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INTRODUCTION

AQSUSTEN 25MG INJECTION contains Progesterone which belongs to the group of medicines called Steroid hormones. It is used for the maintenance of early pregnancy in patients who faced documented history of repeated miscarriages due to luteal phase defect (a problem in menstrual cycle caused due to deficiency of progesterone during the midway of the menstrual cycle).

It can also be used as an adjuvant to infertility techniques (such as in vitro fertilization (IVF) or gamete intra-fallopian transfer (GIFT)) to facilitate successful implantation of the fertilized egg in the uterus. It is also used to prevent threatened abortions and to treat abnormal uterine bleeding caused due to hormonal imbalance.

It can be used as a diagnostic tool in progesterone withdrawal testing to diagnose the endocrinal causes of secondary amenorrhea (irregular or lack of menstrual periods) and to judge the chances of pregnancy among infertile women.

Before receiving AQSUSTEN 25MG INJECTION inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have diabetes, high blood pressure, asthma, epilepsy, or migraine headaches before receiving AQSUSTEN 25MG INJECTION as a precaution.

AQSUSTEN 25MG INJECTION is not recommended for use in patients with breast cancer, ovarian cancer, uterine cancer, blood clot problems or any vaginal infections. AQSUSTEN 25MG INJECTION is not recommended for use in breast-feeding women and in children and adolescents (below 18 years of age).

AQSUSTEN 25MG INJECTION can be used during the first three months of pregnancy. However, it should not be used in women who have ectopic pregnancy (pregnancy outside the womb) and in women who had a history of idiopathic jaundice (severe itching of the skin) or other skin problems during their earlier pregnancies.

The most common side effects of receiving AQSUSTEN 25MG INJECTION are pain, redness, itching, irritation or swelling at the injection site, vaginal bleeding, headache, bloating, nausea, hair loss, abnormal hair growth in the body, darkening of the facial skin or difficulty in sleeping. Consult your doctor if any of these side effect bothers you. Talk to your doctor immediately if you experience any changes in body weight or feel depressed while receiving AQSUSTEN 25MG INJECTION.

USES OF AQSUSTEN 25MG INJECTION

It is used:

  • To maintain early pregnancy in patients with history of repeated miscarriages
  • As an adjunct to infertility techniques (such as in vitro fertilization (IVF) or gamete intra-fallopian transfer (GIFT)) to facilitate successful implantation of the fertilized egg in the uterus
  • To prevent threatened abortions
  • To treat dysfunctional uterine bleeding
  • To diagnose the endocrinal causes of secondary amenorrhea (irregular or lack of menstrual periods) among infertile women

HOW AQSUSTEN 25MG INJECTION WORKS

AQSUSTEN 25MG INJECTION is a steroid hormone used to treat progesterone deficiency in the body. It supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy. It sustains pregnancy among infertile women and in women who face repeated/threatened abortions by increasing the thickness of uterine wall. It also regulates hormonal balance in the body and corrects abnormal uterine bleeding.

DIRECTIONS FOR USE

AQSUSTEN 25MG INJECTION will be given to you only by a doctor or a nurse into the muscles (as intramuscular injection). Your doctor will decide the correct dose and duration of therapy for you according to your age, body weight and disease condition.

SIDE EFFECTS OF AQSUSTEN 25MG INJECTION

COMMON

  • pain, redness, itching, irritation or swelling at the injected site
  • uterine cramps
  • vaginal bleeding or discharge
  • headache
  • bloating, stomach pain, constipation, nausea, vomiting
  • changes in breast, breast pain or tenderness
  • tingling or uncomfortable irritation or itching of the vaginal skin and the surrounding area
  • hardening or bruising of area around the administration site
  • extreme tiredness, exhaustion, lethargy
  • hair loss or abnormal hair growth in the body
  • darkening of facial skin
  • fever

UNCOMMON

  • mood changes
  • dizziness, insomnia (problems in sleeping)
  • stomach and intestinal discomfort (stomach tenderness, gas, painful cramps, retching)
  • skin rashes (raised, itchy bumps, wheals, or red, warm, dry, cracked, blistered or swollen skin)
  • breast swelling or enlargement
  • feeling hot
  • general feeling of discomfort or pain

RARE

Contact your doctor immediately if you experience any of the following side effects after receiving AQSUSTEN 25MG INJECTION:

  • lower stomach pain, thirst, nausea and sometimes vomiting, passing low quantities of concentrated urine, weight gain (signs of overstimulation of the ovaries)
  • feeling extremely depressed
  • jaundice (yellow skin and white of the eyes)
  • severe allergic reaction which may cause trouble in breathing, swelling of the face and throat or a severe rash
  • heart attack (signs include chest or back pain, deep aching, and throbbing in one or both arms, sudden breathlessness, sweating, dizziness, lightheadedness, nausea, palpitations)
  • stroke (signs include severe headache or vomiting, dizziness, vision or speech changes, weakness or numbness of an arm or leg)
  • blood clots in the eyes or anywhere in the body (eye pain, pain and swelling in your ankles, feet, and hands)
  • severe headache or bulging of the eye and changes in vision

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take regular sips of cold drink. Stick to simple meals. Avoid eating oily, fried, or spicy foods. Do not lie down or sleep immediately after eating. If nausea does not improve, consult your doctor.

