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INTRODUCTION
AMCLOV DUO DRY SYRUP contains a combination of Amoxicillin and Clavulanic Acid which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections such as middle ear and sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin and soft tissue infections such as dental infections, bone and joint infections, septic abortion (any abortion complicated by uterine infection), and abdominal infections. The symptoms of a bacterial infection may include fever, difficulty breathing, pus formation, and pain.
Do not take AMCLOV DUO DRY SYRUP if you have a history of hypersensitivity to beta-lactams, including penicillin and cephalosporins, or any other ingredients of this medicine. AMCLOV DUO DRY SYRUP is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction.
Before taking AMCLOV DUO DRY SYRUP, inform your doctor if you are suffering from hepatic or renal impairment. AMCLOV DUO DRY SYRUP should be used with caution in pregnant women and only when necessary. In breastfeeding women, AMCLOV DUO DRY SYRUP should be used with caution.AMCLOV DUO DRY SYRUP should be used with caution in children (aged below 12 years) and elderly patients (above 50 years). Consult your doctor before taking AMCLOV DUO DRY SYRUP.
The common side effects associated with the use of AMCLOV DUO DRY SYRUP are diarrhoea, thrush (a fungal infection in the vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptoms worsen.
USES OF AMCLOV DUO DRY SYRUP
It is used for treating bacterial infections such as:
- middle ear & sinus infections
- respiratory tract infections
- genital tract infections
- urinary tract infections
- skin & soft tissue infections such as dental infections
- bone & joint infections
- septic abortion (any abortion complicated by uterine infection)
- abdominal infections
HOW AMCLOV DUO DRY SYRUP WORKS
AMCLOV DUO DRY SYRUP helps in treating bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.
DIRECTIONS FOR USE
Syrup/Oral Suspension
Take AMCLOV DUO DRY SYRUP as advised by your physician. Shake well before use. Use the dosing syringe, cup, or spoon supplied with the pack to measure the dose accurately. A dosing syringe is recommended to dose a child below the age of 3 months accurately. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.
Dry Syrup/Dry Suspension
Take AMCLOV DUO DRY SYRUP as advised by your physician. Open the sachet, reconstitute the dry powder thoroughly in a glass of water, and swallow the mixture immediately. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.
SIDE EFFECTS OF AMCLOV DUO DRY SYRUP
COMMON
- diarrhoea
- thrush (fungal infection in the vagina, skin folds, or mouth)
- nausea
- vomiting
UNCOMMON
- dizziness
- headache
- indigestion
- skin rash
- itching
- bumpy itchy rash (hives)
RARE
- erythema multiforme (a skin rash that looks like small targets)
- reversible leucopenia including neutropenia (deficiency of white blood cells)
- reversible thrombocytopenia (deficiency of blood platelets)
Stop taking AMCLOV DUO DRY SYRUP and contact your doctor if you experience any of the following side effects:
- signs of allergic reactions on the skin such as skin rash
- signs of vasculitis (inflammation of blood vessels) such as raised red or purple spots on the skin
- signs of allergic reactions such as fever, joint pain, swollen glands in the neck, armpit or groin
- signs of angioedema such as swelling on the face or mouth resulting in difficulty in breathing, or collapse
- erythema multiforme (a skin rash that looks like small targets)
- Stevens-Johnson syndrome (widespread rash with blistering and skin peeling)
- exanthemous pustulosis (widespread red rash with blisters containing pus)
- bullous exfoliative dermatitis (itchy, red, scaly rash with bumps & blisters)
- signs of drug reaction with eosinophilia and systemic symptoms such as flu-like symptoms, rashes, fever, and swelling in glands
- inflammation of the liver (hepatitis)
- jaundice
- severe diarrhoea
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Nausea And Vomiting
Try to take AMCLOV DUO DRY SYRUP with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
AMCLOV DUO DRY SYRUP should be used with caution in pregnant women only if it is considered necessary. Consult your doctor before taking it.
BREASTFEEDING
AMCLOV DUO DRY SYRUP should be used with caution in breastfeeding women. Consult your doctor before taking it.
KIDNEY
AMCLOV DUO DRY SYRUP should be used with caution in patients with renal impairment. Consult your doctor before taking it.
LIVER
AMCLOV DUO DRY SYRUP is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction. It should be used with caution in patients with hepatic impairment. Consult your doctor before taking it.
ALLERGY
Do not take AMCLOV DUO DRY SYRUP if you have a history of hypersensitivity to beta-lactams, including penicillin and cephalosporins, or any other ingredients of this medicine. Consult your doctor before taking it.
OTHERS
Use in Paediatrics
AMCLOV DUO DRY SYRUP should be used with caution in children (below 12 years). Consult your doctor before taking it.
