BEN Q Met LS Tablet 10'S

INTRODUCTION

BEN Q MET LS TABLET is a combination of Glibenclamide and Metformin which belongs to the group of medicines called Antidiabetic agents. It is used in adults to manage type II diabetes mellitus along with diet and exercise.   

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or if the body cannot utilize the secreted insulin properly.

Glibenclamide is a sulfonylurea. It reduces blood glucose levels by making the pancreas secrete more insulin. Metformin is a biguanide. It blocks the amount of glucose produced by the liver. It also reduces the absorption of glucose in the intestines and allows the body to utilize the circulating insulin.

Before taking BEN Q MET LS TABLET, inform your doctor if you have any heart, liver, or kidney problems. You must also inform your doctor if you have any hormonal problems or if you are severely dehydrated, malnourished, starved, on an irregular diet.

BEN Q MET LS TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking BEN Q MET LS TABLET if you are pregnant or planning to become pregnant or are breastfeeding.

One of the most common side effects of taking BEN Q MET LS TABLET is hypoglycemia (low blood sugar levels) which can be identified by symptoms such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of BEN Q MET LS TABLET accordingly.

You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition. Other common side effects of taking BEN Q MET LS TABLET are headache, dizziness, nausea, weight gain and changes in taste. Contact your doctor if any of these side effect worsens.

USES OF BEN Q MET LS TABLET

It is used in adults along with diet and exercise to:

• Manage type II diabetes mellitus

HOW BEN Q MET LS TABLET WORKS

BEN Q MET LS TABLET effectively controls blood sugar levels in patients with type II diabetes mellitus. It contains two medicines namely glibenclamide and metformin. Glibenclamide helps the pancreas to secrete more insulin (a hormone that digest glucose in the body). It reduces blood glucose levels by increasing the amount of insulin secreted by the pancreas. Metformin blocks the amount of glucose produced by the liver. It also reduces the absorption of glucose in the intestines and allows the body to make better use of insulin.

DIRECTIONS FOR USE

Take BEN Q MET LS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. BEN Q MET LS TABLET should be taken preferably with meals to avoid nausea or stomach upset.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take BEN Q MET LS TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.

SIDE EFFECTS OF BEN Q MET LS TABLET

HOW TO MANAGE SIDE EFFECTS

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting

Take BEN Q MET LS TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

BEN Q MET LS TABLET is generally not recommended for use in pregnant women due to lack of safety data. However, consult your doctor for advice.

BREASTFEEDING

Contraindicated

BEN Q MET LS TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. However, consult your doctor for advice.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking BEN Q MET LS TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking BEN Q MET LS TABLET as it may increase your blood sugar levels.

KIDNEY

Contraindicated

BEN Q MET LS TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with other mild to moderate kidney problems. Therefore, consult your doctor for advice.

LIVER

Contraindicated

BEN Q MET LS TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other mild to moderate liver problems. Therefore, consult your doctor for advice.

ALLERGY

Use with Caution

Do not take BEN Q MET LS TABLET if you are allergic to Glibenclamide or Metformin.

HEART DISEASE

Contraindicated

BEN Q MET LS TABLET is not recommended for use in patients with severe heart problems (such as heart failure, recent heart attack, stroke, or other circulation problems). Therefore, consult your doctor for advice.

USE IN PEDIATRICS

Contraindicated

BEN Q MET LS TABLET is generally not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.

USE IN GERIATRICS

Use with Caution

BEN Q MET LS TABLET should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor for advice.

INTERACTIONS

A. Drug-Drug interactions:

Before taking BEN Q MET LS TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines to manage diabetes mellitus (such as insulin, glimepiride, pioglitazone)
• medicines used to manage high blood pressure (Ex. captopril, enalapril, lisinopril, losartan, valsartan, olmesartan, clonidine, guanethidine and reserpine)
• medicines to control blood high cholesterol level (Ex. fenofibrate, colesevalam and nicotinic acid)
• medicines used to manage edema such as diuretics (Ex. furosemide, chlorothiazide)
• medicines used to manage pain and inflammation (such as ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone)
• medicines used to manage asthma (Ex. salbutamol or terbutaline)
• bosentan (a medicine used to manage high blood pressure)
• corticosteroids (used to manage inflammation) Ex. prednisolone
• verapamil (a medicine used to manage heart problems)
• rifampicin (an antibiotic used to manage tuberculosis)
• cimetidine (a medicine used to manage stomach problems)
• medicines to manage bacterial infections (Ex. tetracyclines, chloramphenicol, clarithromycin)
• medicines used to manage fungal infections (Ex. fluconazole, miconazole)
• medicines used for blood thinning (Ex. warfarin)
• medicines used to manage depression (Ex. fluoxetine, escitalopram, sertraline)
• medicines used to manage severe mental disorders (Ex. chlorpromazine)
• medicines used to manage gout (Ex. probenecid, sulfinpyrazone)
• medicines used to manage cancer (Ex. cyclophosphamide, ifosfamide)
• medicines used to manage thyroid deficiency (Ex. thyroxine)
• sympathomimetics (used to improve heartbeat and to manage asthma or nasal congestion) Ex. adrenaline, ephedrine

Overdosage:

If you or anyone else accidentally take too much of BEN Q MET LS TABLET, consult your doctor immediately or go to a hospital straight away. Symptoms of overdose might include rapid breathing, severe drowsiness, slow/irregular heartbeat, passing out or trouble breathing.

