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INTRODUCTION
APIZ 20MG TABLET contains Aripiprazole which belongs to the group of medicines called Anti-psychotic drugs. It is used to treat schizophrenia in both adults and in adolescents (aged between 13-17 years). Schizophrenia is a mental disorder which affects a person’s ability to think, feel and behave correctly. It is characterized by seeing or hearing things which are not present and abnormal thoughts or behavior.
APIZ 20MG TABLET can also be given to children (aged between 6-18 years) to treat Tourette’s disorder which is characterized by uncontrollable repetitive body movements or abnormal sounds (tics).
Take APIZ 20MG TABLET as directed by your physician. Do not skip any dose or stop taking APIZ 20MG TABLET without consulting your doctor. While taking APIZ 20MG TABLET, do not exercise excessively and avoid exposing yourself to hot climate. Drink plenty of water to avoid dehydration.
Before taking APIZ 20MG TABLET inform your doctor you have diabetes, heart problems, fits or blood clots in the body. It is strictly not recommended for use in elderly patients having dementia-related psychosis (a disorder that affects memory, thinking and social abilities).
Avoid consumption of alcohol while taking APIZ 20MG TABLET, as it could make you feel more dizzy or drowsy. Consult your doctor before taking APIZ 20MG TABLET, if you are pregnant or planning to become pregnant or breastfeeding.
APIZ 20MG TABLET may increase your blood sugar or cholesterol levels, therefore your doctor would periodically monitor your blood glucose and cholesterol levels as a precaution.
Patients taking APIZ 20MG TABLET must inform their doctor if they develop any unusual mood changes, increased sex drive, excessive gambling, suicidal thoughts, or worsening depression.
The most common side effects of taking APIZ 20MG TABLET are excessive saliva secretion, uncontrollable muscle movements, dizziness, sleepiness or headache. Consult your doctor if any of the side effect bothers you.
USES OF APIZ 20MG TABLET
It is used to treat:
- schizophrenia in adults and in adolescents (aged between 13-17 years)
- Tourette’s Disorder in children (aged between 6-18 years)
HOW APIZ 20MG TABLET WORKS
APIZ 20MG TABLET is an atypical antipsychotic. It works by regulating the release and uptake of certain chemical messengers (dopamine and serotonin) in the brain that affects thoughts, emotions, body movements, and behaviour. As a result, it improves your ability to think, controls your emotions and body movements and stabilizes your mental health.
DIRECTIONS FOR USE
Take APIZ 20MG TABLET as advised by your physician. It can be taken with or without meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and mental state. Do not stop taking APIZ 20MG TABLET without consulting your doctor, even if you feel better after few days of therapy.
SIDE EFFECTS OF APIZ 20MG TABLET
COMMON
- difficulty in sleeping, anxiety, restlessness
- uncontrollable muscle twitching, jerking or writhing movements
- trembling (feeling shaky)
- headache, tiredness, sleepiness, dizziness
- blurred vision
- constipation, indigestion
- nausea, vomiting, excessive saliva secretion
UNCOMMON
- sign of increased prolactin levels in blood (such as breast milk production, delay in puberty)
- restless legs (urge to move your legs more frequently)
- eye problems (double vision or sensitivity to light)
- fast heartbeat
RARE
Stop taking APIZ 20MG TABLET and consult your doctor if you experience any of the following side effects such as:
- excessive thirst, urination or hunger, stomach problems with fruity odour (signs of diabetes)
- thoughts of harming or killing yourself, worsening depression
- changes in behavior (such as developing urges or cravings to behave unusually, addictive gambling, excessive eating or spending and abnormal high sex drive)
- signs of Neuroleptic Malignant Syndrome (a neurological emergency disorder causing fever, muscle stiffness or pains, vomiting, sweating, dark urine and decrease in consciousness)
- tardive dyskinesia (uncontrollable movements of the mouth, tongue, and the limbs)
- feeling dizzy and faint while standing up (orthostatic hypotension)
- weight gain
- severe allergic reactions (such as severe itching with raised bumps, swelling of the face, lips, tongue and/or throat, which may cause difficulty in swallowing)
- irregular heartbeat, seizure (fits)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Take APIZ 20MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if you continue to feel nauseating for a prolonged period.
Diarrhea:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not take any anti-diarrheal medicines to treat diarrhea on your own. Consult your doctor if your diarrhea persists for a prolonged period.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
APIZ 20MG TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
BREASTFEEDING
APIZ 20MG TABLET should be used in breastfeeding women only if it is considered necessary by the physician. Your doctor will evaluate the risks and benefits of the therapy for you and decide whether APIZ 20MG TABLET should be continued or not depending upon your condition. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience dizziness or blurred vision after taking APIZ 20MG TABLET.
