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ALINFEC 100mg Injection 2ml
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INTRODUCTION
ALINFEC 100MG INJECTION contains Amikacin which belongs to a group of medicines called Aminoglycoside Antibiotic. It is used in the treatment of serious infections caused by the bacteria that are sensitive to amikacin such as respiratory tract and lung infections, gastrointestinal infections, inflammation of the inner lining of the heart, infected burns, or bacterial infections of the blood.
Prior to or during the treatment with ALINFEC 100MG INJECTION, your doctor might ask you take some diagnostic tests to check your kidney function, hearing and levels of ALINFEC 100MG INJECTION in your blood.
ALINFEC 100MG INJECTION is not recommended for use in patients with myasthenia gravis (severe weakness of body muscles). Before receiving ALINFEC 100MG INJECTION inform your doctor if you have kidney problems, hearing difficulty or tinnitus (ringing or buzzing in the ears), an antibiotic-related hearing loss or a mitochondrial mutation disease (a condition caused by variations in the mitochondrial genome).
ALINFEC 100MG INJECTION should be used with caution in pregnant and breast-feeding women only if considered necessary. Contact your doctor before receiving it. Caution must be exercised while using ALINFEC 100MG INJECTION in premature or new-born infants.
ALINFEC 100MG INJECTION should be used with caution in elderly patients above the age of 60 years. Consult your doctor before receiving it. The most common side effects of receiving ALINFEC 100MG INJECTION are tinnitus (ringing in the ears), hearing problem, inner ear damage, decrease in excretion of urine. Consult your doctor if the symptoms do not resolve or worsen.
USES OF ALINFEC 100MG INJECTION
- it is used in the treatment of serious infections caused by the bacteria that are sensitive to amikacin
HOW ALINFEC 100MG INJECTION WORKS
ALINFEC 100MG INJECTION acts on the bacteria and disrupt the important life functions of the bacteria. It interferes with the present bacteria and disrupts the cell membrane along with hampering its various cellular function which leads to bacterial death. It also stops the further spread of the infection this way.
DIRECTIONS FOR USE
ALINFEC 100MG INJECTION will be given to you only by a doctor or a nurse into a vein or muscle as an intramuscular or intravenous injection or as infusion (drip). Your doctor will determine the correct dose and duration for you based upon your body weight, age and severity of disease condition.
SIDE EFFECTS OF ALINFEC 100MG INJECTION
COMMON
- tinnitus (ringing sensation in the ears)
- hearing problem, inner ear damage
- kidney function problems (nausea, vomiting, loss of appetite, changes in urination, sleep problems)
- decrease in excretion of urine
UNCOMMON
- infections caused by resistant yeast or bacteria
- nausea
- vomiting
- rash
RARE
- changes in level of blood cells such as reduced platelets and red blood cells, reduced or increased white blood cells (fatigue, weight loss, feeling of being unwell, paleness)
- low levels of magnesium in the blood (fatigues, muscle weakness or cramps, numbness)
- tremors
- sensory disturbances
- headache
- dizziness or vertigo (spinning feeling)
- balance disorders
- abnormal tingling or ‘pins and needles’ feeling
- blindness or other vision disturbances
- retinopathy (changes in the retina of your eye)
- low blood pressure
- phlebitis (inflammation of vein walls)
- itching, hives, joint pain
- muscle twitching
- fever
- liver function changes (dark urine, pale stool, fever, abdominal pain, jaundice)
- increase in heart rate
- heart muscle inflammation
Stop receiving ALINFEC 100MG INJECTION and inform your doctor immediately if you experience any of the following side effects:
- persisting ringing in your ears
- decrease in the amount of urine you produce
- severe allergic reaction characterised by sudden itchy rash (hives), swelling of the feet, ankles, hands, face, lips, mouth or throat (which may cause difficulty in swallowing or breathing), feeling of faintness
- paralysis
- deafness or loss of hearing
- sudden loss of breathing
- severe kidney failure
HOW TO MANAGE SIDE EFFECTS
Nausea:
Stick to simple meals while receiving ALINFEC 100MG INJECTION. Avoid eating rich or spicy food. Do not take any medication by yourself. Ask for your doctor’s advice if nausea doesn’t improve or worsens.
Vomiting:
Eat light, bland foods and avoid oily, deep fried or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve or worsens.
Headache:
Rest and relax. Consume plenty of electrolytes and water. If necessary, apply a balm to the head to relieve the pain. Do not consume alcohol. Consult your doctor if the headache did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. If you feel dizzy, avoid from driving or operating machinery. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if dizziness worsens.
Rash:
Hot water may irritate your skin, so avoid taking hot showers. Do not scratch the affected area. Contact your doctor if rash worsens.
WARNING & PRECAUTIONS
PREGNANCY
ALINFEC 100MG INJECTION should be used with caution in pregnant women only if considered necessary. Contact your doctor before receiving ALINFEC 100MG INJECTION.