SYNOPSIS

MORE INFORMATION

• Keep BEN Q MET LS TABLET out of reach of children
• Store at room temperature

FAQs ABOUT BEN Q MET LS TABLET

Q: Does BEN Q MET LS TABLET cause weight gain?

A: Yes. BEN Q MET LS TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if it bothers you, consult your doctor.

Q: How to take BEN Q MET LS TABLET?

A: You must take BEN Q MET LS TABLET as advised by your physician. Try to take BEN Q MET LS TABLET preferably after meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Q: Can BEN Q MET LS TABLET be taken with insulin?

A: Consult your doctor before taking BEN Q MET LS TABLET along with insulin, as it may increase the chances of hypoglycemia (decreased blood sugar levels).

Q: How much BEN Q MET LS TABLET should I take?

A: BEN Q MET LS TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Q: What should I do if I experience low blood sugar after taking BEN Q MET LS TABLET?

A: Low blood sugar is a common side effect of taking BEN Q MET LS TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. If you cannot any improvement in your condition or if your condition worsen, contact your doctor.

Q: Can BEN Q MET LS TABLET cause dizziness?

A: Yes. Dizziness is a common side effect of using BEN Q MET LS TABLET. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid smoking and consumption of alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking BEN Q MET LS TABLET.

Q: What are the side effects of BEN Q MET LS TABLET?

A: One of the most common side effects of taking BEN Q MET LS TABLET is hypoglycemia (low blood sugar levels). To manage this, you can snack on foods rich in sugars such as biscuits, candies etc. Other common side effects of taking BEN Q MET LS TABLET are headache, dizziness, nausea, weight gain and changes in taste. Contact your doctor if any of these side effect worsens.

Q: What precautions do I need to follow while taking BEN Q MET LS TABLET?

A: Before taking BEN Q MET LS TABLET, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have hormonal problems or if you are malnourished. BEN Q MET LS TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking BEN Q MET LS TABLET if you are pregnant or planning to become pregnant. During therapy with BEN Q MET LS TABLET, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.

Q: What BEN Q MET LS TABLET does to your body?

A: BEN Q MET LS TABLET effectively controls blood sugar levels in patients with type II diabetes mellitus. It reduces blood glucose levels by increasing the amount of insulin secreted by the pancreas and by blocking the amount of glucose produced by the liver. It also reduces the absorption of glucose in the intestines and allows the body to make better use of insulin.

Q: What is the use of BEN Q MET LS TABLET?

A: BEN Q MET LS TABLET is used in adults to manage type II diabetes mellitus along with diet and exercise.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270 & 275.

2. Alan J Garber, Daniel S Donovan Jr, Paresh Dandona, Simon Bruce, Jong-Soon Park. Efficacy of glyburide/metformin tablets compared with initial monotherapy in type 2 diabetes. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. August 2003. [Accessed on 21st November 2023] https://pubmed.ncbi.nlm.nih.gov/12915642/

3. Virendra Rambiritch, Breminand Maharaj and Poobalan Naidoo. Glibenclamide in patients with poorly controlled type 2 diabetes: a 12-week, prospective, single-center, open-label, dose-escalation study. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC. PubMed Central. April 2014. [Accessed on 21st November 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983009/

4. Chanelle Medical. Health Product Regulatory Authority. (HPRA). [Revised in May 2016] [Accessed on 21st November 2023] https://www.hpra.ie/img/uploaded/swedocuments/2179143.PA0688_040_002.752e1eeb-1045-476a-97ac-9f7549199666.000001Product%20Leaflet%20Approved%205mg.160725.pdf

5. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 21st November 2023] https://www.medicines.org.uk/emc/files/pil.594.pdf

6. Bristol-Myers Squibb Company; U.S. Food & Drug Administration; [Revised on December 2018] [Accessed on 21st November 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021178s018lbl.pdf

7. Central Drugs Standard Control Organization. Glibenclamide+Metformin. [Accessed on 21st November 2023] https://cdscoonline.gov.in/CDSCO/Drugs

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 21 Nov 2023 | 05:23 PM(IST)