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INTRODUCTION
AMOTID FORTE 250 SYRUP contains Amoxycillin which belongs to the group of medicines called Penicillin. AMOTID FORTE 250 SYRUP is used to treat bacterial infections in pediatric patients caused by susceptible strains of gram-positive and gram-negative bacteria that affect different parts of the body.
AMOTID FORTE 250 SYRUP is also used in combination with other medicines in pediatric patients to treat stomach ulcers. It is not recommended for use in children allergic to amoxicillin, penicillin, and/or other antibiotics.
Before administering AMOTID FORTE 250 SYRUP, inform your doctor if the child has glandular fever (viral infection caused by Epstein Barr Virus), is unable to urinate regularly, has kidney problems, and/or liver problems (such as hepatic impairment).
AMOTID FORTE 250 SYRUP is not recommended for use in pregnant and breastfeeding women since it is used only in children and adolescents (aged below 18 years). It is also not recommended for use in elderly patients.
The most common side effects of taking AMOTID FORTE 250 SYRUP are skin rash, nausea and diarrhoea. Consult your doctor before taking the medicine.
USES OF AMOTID FORTE 250 SYRUP
Used in paediatric patients:
- To treat bacterial infections caused by susceptible strains of gram-positive and gram-negative bacteria that affect different parts of the body
- To treat stomach ulcers (in combination with other medicines)
HOW AMOTID FORTE 250 SYRUP WORKS
AMOTID FORTE 250 SYRUP works by inhibiting the synthesis of penicillin-binding proteins which leads to the activation of autolytic enzymes in bacterial cell wall resulting in lysis/destruction of bacterial cell wall thus preventing the spread of infection in affected children.
DIRECTIONS FOR USE
Administer AMOTID FORTE 250 SYRUP in a child as advised by your physician. Shake well before use. Your doctor will decide the exact dose and duration of treatment for the child depending on the child’s age, body weight and disease condition.
SIDE EFFECTS OF AMOTID FORTE 250 SYRUP
COMMON
- skin rash
- diarrhoea
- nausea
UNCOMMON
- vomiting
- mild itchy rash (round, pink-red patches), ‘hive-like’ swollen areas on the forearms, legs, palms, hands or feet
RARE
Stop administering AMOTID FORTE 250 SYRUP and consult your doctor immediately in case the child experiences:
- signs of allergic reactions such as skin itching/rash, swelling of the face/lips/tongue/body, and/or breathing difficulties
- signs of inflammation of blood vessel walls (due to allergic reaction) such as rash/pinpoint red round spots under the skin surface or bruising of the skin, joint pain (arthritis) and kidney problems
- signs of a delayed allergic reaction (that occurs usually after 7 to 12 days of use) such as rashes, rashes, fever, joint pains and enlargement of lymph nodes under the arms
- signs of erythema multiforme (skin reaction) such as itchy reddish-purple patches on the skin (especially on the palms of the hands or soles of the feet), ‘hive-like’ raised swollen areas on the skin, tender areas on the surfaces of the mouth, eyes and genitals, fever, tiredness)
- signs of other severe skin reactions include changes in skin colour, bumps under the skin, blistering, pustules, peeling, redness, pain, itching, scaling, fever, headaches and body aches
- signs of Dress (Drug Reaction with Eosinophilia and Systemic Symptoms) such as flu-like symptoms such as rash, fever, swollen glands, and abnormal blood test results (including increased white blood cells (eosinophilia) and liver enzymes)
- signs of problems (associated with blood cell) such as fever, chills, sore throat or other signs of an infection, or bruise easily
- signs of Jarisch-Herxheimer reaction (acute febrile reaction) such as fever, chills, headache, muscle pain and skin rash
- inflammation of the colon with diarrhoea (sometimes containing blood), pain and fever
- signs of serious (reversible) liver effects such as severe diarrhoea with bleeding, blisters/ redness/bruising of the skin, darker urine/paler stools, yellowing of the skin/the whites of the eyes (jaundice)
HOW TO MANAGE SIDE EFFECTS
Nausea/vomiting:
Have the child take this medicine with or just after a meal or a snack. Let the child stick to simple meals and avoid having rich or spicy food.
Diarrhoea:
Ask the child to drink lots of fluids such as water or fruit juices so that the child is sufficiently hydrated. Do not administer any medicine to treat the condition. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
AMOTID FORTE 250 SYRUP is not recommended for use in pregnant women as it is used only in children.
BREASTFEEDING
AMOTID FORTE 250 SYRUP is not recommended for use in breastfeeding women as it is used only in children.
KIDNEY
AMOTID FORTE 250 SYRUP should be taken with caution in children with kidney problems. Consult and inform your doctor before taking the medicine.
