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INTRODUCTION
APIVAS 5 TABLET contains Apixaban, which belongs to the group of medicines called Anticoagulants. It is used to prevent blood clots in patients with an irregular heartbeat (atrial fibrillation). These blood clots can dislodge and travel throughout the body, resulting in systemic embolism and stroke.
APIVAS 5 TABLET also helps in the treatment of blood clots in the legs (deep vein thrombosis) and the veins of the lungs (pulmonary embolism) and in the prevention of their recurrence in either legs or lungs.
APIVAS 5 TABLET should be taken with caution in patients who have liver or kidney disease. APIVAS 5 TABLET is contraindicated in patients who have active bleeding or have a disease that can lead to active bleeding, such as an active ulcer or a recent bleed in the brain.
APIVAS 5 TABLET should be used with caution during pregnancy or breastfeeding. APIVAS 5 TABLET is not recommended for use by children and adolescents (under the age of 18). APIVAS 5 TABLET should be used with caution in elderly patients over the age of 80.
The most common side effects of taking APIVAS 5 TABLET are bleeding (eyes, nose, gums, urine, rectum, stomach or bowel), bruising or swelling, anaemia, low blood pressure and a quickened heart rate. If any of these symptoms worsen, contact your doctor immediately.
USES OF APIVAS 5 TABLET
- Treats blood clots formed in the legs (deep vein thrombosis) and blood clots formed in the veins of the lungs (pulmonary embolism)
- Prevents the forming of blood clots in heart patients with an irregular heartbeat (atrial fibrillation)
HOW APIVAS 5 TABLET WORKS
APIVAS 5 TABLET helps to prevent the formation of blood clots by acting on the blood clotting mechanism of the body. It blocks clotting factor Xa which is an essential factor in the clotting mechanism.
DIRECTIONS FOR USE
Take APIVAS 5 TABLET as advised by your physician. Swallow the medicine with a glass of water. If you have difficulty swallowing the tablet as a whole, talk to your doctor about other ways to take APIVAS 5 TABLET. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF APIVAS 5 TABLET
COMMON
- bleeding affecting (eyes, stomach or bowel, rectum, blood in the urine, nose and gums)
- bruising and swelling
- anaemia which may lead to tiredness or paleness
- low blood pressure (faint or have a quickened heartbeat)
- nausea
UNCOMMON
- bleeding in the brain or spinal column, in the mouth or blood in spit when coughing, into the abdomen, from the vagina
- bright/red blood in the stools
- bleeding occurring after the operation including bruising and swelling
- leaking of blood/liquid from the surgical wound/incision (wound secretion) or injection site
- bleeding from a haemorrhoid
- reduced count of platelets in your blood
- yellowing of the skin and eyes
- skin rash
- itching
- hair loss
RARE
- bleeding in the lungs or your throat, into the space behind the abdominal cavity, into a muscle
- skin rash forming blisters and looks like small targets (dark spots in the centre surrounded by a paler area, with a dark ring around the edge) (erythema multiforme)
Stop taking APIVAS 5 TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction (hypersensitivity) causing swelling of lips, mouth, tongue and throat
- breathing difficulties
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
WARNING & PRECAUTIONS
PREGNANCY
The effects of APIVAS 5 TABLET on pregnancy and the unborn child are not known, hence it is not recommended to take it during pregnancy. Consult your doctor before taking it.
BREASTFEEDING
It is not known if APIVAS 5 TABLET passes into human breast milk. Consult your doctor before taking this medicine while breastfeeding.
DRIVING AND USING MACHINES
APIVAS 5 TABLET does not impair the ability to drive or use machines. Consult your doctor.
KIDNEY
APIVAS 5 TABLET should be taken with caution in patients with severe kidney disease or who are on dialysis. Consult your doctor before taking it.
LIVER
APIVAS 5 TABLET is not recommended for use in patients having liver diseases such as hepatic coagulopathy. It should be used with caution in patients with liver problems or a history of liver problems. Consult your doctor before taking it.
ALLERGY
Do not take APIVAS 5 TABLET if you are allergic to Apixaban.
HEART DISEASE
APIVAS 5 TABLET should be taken with caution in patients with prosthetic heart valves. Consult your doctor before taking it.
OTHERS
Before taking APIVAS 5 TABLET, inform your doctor if you:
- have bleeding disorders
- have very high blood pressure
- have antiphospholipid syndrome (a disorder of the immune system that increases the risk of blood clots)
- have to undergo surgery which will cause bleeding
- have lactose intolerance
Use in pediatrics:
- APIVAS 5 TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it.
Use in geriatrics:
- APIVAS 5 TABLET should be used with caution in elderly patients (aged above 80 years). Consult your doctor before taking it.