ALCOHOL
Avoid consumption of alcohol while taking APIZ 20MG TABLET as it could make you feel more dizzy or drowsy.
ALLERGY
Do not take APIZ 20MG TABLET if you are allergic to aripiprazole.
HEART DISEASE
APIZ 20MG TABLET should be used with caution in patients having heart problems (such as history of myocardial infarction or stroke, or abnormal blood pressure). Consult your doctor before taking it.
OTHERS
Before taking APIZ 20MG TABLET, inform your doctor if you:
- have diabetes or family history of diabetes
- have involuntary, irregular muscle movements, especially in the face
- have muscle stiffness or inflexibility with high fever, sweating, altered mental status, or very rapid or irregular heartbeat
- have fits (seizures)
- have blood clots, or family history of blood clots
- have difficult in swallowing
- have previous experience of excessive gambling
- have low WBC count
Use in Pediatrics
APIZ 20MG TABLET should be used in children and adolescents (aged 13 years or older) only if prescribed by the physician. It is generally not recommended for use in children (aged below 6 years) due to lack of safety data. Therefore, consult your doctor before taking it.
Use in Geriatrics
APIZ 20MG TABLET should be used with caution in elderly patients (65 years and above). It is strictly not recommended for use in elders having dementia-related psychosis. Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions
Before taking APIZ 20MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat abnormal heart rhythm (Ex. quinidine, amiodarone, flecainide)
- medicines used to treat depression (Ex. fluoxetine, paroxetine, venlafaxine, St. John's Wort, amitriptyline, clomipramine)
- tryptophan (an amino acid used to maintain brain health)
- medicines used to treat fungal infections (Ex. ketoconazole, itraconazole)
- medicines used to treat HIV infection (Ex. efavirenz, nevirapine, indinavir, ritonavir)
- medicines used to treat epilepsy (Ex. carbamazepine, phenytoin)
- medicines used to treat tuberculosis (Ex. rifabutin, rifampicin)
- medicines used to treat high blood pressure (Ex. captopril, enalapril, atenolol, propranolol, etc.)
- medicines used to reduce anxiety and to induce sleep (Ex. alprazolam, midazolam, lorazepam)
- medicines used for pain relief (Ex. tramadol and pethidine)
- medicines used to treat migraine headache (Ex. sumatriptan and zolmitriptan)
Overdosage
If you or anyone else accidentally took more APIZ 20MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include abnormal heart rate, agitation, problems with speech, unusual movements (especially face or tongue), sudden confusion, fits, fever, abnormal breathing, sweating, muscle stiffness, high or low blood pressure or drowsiness.
SYNOPSIS
| Drug | : | Aripiprazole |
| Pharmacological Category | : | Atypical anti-psychotic drug |
| Therapeutic Indication | : | Schizophrenia, Tourette’s Disorder |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
- Keep APIZ 20MG TABLET out of reach of children
- Store APIZ 20MG TABLET at room temperature
FAQs ABOUT APIZ 20MG TABLET
Does APIZ 20MG TABLET increase blood sugar levels?
Yes. APIZ 20MG TABLET can increase blood sugar levels and can precipitate diabetes. It can be identified by symptoms such as tiredness, increased thirst or hunger, frequent urination, and fruity breath. Consult your doctor if you experience any such symptoms. Also, it is important to inform your doctor if you already have diabetes or having a family history of diabetes as a precaution.
What are the uses of APIZ 20MG TABLET?
APIZ 20MG TABLET is an antipsychotic medicine. It is used in the treatment of schizophrenia, mania and depression. It also helps to control abnormal body movements and behavioral problems in children having Tic disorder or Autism.
Is APIZ 20MG TABLET a sleeping medicine?
APIZ 20MG TABLET is not a sleeping pill. But it can make you feel sleepy, because it works by regulating the release and uptake of certain chemical messengers (dopamine and serotonin) in the brain that affects your thoughts and sleep patterns.
What are the side effects of APIZ 20MG TABLET?
APIZ 20MG TABLET can cause difficulty in sleeping, restlessness, uncontrollable muscle movements, headache, tiredness, sleepiness, dizziness, or excessive saliva secretion. Consult your doctor if any of the side effect troubles you. Also, inform your doctor if you experience any unusual mood changes, increased sex drive, excessive gambling, suicidal thoughts, or worsening depression.
