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INTRODUCTION
BARINAT 1MG TABLET contains Baricitinib which belongs to the group of medicines called Janus kinase inhibitors. BARINAT 1MG TABLET is used to treat adults with moderate to severe rheumatoid arthritis (inflammatory disease of the joints), who have responded inadequately to, or who are intolerant to previous therapies. BARINAT 1MG TABLET is also used to treat adults with moderate to severe atopic dermatitis (atopic eczema).
Prior to the treatment, your doctor may want you to take several blood tests to understand your existing condition like low red blood cell count (anaemia), low white blood cell count (neutropenia or lymphopenia), high cholesterol levels or high levels of liver enzymes, to ensure that treatment with BARINAT 1MG TABLET is not causing problems. Along with this, your doctor may test you for TB before starting treatment with BARINAT 1MG TABLET.
BARINAT 1MG TABLET is not recommended for use in patients having liver, kidney, heart diseases, stroke, and active infections like Tuberculosis. You will not be given certain live vaccines while using BARINAT 1MG TABLET.
Inform your doctor if you have diabetes, chronic lung disease, low red blood cells, HIV, or a weak immune system. Infections like tuberculosis, multidermatomal herpes zoster, esophageal candidiasis, pneumocystosis, acute histoplasmosis, cryptococcosis, cytomegalovirus, and BK virus or if you often get infections.
BARINAT 1MG TABLET is not recommended for use in pregnant and breast feeding. Consult your doctor before taking. BARINAT 1MG TABLET is not recommended for use in children and adolescents under 18 years of age and should be used with caution in elderly patients above 75 years of age.
The most common side effects of taking BARINAT 1MG TABLET are signs of cold sores, shingles (painful skin rash with blisters) and infections of the throat, nose (cold, sinus) stomach (gastroenteritis), lungs (pneumonia), urinary tract infections, headache, nausea, stomach pain, high levels of blood cholesterol and liver enzymes shown by blood test.
USES OF BARINAT 1MG TABLET
It is used to treat moderate to severe:
- rheumatoid arthritis
- atopic dermatitis or atopic eczema
HOW BARINAT 1MG TABLET WORKS
For rheumatoid arthritis, BARINAT 1MG TABLET works by reducing the activity of an enzyme called Janus kinase, which is involved in inflammation. By reducing the activity of Janus kinase enzyme, it helps to reduce pain, stiffness and swelling in your joints, tiredness and helps to slow down the damage to the bone and cartilage in the joints. For atopic dermatitis, BARINAT 1MG TABLET works by reducing the activity of Janus kinase enzyme and helps to improve the condition of skin and reduce itching. It also helps to improve your sleep disturbance due to itching and overall quality of life.
DIRECTIONS FOR USE
Take BARINAT 1MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF BARINAT 1MG TABLET
COMMON
- upper respiratory tract infections
- elevated creatine
- throat and nose infections
- high levels of blood cholesterol
- cold sores (herpes simplex)
- gastroenteritis (infection of the stomach, diarrhea)
- urinary infection
- pneumonia
- increased platelets count (thrombocytosis)
- headache
- nausea
- stomach pain
- high levels of liver enzymes
- rash, acne
- high levels of creatine kinase enzymes
UNCOMMON
- neutropenia (low white blood cells)
- high levels of triglycerides in blood
- weight gain
- swelling of the face, urticaria
- blood clot in the veins of the legs (deep vein thrombosis and lungs)
- diverticulitis (inflammation of small pockets in the lining of your intestine)
RARE
Stop taking BARINAT 1MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- chest tightness, wheezing
- severe dizziness or light-headedness
- allergic reaction such as swelling of the lips, tongue and throat
- hives (itching or skin rash)
- anaphylactic reactions
- severe abdominal pain accompanied with fever, nausea and vomiting.
- symptoms of an infection such as fever, sweating, or chills, muscle aches, cough, shortness of breath, blood in your phlegm, weight loss, warm, red, or painful skin or diarrhea or stomach, burning when you urinate or sores on your body, pain, urinating more often than normal, feeling tired
- pneumonia and urinary tract infection
- active serious infection, including localized infections
- recurrent infections
- tuberculosis (signs include fever, night sweats, weight loss) which may present with pulmonary or extra pulmonary disease
- bacterial, invasive fungal, viral, and other opportunistic infections like multidermatomal herpes zoster, esophageal candidiasis, pneumocystosis, acute histoplasmosis, cryptococcosis, cytomegalovirus, and BK virus
- cancer (lymphoma and skin cancers)
- blood clots in leg and lungs
- diverticulitis (inflammation of small pockets in large intestine) or ulcers in your stomach or intestines
- discomfort in the center of your chest, severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw pain or discomfort in your arms, back, neck, jaw, or stomach, shortness of breath with or without chest discomfort) and stroke (weakness in one part or on one side of your body, slurred speech)
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea and Vomiting:
Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-treat on your own and contact your doctor if the symptom did not improve on its own.
WARNING & PRECAUTIONS
PREGNANCY
BARINAT 1MG TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking.
BREASTFEEDING
BARINAT 1MG TABLET is generally not recommended for use in breastfeeding women as it is not known if this medicine passes into breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
BARINAT 1MG TABLET has no effect on the ability to drive or operate any machines.
