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INTRODUCTION
BASALOG 100IU INJECTION contains Insulin glargine, which belongs to the group of medicines called Antidiabetics. It is used to manage diabetes mellitus, a disease where the body does not produce enough insulin to control the level of blood sugar, resulting in high blood sugar levels. Symptoms include increased thirst, frequent urination, extreme hunger, unexplained weight loss, fatigue, irritability, blurred vision, slow-healing sores, frequent infections, and increased ketone levels in urine.
Your doctor might want you to make certain lifestyle changes like eating a healthy diet, not skipping meals, maintaining your weight, quitting alcohol and smoking and exercising regularly. Before the management, your doctor might want to take certain blood and urine tests to understand your existing condition.
Before receiving BASALOG 100IU INJECTION, inform your doctor if you have low blood sugar, kidney, liver or heart problems, if you’re not eating enough, are ill or have a major injury before going abroad. Avoid drinking alcohol while receiving BASALOG 100IU INJECTION. Inform your doctor if you are pregnant or breastfeeding before receiving BASALOG 100IU INJECTION.
BASALOG 100IU INJECTION is not recommended for children under the age of two. The most common side effects of receiving BASALOG 100IU INJECTION are skin allergies at the injection site, pain, swelling, itching, and redness. Consult your doctor if your symptoms get worse or persist.
USES OF BASALOG 100IU INJECTION
- Manage diabetes mellitus
HOW BASALOG 100IU INJECTION WORKS
BASALOG 100IU INJECTION lowers the blood glucose facilitated by increased protein synthesis and uptake of glucose, following the binding of insulin to receptors on muscle and fat cells and then inhibiting glucose output from the liver.
DIRECTIONS FOR USE
BASALOG 100IU INJECTION will be given to you only by a doctor or a nurse under the skin (subcutaneously, usually thighs, upper arm or abdomen. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
SIDE EFFECTS OF BASALOG 100IU INJECTION
COMMON
- redness, swelling or itching around the area of the injection
- injecting at the same place, the fatty tissue may thicken (lipohypertrophy)
UNCOMMON
- injecting at the same place, the fatty tissue may shrink (lipoatrophy)
RARE
- having proliferative retinopathy (an eye disease related to diabetes) severe hypoglycemic attacks can cause temporary loss of vision
- cause temporary build-up of water in the body, with swelling in the calves and ankles
Stop receiving BASALOG 100IU INJECTION and contact your doctor immediately if you experience any of the following side effects:
- widespread skin reactions (rash and itching all over the body), severe swelling of skin or mucous membranes (angioedema), shortness of breath, a fall in blood pressure with rapid heartbeat and sweating
- signs of heart failure such as unusual shortness of breath or rapid increase in weight or localized swelling (oedema)
- severe hypoglycemia (low blood sugar, headaches, intense hunger, nausea, vomiting, tiredness, sleepiness, restlessness, aggressive behaviour, lapses in concentration, impaired reactions, depression, confusion, speech disturbances, visual disorders, trembling, paralysis, tingling sensation, dizziness, loss of self-control, convulsions, loss of consciousness
- thirst, increased need to urinate, tiredness, dry skin, reddening of the face, loss of appetite, low blood pressure, fast heartbeat, and glucose and ketone bodies in urine. stomach pain, fast and deep breathing, sleepiness or even loss of consciousness may be signs of a serious condition (ketoacidosis)
WARNING & PRECAUTIONS
PREGNANCY
Consult your doctorIf you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before receiving BASALOG 100IU INJECTION. Careful control of your diabetes, particularly the prevention of hypoglycemia, is important for the health of the baby. The dose will be adjusted by your doctor.
BREASTFEEDING
Consult your doctorInform your doctor if you are breastfeeding before receiving BASALOG 100IU INJECTION as it is not known if it is excreted in breast milk. The dose and diet will be adjusted by your doctor.
DRIVING AND USING MACHINES
Use with CautionDo not drive or use machines while receiving BASALOG 100IU INJECTION as your blood sugar can be low or high and your concentration and ability to react might be affected. Consult your doctor if you have frequent episodes of hypoglycemia.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while receiving BASALOG 100IU INJECTION as it can raise or lower your blood sugar levels.
KIDNEY
Use with CautionBASALOG 100IU INJECTION should be used with caution in patients with kidney disease. Your dose will be adjusted depending on your age, body weight and disease condition. Consult your doctor before receiving BASALOG 100IU INJECTION.
LIVER
Use with CautionBASALOG 100IU INJECTION should be used with caution in patients with liver disease. Your dose will be adjusted depending on your age, body weight and disease condition. Consult your doctor before receiving it.
ALLERGY
ContraindicatedBefore receiving BASALOG 100IU INJECTION inform your doctor if you are allergic to Insulin glargine or any of the other ingredients in this medicine.
HEART DISEASE
Use with CautionBASALOG 100IU INJECTION should be used with caution in patients with heart disease or stroke. Consult your doctor before receiving BASALOG 100IU INJECTION.
USE IN PEDIATRICS
ContraindicatedBASALOG 100IU INJECTION is not recommended for use in children below 2 years of age. Consult your doctor before receiving BASALOG 100IU INJECTION.
USE IN GERIATRICS
Use with CautionBASALOG 100IU INJECTION should be used with caution in patients above 65 years of age. The dose will be adjusted and regular blood and kidney tests will be conducted. Consult your doctor before receiving BASALOG 100IU INJECTION.
