it may prevent drug-related interactions and serious side effects. The most common side effects of BISONEXT AM 2.5 TABLET are headache, dizziness, stomach pain, tiredness, and nausea. Consult your doctor for advice if your symptoms get worse over time.
USES OF BISONEXT AM 2.5 TABLET
- Treats mild to moderate hypertension (high blood pressure)
HOW BISONEXT AM 2.5 TABLET WORKS
BISONEXT AM 2.5 TABLET helps to reduce high blood pressure, where amlodipine works by inhibiting the movement of calcium ions into both vascular smooth muscle and cardiac muscle, resulting in lower blood pressure by relaxing the blood vessels and improving the flow of blood to the heart muscles, and bisoprolol is a beta-blocker that works by reducing the force of contraction of the heart muscles by blocking the effects of certain hormones called adrenaline and making the heart beat more easily, thus lowering the blood pressure.
DIRECTIONS FOR USE
Always take BISONEXT AM 2.5 TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole, and do not crush or chew the medicine. Do not stop taking BISONEXT AM 2.5 TABLET without informing your doctor.
SIDE EFFECTS OF BISONEXT AM 2.5 TABLET
COMMON
- ankle swelling, oedema (fluid retention)
- headache
- dizziness, sleepiness
- coldness or numbness sensation in hands or feet
- palpitations (fast heartbeat), flushing
- stomach pain
- nausea, vomiting
- diarrhea, constipation
- altered bowel habits, indigestion
- weakness, tiredness
- muscle cramps
- visual disturbances, double vision
- low blood pressure
UNCOMMON
- enlarged breast in men (gynecomastia) or discomfort in men
- irritability, sleep problems
- depression, mood changes, anxiety
- pain, numbness, tingling or prickling sensation in arms, legs, or feet
- dry mouth
- excess sweating
- uncontrolled shaking, loss of pain sensation
- orthostatic hypotension (dizziness while standing up from sitting or lying position)
- fainting
- altered taste sensation
- rhinitis (runny nose due to inflammation of the nose lining)
- urinary urgency at night-time, frequent urination, difficulty in passing urine
- ringing or buzzing sensation in ears
- chest pain, increased heart rate
- breathing difficulty, cough, inflammation of the mucosa
- swollen gums
- back, muscle or joint pain
- muscle weakness
- impotence (inability to achieve erection)
- increase or decrease in weight
- hair loss
- skin rash, itching, discoloration of the skin
RARE
- confusion
- hearing problems
- dry eyes (reduced tear flow)
- nightmares, hallucinations
Stop taking BISONEXT AM 2.5 TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe skin reactions such as stevens-johnson syndrome, toxic epidermal necrolysis (skin rash, itching, blistering, and reddening of skin all over the body, peeling and swelling of the skin, swelling of mucous membrane)
- signs of an inflamed pancreas (severe pain in abdomen and back, feeling unwell)
- slow or abnormal heartbeat, heart attack
- severe allergic reactions (such as swelling of the eyelids, face, neck, lips, mouth, tongue, throat, or airways, chest pain and sudden wheezing which can lead to difficulty in breathing or swallowing)
- dizziness, weakness or breathing difficulties
HOW TO MANAGE SIDE EFFECTS
Headache:
Apply a hot or cold-water bag to your head. Try taking a rest in a quiet and dark room. Drink tea or coffee. Consult your doctor if your symptoms worsen.
Stomach pain:
Take some time to rest and relax. Eat and drink slowly, or try to have smaller, more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.
Diarrhoea:
Drink plenty of fluids, such as water, fruit juices, or electrolytes (ORS), to avoid dehydration in your body. Consult your doctor if your symptom does not improve.
Constipation:
Consume fiber-rich foods such as fresh fruits and vegetables and whole grain cereals, as well as plenty of fluids. Exercise more regularly and stay active. Consult your doctor if your symptoms worsen.
