Azmarda 100mg Tablet 14'S

Hypertension Rx required

Best Price*  ₹ 935.24
MRP ₹1,169.05
(Inclusive of all taxes) *14 Tablet(s) in a Strip * Mkt: Cipla Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

AZMARDA is a combination of Sacubitril and Valsartan which belongs to a group of medicines called angiotensin receptor neprilysin inhibitors. It is indicated to reduce the risk of cardiovascular death and hospitalization for patients with long-term heart failure and reduced ejection fraction. Heart failure is a condition when the heart is weak and cannot pump enough blood to the lungs and to the rest of the body. 

Sacubitril and valsartan are used to treat heart failure by relaxing the blood vessels and reducing the sodium and fluid build up in the body resulting in improved flow of blood throughout the body and making it easier for heart to pump the blood.

Before taking AZMARDA inform your doctor if you have liver, kidney or heart problems and conditions such as diabetes or low blood pressure. It is not recommended for use in pregnant and breast-feeding women. AZMARDA is not suitable for use in children and adolescents under 18 years of age. Do not drive or operate any machines if you experience side effects such as dizziness or extreme tiredness. The common side effects of AZMARDA are dizziness, headache, tiredness and low blood pressure. Consult your doctor if any of your symptoms worsen.

USES OF AZMARDA

  • used to treat long-term heart failure in adults

HOW AZMARDA WORKS

AZMARDA works by blocking a specific enzyme and receptor in your body which relaxes the blood vessels and makes it easier for your heart to pump blood around your body and helps to retain less water in the body.

DIRECTIONS FOR USE

Always take AZMARDA as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will adjust the dose of AZMARDA depending upon treatment response and risk of developing side effects.

SIDE EFFECTS OF AZMARDA

COMMON

  • low blood pressure (causing dizziness, light-headedness)
  • signs of high potassium levels in blood (irregular heartbeat, muscle weakness)
  • cough
  • diarrhea
  • anemia (low level of red blood cells)
  • tiredness
  • headache
  • fainting or spinning sensation
  • weakness
  • orthostatic hypotension (dizziness due to low blood pressure especially while standing from sitting or lying position)
  • nausea
  • gastritis (stomach pain, nausea)
  • signs of low blood sugar (sweating, increased heartbeat, shakiness, hungry)

UNCOMMON

  • rash and itching due to allergic reactions

RARE

  • hallucinations
  • changes in sleeping cycle

Stop taking AZMARDA and contact your doctor immediately if you experience any of the following side effects:

  • severe allergic reactions (such as rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take this medicine with, or just after, a meal or snack and stick to simple meals and do not eat oil rich or spicy food.

Diarrhea:

Drink plenty of fluids such as water, fruit juices or electrolytes to avoid dehydration in your body.

Dizziness:

Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids.

Tiredness:

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule.

Headache:

Apply hot or cold-water bag on your head. Try taking rest in a quiet and dark room. Drink tea or coffee.

WARNING & PRECAUTIONS

PREGNANCY

AZMARDA is not recommended for use in early pregnancy and it should not be taken more than 3 months during pregnancy as it can cause serious harm to the baby especially if it is used after third month of pregnancy.

BREASTFEEDING

AZMARDA is not recommended for use in breastfeeding women. Consult your doctor for advice.

DRIVING AND USING MACHINES

While taking AZMARDA if you experience dizziness or tiredness, do not drive or operate any machines or use tools and other activities which requires concentration.

ALCOHOL

Consumption of alcohol is not recommended during treatment with AZMARDA as it can worsen the condition of the patient.

KIDNEY

AZMARDA should be used with caution in patients with severe kidney disease and dose may be adjusted with the lowest effective dose. Also caution measures should be exercised in patients with renal artery stenosis (narrowed renal artery). Consult your doctor for advice.

LIVER

AZMARDA is not recommended for use in patients with severe liver disease. Consult your doctor for advice.

ALLERGY

Do not take if you are allergic to Sacubitril and Valsartan or any other inactive preparations of AZMARDA.

LUNGS

It is not known how AZMARDA would react in patients with respiratory diseases. Consult your doctor for advice before taking.

HEART DISEASE

It is not known how AZMARDA would react in patients with heart disease. Consult your doctor for advice before taking.