Headache:

Apply hot or cold-water bag on your head. Drink plenty of fluids. Try taking rest in a quiet and dark room. Apply pain relieving balm on your forehead if necessary. Consult your doctor if your headache does not reduce.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Do minimal exercises (such as walking). If the symptom does not improve, consult your doctor.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. If the symptom gets worse consult your doctor.

Bloating:

Try to increase your physical activity during daytime. Do not or limit the intake of carbonated drinks. Avoid eating foods which causes bloating such as beans, lentils, and others. Always eat smaller and frequent meals and chew your food properly while eating. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

AQSUSTEN 25MG INJECTION can be used during the first three months of pregnancy if prescribed by the doctor. It is strictly not recommended for use in women with ectopic pregnancy (pregnancy outside the womb) and in women who had a history of idiopathic jaundice (severe itching of the skin), severe itching or pemphigoid gestationis (an abnormal lesions on the skin caused due to autoimmune reactions) during their earlier pregnancies. Therefore, consult your doctor for advice.

BREASTFEEDING

AQSUSTEN 25MG INJECTION is not recommended for use during breast-feeding. Therefore, consult your doctor before receiving it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy or drowsy after receiving AQSUSTEN 25MG INJECTION.

ALCOHOL

Avoid consumption of alcohol while receiving AQSUSTEN 25MG INJECTION.

KIDNEY

AQSUSTEN 25MG INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.

LIVER

AQSUSTEN 25MG INJECTION is not recommended for use in patients who have or had any liver problems in the past. Therefore, consult your doctor before receiving it.

ALLERGY

Do not receive AQSUSTEN 25MG INJECTION if you are allergic to Progesterone or to any of the other ingredients of this medicine.

LUNGS

AQSUSTEN 25MG INJECTION is not recommended for use in patients who have or had any blood clots in the lungs (pulmonary embolism). It should be used with caution in patients with asthma. Therefore, consult your doctor before receiving it.

HEART DISEASE

AQSUSTEN 25MG INJECTION should be used with caution in patients with heart problems. Therefore, consult your doctor before receiving it.

OTHERS

AQSUSTEN 25MG INJECTION is not recommended for use if you:

  • have vaginal infection or unusual vaginal bleeding (other than normal periods)
  • had miscarriage and your doctor suspects about the existence of few more tissue in the uterus
  • have known or suspected cancer of the breast, ovaries or uterus
  • had or have blood clots in the legs (thrombophlebitis), eyes (retinal thrombosis) or anywhere in the body (venous or arterial thromboembolism) or stroke

Before receiving AQSUSTEN 25MG INJECTION, inform your doctor if you:

  • have fits
  • have migraine headache (severe headache affecting one side of the head)
  • have porphyria (an inherited blood disorder)
  • have sensitivity to light (photosensitivity)
  • have diabetes (high blood sugar)
  • have high blood pressure
  • have depression
  • have a habit of smoking
  • are overweight or obese
  • are aged 35 years or above
  • have any risk of atherosclerosis (such as high blood fat levels)
  • are scheduled for any blood tests

Use in pediatrics:

AQSUSTEN 25MG INJECTION is not recommended for use in children and adolescents (under 18 years of age). Therefore, consult your doctor before administration.

Use in geriatrics:

There is no proper information about the use of AQSUSTEN 25MG INJECTION in elderly patients (aged 65 years and above). Therefore, consult your doctor for advice.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving AQSUSTEN 25MG INJECTION, inform your doctor if you are taking any of the following medicines:

  • medicines used to treat epilepsy (Ex. carbamazepine, phenytoin, phenobarbital)
  • bromocriptine (a medicine used to stop breast milk secretion, infertility, or Parkinson’s disease)
  • rifampicin (a medicine used to treat bacterial infections)
  • medicines used to treat fungal infections (Ex. griseofulvin, ketoconazole)
  • St. john’s wort (a medicine used to treat depression)
  • cyclosporine (a medicine used to suppress immune function)
  • medicines used to treat diabetes (Ex. glimepiride, metformin)

 Overdosage:

AQSUSTEN 25MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms such as drowsiness after receiving AQSUSTEN 25MG INJECTION.