KIDNEY
BARINAT 1MG TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking.
LIVER
BARINAT 1MG TABLET should be used with caution in patients with liver disease. Consult your doctor before taking.
ALLERGY
Do not take BARINAT 1MG TABLET if you are allergic to Baricitinib or any of the other ingredients of this medicine.
LUNGS
BARINAT 1MG TABLET should be used with caution in patients with lung diseases (pulmonary embolism). Consult your doctor before taking.
OTHERS
Before taking BARINAT 1MG TABLET, inform your doctor if you have:
- infections
- herpes infection (shingles) symptoms such as painful skin rash with blisters
- hepatitis B or C
- cancer such as Lymphoma and other cancers including skin cancers
- blood clots in the veins of your legs (deep vein thrombosis)
- diverticulitis (inflammation of small pockets in large intestine) or ulcers in stomach or intestines
- low red blood cell count (anaemia), low white blood cell count (neutropenia or lymphopenia), high blood fat (cholesterol) or high levels of liver enzymes
- any stomach pain
- diabetes
- HIV, or a weak immune system
- an infection other than COVID-19
Use in pediatrics:
BARINAT 1MG TABLET is not recommended for use in children and adolescents under 18 years of age.
Use in geriatrics:
BARINAT 1MG TABLET should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking.
INTERACTIONS
A. Drug - Drug interactions:
Before taking BARINAT 1MG TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to treat gout ( Ex. probenecid)
- injectable anti-rheumatic medicines (used to treat rheumatoid arthritis) Ex. tocilizumab, etanercept, adalimumab
- injectable medicines acting on immune system (targeted biologic antibody therapies)
- medicine to control immune response (Ex. azathioprine, tacrolimus or cyclosporine)
- other medicines belonging to the group of Janus kinase inhibitors (Ex. ruxolitinib)
- medicines used to treat pain and inflammation (Ex. NSAIDs)
- medicines used to treat severe pain (Ex. opioids)
- corticosteroids (used to treat inflammatory conditions)
Overdosage:
If you or anyone else accidentally takes too much of BARINAT 1MG TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Baricitinib |
| Pharmacological Category | : | Janus kinase inhibitor |
| Therapeutic Indication | : | Rheumatoid arthritis, Atopic dermatitis |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep BARINAT 1MG TABLET out of the sight and reach of children
- Store BARINAT 1MG TABLET below 25°C
FAQs ABOUT BARINAT 1MG TABLET
Does BARINAT 1MG TABLET cause cancer?
BARINAT 1MG TABLET may increase your risk of developing certain cancers, such as lymphoma or lung cancer. Consult your doctor before taking.
Can I use BARINAT 1MG TABLET in pregnant?
No. BARINAT 1MG TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking BARINAT 1MG TABLET.
How BARINAT 1MG TABLET works?
For rheumatoid arthritis, BARINAT 1MG TABLET works by reducing the activity of an enzyme called Janus kinase, which is involved in inflammation. By reducing the activity of Janus kinase enzyme, it helps to reduce pain, stiffness and swelling in your joints, tiredness and helps to slow down the damage to the bone and cartilage in the joints. For atopic dermatitis, BARINAT 1MG TABLET works by reducing the activity of Janus kinase enzyme and helps to improve the condition of skin and reduce itching. It also helps to improve your sleep disturbance due to itching and overall quality of life.
What side effects can be expected while taking BARINAT 1MG TABLET?
The most common side effects of taking BARINAT 1MG TABLET are signs of cold sores, shingles (painful skin rash with blisters) and infections of the throat, nose (cold, sinus) stomach (gastroenteritis), lungs (pneumonia), urinary tract infections, headache, nausea, stomach pain, high levels of blood cholesterol and liver enzymes shown by blood test.
Does BARINAT 1MG TABLET affect immunity?
Yes. BARINAT 1MG TABLET may affect the immunity and makes you to prone to infections like throat, nose and chest infections, cold sores, urinary tract infections and stomach upsets. Consult your doctor before taking BARINAT 1MG TABLET.
Can BARINAT 1MG TABLET cause bradycardia?
BARINAT 1MG TABLET may cause bradycardia, when used with other medicines. Consult your doctor before taking BARINAT 1MG TABLET.
REFERENCES
1. Lilly S.A., Avda. de la Industria. Electronic Medicines Compendium (EMC). [Revised on January 2021] [Accessed on 27th April 2022] https://www.medicines.org.uk/emc/files/pil.2434.pdf
2. Eli Lilly and Company. U.S. Food & Drug Administration. [Revised on May 2018] [Accessed on 27th April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/207924s000lbl.pdf
3. Lilly S.A. European Medical Agency (EMA). [Revised on NA] [Accessed on 27th April 2022] https://www.ema.europa.eu/en/documents/product-information/olumiant-epar-product-information_en.pdf
4. Eli Lilly and Company. Baricitinib. [Revised on December 2021] [Accessed on 27th April 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=866e9f35-9035-4581-a4b1-75a621ab55cf
USEFUL DIAGNOSTIC TESTS
- Rheumatoid Factor - Agglutination
- Rheumatoid Factor - Turbidometry
- Rheumatoid Factor IgG Antibody
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 03 Dec 2022 | 10:11 PM(IST)
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.