What is the best time to take APIZ 20MG TABLET?
APIZ 20MG TABLET can be taken with or without meals preferably in the mornings. However, your doctor will decide the time of consumption depending upon your age, body weight and health condition.
Will APIZ 20MG TABLET work instantly?
No. It may take a few weeks for APIZ 20MG TABLET to subside the symptoms of your illness, and so do not skip any dose or stop taking APIZ 20MG TABLET without consulting your doctor. Sudden withdrawal of therapy may cause the symptoms to reoccur.
Does APIZ 20MG TABLET make you feel high?
Yes. APIZ 20MG TABLET works by regulating the release and uptake of certain chemical messengers (dopamine and serotonin) in the brain that affects your thoughts, mood, body movements and behavior. Therefore, it can change your behavior and make you feel high, develop unusual urges or cravings, or make you eat or spend more unusually. Inform your doctor if you experience any of these symptoms.
Is APIZ 20MG TABLET a narcotic?
No. APIZ 20MG TABLET is an antipsychotic medicine. It is not a narcotic.
Is APIZ 20MG TABLET same as Xanax?
No. APIZ 20MG TABLET is an antipsychotic medicine. It contains aripiprazole which is an atypical antipsychotic used to treat mental illnesses. Xanax is a prescription medicine containing alprazolam. It is a tranquilizer used to reduce anxiety and to induce sleep.
What can be done if I forget to take a dose of APIZ 20MG TABLET?
If you forgot to take a dose of APIZ 20MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next one regularly. Do not take a double dose to make up the missed dose as it could lead to toxicity.
Can I stop taking APIZ 20MG TABLET once my symptoms subside?
Do not stop taking APIZ 20MG TABLET on your own without consulting a doctor. Sudden withdrawal of therapy may cause the symptoms to reoccur.
What are the most important precautions to be followed while using APIZ 20MG TABLET?
Before taking APIZ 20MG TABLET, inform your doctor if you have diabetes, heart problems or fits. It is strictly not recommended for use in elderly patients having dementia-related psychosis. Avoid consumption of alcohol while taking APIZ 20MG TABLET, as it could make you feel more dizzy or drowsy. Avoid getting over-heated or dehydrated while taking APIZ 20MG TABLET. Do not drive or operate any heavy tools or machines. Do not skip your routine health check-ups and blood tests. Take APIZ 20MG TABLET regularly as instructed by your physician. Do not skip a dose or stop taking APIZ 20MG TABLET without consulting your doctor.
Can APIZ 20MG TABLET cause hiccups?
Yes. APIZ 20MG TABLET may cause transient and persistent hiccups among adult and adolescent patients. Consult your doctor if it bothers you.
Can APIZ 20MG TABLET make you feel tired?
Yes. APIZ 20MG TABLET can make you feel tired. It is because of its effects on the chemical messengers (serotonin) that controls sleep patterns and activities. If you experience tiredness, rest and relax. Avoid driving or operating any heavy tools or machines on your own. Consult your doctor if you experience severe tiredness.
Can I use APIZ 20MG TABLET without consulting a doctor?
No. Do not take APIZ 20MG TABLET without consulting your doctor.
REFERENCES
1. KD. Tripathi. Anticholinergic Drugs and Drugs Acting on Central Nervous System. Essentials of medical pharmacology. Seventh edition. 2013. Page – 442.
2. Stip E, Tourjman V. Aripiprazole in schizophrenia and schizoaffective disorder: A review. disorder. Clinical Therapeutics. National Library of Medicine, National Institute of Health. (2010) https://pubmed.ncbi.nlm.nih.gov/20152550/
3. Padala PR, Qadri SF, Madaan V. Aripiprazole for the treatment of Tourette's disorder. Primary care companion to Journal of Clinical psychiatry. National Library of Medicine, National Institute of Health. 2005. [Accessed on 17th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1324961/#:~:text=Tourette's%20disorder%20is%20a%20neuropsychiatric%20disorder%20characterized%20by%20recurrent%20motor,treatment%20of%20tics%20with%20aripiprazole.
4. Otsuka Pharmaceutical Co. U.S. Food & Drug Administration. [Revised in December 2014] [Accessed on 7th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021436s038,021713s030,021729s022,021866s023lbl.pdf
5. Torrent Pharmaceuticals Ltd. ARIP MT. [Revised in August 2019] [Accessed on 7th May 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/573.pdf
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 23 Nov 2022 | 12:45 PM(IST)
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