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INTRODUCTION

APIPRO is a combination of Cyproheptadine and Tricholine Citrate which belongs to the group of medicines called Antihistamines and Bile acid-binding agents respectively. It is indicated for loss of appetite, weight loss and anorexia nervosa (eating disorder). It is used as an adjunct to anti-tubercular and antiretroviral regimens for weight gain.

It is also used to treat allergic rhinitis (allergic reaction that causes sneezing, congestion, itchy nose and sore throat), conjunctivitis (inflammation or infection of the conjunctiva), migraine (recurrent throbbing headache that typically affects one side of the head), asthma (airways become inflamed, narrow and swell and produce extra mucus and it causes breathing difficulty) and hepatic disorders. In children, it is indicated to gain weight who have an inadequate dietary intake or loss of appetite and who suffer from anemia, liver or digestive disorder.

APIPRO is not recommended for use in patients who have or had angle-closure glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy (enlarged prostate), bladder neck obstruction, and pyloroduodenal obstruction. Avoid consumption of alcohol during treatment with APIPRO, as it may increase the risk of stomach problems. Before taking APIPRO, inform your doctor if you have a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, liver or kidney problems and high blood pressure.

APIPRO is not recommended for use in pregnant and breastfeeding women. It is recommended for use in children and adolescents (below 18 years of age) after doctor’s advice. The most common side effects of taking APIPRO are drowsiness, dizziness, insomnia, blurred vision, loss of coordination, skin rash, gastrointestinal upset, nausea, or vomiting. Consult your doctor if any of the symptom worsens.

USES OF APIPRO

Treats following conditions:

  • loss of appetite
  • weight loss
  • anorexia nervosa (eating disorder)
  • migraine
  • allergic rhinitis and conjunctivitis
  • asthma
  • hepatic disorders
  • used as an adjunct to anti-tubercular and antiretroviral regimens to gain weight
  • to gain weight in children (due to inadequate dietary intake or loss of appetite, and also in children suffering from anemia, liver, or digestive disorder)

HOW APIPRO WORKS

APIPRO contains cyproheptadine and tricholine citrate, where cyproheptadine works by reducing the effect of serotonin (a chemical messenger) in the hypothalamus which helps in regulating appetite thereby preventing weight loss and tricholine citrate is a bile acid-binding agent that works by removing the bile acids from the body and liver uses cholesterol to produce more bile acids resulting in decreased cholesterol level in the body.

DIRECTIONS FOR USE

Take APIPRO as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF APIPRO

COMMON

  • drowsiness, dizziness
  • sleeplessness
  • blurred vision
  • loss of coordination
  • skin rash
  • signs of gastrointestinal upset such as body chills, burning sensation, cramps, discomfort, and diarrhea
  • nausea, vomiting
  • constipation
  • dry mouth

RARE

Stop taking APIPRO and contact your physician immediately if you experience this side effect:

  • persistent problem or experiencing any other side effects

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult your doctor if the symptom gets worse.
Nausea or vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not perform strenuous activities or lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active (going for daily walk or run). Consult your doctor if the symptom does not improve.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

APIPRO is not recommended for use in pregnant women. Consult your doctor for advice.

BREASTFEEDING

APIPRO is not recommended for use in breastfeeding women. Consult your doctor for advice.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you experience dizziness or drowsiness after taking APIPRO.

ALCOHOL

Avoid consumption of alcohol while taking APIPRO since it may increase the risk of stomach problems.

KIDNEY

APIPRO should be used with caution in patients with kidney disease such as renal failure. Consult your doctor before taking APIPRO.

LIVER

APIPRO should be used with caution in patients with liver problems such as liver impairment. Consult your doctor before taking APIPRO.

ALLERGY

Do not take APIPRO if you are allergic to cyproheptadine, tricholine citrate, or any of the other ingredients of this medicine.

LUNGS

APIPRO should be used with caution in patients with a history of bronchial asthma. Consult your doctor before taking APIPRO.

HEART DISEASE

APIPRO should be used with caution in patients with cardiovascular disease. Consult your doctor before taking APIPRO.

OTHERS

APIPRO is not recommended for use if you have:

  • or had angle-closure glaucoma (eye disorder)
  • stenosing peptic ulcer
  • symptomatic prostatic hypertrophy (enlarged prostate gland)
  • bladder neck obstruction
  • signs of pyloroduodenal obstruction (gastric outlet obstruction) such as vomiting

Before taking APIPRO, inform your doctor if you have:       

  • increased intraocular pressure (fluid pressure inside the eye)
  • signs of hyperthyroidism (overactive thyroid) such as unintentional weight loss, rapid or irregular heartbeat
  • high blood pressure

Use in pediatrics:

APIPRO is recommended for use in children and adolescents (below 18 years of age). Consult child’s doctor for advice before administration of APIPRO to your child.

