INTRODUCTION

ANTHACAINE contains Lignocaine (Lidocaine) which belongs to a group of medicines called local anaesthetics which produces a temporary loss of feeling or numbness of the area. It is used before certain types of examination, production of anesthesia of accessible mucous membranes of the oropharynx and for the temporary relief of pain associated with minor burns, sunburn, abrasions of the skin, insect bites and hemorrhoids.

Lignocaine (Lidocaine) is a potent local anaesthetic of the amide type. Like other local anaesthetics, it prevents both the generation and conduction of nerve impulses by slowing depolarisation. This results from blocking of the large transient increase in permeability of the cell membrane to sodium ions that follows initial depolarisation of the membrane. It acts reversible blockade of impulse propagation by prevention of sodium flux. As a local anesthetic, lidocaine blocks initiation and conduction of nerve impulses by decreasing the permeability of the nerve cell membrane to sodium ions.

Before using ANTHACAINE tell your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. Your doctor will give the correct dose depends on your child’s age and body weight. The common side effects are dizziness, irritation, redness at the application site. Avoid contact with eyes.

USES OF ANTHACAINE

Used to,

• To produce anesthesia (temporary loss of feeling or numbness) in mucous membranes of the throat and lungs examined by your doctor
• Relieve pain associated with minor burns, sunburn, abrasions of the skin, insect bites and hemorrhoids

HOW ANTHACAINE WORKS

ANTHACAINE blocks nerve transmission, when applied to a limited area of the body, which they bind to the sodium channels in the nerve membrane and prevent the entry of sodium ions in response to the membrane’s depolarization.

DIRECTIONS FOR USE

Always use ANTHACAINE as prescribed by your doctor. Your doctor will give dose depends on type of pain. Check the label for direction before use.

• Wash your hands before and after using the medicine
• Apply required amount of medicine to the affected area and gently rub in until it is evenly distributed.

SIDE EFFECTS OF ANTHACAINE

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• mexiletine, propranolol (treats uneven heart beats)
• prilocaine or bupivacaine (other local anaesthetics)
• cimetidine (treats gastrointestinal problems)
• fluvoxamine (treats depression)
• phenytoin, phenobarbitone, primodone and carbamazepine (treats epilepsy)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ANTHACAINE

When does ANTHACAINE starts to work?

It starts working within 5 minutes after you apply it, the pain relief effect lasts about 4 hours for wounds caused by burning.

Does ANTHACAINE use during pregnancy?

It should be used with caution during pregnancy, or if you are trying to get pregnant. Consult your doctor for advice.

Does ANTHACAINE cause dizziness?

It may cause drowsiness or dizziness, do not drive or handle any machines if you experience these reactions.

REFERENCES

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2. Catterall WA, Mackie K. Local Anesthetics. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 572-573.

3. Hume JR, Grant AO. Agents Used in Cardiac Arrhythmias. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 238-239.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 798-799.

5. Ratpaporn Piyawetchakarn and Kittipat Charoenkwan. Effects of lidocaine spray for reducing pain during endometrial aspiration biopsy: A randomized controlled trial. Feb 9 , 2019; [Accessed Feb 1, 2021]

6. AstraZeneca Pty Ltd. March, 2009; [Revised on Nov, 2009] [Accessed Feb 1, 2021] https://www.nps.org.au/assets/medicines/7394be73-9c57-418a-9d58-a53300fed4f1-reduced.pdf

7. Lagaay International BV. [Accessed Feb 1, 2021] https://www.lagaay.com/Catalogus/Product%20information/033440/Lidocaine%20gel%20leaflet.pdf

8. Teligent Pharma, Inc. [Revised on Oct, 2018] [Accessed Feb 1, 2021] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=12639881-632d-445d-9ff5-b84567f49179

9. Galt Pharmaceuticals, LLC. [Revised on Jan, 2020] [Accessed Feb 1, 2021] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=12ca5385-7581-4f6f-9c30-d08d6d575dbe

10. AstraZeneca Canada Inc. October, 1954, [Revised on Jan, 2020] [Accessed Dec 21, 2006] https://pdf.hres.ca/dpd_pm/00003402.PDF