INTERACTIONS
A. Drug–Drug Interactions:
- medicines for fungal infections (Ex. ketoconazole)
- antiviral medicines for HIV / AIDS (Ex. ritonavir)
- other medicines that are used to reduce blood clotting (Ex. enoxaparin)
- anti-inflammatory or pain-relieving medicines (Ex. acetylsalicylic acid, naproxen)
- medicines for high blood pressure or heart problems (Ex. diltiazem)
- selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors (used in the treatment of depression) (Ex. escitalopram)
- medicines to prevent epilepsy or seizures (Ex. phenytoin, etc.)
- St John’s Wort (herbal supplement used in the treatment of depression)
- medicines to treat tuberculosis or other infections (Ex. rifampicin)
Overdosage:
If you or anyone else accidentally take too much of APIVAS 5 TABLET, consult your doctor immediately or visit the nearby hospital. Overdose of APIVAS 5 TABLET can result in increased bleeding.
SYNOPSIS
| Drug | : | Apixaban |
| Pharmacological Category | : | Anti-coagulants |
| Therapeutic Indication | : | Prevention of blood clots in atrial fibrillation, Deep vein thrombosis, Pulmonary embolism |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep APIVAS 5 TABLET out of reach of children
- Store below 30°C
FAQs ABOUT APIVAS 5 TABLET
Is APIVAS 5 TABLET a blood thinner?
Yes. [GBKEYWORD] is a blood thinner, also called an anticoagulant. It prevents blood clot formation and makes it easier for the blood to flow through the body. APIVAS 5 TABLET blocks an essential factor of the clotting mechanism, thereby making it easy for the blood to flow.
What precautions should I take while taking APIVAS 5 TABLET?
Patients taking APIVAS 5 TABLET should inform their doctor about their pre-existing liver, heart or kidney disease. As APIVAS 5 TABLET is an anti-coagulant and helps in the prevention of blood clot formation, it is important to tell your doctor about any bleeding disorder or any active condition that can cause a bleed. Consult your doctor before taking it.
What if I forget to take a dose of APIVAS 5 TABLET?
Take the dose as soon as you remember, then take the next dose of APIVAS 5 TABLET at the usual time and then continue as normal. Consult your doctor once.
Is APIVAS 5 TABLET safe during pregnancy and breastfeeding?
No, APIVAS 5 TABLET is not recommended for use during pregnancy and breastfeeding. If you are pregnant, breastfeeding or planning to have a baby, consult your doctor before taking APIVAS 5 TABLET. If you become pregnant while taking APIVAS 5 TABLET, contact your doctor immediately.
What is APIVAS 5 TABLET used for?
APIVAS 5 TABLET is used to prevent blood clots in patients with an irregular heartbeat (atrial fibrillation). These blood clots have the potential to dislodge and travel throughout the body, resulting in systemic embolism and stroke.APIVAS 5 TABLET also helps in the treatment of blood clots in the legs (deep vein thrombosis) and the veins of the lungs (pulmonary embolism) and in the prevention of their recurrence in either legs or lungs.
What are the side effects of taking APIVAS 5 TABLET?
The most common side effects of taking APIVAS 5 TABLET are bleeding (eyes, nose, gums, urine, rectum, stomach or bowel), tiredness or paleness due to anaemia, low blood pressure and nausea. Consult your doctor if any of these symptoms get worse.
What foods should I avoid while taking APIVAS 5 TABLET?
Avoid consuming grapefruits or juices as it impacts the effects of APIVAS 5 TABLET, which may lead to bleeding. To prevent such complications, consult your doctor before taking APIVAS 5 TABLET.
REFERENCES
1. Joseph T. DiPiro, Robert L. Talbert, Cardiovascular Diseases, Pharmacotherapy: A Pathophysiologic Approach, Eighth Edition. 2011. Page – 324.
2. Joseph P. Broderick, Jordan B. Bonomo, Brett M. Kissela, Jane C. Khoury, Charles J. Moomaw, Kathleen Alwell, Daniel Woo, Matthew L. Flaherty, Pooja Khatri, Opeolu Adeoye, Simona Ferioli, Dawn O. Kleindorfer. Withdrawal of Antithrombotic Agents and Its Impact on Ischemic Stroke Occurrence. NIH. National Library of Medicine. National Center for Biotechnology Information. PubMed Central. June 2011. [Accessed on 20th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166233/
3. Catalent Anagni S.R.L. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 20th April 2022]. https://www.medicines.org.uk/emc/files/pil.2878.pdf
4. Bristol-Myers Squibb Company, Pfizer Inc. Bristol Myers Squib. [Revised in September 2021] [Accessed on 20th April 2022]. https://packageinserts.bms.com/pi/pi_eliquis.pdf
USEFUL DIAGNOSTIC TESTS
- CBC
- Echocardiography
- Electrocardiogram
- Duplex Ultrasound
- Chest Xray
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