Use in geriatrics:

APIPRO is generally not recommended for use in elderly patients unless it is indicated necessary for use. Consult your doctor before taking APIPRO.

INTERACTIONS

A. Drug-Drug interactions:

Before taking APIPRO, inform your doctor, if you are taking any of the following medicines:

  • monoamine oxidase inhibitors (MAOIs) such as phenelzine, selegiline (used to treat depression)
  • hypnotics (Ex. quazepam), sedatives (Ex. barbiturates such as phenobarbital) and tranquilizers (Ex. diazepam) (used to treat insomnia)
  • antianxiety agents (Ex. alprazolam and chlordiazepoxide) (used to treat anxiety)

Overdosage:

If you or anyone else accidentally take too much of APIPRO, consult your physician immediately or visit the nearby hospital. Symptoms of overdosage are hallucinations, depression and fits.

SYNOPSIS

Drug :   Cyproheptadine, Tricholine Citrate
Pharmacological Category :   Antihistamine, Bile acid-binding agent
Therapeutic Indication :   Loss of appetite, weight loss, anorexia nervosa, weight gain, allergic rhinitis, conjunctivitis, migraine, asthma, hepatic disorders and weight gain in children
Dosage Forms :   Drops, Syrup

MORE INFORMATION

  • Keep APIPRO out of reach of children
  • Store at room temperature

FAQs ABOUT APIPRO

Can I consume alcohol during treatment with APIPRO?

Avoid consuming alcohol while taking APIPRO as it has additive effects and may increase the risk of stomach problems. Consult your doctor for advice before taking APIPRO.

Does APIPRO cause dry mouth?

Yes, APIPRO may cause dry mouth in some individuals. To manage this effect, try to sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve or gets worse.

Is APIPRO safe to use in children?

APIPRO can be given to children and adolescents (below 18 years of age) only if prescribed by the doctor. The dose may vary based on the child’s age, body weight and disease condition.

Can I take APIPRO along with antidepressants?

No, APIPRO should not be taken along with antidepressants especially with monoamine oxidase inhibitors (MAOIs) (such as phenelzine, selegiline) because it may prolong and increase the effects of APIPRO. Consult your doctor before taking APIPRO with any other medicines to avoid unwanted effects.

Can I drive after taking APIPRO?

Avoid driving and operating any machines after taking APIPRO because it may cause drowsiness and dizziness. Patients should be warned about engaging in activities requiring mental alertness and motor coordination. Consult your doctor for advice before taking APIPRO.

REFERENCES

1. KD. Tripathi. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine. Essentials of medical pharmacology. Seventh edition. 2013. Page – 174.

2. Randal A. Skidgel. Histamine, Bradykinin, and Their Antagonists. Goodman & Gilman’s The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 711-726.

3. Mayuresh Dilip Kiran, Shaheen Naseem Sheikh, Lalit Jeevan Pawaskar. Safety and Efficacy of a Combination of Cyproheptadine and Tricholine Citrate: Phase IV Study. Annals of International Medical and Dental Research. December 2017. [Accessed on 17th June 2022] https://www.readcube.com/articles/10.21276%2Faimdr.2018.4.2.pe1

4. Khadijehsadat Najib, Mozhgan Moghtaderi, Zohreh Karamizadeh and Ebrahim Fallahzadeh.  Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial. Iranian Journal of Pediatrics. NIH. National Library of Medicine, National center for biotechnology information. December 2014. [Accessed on 17th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442838/

5. Centaur Pharmaceutical Pvt. Ltd. Oraxin syrup and drop (Cyproheptadine and Tricholine citrate). [Revised in January 2021] [Accessed on 17th June 2022] https://www.centaurpharma.com/downloads/2021/pediatrics/nutritional-and-vitamins/Oraxin%20syrup%20and%20drop.pdf

6. Alaina Pharma. Cyproheptadine and Tricholine citrate syrup. [Accessed on 17th June 2022] http://alainapharma.com/Cyproheptadine%20and%20Tricholine%20Citrate%20Syrup.html

USEFUL DIAGNOSTIC TESTS

  • Upper gastrointestinal (GI) endoscopy and biopsy
  • Complete Blood Count

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    220 g
    Ingredient
    CYPROHEPTADINE 2 mg+Tricholine 275 mg
    Hsn Code
    30049069
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