INTRODUCTION

ALZIL 10MG contains Donepezil which belongs to a group of medicines called acetyl cholinesterase inhibitors. It is used to treat the symptoms of dementia in people diagnosed as having mild and moderately severe Alzheimer’s disease. Alzheimer's disease is a progressive disorder that causes brain cells to degenerate and die. Dementia is continuous decline in thinking, behavioral and social skills that disrupts a person's ability to function independently. The symptoms include increasing memory loss, confusion and behavioral changes. As a result, patients with Alzheimer’s disease find it more difficult to carry out their normal daily activities.

ALZIL 10MG works by stopping acetylcholine from being broken down in your brain. Acetylcholine is an important substance that allows better communication between nerve cells. Always take this medicine as prescribed by your doctor. Before using this medicine, inform your doctor if you have heart problems, stomach ulcers, epilepsy, or asthma, pregnant or breastfeeding. It is not recommended for use in children and adolescents below 18 years of age. The common side effects are diarrhoea, headache, tiredness and hallucinations.

USES OF ALZIL 10MG

• Alzheimer’s disease (dementia)

HOW ALZIL 10MG WORKS

ALZIL 10MG works by stopping acetylcholine from being broken down in your brain. Acetylcholine is an important substance that allows better communication between nerve cells. Always take this medicine as prescribed by your doctor.

DIRECTIONS FOR USE

Take this ALZIL 10MG according to the dose and frequency as advised by your doctor. Swallow it as a whole. Do not chew, crush or break the medicine. It may be taken with or without food.

SIDE EFFECTS OF ALZIL 10MG

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Drowsiness or dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

Constipation:

Eat fruits, vegetables whole grains and high fiber rich foods.

Feeling sick (nausea) or indigestion:

Stick to simple normal meals and do not eat rich or spicy foods.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

• galantamine
• ibuprofen, diclofenac sodium
• tolterodine
• erythromycin, rifampicin
• ketoconazole
• fluoxetine
• phenytoin, carbamazepine
• quinidine, beta-blockers (propanolol and atenolol)
• diazepam, succinylcholine
• general anaesthetics

SYNOPSIS

MORE INFORMATION

Do not store above 30ºC and keep out of reach of children.

FAQs ABOUT ALZIL 10MG

For how long does ALZIL 10MG stay in your system?

It gets removed from the body very slowly. It takes about two weeks or more for this medicine to be completely removed from the system.

Does ALZIL 10MG cause depression?

No, it does not cause depression. If you are experiencing symptoms, then it could be due to existing Alzheimer’s disease.

Can ALZIL 10MG cause insomnia?

Yes, it may cause insomnia (sleeplessness). Dizziness and fainting can also be seen as common side effects.

REFERENCES

1. KD Tripathi MD. Drugs acting on central nervous system. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 490.

2. Palmer Taylor. Anti-cholinesterase agents. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 253.

3. Stahl SM, editor. Donepezil. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. Page - 199-202.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 426-27.

5. Ramón Cacabelos. Donepezil in Alzheimer’s disease: From conventional trials to Pharmacogenetics: Neuropsychiatric disease and treatment. Jun 2007; [Accessed Dec 5, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654795/

6. Accord Healthcare Limited, Electronic Medicines Compendium (EMC); [Revised Feb 2019] [Accessed Dec 5, 2020] https://www.medicines.org.uk/emc/files/pil.6065.pdf

7. Eisai Inc., 1996; U.S. Food & Drug Administration; [Accessed Dec 5, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020690s035,021720s008,022568s005lbl.pdf