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INTRODUCTION
ASAR contain Azilsartan medoxomil which belongs to a group of medicine called angiotensin II receptor antagonists (AIIRAs). Angiotensin II is a substance occur naturally in body which tightens the blood vessels, thereby increasing your blood pressure. This medicine blocks this effect so that the blood vessels relax which helps lower your blood pressure.
It is used for treating high blood pressure (essential hypertension) in adult patients (over18 years of age). High blood pressure is a condition in which the force of the blood against the artery walls is high. The common side effects are dizziness, diarrhoea, increased blood creatine phosphokinase. It is not recommended for use in children and adolescents under 18 years. Before taking this medicine tell your doctor if you have ever had kidney, heart or liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF ASAR
- Treat high blood pressure
HOW ASAR WORKS
ASAR works by relaxing the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure and allows the blood to flow more smoothly to different organs and the heart to pump more efficiently.
DIRECTIONS FOR USE
Always take ASAR exactly as your doctor has told you. This medicine must be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF ASAR
SERIOUS
- allergic reactions such as difficulties in breathing, or swallowing, or swelling of the face, lips, tongue, throat (angioedema), itching of the skin with raised lumps
COMMON
- dizziness
- diarrhoea
- increased blood creatine phosphokinase (an indicator of muscle damage)
RARE
- changes in blood test results including decreased levels of a protein in the red blood cells (haemoglobin)
HOW TO MANAGE SIDE EFFECTS
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Diarrhoea:
Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talk to a doctor.
WARNING & PRECAUTIONS
PREGNANCY
ASAR is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
ASAR is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine, since it may cause tiredness or dizziness.
ALCOHOL
Consumption of alcohol is not recommended during treatment with ASAR.
KIDNEY
ASAR is not recommended in patients with active kidney diseases. Before taking, discuss the risks and benefits with your doctor.
LIVER
ASAR should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take ASAR if you are allergic (hypersensitive) to azilsartan medoxomil or any other ingredients in this medicine.
HEART DISEASE
ASAR should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had condition such as,
- diabetes
- ever had a stroke
- low blood pressure or feel dizzy or lightheaded
- recent severe vomiting, or have diarrhoea
- raised levels of potassium in your blood (as shown in blood tests)
- a disease of the adrenal gland called primary hyperaldosteronism
INTERACTIONS
Talk to your doctor if you are taking,
- lithium (used to treat mental health problems)
- non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, diclofenac, or celecoxib (used to treat pain and inflammation)
- acetylsalicyclic acid (used to treat pain and inflammation)
- potassium supplements, potassium-sparing medicines or salt substitutes containing potassium (used for increasing the amount of potassium in your blood)
- heparin (used for thin blood)
- diuretics
- aliskiren or other medicine to lower your blood pressure (angiotensin converting enzyme inhibitor or angiotensin II receptor blocker such as enalapril, lisinopril, ramipril or valsartan, telmisartan, irbesartan
SYNOPSIS
| Drug | : | Azilsartan |
| Pharmacological Category | : | Angiotensin II receptor antagonists |
| Therapeutic Indication | : | High blood pressure (hypertension) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT ASAR
What is high blood pressure?
High blood pressure is a condition in which the force of the blood against the artery walls is high.
Which class does ASAR belong to?
This medicine belongs to a group of medicine called angiotensin II receptor antagonist (AIIRAs). Angiotensin II is a substance which occur naturally in the body. It tightens the blood vessels which in turn increases the blood pressure. It blocks this effect so that the blood vessels relax which helps lower your blood pressure.
How long it takes for ASAR to show effect?
A reduction in your blood pressure will be measurable within 2 weeks of initiation of treatment and the full effect of your dose will be observed by 4 weeks.
REFERENCES
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page – 358-359.
2. Caroline M Perry 1. Azilsartan medoxomil: a review of its use in hypertension. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 1 Sep 2012. [Accessed 27 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/22877322/
3. Emiliano Angeloni. Azilsartan medoxomil in the management of hypertension: an evidence-based review of its place in therapy. US National Library of Medicines, National Institutes of Health. 5 Apr 2016. [Accessed 27 Nov 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829189/
4. Takeda Ireland Limited, Jan 2020; Electronic Medicines Compendium (EMC); [Accessed 27 Nov 2020] https://www.medicines.org.uk/emc/files/pil.4074.pdf
USEFUL DIAGNOSTIC TESTS
- Kidney function test
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