LIVER
AMOTID FORTE 250 SYRUP should be taken with caution in children with liver problems such as hepatic impairment. Consult and inform your doctor before taking the medicine
ALLERGY
Do not administer AMOTID FORTE 250 SYRUP if the child is allergic to Amoxicillin, other penicillin or antibiotics, and/or any of the other ingredients of this medicine.
OTHERS
Before taking AMOTID FORTE 250 SYRUP inform your doctor if the child:
- has been not urinating regularly
- have signs of glandular fever (viral infection caused by Epstein-Barr virus) such as fever, sore throat, swollen glands and extreme tiredness)
Use in Paediatrics:
AMOTID FORTE 250 SYRUP is recommended for use in children and adolescents (below 18 years of age). Consult your doctor before taking the medicine.
Use in Geriatrics:
AMOTID FORTE 250 SYRUP is not recommended for use in elderly patients as it is used only in children.
INTERACTIONS
A. Drug-Drug interactions:
Before taking AMOTID FORTE 250 SYRUP, inform your doctor if the child is on any of the following medicine:
- medicines used to treat gout (Ex. allopurinol, probenecid)
- medicines used to treat blood clots (Ex. warfarin)
- medicines used to treat infections caused by bacteria including pneumonia and other respiratory tract infections such as tetracycline (Ex. lymecycline, methacycline, minocycline)
- methotrexate (used to treat certain types of cancer)
- oral typhoid vaccine (used to prevent typhoid fever)
Overdosage:
If the child or anyone else accidentally takes too much of AMOTID FORTE 250 SYRUP, Consult and inform your doctor immediately or visit the nearby hospital. Symptoms of overdose are stomach upset (associated with signs such as nausea/vomiting/diarrhoea), and/or crystals in the urine (associated with signs such as cloudy urine and difficulty while urinating).
SYNOPSIS
| Drug | : | Amoxycillin |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial infections in different parts of the body |
| Dosage Forms | : | Tablet, Dispersible Tablet, Capsule, Chewable tablet, Oral Suspension, Oral Drops, Syrup, Dry Syrup, Injection |
MORE INFORMATION
- Keep AMOTID FORTE 250 SYRUP out of reach of children
- Store AMOTID FORTE 250 SYRUP below 25°C
FAQs ABOUT AMOTID FORTE 250 SYRUP
Q. What AMOTID FORTE 250 SYRUP is used for?
A. AMOTID FORTE 250 SYRUP is used in pediatric patients to treat bacterial infections caused by susceptible strains of gram-positive and gram-negative bacteria (affecting different parts of the body) which is also used in combination with other medicines to treat stomach ulcers.
Q. How does AMOTID FORTE 250 SYRUP work?
A. AMOTID FORTE 250 SYRUP works by inhibiting the synthesis of penicillin-binding proteins which leads to the activation of autolytic enzymes in bacterial cell wall resulting in lysis/destruction of bacterial cell wall thus preventing the spread of infection in affected children.
Q. Can AMOTID FORTE 250 SYRUP stain teeth?
A. Yes, AMOTID FORTE 250 SYRUP may stain the teeth which may occur very rarely in children. Good oral hygiene practices like brushing teeth may help to prevent it. Consult your doctor if the symptom persists.
Q. What are the side effects of AMOTID FORTE 250 SYRUP?
A. The most common side effects of taking AMOTID FORTE 250 SYRUP are skin rash, nausea, and/or diarrhoea. These symptoms will subside after treatment. Consult your doctor if any of these symptoms worsen in the child.
Q. Can AMOTID FORTE 250 SYRUP be used in children affected with liver problems?
A. Yes, AMOTID FORTE 250 SYRUP can be used but with caution in children with liver problems such as hepatic impairment. Consult and inform your doctor before administering the medicine to the child.
REFERENCES
1. K.D.Tripathi. Beta- Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page - 723.
2. Bobak J. Akhavan; Niloufar R. Khanna; Praveen Vijhani. Amoxicillin. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. August 2021. [Accessed on 30th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK482250/
3. Raúl J. Andrade and Paul M. Tulkens. Hepatic safety of antibiotics used in primary care. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. July 2011. [Accessed on 30th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112029/
4. Athlone Laboratories Limited. Electronic Medicines Compendium (EMC). [Revised in July 2020] [Accessed on 30th September 2022] https://www.medicines.org.uk/emc/files/pil.2137.pdf
5. TGP The Generics Pharmacy. Benedex. [Accessed on 30th September 2022] https://tgp.com.ph/product/amoxicillin-drops-100mg-ml-10ml-benedex-1/
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Bacterial culture test
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