Avastin 400mg Injection 16ml

Cancer/Oncology Rx required
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INTRODUCTION

AVASTIN 400MG contains Bevacizumab which belongs to a group of medicines called antiangiogenic agents. It is indicated to treat metastatic colorectal cancer, first-line non-squamous non small cell lung cancer, recurrent glioblastoma (GBM), metastatic renal cell carcinoma, persistent, recurrent, or metastatic cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer and hepatocellular carcinoma.

Bevacizumab is a humanized monoclonal IgG1 antibody which contains human framework regions and murine complementarity determining regions. This binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in invitro models of angiogenesis. Bevacizumab reduces microvascular growth and inhibition of metastatic disease progression.

Before receiving this AVASTIN 400MG, tell your physician if you have liver, kidney or heart problems, are pregnant or breastfeeding. This medicine is not suitable for use in children and adolescents below 18 years of age. The common side effects are nose or rectal bleeding, headache, back pain or increased blood pressure.

USES OF AVASTIN 400MG

Treats,

  • Metastatic colorectal cancer
  • First-line non-squamous non small cell lung cancer
  • Recurrent glioblastoma (GBM)
  • Metastatic renal cell carcinoma
  • Persistent, recurrent, or metastatic cervical cancer
  • Epithelial ovarian
  • Fallopian tube, or primary peritoneal cancer and
  • Hepatocellular carcinoma

HOW AVASTIN 400MG WORKS

Bevacizumab belongs to antiangiogenic agents which works by stopping the formation of blood vessels that bring oxygen and nutrients to tumors and slows the growth and spread of tumors.

DIRECTIONS FOR USE

AVASTIN 400MG will be administered as an intravenous infusion by your doctor or nurse.

SIDE EFFECTS OF AVASTIN 400MG

COMMON

  • nosebleed or rectal bleeding
  • increased blood pressure
  • headache
  • back pain
  • dry or watery eyes
  • flaky or dry skin
  • runny nose or sneezing
  • changes in your sense of taste

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.

Back pain:

Use an ice pack or over the counter medicines to relieve pain.

WARNING & PRECAUTIONS

PREGNANCY

AVASTIN 400MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your Doctor.

BREASTFEEDING

AVASTIN 400MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your Doctor.

KIDNEY

AVASTIN 400MG should be used with caution in patients suffering from kidney diseases. Consult your doctor for advice.

LIVER

AVASTIN 400MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Tell your doctor if you are allergic (hypersensitive) to Bevacizumab.

LUNGS

AVASTIN 400MG should be used with caution in patients suffering from chronic lung disease. Consult your doctor for advice.

HEART DISEASE

AVASTIN 400MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.

OTHERS

Tell your doctor before taking this medicine if you have or had:

  • ovarian cancer
  • hemoptysis
  • arterial thromboembolism
  • diabetes
  • pulmonary embolism
  • hypertension

INTERACTIONS

Tell your doctor if you are taking,

  • paclitaxel
  • carboplatin

SYNOPSIS

Drug :   Bevacizumab
Pharmacological Category :   Antiangiogenic agents
Therapeutic Indication :   Metastatic colorectal cancer, First-line non-squamous non small cell lung cancer, Hepatocellular carcinoma
Dosage Forms :   Injection

MORE INFORMATION

  • Keep out of reach of children
  • Store at 2 - 8°C

FAQs ABOUT AVASTIN 400MG

Can AVASTIN 400MG be used during pregnancy?

It is not suitable for use in pregnant women, unless prescribed by your doctor.

How AVASTIN 400MG works differently from chemotherapy?

It prevents the growth of new blood vessels that feed tumors and causes the tumour to shrink, or to stop growing.

How is AVASTIN 400MG given?

It will be administered intravenously by your doctor or nurse.

REFERENCES

1. KD Tripathi MD. Anticancer drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 871.

2. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1739-1740.

3. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 955.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 142-143.

5. Filis Kazazi-Hyseni, Jos H. Beijnen and Jan H. M. Schellens. Bevacizumab. Aug 15, 2010. [Accessed on June 16, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228024/

6. Genentech, Inc. 2004. [Revised on Jan, 2021] [Accessed on June 16, 2021] https://www.gene.com/download/pdf/avastin_prescribing.pdf

7. Abevmy. Oct 06, 2017. [Accessed on June 16, 2021] https://5.imimg.com/data5/CN/TA/HA/GLADMIN-112814/abevmy-cancer-injection.pdf

USEFUL DIAGNOSTIC TESTS

  • Carcino Embryonic Antigen
  • Complete Blood Count
  • Human Papilloma Virus
  • Papanicolaou (PAP) Cytology

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    20 g
    Ingredient
    BEVACIZUMAB 400MG
    Hsn Code
    30049035
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