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AZTROHIGH 500 Injection 1's
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INTRODUCTION
AZTROHIGH 500 INJECTION contains Aztreonam which belongs to the group of medicines called Antibiotics. It is used to treat serious bacterial infections such as urinary tract infections (including pyelonephritis and cystitis and asymptomatic bacteriuria), lower respiratory tract infections (including pneumonia and bronchitis), bacteraemia/septicemia, bone and joint infections, skin and skin-structure infections (including those associated with postoperative wounds, ulcers and burns).
AZTROHIGH 500 INJECTION is also used to treat intra-abdominal infections (including peritonitis), gynaecologic infections (including pelvic inflammatory disease, endometritis and pelvic cellulitis) and gonorrhoea (acute uncomplicated urogenital or anorectal infections).
AZTROHIGH 500 INJECTION should be used with caution in patients with liver, kidney disease and fits. AZTROHIGH 500 INJECTION is generally not recommended for use in pregnant women unless it is considered clearly necessary. It is not recommended for use in breastfeeding women. Consult your doctor before receiving it.
AZTROHIGH 500 INJECTION should be used with caution in new born older than one week and in elderly patients. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
The most common side effects of receiving AZTROHIGH 500 INJECTION are cough, nasal congestion, wheezing, throat pain, fever, chest discomfort abdominal pain and vomiting. Contact your doctor if any of the symptoms worsen.
USES OF AZTROHIGH 500 INJECTION
To treat serious bacterial infections such as:
- urinary tract infections
- lower respiratory tract infections
- bacteraemia/septicemia
- bone and joint infections
- skin and skin-structure infections
- intra-abdominal infections
- gynaecologic infections
- gonorrhoea
HOW AZTROHIGH 500 INJECTION WORKS
AZTROHIGH 500 INJECTION is a bactericidal agent that works by preventing the formation of the protective covering of the bacteria (bacterial cell wall) which is essential for the survival of bacteria. Thus, helps to treat bacterial infection effectively.
DIRECTIONS FOR USE
AZTROHIGH 500 INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection/infusion or into the muscle as intramuscular injection. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF AZTROHIGH 500 INJECTION
COMMON
- cough, nasal congestion, wheezing
- throat pain, fever
- chest discomfort
- abdominal pain, vomiting
UNCOMMON
- discomfort and swelling at intramuscular injection site
- nausea, diarrhea
- rash
RARE
- dizziness, ringing in the ears
- double vision
- bleeding of the stomach
- painful or swollen colon or liver
- bad breath
- weakness
- yellowing of the skin
- thrush or other vaginal irritation
- fits
- headache
- wheezing
- breast tenderness
- sneezing
- tingling/numbness
- difficulty sleeping
- change in heartbeat, fall in blood pressure
- confusion
- bleeding, spontaneous bruising
- muscle pain
- general discomfort
- increase in time taken for a cut to stop bleeding
- phlebitis or thrombophlebitis (inflammation or swelling of vein at the intra venous injection site)
Stop receiving AZTROHIGH 500 INJECTION and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (signs include swelling of the face, lips, tongue and/or throat with difficulty in swallowing or breathing)
- serious bowel inflammation (signs include severe, persistent or bloody diarrhea associated with stomach pain or fever)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Try to receive this medicine with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Contact your doctor if your nausea and vomiting did not improve.
Diarrhea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Contact your doctor if your diarrhoea did not improve.
Stomach discomfort:
Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-treat and contact your doctor if the stomach pain did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating Solution) and apply a pain-relieving balm on the head if necessary. Contact your doctor if your headache did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Contact your doctor if your dizziness did not improve.
WARNING & PRECAUTIONS
PREGNANCY
AZTROHIGH 500 INJECTION is generally not recommended for use in pregnant women unless it is considered clearly necessary. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
BREASTFEEDING
AZTROHIGH 500 INJECTION is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you have unexplained confusion, altered mental function, seizure, movement disorders after receiving AZTROHIGH 500 INJECTION.
KIDNEY
AZTROHIGH 500 INJECTION should be used with caution in patients with kidney disease and may require dose adjustment. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
LIVER
AZTROHIGH 500 INJECTION should be used with caution in patients with liver disease such as alcoholic cirrhosis and may require dose adjustment. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
ALLERGY
Do not receive AZTROHIGH 500 INJECTION if you are allergic to Aztreonam or L-arginine or any other ingredients of this medicine.