Nausea and vomiting:
Try to take this medicine with, or just after, a meal or snack, stick to simple meals and do not eat oil-rich or spicy food. Consult your doctor if your symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
BISONEXT AM 2.5 TABLET is not recommended for use in pregnancy as it may cause serious harm to the pregnancy and unborn child by increasing the risk of miscarriage, premature birth, low blood sugar levels, and a decreased heart rate in the newborn baby. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
BREASTFEEDING
BISONEXT AM 2.5 TABLET is not recommended for use by breastfeeding women. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience tiredness, dizziness, or drowsiness, as it may impair your ability to drive or work. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
ALCOHOL
Consumption of alcohol is not recommended during treatment with BISONEXT AM 2.5 TABLET as it may increase the risk of tiredness, dizziness, and drowsiness.
KIDNEY
BISONEXT AM 2.5 TABLET should be used with caution in patients with severe kidney disease and in patients who are undergoing dialysis. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
LIVER
BISONEXT AM 2.5 TABLET should be used with caution in patients with liver impairment. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
ALLERGY
Do not take BISONEXT AM 2.5 TABLET if you are allergic to Amlodipine and Bisoprolol or if you are allergic to other drugs of the same class (calcium-channel blockers such as nifedipine, felodipine, nimodipine).
LUNGS
BISONEXT AM 2.5 TABLET is not recommended for use in patients with asthma or chronic lung disease. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
HEART DISEASE
BISONEXT AM 2.5 TABLET is not recommended for use in patients with cardiogenic shock (where the heart cannot pump sufficient blood around the body), aortic stenosis (narrowing of the aortic heart valve), chest pain at resting position, slow or irregular heart rate, very low blood pressure, heart failure or heart attack. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
OTHERS
BISONEXT AM 2.5 TABLET is not recommended for you, if you have:
- untreated phaeochromocytoma
- metabolic acidosis (excess acid in the blood)
- poor blood circulation problems (such as Raynaud’s syndrome causing the tingling sensation in fingers and toes or pale discoloration of the skin)
Before taking BISONEXT AM 2.5 TABLET, inform your doctor if you have:
- diabetes
- psoriasis (a skin condition)
- strict fasting from solid foods
- thyroid problem
- ongoing desensitization therapy (for prevention of allergic reactions such as hay fever)
- upcoming surgery or procedures
- peripheral artery disease (poor blood circulation to legs or rarely in arms due to fat deposition in arteries)
Use in pediatrics:
BISONEXT AM 2.5 TABLET is not recommended for use in children and adolescents under 18 years of age. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
Use in geriatrics:
BISONEXT AM 2.5 TABLET should be used with caution in elderly patients especially when the dose is increased. Consult your doctor for advice before taking BISONEXT AM 2.5 TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking BISONEXT AM 2.5 TABLET inform your doctor, if you are taking any of these medicines:
- ketoconazole, itraconazole (used to treat fungal infections)
- amiodarone, clonidine, digoxin, quinidine, moxonidine, methyldopa, lidocaine, verapamil, diltiazem (used to treat low blood pressure or heart problems)
- erythromycin, clarithromycin, rifampicin, telithromycin (used to treat bacterial infections)
- imipramine, amitriptyline, moclobemide, nefazodone (used to treat depression)
- ritonavir, nelfinavir, indinavir (used to treat HIV)
- phenobarbital, phenytoin, carbamazepine (used to treat seizures)
- st. john’s wort (herbal preparation used to treat depression)
- dexamethasone (used to treat rheumatoid arthritis)
- dantrolene infusion (used to treat severe body temperature abnormalities)
- simvastatin, (used to treat high cholesterol)
- cyclosporine, tacrolimus (used to alter the immune system response)
- sildenafil (used to treat impotence)
- levomepromazine (used to treat mental illness)
- aspirin, diclofenac, indomethacin, ibuprofen, naproxen (used to treat pain)
- mefloquine (used to treat malaria)
- adrenaline, dobutamine, noradrenaline (used to treat shock)
- salbutamol, theophylline (used to treat asthma)
- oxymetazoline, naphazoline (used to treat blocked nose)
- travoprost, bimatoprost, bisoprolol (used to treat glaucoma)
- dihydroergotamine, rizatriptan (used to treat headaches or migraine)
- insulin or oral diabetic agents such as metformin, vildagliptin (used to treat diabetes)
B. Drug-Food interactions:
Do not eat grapefruit or drink grapefruit juice while taking BISONEXT AM 2.5 TABLET as it increases the level of this medicine in the blood, resulting in unpredictable blood pressure-lowering effects. Consult your doctor before taking BISONEXT AM 2.5 TABLET.
