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Benzz 100mg Injection 1's
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INTRODUCTION
BENZZ 100MG INJECTION contains Bendamustine which belongs to the group of medicines called Anti-cancer agents. It is used to treat certain forms of cancer such as chronic lymphocytic leukemia (cancer of blood and bone marrow), Non-Hodgkin lymphomas (lymph cancer) and Multiple myeloma (cancer of plasma cells).
BENZZ 100MG INJECTION can be used either alone or in combination with other anti-cancer agents to achieve better results. Therapy with BENZZ 100MG INJECTION is chosen only when the use of other first line medicines is not suitable.
The use of BENZZ 100MG INJECTION may cause abnormal decrease in white blood cells (WBC) and platelet count in the blood. To avoid this, your doctor will closely monitor your blood count periodically before and during treatment with BENZZ 100MG INJECTION.
Before receiving BENZZ 100MG INJECTION inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have severe bone marrow depression, any infections or severe changes in white blood cells and platelet count.
BENZZ 100MG INJECTION should not be used in pregnant or breastfeeding women as it may cause serious harm to the growing fetus or nursing infant. Consult your doctor for advice.
The most common side effects of receiving BENZZ 100MG INJECTION are nausea, vomiting, hair loss, oral sores, diarrhea, constipation, fever, dehydration, headache, and tiredness. Contact your doctor if any of these side effect bothers you.
USES OF BENZZ 100MG INJECTION
It is used either alone or in combination with other anticancer medicines to treat:
- Chronic Lymphocytic Leukemia
- Non-Hodgkin’s Lymphoma
- Multiple Myeloma
HOW BENZZ 100MG INJECTION WORKS
BENZZ 100MG INJECTION belongs to anticancer agent which acts by damaging the genetic material (either DNA or RNA) of cancer cells which prevents the cancer cells from growing and multiplying within the body.
DIRECTIONS FOR USE
BENZZ 100MG INJECTION will be administered into the vein only by a doctor or a nurse. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF BENZZ 100MG INJECTION
COMMON
- headache
- nausea, vomiting
- signs of low red blood cells (weakness, tiredness, dizziness, and shortness of breath)
- signs of low platelet counts (easy bruising or bleeding from gums)
- sings of low white blood cells (repeated fevers and infections)
- mucosal inflammation (oral sores)
- bleeding
- increased or decreased blood pressure
- irregular heart rhythm
- disturbed lung function (cough, shortness of breath, tiredness)
- fever, tiredness
- amenorrhea (missed periods in women)
- diarrhea, constipation, changes in metabolism, loss of appetite
- dehydration
- hair loss
- skin changes, skin rash or itching
- sleeping disturbances
- dizziness
- pain, chills
UNCOMMON
- heart attack, chest pain
- heart failure
- fluid accumulation in heart sac
- acute leukemia (cancer of blood and bone marrow)
RARE
- drowsiness
- infection of blood
- loss of voice
- excessive sweating
- acute circulatory collapse (blood circulation problem)
- skin reddening, skin inflammation (dermatitis)
Contact your doctor immediately if you experience any of the following side effects after receiving BENZZ 100MG INJECTION:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, throat, tongue causing difficulty in breathing or swallowing)
- severe skin reactions such as stevens-Johnson syndrome and toxic epidermal necrolysis (causing skin peeling, red raised lesion, ulcer of the mouth including throat, nose, genitals, and eyes)
- medicine induced allergic reactions (high body temperature, widespread of skin rash, and enlarged lymph nodes)
- pain in your side, bloody urine, decreased urine output (signs of tumor lysis syndrome)
- signs of serious brain infection (such as memory loss, difficulty in thinking, difficulty in walking or vision loss)
- unusual skin changes
HOW TO MANAGE SIDE EFFECTS
Headache:
Try to take rest. Apply a pain-relieving balm on your forehead. If the symptom does not improve, consult with your doctor.
Dizziness:
Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. If your symptom does not improve consult your doctor.
Diarrhea:
Drink plenty of fluids such as water, fruit juices or electrolytes to avoid dehydration in your body. Consult your doctor if your symptom worsens.
Constipation:
Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Consult your doctor if your symptom worsens.
Skin rash:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
WARNING & PRECAUTIONS
PREGNANCY
BENZZ 100MG INJECTION is not recommended for use in pregnant women as it may cause severe harm to the growing fetus. Women of childbearing age must use a suitable contraceptive before and during treatment with BENZZ 100MG INJECTION to avoid pregnancy.
BREASTFEEDING
BENZZ 100MG INJECTION is not recommended for use in breastfeeding women. However, consult your doctor before receiving it. Your doctor may ask you to discontinue breastfeeding if treatment with BENZZ 100MG INJECTION is considered necessary.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience tiredness, dizziness, or lack of concentration after receiving BENZZ 100MG INJECTION.
ALCOHOL
Consumption of alcohol is not recommended during treatment with BENZZ 100MG INJECTION.
KIDNEY
BENZZ 100MG INJECTION is not recommended for use in patients with severe kidney impairment. It should be used with caution in patients with mild to moderate kidney impairment. Consult your doctor before receiving it.
LIVER
BENZZ 100MG INJECTION is not recommended for use in patients with moderate to severe liver impairment (jaundice). It should be used with caution in patients with mild liver dysfunction. Consult your doctor before receiving it.
ALLERGY
Do not receive BENZZ 100MG INJECTION if you are allergic to Bendamustine or any other ingredients of this medicine.
LUNGS
BENZZ 100MG INJECTION should be used with caution in patients with respiratory diseases such as bronchitis. Consult your doctor before receiving it.