OTHERS
BASALOG 100IU INJECTION is not recommended for use if you:
- hypersensitivity to the contents of this medicine
Before receiving BASALOG 100IU INJECTION, inform your doctor if you:
- are not well or have a major injury
- are not eating enough
- are going abroad, travelling over different time zones may affect your need for insulin
INTERACTIONS
A. Drug-Drug interactions:
Before receiving BASALOG 100IU INJECTION, inform your doctor if you are taking any of the following medicine:
- other medicines for the treatment of diabetes (metformin, repaglinide etc.)
- monoamine oxidase inhibitors (MAOI) (used to treat depression) (phenelzine, selegiline)
- beta-blockers (used to treat high blood pressure) (metoprolol, atenolol, clonidine, guanethidine and reserpine)
- angiotensin-converting enzyme (ACE) inhibitors (used to treat certain heart conditions or high blood pressure) (benazepril, captopril, disopyramide)
- salicylates (used to relieve pain and lower fever) (aspirin, pentoxifylline, propoxyphene)
- sulphonamides (used to treat infections) (sulfamethoxazole)
- oral contraceptives (birth control pills like oestrogens and progestogens)
- thiazides (used to treat high blood pressure or excessive fluid retention) (chlorothiazide, diazoxide)
- glucocorticoids (such as ‘cortisone’ used to treat inflammation)
- thyroid hormones (used to treat thyroid gland disorders)
- growth hormone (medicine for stimulation of skeletal and somatic growth and pronounced influence on the body’s metabolic processes like somatropin)
- danazol (medicine acting on ovulation)
- pioglitazone (tablets used for the treatment of type 2 diabetes)
- disopyramide (used to treat certain heart conditions)
- fluoxetine (used to treat depression)
- fibrates (used to lower high levels of blood lipids)
- diuretics (used to treat high blood pressure or excessive fluid retention)
- glucagon (pancreas hormone used to treat severe hypoglycaemia)
- isoniazid (used to treat tuberculosis)
- phenothiazine derivatives, lithium salts (used to treat psychiatric disorders), atypical antipsychotic medicines (such as olanzapine and clozapine)
- sympathomimetic medicines (such as epinephrine, salbutamol, and terbutaline used to treat asthma)
- protease inhibitors (Ex. darunavir, indinavir used to treat HIV)
- pentamidine (used to treat some infections caused by parasites)
Overdosage:
BASALOG 100IU INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms of low blood sugar.
SYNOPSIS
| Drug | : | Insulin glargine |
| Pharmacological Category | : | Antidiabetic |
| Therapeutic Indication | : | Diabetes mellitus |
| Dosage Forms | : | Injection, Cartridge, Prefilled pen |
MORE INFORMATION
- Keep BASALOG 100IU INJECTION out of reach from children
- Store in a refrigerator (2-8°C)
FAQs ABOUT BASALOG 100IU INJECTION
Q: What is BASALOG 100IU INJECTION used for?
A: BASALOG 100IU INJECTION is used to manage diabetes mellitus, a disease where the body does not produce enough insulin to control the level of blood sugar, resulting in high blood sugar levels.
Q: What should I do if I experience low blood sugar during management with BASALOG 100IU INJECTION?
A: Take glucose tablets or high-sugar snacks (sweets, biscuits, fruit juice) if you experience low blood sugar while taking BASALOG 100IU INJECTION. Measure your blood sugar and rest. Carry glucose tablets or sugar snacks with you in case of emergencies.
Q: Can I receive BASALOG 100IU INJECTION during pregnancy?
A: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before receiving BASALOG 100IU INJECTION. Careful control of your diabetes, particularly the prevention of hypoglycemia, is important for the health of your baby. The dose will be adjusted by your doctor.
Q: Can BASALOG 100IU INJECTION be used in patients with kidney and liver problems?
A: BASALOG 100IU INJECTION should be used with caution in patients with liver and kidney disease. Your dose will be adjusted depending on your age, body weight and disease condition. Consult your doctor before receiving BASALOG 100IU INJECTION.
Q: How does BASALOG 100IU INJECTION work?
A: BASALOG 100IU INJECTION lowers blood glucose levels due to the facilitated uptake of glucose following the binding of insulin to receptors on muscle and fat cells, inhibiting glucose output from the liver. Your doctor might also want you to make certain lifestyle changes, like eating a healthy diet, not skipping meals, maintaining your weight, quitting alcohol and smoking, and exercising regularly.
REFERENCES
1. KD Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eighth Edition. 2019. Page –287.
2. Christopher J. Dunn, Greg L. Plosker, Gillian M. Keating, Kate McKeage & Lesley J. Scott. An Updated Review of its Use in the Management of Diabetes Mellitus. [Revised in September 2012] [Accessed on 29th June 2022] https://link.springer.com/article/10.2165/00003495-200363160-00007
3. Kate Mckeage, Karen L Goa. A Review of its Therapeutic Use as a Long-Acting Agent for the Management of Type 1 and 2 Diabetes Mellitus. [Revised in September 2012] [Accessed on 28th June 2022] https://link.springer.com/article/10.2165/00003495-200161110-00007
4. Sanofi-Aventis Deutschland GmbH. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 29th June 2022] https://www.medicines.org.uk/emc/files/pil.8098.pdf
5. Insulin glargine. Mayoclinic. [Revised in October 2020] [Accessed on 29th June 2022] https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444#:~:text=Diabetes%20mellitus%20refers%20to%20a,brain's%20main%20source%20o
USEFUL DIAGNOSTIC TESTS
- Blood sugar tests
- Urine tests
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 28 Oct 2023 | 06:04 PM(IST)
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