OTHERS
Before receiving AZTROHIGH 500 INJECTION, inform your doctor if you:
- have ever had an allergic reaction to any antibiotics
- have diarrhoea or usually get diarrhoea when you take antibiotics or have ever suffered from problems with your stomach or intestines
- have blood disorders Ex. pancytopenia (severe reduction in blood cells causing weakness, bruising or prone to infections)
- have skin disorders, including serious illness with blistering of the skin (toxic epidermal necrolysis)
- are going to have coomb’s test (a test for some blood problems)
- have fits
Use in pediatrics:
AZTROHIGH 500 INJECTION should be used with caution in new born older than one week. There is no safety information on use of this medicine in new born less than one week old. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
Use in geriatrics:
GBNKEYWORD] should be used with caution in elderly patients due to decrease in kidney function. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving AZTROHIGH 500 INJECTION, inform your doctor if you are receiving any of the following medicine:
- probenecid (used to treat gout)
- anticoagulants (medicines used to thin blood) Ex. warfarin
- furosemide (used to remove extra fluid in the body (edema))
- opioids (medicines used to treat severe pain) Ex. tramadol
- diphenoxylate with atropine (a combination medicine used to treat diarrhea)
- aminoglycosides (medicines used to treat bacterial infections) Ex. amikacin, kanamycin
Overdosage:
AZTROHIGH 500 INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience unexplained confusion, altered mental function, coma, seizure, movement disorders or weakness.
SYNOPSIS
| Drug | : | Aztreonam |
| Pharmacological Category | : | Monobactams |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep AZTROHIGH 500 INJECTION out of reach of children
- Store AZTROHIGH 500 INJECTION below 30°C
FAQs ABOUT AZTROHIGH 500 INJECTION
Does AZTROHIGH 500 INJECTION treats viral infections?
No, AZTROHIGH 500 INJECTION do not treat viral infections like common cold, flu and other viral infections. It should be used only to treat bacterial infections. Do not take antibiotics when they are not needed as it increases your risk of getting an infection later that resists antibiotic treatment. Consult your doctor before receiving AZTROHIGH 500 INJECTION.
Can AZTROHIGH 500 INJECTION cause diarrhea?
Yes, AZTROHIGH 500 INJECTION may cause diarrhea in some individuals. Drink more fluids like water or fruit juices to keep yourself hydrated. Avoid taking any medicine for diarrhea on your own. Please consult your doctor if the symptom of diarrhea did not improve or worsen.
Can I stop using AZTROHIGH 500 INJECTION if I feel better?
Although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the treatment and increase the likelihood that bacteria will develop resistance and will not be treatable by AZTROHIGH 500 INJECTION or other antibacterial drugs in the future.
Is AZTROHIGH 500 INJECTION safe during pregnancy?
AZTROHIGH 500 INJECTION is generally not recommended for use in pregnant women unless it is considered clearly necessary. Inform your doctor if you are pregnant or are planning for pregnancy before receiving AZTROHIGH 500 INJECTION.
Does AZTROHIGH 500 INJECTION cause dizziness?
AZTROHIGH 500 INJECTION may cause dizziness. Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Contact your doctor if your dizziness did not improve.
How long does it take for AZTROHIGH 500 INJECTION to work?
AZTROHIGH 500 INJECTION will be administer to you by a doctor or nurse. You should start to feel the effects of this medicine at about 1 hour of administration. The full effects of this medication are usually felt about few days after your dose. Contact your doctor if your symptoms did not improve.
REFERENCES
1. KD. Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 730.
2. Robert. J. Kizior, Keith J. Hodgson. Aztreonam. Saunders Nursing Drug Handbook. 2021. 29th edition. 2021. Page- 108.
3. Michael Hogan, Mary Barna Bridgeman, Gee Hee Min, Deepali Dixit, Patrick J Bridgeman and Navaneeth Narayanan. Effectiveness of empiric aztreonam compared to other beta-lactams for treatment of Pseudomonas aeruginosa infections. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. October 2018. [Accessed on 16th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208932/
4. Jared L. Crandona and David P. Nicolau. Human Simulated Studies of Aztreonam and Aztreonam-Avibactam to Evaluate Activity against Challenging Gram-Negative Organisms, Including Metallo-β-Lactamase Producers. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. July 2013. [Accessed on 16th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697389/
5. Catalent Anagni S.R.L. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 16th August 2022] https://www.medicines.org.uk/emc/files/pil.3773.pdf
6. Bristol-Myers Squibb (NZ) Limited. New Zealand Medicines and Medical Devices Safety Authority (MEDSAFE). [Accessed on 16th August 2022] https://www.medsafe.govt.nz/profs/Datasheet/a/Azactaminj.pdf
7. Aztreonam. Aristo Pharmaceuticals Pvt Ltd. [Accessed on 16th August 2022] https://www.aristopharma.co.in/products/
8. Drugbank.com. Aztreonam. [Accessed on 16th August 2022] https://go.drugbank.com/drugs/DB00355
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Peripheral smear examination
- Culture sensitivity tests
AUTHOR DETAILS
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 11 Jan 2023 | 05:20 PM(IST)
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