Overdosage:
Consult your doctor right away if you or anyone else takes too much BISONEXT AM 2.5 TABLET. Overdosage may cause side effects such as extreme dizziness, light-headedness, tiredness, fainting or weakness, breathing difficulty, wheezing, an increase in the frequency of urination, cold or sweaty skin due to a severe drop in blood pressure, low sugar levels in the blood, and a slow heart rate.
SYNOPSIS
| Drug | : | Amlodipine, Bisoprolol |
| Pharmacological Category | : | Calcium-channel blockers, Beta-blockers |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep BISONEXT AM 2.5 TABLET out of reach from children
- Store at room temperature
FAQs ABOUT BISONEXT AM 2.5 TABLET
Can BISONEXT AM 2.5 TABLET be taken during pregnancy?
No, BISONEXT AM 2.5 TABLET is not recommended for use during pregnancy as it may cause serious harm to the pregnancy and unborn children, such as miscarriage, premature birth, decreased heart rate, and low blood sugar levels. If you are planning to get pregnant, you must tell your doctor before taking BISONEXT AM 2.5 TABLET.
Is BISONEXT AM 2.5 TABLET capable of causing oedema?
Yes, BISONEXT AM 2.5 TABLET can cause swelling of the ankles by the accumulation of fluids, especially in the ankles (oedema). It is usually common when taken in higher doses. Do not stop taking BISONEXT AM 2.5 TABLET without informing your doctor. Your doctor may advise you to wear compression stockings or keep your legs up when sitting for long hours. Consult your doctor immediately when your symptoms persist or worsen.
What should I do if I miss taking BISONEXT AM 2.5 TABLET?
You should take BISONEXT AM 2.5 TABLET immediately when you remember. If it is time for your next dose, skip it and follow your regular dose schedule. Do not double the dose to make up for your missed dose.
Does BISONEXT AM 2.5 TABLET impair my ability to drive?
Yes, BISONEXT AM 2.5 TABLET may cause dizziness or drowsiness; do not drive or operate any machines that require concentration because it can impair your ability to drive or work. You may ask someone to drive for you or follow appropriate precautions before driving after consulting with your doctor.
Can BISONEXT AM 2.5 TABLET be used in the elderly?
Yes, BISONEXT AM 2.5 TABLET should be used with caution in elderly patients over 65 years of age, especially when taken in higher doses. Your doctor may initiate the treatment with the lowest effective dose, which may prevent the risk of increased side effects.
For how long should I take BISONEXT AM 2.5 TABLET?
You should continue taking BISONEXT AM 2.5 TABLET unless your doctor tells you to stop the medicine. Blood pressure medicines will usually be taken for a lifetime to prevent complications due to high blood pressure. Your doctor may change treatment with other hypertension drugs if you do not attain effective therapeutic outcomes with BISONEXT AM 2.5 TABLET.
REFERENCES
1. KD Tripathi. Antihypertensive drugs & Antiadrenergic drugs (adrenergic receptor antagonists) and drugs for glaucoma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 549 & 562; 149.
2. Merck KGaA, Darmstadt, Germany. Fixed Dose Combination of Bisoprolol and Amlodipine in the Treatment of Hypertension. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on January 2017] [Accessed 6th April 2022] https://clinicaltrials.gov/ct2/show/NCT01977794
3. D Czarnecka, E M W Koch, U Gottwald-Hostalek. Benefits of a fixed-dose combination of bisoprolol and amlodipine in the treatment of hypertension in daily practice: results of more than 4000 patients. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2015. [Accessed 6th April 2022] https://pubmed.ncbi.nlm.nih.gov/25753136/
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed 6th April 2022] https://www.medicines.org.uk/emc/files/pil.6068.pdf
5. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed 6th April 2022] https://www.medicines.org.uk/emc/files/pil.3090.pdf
6. Torrent pharmaceuticals Ltd. CORBIS AM Tablet (Bisoprolol and Amlodipine). Torrent Pharma. [Revised on April 2021] [Accessed 6th April 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2844.pdf
USEFUL DIAGNOSTIC TESTS
- Kidney Function Test
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 20 Dec 2022 | 04:19 PM(IST)
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