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INTRODUCTION

ANXIPROL 100 TABLET contains Opipramol which belongs to the group of medicines called Antidepressants. ANXIPROL 100 TABLET is used to treat generalised anxiety disorder and somatic disturbances (a mental health condition in which a person feels significantly distressed about physical symptoms such as pain or fatigue and has abnormal thoughts, feelings and behaviours in response to them). Generalised anxiety disorder is a mental health disorder that produces fear, worry, and a constant feeling of being overwhelmed. It is characterized by symptoms such as excessive, persistent, and unrealistic worry about everyday things.

Opipramol works by binding to certain receptors (sigma receptor) in the brain and spinal cord, as a result it works in the N-methyl-D-aspartate (NMDA) receptor system and influences the neurotransmitters glutamate and dopamine (messenger substances in the brain) and produces a calming and anxiety-relieving effect followed by enhancement of mood.

ANXIPROL 100 TABLET should be used during first trimester of pregnancy unless clearly advised by your doctor and it is not recommended for use in breastfeeding women. Contact your doctor before taking it. ANXIPROL 100 TABLET is not recommended for use in patients with liver or kidney disease, heart problems such as pre-existing high-grade atrioventricular block or supraventricular or ventricular conduction disturbances, acute urinary retention, untreated glaucoma, brain damage and fits.

ANXIPROL 100 TABLET should be used with caution in children (above 6 years of age) and child’s doctor may adjust the dose depending upon body weight. The most common side effects of taking ANXIPROL 100 TABLET are fatigue, dry mouth, stuffy nose and low blood pressure. Contact your physician if any of the symptoms worsen.

USES OF ANXIPROL 100 TABLET

Treats:

  • generalised anxiety disorder
  • somatic disturbances

HOW ANXIPROL 100 TABLET WORKS

ANXIPROL 100 TABLET works by binding to certain receptors (sigma receptor) in the brain and spinal cord, as a result it works in the N-methyl-D-aspartate (NMDA) receptor system and influences the neurotransmitters glutamate and dopamine (messenger substances in the brain) and produces a calming and anxiety-relieving effect followed by enhancement of mood.

DIRECTIONS FOR USE

Take ANXIPROL 100 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ANXIPROL 100 TABLET

COMMON

  • tiredness
  • dry mouth
  • stuffy nose
  • low blood pressure
  • orthostatic dysregulation (low blood pressure when standing up from sitting or lying position)

UNCOMMON

  • dizziness
  • drowsiness
  • micturition disorders (such as increased frequency of urine, urgency and loss of bladder control)
  • difficulty in focusing nearby objects
  • tremor
  • weight gain
  • thirst
  • allergic skin reactions (rash, urticaria)
  • erectile impotence (inability to maintain erection)
  • ejaculation disorders
  • constipation
  • fast heart rate
  • palpitation (sensation of heart beating too hard or fast or irregularly)

RARE

  • agitation
  • headache
  • tingling or prickling sensation in arms or feet
  • confusion and delirium (in elderly after abrupt withdrawal)
  • edema (fluid retention)
  • galactorrhea (excessive flow of milk)
  • urinary retention
  • restlessness, sweating
  • insomnia
  • stomach discomfort
  • taste disturbances
  • paralytic ileus (impaired motor activity of bowel)
  • nausea, vomiting
  • collapsed state

Stop taking ANXIPROL 100 TABLET and contact your physician immediately if you experience any of the following side effects:

  • fever, flu like symptoms, chest pain, and hypersensitivity reactions including delayed reactions

HOW TO MANAGE SIDE EFFECTS

Constipation

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.

Dizziness Or Drowsiness

Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. Consult your doctor if the symptom does not improve or worsens.

Headache

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Take this medicine with, or just after, a meal or snack and stick to simple meals and do not eat oil rich or spicy food. Consult your doctor if the symptom does not improve.

Tiredness

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY
Monitoring required

ANXIPROL 100 TABLET can be used with caution in pregnancy, especially in the first trimester of pregnancy only if considered clearly necessary. Contact your doctor before taking ANXIPROL 100 TABLET.

BREASTFEEDING
Contraindicated

ANXIPROL 100 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk in small amounts. Contact your doctor before taking ANXIPROL 100 TABLET.

DRIVING AND USING MACHINES
Use with Caution

Do not drive or operate any machines after taking ANXIPROL 100 TABLET as it may change responsiveness of normal functions.

ALCOHOL
Consult your doctor

Avoid consumption of alcohol while taking ANXIPROL 100 TABLET as it may cause drowsiness.

KIDNEY
Contraindicated

ANXIPROL 100 TABLET is not recommended for use in patients with kidney disease. Contact your doctor before taking ANXIPROL 100 TABLET.

LIVER
Contraindicated

ANXIPROL 100 TABLET is not recommended for use in patients with liver disease. Contact your doctor before taking ANXIPROL 100 TABLET.

ALLERGY
Contraindicated

Do not take ANXIPROL 100 TABLET if you are allergic to opipramol or to other ingredients of this medicine.

HEART DISEASE
Contraindicated

ANXIPROL 100 TABLET is not recommended for use in patients with pre-existing high-grade AV block or supraventricular or ventricular conduction disturbances. Contact your doctor before taking ANXIPROL 100 TABLET.

USE IN PEDIATRICS
Use with Caution

ANXIPROL 100 TABLET should be used with caution in children above 6 years of age and dose may be adjusted depending upon body weight. Consult child’s doctor for advice.

