AMTAS PRP Tablet 10's

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Drug Information for AMTAS PRP Tablet 10's

What is AMTAS PRP?

  • AMTAS PRP is a combination of two active ingredients Amlodipine Besylate and Perindopril
  • Perindopril is an ACE (angiotensin converting enzyme) inhibitor
  • Amlodipine is a calcium antagonist which belongs to a class of medicines called dihydropyridines







What AMTAS PRP is used for?

  • AMTAS PRP is used to treat high blood pressure (hypertension) and/or to treat stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked)
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Talk to your doctor before taking this medicine, If you:

  • are allergic to perindopril tert-butylamine or any other ACE inhibitor, amlodipine besylate or any other dihydropyridines, or any of the other ingredients of this medicine
  • have cardiogenic shock, stenosis or unstable angina
  • have severe low blood pressure (severe hypotension)
  • suffer from heart failure
  • have diabetes or impaired kidney function
  • have hypertrophic cardiomyopathy or renal artery stenosis
  • have impaired liver function
  • have kidney problems or if you are receiving dialysis
  • have collagen vascular disease such as systemic lupus erythematosus or scleroderma
  • are on a salt restricted diet or use salt substitutes which contain potassium (a well-balanced potassium blood level is essential)
  • are going to have a general anaesthetic and/or major surgery
  • are to undergo LDL apheresis (the removal of cholesterol from your blood by a machine)
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  • If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
  • AMTAS PRP is not recommended in early pregnancy and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy
  • AMTAS PRP is not recommended for mothers who are breast-feeding
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  • AMTAS PRP is not recommended for use in children and adolescents
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  • AMTAS PRP does not affect alertness but you might experience dizziness or weakness due to low blood pressure which could affect your ability to drive or operate machinery
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Tell your doctor if you are taking, have recently taken or might take any other medicines. You should avoid AMTAS PRP with:

  • lithium (used to treat mania or depression)
  • estramustine (used in cancer therapy)
  • potassium-sparing diuretics (spironolactone, triamterene), potassium supplements or salt substitutes containing potassium
  • medicines which increase the amount of urine produced by the kidneys
  • non-steroidal anti-inflammatory drugs (e.g. ibuprofen) for pain relief or high dose acetylsalicylic acid
  • medicines to treat diabetes (such as insulin)
  • medicines to treat mental disorders such as depression, anxiety, schizophrenia etc. (e.g. tricyclic antidepressants, antipsychotics, imipramine-like antidepressants, neuroleptics)
  • immunosuppressants (medicines which reduce the defense mechanism of the body)
  • auto-immune disorders or following transplant surgery (e.g. ciclosporin)
  • allopurinol (for the treatment of gout)
  • procainamide (for the treatment of an irregular heart beat)
  • vasodilators including nitrates (products that widen the blood vessels
  • heparin (medicines used to thin blood)
  • ephedrine, noradrenaline or adrenaline (medicines used to treat low blood pressure, shock or asthma)
  • baclofen used to treat muscle stiffness in diseases such as multiple sclerosis,
  • some antibiotics such as rifampicin
  • antiepileptic agents such as carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone
  • itraconazole, ketoconazole (medicines used for treatment of fungal infections), alpha-blockers used for the treatment of enlarged prostate such as prazosin, alfuzosin, doxazosin, tamsulosin, terazosin
  • amifostine (used to prevent or reduce side effects caused by other medicines or radiation therapy that are used to treat cancer)
  • corticosteroids (used to treat various conditions including severe asthma and rheumatoid arthritis)
  • gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis)
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  • Always take this medicine exactly as your doctor has told you
  • Swallow your tablet with a glass of water, preferably at the same time each day, in the morning, before a meal
  • Your doctor will decide on the correct dose for you

If you take more AMTAS PRP

  • If you take too many tablets, contact your nearest accident and emergency department or tell your doctor immediately. The most likely symptoms of overdose are low blood pressure which can make you feel dizzy or faint. If this happens, lying down with your legs raised can help

 If you forget to take AMTAS PRP

  • If you forget to take a dose of AMTAS PRP, take the next dose at the usual time. Do not take a double dose to make up for a forgotten tablet

 If you stop taking AMTAS PRP

  • As the treatment with AMTAS PRP is usually life-long, you should discuss with your doctor before you stop taking your tablets
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Like all medicines, this medicine can cause side effects, although not everybody gets them.





  • allergic reaction such as swelling of the face, lips, mouth, tongue or throat
  • difficulty in breathing
  • severe dizziness or fainting
  • unusual fast or irregular heartbeat
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  • vertigo
  • pins and needles
  • somnolence (sleepiness)
  • vision disturbances
  • tinnitus (sensation of noises in the ears)
  • palpitations (very fast heartbeat)
  • flushing (hot or warm feeling in your face)
  • light-headedness due to low blood pressure
  • cough
  • shortness of breath
  • nausea, vomiting
  • abdominal pain
  • taste disturbances
  • dyspepsia or difficulty of digestion
  • diarrhoea or constipation
  • muscle cramps
  • feeling of tiredness
  • oedema (swelling of your legs or ankles)
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  • mood swings
  • sleep disturbances
  • trembling, syncope (temporary loss of consciousness)
  • loss of pain sensation
  • rhinitis (blocked up or runny nose)
  • changed bowel habits
  • hair loss
  • red or discoloured patches on skin
  • back, muscle or joint pain, chest pain
  • increased need to urinate especially during the night
  • malaise (general feeling of being unwell)
  • bronchospasm (tightening of the chest, wheezing and shortness of breath)
  • dry mouth
  • angioedema (symptoms such as wheezing, swelling of the face or tongue)
  • kidney problems
  • impotence
  • increased sweating
  • breast enlargement in men
  • weight increase or decrease
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  • confusion
  • cardiovascular disorders (irregular heartbeat, angina, heart attack and stroke)
  • eosinophilic pneumonia (a rare type of pneumonia)
  • erythema multiforme (a skin rash which often starts with red itchy patches on your face, arms or legs)
  • disorders of the blood, pancreas
  • peripheral neuropathy (disease that produces loss of sensations inability to control muscles)
  • hypertonia (abnormal increase in muscle tension)
  • vasculitis (inflammation of blood vessels of the skin)
  • swelling of the gums
  • high blood sugar
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  • Keep this medicine out of reach of children
  • Do not use this medicine after the expiry date
  • Protect from light and moisture
  • Store at room temperature (15-25ºC)
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The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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