OTHERS

Before taking AZMARDA, inform your doctor if you have:

  • various conditions such as diabetes or low blood pressure
  • dehydration problems
  • hallucinations, paranoia, or changes in sleeping pattern

Use in pediatrics:

AZMARDA is not recommended for use in children and adolescents less than 18 years of age. Consult your doctor for advice.

Use in geriatrics:

AZMARDA should be used with caution in elderly patients particularly with kidney disease. Consult your doctor for advice.

INTERACTIONS

A. Drug-Drug interactions:

Before taking AZMARDA inform to your doctor, if you are taking, 

  • enalapril, lisinopril or ramipril (treats high blood pressure or heart failure)
  • aliskiren and other angiotensin receptor blockers such as telmisartan, losartan (treats high blood pressure)
  • atorvastatin (lowers high cholesterol levels)
  • sildenafil (treat erectile dysfunction and lung hypertension)
  • potassium supplements, salt substitutes containing potassium, potassium-sparing medicines (used to retain potassium in the blood)
  • heparin (treats blood clot)
  • non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen, indomethacin, or selective cyclooxygenase-2 (Cox-2) inhibitors such as celecoxib, etoricoxib (treats pain and inflammation)
  • lithium (used to treat psychiatric illness)
  • furosemide (used to remove excess fluid from the body through increased urination)
  • nitroglycerine (treats angina pectoris)
  • rifamycin (treats infections)
  • ciclosporin (used to prevent rejection of transplanted organs)
  • ritonavir (used to treat HIV/AIDS)
  • metformin (treats diabetes)

Overdosage:

If you or anyone else accidentally take too much of AZMARDA, consult your doctor immediately. Overdosage of AZMARDA can cause side effects due to decrease in blood pressure such as dizziness or fainting.

SYNOPSIS

Drug :   Sacubitril and Valsartan
Pharmacological Category :   Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Indication :   Heart failure
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep out of reach of children
  • Store at room temperature

FAQs ABOUT AZMARDA

Can I use AZMARDA in pregnancy?

No, AZMARDA should be avoided in early pregnancy and should not be taken more than 3 months during pregnancy, as it can cause serious harm to developing fetus. Consult your doctor when you are pregnant or planning to become pregnant.

How quickly does AZMARDA work?

Usually, AZMARDA reaches the steady state levels in 3 days, it will vary from person to person and may take longer days to show its therapeutic effects due to factors such as age, weight, body fluid and other conditions.

What should I tell my doctor before taking AZMARDA?

Before taking AZMARDA inform your doctor about your past medical and medication history, including liver or kidney disease and dehydration problems due to severe diarrhea or vomiting, including history of facial swelling (angioedema) due to any factors.

Is AZMARDA safe to use in kidney disease patients?

AZMARDA can be used in patients with mild or moderate kidney disease and it should be used with caution in severe kidney disease, starting with the lowest effective dose based on kidney function. Your doctor may prescribe this medicine with caution if you have problems in your arteries carrying blood to the kidneys.

REFERENCES

1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 508.

2. Loretta Fala. Entresto (Sacubitril/Valsartan): First-in-Class Angiotensin Receptor Neprilysin Inhibitor FDA Approved for Patients with Heart Failure. [Accessed on July 01, 2021] ncbi.nlm.nih.gov/pmc/articles/PMC4636283/

3.  Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure? 2018; [Accessed on July 01, 2021] https://pubmed.ncbi.nlm.nih.gov/29532764/

4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC) [Revised on April, 2021] [Accessed on July 01, 2021] https://www.medicines.org.uk/emc/files/pil.7751.pdf

5. Novartis Pharmaceuticals. U.S. Food & Drug Administration. [Revised in February 2021] [Accessed on July 01, 2021].                                                             https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf

6. Novartis Pharmaceuticals Canada Inc. [Revised on Oct 24, 2017] [Accessed on July 01, 2021] [Product Monograph Template - Standard] - Ask Novartis ...https://www.ask.novartispharma.ca › download

7. Ciplamed Ltd. [Revised on March, 2017] [Accessed on July 01, 2021] https://www.ciplamed.com/content/azmarda-tablets

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    25 g
    Ingredient
    SACUBITRIL 49MG+VALSARTAN 51MG
    Hsn Code
    30049099
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Azmarda 100mg Tablet 14'S

Azmarda 100mg Tablet 14'S Mkt: Cipla Ltd

M.R.P.: Rs.1,169.05
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