OTHERS

ANXIPROL 100 TABLET is not recommended for use, if you have:

  • acute urinary retention
  • acute delirium
  • untreated narrow angle glaucoma
  • prostatic hypertrophy with urinary retention
  • paralytic ileus (obstruction of intestine due to paralysis of the intestinal muscles)
  • brain damage
  • cerebrovascular insufficiency
  • epilepsy
  • pyloric stenosis (opening between the stomach and small intestine thickens)
  • bowel obstruction
  • rare hereditary problems such as galactose intolerance, lapp lactase deficiency, glucose-galactose malabsorption and sucrose-isomaltase insufficiency

Before taking ANXIPROL 100 TABLET, inform your doctor if you:

  • low potassium levels

INTERACTIONS

A. Drug-Drug interactions:

Before taking ANXIPROL 100 TABLET, inform your doctor if you are taking any of the following medicines:

  • neuroleptics such as chlorpromazine, haloperidol, risperidone and fluphenazine (medicines used to treat schizophrenia and other psychoses)
  • barbiturates Ex. phenobarbitone, methylphenobarbital and phenytoin (medicines used for fits)
  • benzodiazepines Ex. alprazolam, diazepam (medicines used to treat anxiety and panic disorders)
  • anticholinergics such as trihexyphenidyl, benztropine and monoamine oxidase inhibitor (MAO) inhibitors like selegiline, rasagiline (medicines used to treat parkinson’s disease)
  • fluoxetine and fluvoxamine (medicines used to treat depression and anxiety disorders)
  • beta-blockers such as propranolol (medicines used to treat hypertension and heart diseases)
  • propafenone, quinidine (used to treat heart rhythm disorders)
  • tricyclic antidepressants Ex. imipramine, desipramine (medicines used to treat depression)
  • analgesics (medicines used to treat pain) Ex. ibuprofen, diclofenac
  • guanethidine, clonidine (medicines used to treat high blood pressure)
  • cimetidine (medicines used to treat gastric ulcers)
  • warfarin (medicines used to treat or prevent blood clots)
  • sympathomimetics like dobutamine (medicines used for decompensated heart failure)

Overdosage:

If you or anyone else accidentally take too much of ANXIPROL 100 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are dizziness, drowsiness, restlessness, insomnia, altered consciousness, temporary confusion, increased anxiety, impaired coordination, convulsions (fits), low urine output, low or no urine production, fast or slow heart rate, atrioventricular block (type of heart block), respiratory depression and rarely cardiac arrest.

SYNOPSIS

Drug :   Opipramol
Pharmacological Category :   Antidepressants
Therapeutic Indication :   Generalised anxiety disorder, Depression, Somatic disturbances
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep ANXIPROL 100 TABLET out of reach to children
  • Store ANXIPROL 100 TABLET at room temperature

FAQs ABOUT ANXIPROL 100 TABLET

Q: What is ANXIPROL 100 TABLET used for?

A: ANXIPROL 100 TABLET is used to treat generalised anxiety disorder, and somatic disturbances. It is used in adults and in children above 6 years of age. Consult your doctor before taking ANXIPROL 100 TABLET if you have any pre-existing disease condition or problems.

Q: What are the common side effects of taking ANXIPROL 100 TABLET?

A: The most common side effects of taking ANXIPROL 100 TABLET are fatigue, dry mouth, stuffy nose, low blood pressure, and orthostatic dysregulation (low blood pressure when standing up from sitting or lying position). Contact your physician if any of the symptoms worsen.

Q: Is ANXIPROL 100 TABLET safe during pregnancy?

A: ANXIPROL 100 TABLET should be used with caution in pregnancy, especially in the first trimester of pregnancy only if considered clearly necessary. Contact your doctor before taking ANXIPROL 100 TABLET if you are pregnant or planning to become pregnant.

Q: Can I drive after taking ANXIPROL 100 TABLET?

A: Do not drive or operate any machines after taking ANXIPROL 100 TABLET as it may change responsiveness of normal functions. You may ask someone to drive for you or consult your doctor for further precautions.

Q: Can ANXIPROL 100 TABLET be used in patients with heart problems?

A: ANXIPROL 100 TABLET is not recommended for use in patients with heart problems such as pre-existing high-grade atrioventricular block (type of heart block) or supraventricular or ventricular conduction disturbances. Contact your doctor for advice before taking ANXIPROL 100 TABLET.  

REFERENCES

1. Christof Schaefer, Paul Peters, Richard K. Mille. Tri- and tetracyclic antidepressants. Drugs during Pregnancy and lactation. Third edition. 2015. Page – 302.

2. Maximilian Gahr , Christoph Hiemke, Bernhard J Connemann. Opipramol. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 2017. [Accessed on 25th June 2022] https://pubmed.ncbi.nlm.nih.gov/28320023/

3. Klaus Gerlach, Thomas Uhlig, Jasmin Plathof, Andre Klassen, Klaus-Dieter Stoll, Peter Schmucker, Michael Hueppe. Effects of opipramol as an evening anaesthesiologic premedication. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2022. [Accessed on 25th June 2022] https://pubmed.ncbi.nlm.nih.gov/12422064/

4. Torrent Pharmaceuticals Ltd. Jolivel (Opipramol Dihydrochloride Tablets). [Revised in August 2015] [Accessed on 25th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2744.pdf

USEFUL DIAGNOSTIC TESTS

  • Complete blood count
  • Liver function test

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 20 Mar 2023 | 09:03 AM(IST)

PRODUCT DETAILS
    Net Qty
    1 N
    Shelf Life
    720
    Item Weight
    17.5 g
    Ingredient
    Opipramol 100 mg
    Hsn Code
    30049099
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ANXIPROL 100 Tablet 10's
ANXIPROL 100 Tablet 10's Mkt: IKON PHARMACHEM PVT LTD
₹ 104.96 MRP ₹ 128.00