HEART DISEASE
BENZZ 100MG INJECTION should be used with caution in patients with heart disease (such as chest pain, heart attack or irregular heart rhythm). Consult your doctor before receiving it.
OTHERS
BENZZ 100MG INJECTION is not recommended for use if you:
- have bone marrow depression
- have serious changes in white blood cells or platelet counts in the blood
- have recently or had any major surgery (less than 30 days before starting this treatment)
- have an infection accompanied with low white blood cell count
Before receiving BENZZ 100MG INJECTION, inform your doctor if you:
- have signs or symptoms of infection (fever, weakness, body pain including lungs symptoms such as cough, shortness of breath, wheezing or chest pain)
- have any skin reactions or light sensitivity
Use in pediatrics:
The safety and effectiveness of BENZZ 100MG INJECTION in children have not been established. Consult your doctor for advice.
Use in geriatrics:
BENZZ 100MG INJECTION should be used with caution in the elderly patients. Consult your doctor before receiving the medicine.
INTERACTIONS
A. Drug-Drug Interactions:
Before receiving BENZZ 100MG INJECTION, inform your doctor, if you are taking any of the following medicine:
- medicines used to treat to stomach ulcers (Ex. omeprazole, esomeprazole)
- ciprofloxacin (used to treat bacterial infections)
- fluvoxamine (used to treat obsessive-compulsive disorder)
- vaccines used to prevent viral infections (cholera live vaccine, H1N1 live vaccine, zoster live vaccine)
- methotrexate (used to treat psoriasis or rheumatoid arthritis)
- yellow fever vaccine (used to protect against yellow fever)
Overdosage:
BENZZ 100MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Bendamustine |
| Pharmacological Category | : | Alkylating agents |
| Therapeutic Indication | : | Chronic lymphocytic leukemia, Non-Hodgkin’s Myeloma, Multiple Myeloma |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep BENZZ 100MG INJECTION out of reach of children
- Store at a temperature not exceeding 35°C
FAQs ABOUT BENZZ 100MG INJECTION
What is the use of BENZZ 100MG INJECTION?
BENZZ 100MG INJECTION is an anticancer medicine used to treat certain forms of cancer such as chronic lymphocytic leukemia (cancer of blood and bone marrow), Non-Hodgkin lymphomas (lymph cancer) and multiple myeloma (cancer of plasma cells).
Is BENZZ 100MG INJECTION a chemotherapy?
Yes. BENZZ 100MG INJECTION is a chemotherapy. It acts by preventing the growth and multiplication of cancer cells within the body.
Is the use of BENZZ 100MG INJECTION safe?
BENZZ 100MG INJECTION is safe when used under proper medical supervision and at the prescribed doses.
What are the side effects of BENZZ 100MG INJECTION?
BENZZ 100MG INJECTION may cause abnormal decrease in white blood cells and platelet counts. It may also cause nausea, vomiting, headache, dizziness, tiredness, mouth sores, fever, hair loss and skin changes. Consult your doctor for advice if the side effects persist for a longer duration.
Can the use of BENZZ 100MG INJECTION cause skin damage?
Yes. The use of BENZZ 100MG INJECTION may cause unusual changes in the skin. Consult your doctor immediately if you any notice any unusual skin changes.
How BENZZ 100MG INJECTION works?
BENZZ 100MG INJECTION belongs to anticancer agent which acts by damaging the genetic material (either DNA or RNA) of cancer cells which prevents the cancer cells from growing and multiplying within the body.
Can the use of BENZZ 100MG INJECTION cause hair loss?
Yes. Hair loss is one of the common side effects of taking a chemotherapy medicine like BENZZ 100MG INJECTION. Consult your doctor if it bothers you.
Can the use of BENZZ 100MG INJECTION cause constipation?
Yes. BENZZ 100MG INJECTION may cause constipation in some individuals. If you experience constipation, take plenty of fiber rich foods (such as cereals, pulses, fruits) in your diet. Drink plenty of water. If it bothers you, consult your doctor.
REFERENCES
1. Guido Marcucci, Meir Wetzler, John C. Byrd, Krzysztof Mrózek, and Clara D. Bloomfield. Leukemias. Textbook of Medical Oncology. 4th Edition. 2009. Edited by Franco Cavalli Stan B Kaye Heine H Hansen James O Armitage Martine J Piccart-Gebhart. Informa Healthcare. Page – 229.
2. RS Satoskar, SD Bhandarkar, Nirmala N. Rege. Alkylating agents. Chemotherapy of Malignancy. Pharmacology and Pharmacotherapeutics. 24th Edition. 2015. Page – 1274.
3. Martina Bogeljic Patekar, Vibor Milunovic, Karla Misura Jakobac, Drazen Perica, Inga Mandac Rogulj, Marin Kursar, Ana Planinc-Peraica, and Slobodanka Ostojic Kolonic. Bendamustine: an old drug in the new era for patients with Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia. NIH. National Library of Medicine. National Center for Biotechnology Information. September 2018. [Accessed on 3rd September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536274/
4. Ibrahim T Aldoss, Susan M Blumel, and Philip J Bierman. The role of Bendamustine in the treatment of indolent non-Hodgkin lymphoma. NIH. National Library of Medicine. National Center for Biotechnology Information. November 2009. [Accessed on 3rd September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004665/
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 3rd September 2022] https://www.medicines.org.uk/emc/files/pil.5095.pdf
6. Cephalon, Inc. U.S. Food & Drug Administration. [Revised in October 2008] [Accessed on 3rd September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022303lbl.pdf
7. Central Drugs Standard Control Organization. Bendamustine. [Revised in September 2014]. [Accessed on 3rd September 2022] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
- Kidney Function Test
- Peripheral Smear Examination
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