SYNOPSIS

Drug :  

Progesterone

Pharmacological Category :  

Progestins (female hormones)

Therapeutic Indication :  

Supports early pregnancy, Treats Abnormal uterine bleeding, Diagnose the causes for secondary amenorrhea, Prevents threatened abortion

Dosage Forms :  

Tablet, Soft gel Capsule, Pessaries, Injection, Vaginal Gel, Vaginal spray

MORE INFORMATION

  • Keep AQSUSTEN 25MG INJECTION out of reach of children
  • Store AQSUSTEN 25MG INJECTION at room temperature

FAQs ABOUT AQSUSTEN 25MG INJECTION

Does AQSUSTEN 25MG INJECTION cause weight gain?

Yes, AQSUSTEN 25MG INJECTION might cause weight gain due to overstimulation of ovaries in some individuals. Stop receiving AQSUSTEN 25MG INJECTION and consult your doctor as soon as you notice that your weight has increased abnormally.

Does AQSUSTEN 25MG INJECTION make you feel tired?

Yes. AQSUSTEN 25MG INJECTION may cause tiredness in some individuals. To manage this, drink plenty of fluids and eat balanced diet and frequent meals. Get enough rest and follow regular sleep schedule.

How is AQSUSTEN 25MG INJECTION administered?

AQSUSTEN 25MG INJECTION will be given to you only by a doctor or by a nurse into the muscle (intramuscular injection). Your doctor will decide the correct dose and duration of therapy with AQSUSTEN 25MG INJECTION for you depending on your age, body weight and disease condition.

Who should avoid taking AQSUSTEN 25MG INJECTION?

AQSUSTEN 25MG INJECTION is not recommended for use in women who have or had ectopic pregnancy and in women who have a history of repeated miscarriages, idiopathic jaundice (severe itching of the skin), severe itching or pemphigoid gestationis (an abnormal lesions on the skin caused due to autoimmune reactions) during their earlier pregnancies. It should not be used in patients with breast cancer, ovarian cancer, or uterine cancer. You must also inform your doctor before taking AQSUSTEN 25MG INJECTION if you have any severe liver problems, blood clot problems or any vaginal infections before receiving AQSUSTEN 25MG INJECTION.

Why is AQSUSTEN 25MG INJECTION necessary for pregnancy?

AQSUSTEN 25MG INJECTION supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy. It sustains pregnancy among infertile women and in women who face repeated/threatened abortions by increasing the thickness of uterine wall.

When is progesterone produced in the reproductive cycle?

The typical menstrual cycle takes approximately 28 to 32 days and is divided into three distinct phases namely the follicular phase, the ovulatory phase and the luteal phase. The luteal phase is the period when the body produces progesterone, the hormone that makes the uterus prepare its lining to receive the egg.

What are the side effects of AQSUSTEN 25MG INJECTION?

The most common side effects of receiving AQSUSTEN 25MG INJECTION are injection site reactions (pain, swelling, redness and itching), stomach pain, breast pain, darkening of facial skin, hair loss, abnormal hair growth in the body, nausea, and difficulty in sleeping. Consult your doctor if any of these side effects bothers you.

REFERENCES

1. KD. Tripathi. Estrogens, Progestins, and Contraceptives. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 316.

2. Michaela Jewson, Prashant Purohit, Mary Ann Lumsden. Progesterone and abnormal uterine bleeding/menstrual disorders. ScienceDirect. November 2020. [Accessed on 21st July 2022] https://www.sciencedirect.com/science/article/abs/pii/S152169342030081X

3. Institut Biochimique SA. Progesterone. Product Monograph. Inprosub (Progesterone Injection) [Revised in June 2021] [Accessed on 21st July 2022] https://pdf.hres.ca/dpd_pm/00062667.PDF

4. Pharmasure Limited. Lubion 25 mg solution for injection. Progesterone. [Revised in March 2018] [Accessed on 21st July 2022] https://www.pharmasure.co.uk/uploads/uk-PIL-Lubion-UI.pdf

USEFUL DIAGNOSTIC TESTS

  • Saline-infusion sonography
  • Ultrasound
  • Anti-mullerian hormone

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 14 Oct 2022 | 10:07 AM(IST)

VIDEOS

Progesterone INJECTION - Drug Information

Progesterone INJECTION : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage

PRODUCT DETAILS

    Country Of Origin
    India
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The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

AQSUSTEN 25mg Injection 1.119ml

AQSUSTEN 25mg Injection 1.119ml Mkt: Sun Pharmaceutical Industries Ltd

₹ 93.48 MRP ₹ 114.00