Use in Geriatrics
AMCLOV DUO DRY SYRUP should be used with caution in elderly patients (above 50 years). Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interactions
Before taking AMCLOV DUO DRY SYRUP, inform your doctor, if you are taking any of the following medicine:
- medicine used to treat gout Ex. allopurinol, probenecid
- medicine used to delay blood clotting Ex. warfarin, acenocoumarol
- mycophenolate mofetil (a medicine used to prevent organ rejection after an organ transplant)
- contraceptives (medicines used to prevent conception) Ex. oestrogen
Overdosage:
If you or anyone else accidentally takes too much of AMCLOV DUO DRY SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal
SYNOPSIS
| Drug | : | Amoxicillin, Clavulanic Acid |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Drops, Injections |
MORE INFORMATION
- Keep the medicine out of sight and reach from children
- Store AMCLOV DUO DRY SYRUP at a temperature not exceeding 25°C (77°F)
FAQs ABOUT AMCLOV DUO DRY SYRUP
Q: What is the function of AMCLOV DUO DRY SYRUP?
A: AMCLOV DUO DRY SYRUP is used for treating bacterial infections including middle ear and sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin and soft tissue infections such as dental infections, bone and joint infections, septic abortion (any abortion complicated by uterine infection), and abdominal infections.
Q: What happens if you take more AMCLOV DUO DRY SYRUP than your required dose?
A: If you or anyone else accidentally takes too much AMCLOV DUO DRY SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation), fluid and electrolyte disturbances, and amoxicillin crystalluria, which may lead to renal failure in some cases.
Q: What side effects are seen with AMCLOV DUO DRY SYRUP?
A: The common side effects associated with the use of AMCLOV DUO DRY SYRUP are diarrhoea, thrush (a fungal infection in the vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptoms worsen.
Q: Who should avoid taking AMCLOV DUO DRY SYRUP?
A: Do not take AMCLOV DUO DRY SYRUP if you have a history of hypersensitivity to beta-lactams, including penicillin and cephalosporins, or any other ingredients of this medicine. It is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction.
Q: Is AMCLOV DUO DRY SYRUP safe to use in children's books?
A: AMCLOV DUO DRY SYRUP should be used with caution in children (those under the age of 12). A graduated syringe is used to dispense the correct volume of suspension to children (under 3 months). For administering this medicine to children (aged 2 years or below), suspensions should be diluted to half-strength with water. Consult your doctor before taking it.
Q: How does AMCLOV DUO DRY SYRUP work?
A: AMCLOV DUO DRY SYRUP helps in treating bacterial infection, where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall, whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.
Q: What is the method for taking AMCLOV DUO DRY SYRUP?
A: Syrup/Oral Suspension
Take AMCLOV DUO DRY SYRUP as advised by your physician. Shake well before use. Use the dosing syringe, cup, or spoon supplied with the pack to measure the dose accurately. A dosing syringe is recommended to dose children below 3 months accurately. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.
Dry Syrup/Dry Suspension
Take AMCLOV DUO DRY SYRUP as advised by your physician. Open the sachet, reconstitute the dry powder thoroughly in a glass of water, and swallow the mixture immediately. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.
Q: What if I forget to take my AMCLOV DUO DRY SYRUP dose?
A: If you forgot to take AMCLOV DUO DRY SYRUP dose, take it as early as possible. Do not take a double dose to compensate for the missed dose. Consult your doctor before taking it if you are not sure what to do.
Q: When should I discontinue using AMCLOV DUO DRY SYRUP?
A: Do not stop taking AMCLOV DUO DRY SYRUP without thoroughly discussing it with your doctor until the treatment course is completed, even if you start feeling better. This is because if some bacteria survive due to incomplete medication, they may relapse into the infection.
Q: Is AMCLOV DUO DRY SYRUP safe to use in patients with liver disease?
A: AMCLOV DUO DRY SYRUP is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction. It should be used with caution in patients with hepatic impairment. Consult your doctor before taking AMCLOV DUO DRY SYRUP.
REFERENCES
1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 723.
2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. December 2021. [Assessed on 26th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/
3. GSK group of companies. Augmentin. [Revised in December 2017] [Assessed on 27th October 2022] https://gskpro.com/content/dam/global/hcpportal/en_MU/PI/Clavulin-228.5mg5ml-Susp-GDS-24.pdf
4. Micro Labs Ltd. Erox CV 228.5 Dry Syrup. [Assessed on 27th October 2022] http://www.microlabsltd.com/elibrary/node/2170
5. Micro Labs Ltd. Erox CV 457 Dry Syrup. [Assessed on 27th October 2022] http://www.microlabsltd.com/elibrary/node/2181
6. Geno Pharmaceuticals Pvt. Ltd. Genomox-CV. [Assessed on 27th October 2022] https://genopharma.com/pharma/
USEFUL DIAGNOSTIC TESTS
- blood tests
- urine tests
- liver function test
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