BREASTFEEDING
ALINFEC 100MG INJECTION should be used with caution in breast feeding women only if considered necessary as it is not known if it is excreted into breast milk. Contact your doctor before receiving ALINFEC 100MG INJECTION.
DRIVING AND USING MACHINES
Do not drive or operate machines, if you feel dizzy after receiving ALINFEC 100MG INJECTION.
KIDNEY
ALINFEC 100MG INJECTION should be used with caution in patients with kidney problems. Your doctor might monitor your kidney function. Consult your doctor before receiving ALINFEC 100MG INJECTION.
ALLERGY
Do not receive ALINFEC 100MG INJECTION if you are allergic (hypersensitive) to amikacin or any other aminoglycoside or allergic to sulphites or to other ingredients of this medicine.
OTHERS
ALINFEC 100MG INJECTION is not recommended for use if you:
- suffer from myasthenia gravis (severe weakness of body muscles)
Before receiving ALINFEC 100MG INJECTION, inform your doctor if you:
- have tinnitus or difficulty hearing (ringing or buzzing in the ears)
- or any member of your family suffers from an antibiotic-related hearing loss
- or any member of your family have mitochondrial mutation disease (a condition caused by variations in the mitochondrial genome, the components of your cells that help make energy)
Use in paediatrics:
ALINFEC 100MG INJECTION should be used with caution in premature and new-born infants. Ask your child’s doctor for advice.
Use in geriatrics:
ALINFEC 100MG INJECTION should be used with caution in elderly patients. Your doctor might adjust your dose depending on your kidney function. Consult your doctor before receiving ALINFEC 100MG INJECTION.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving ALINFEC 100MG INJECTION, inform your doctor if you are taking any of the following medicines:
- diuretics (water tablets) such as furosemide and ethacrynic acid (used to get rid of fluid build-up in the body)
- indomethacin (used to reduce inflammation)
- other antibiotics such as penicillin, cephalosporins, gentamycin, tobramycin (used to treat certain infections)
- bisphosphonates such as alendronate (medicine used to treat bone mass loss)
- vitamin B1 (thiamine) (medicine used to metabolize carbohydrates, proteins, and fats)
- platinum compounds (metals used in chemotherapy) such as cisplatin, carboplatin, oxaliplatin
- muscle relaxants such as atracurium, rocuronium, vecuronium (used to relax muscles)
- anaesthetics such as methoxyflurane (used before surgery)
Overdosage:
ALINFEC 100MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, inform your doctor immediately if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Amikacin |
| Pharmacological Category | : | Aminoglycoside Antibiotics |
| Therapeutic Indication | : | Serious bacterial infections |
| Dosage Forms | : | Eye drops, Injection, Infusion |
MORE INFORMATION
- Keep ALINFEC 100MG INJECTION out of the sight and reach of children.
- Store ALINFEC 100MG INJECTION below 25°C
FAQs ABOUT ALINFEC 100MG INJECTION
What is ALINFEC 100MG INJECTION and why is it prescribed?
ALINFEC 100MG INJECTION contains Amikacin which belongs to a group of medicines called Aminoglycoside Antibiotic. It is used in the treatment of serious infections caused by the bacteria that are sensitive to amikacin
How much time does it take to administer ALINFEC 100MG INJECTION?
ALINFEC 100MG INJECTION will be given to you only by a doctor or a nurse into a vein or muscle as an intramuscular or intravenous injection or as infusion (drip). If given as an infusion, it may take from 30-60 minutes and 1-2 hours for infants. Your doctor will determine the correct dose and duration of ALINFEC 100MG INJECTION for you based upon your body weight, age and severity of disease condition.
Is it safe to use ALINFEC 100MG INJECTION in children?
ALINFEC 100MG INJECTION should be used with caution in premature and neonatal infants and kidney function should be monitored. Consult your doctor before receiving ALINFEC 100MG INJECTION
Can I receive ALINFEC 100MG INJECTION while breast feeding?
ALINFEC 100MG INJECTION should be used in breastfeeding women only if considered necessary as it is not known whether ALINFEC 100MG INJECTION passes through into breast milk. Contact your doctor before receiving ALINFEC 100MG INJECTION.
Do I need to undergo any tests prior to, or while being treated with ALINFEC 100MG INJECTION?
Prior to or during the treatment with ALINFEC 100MG INJECTION, your doctor might ask you take some diagnostic tests to check your kidney function, hearing and levels of ALINFEC 100MG INJECTION in your blood. You doctor will also make sure that you are well hydrated.
REFERENCES
1. K.D. Tripathi. Aminoglycoside Antibiotics. Essentials of medical pharmacology. Eighth edition. 2019. Page – 799.
2. Sizar O, Rahman S, Sundareshan V. Amikacin. StatPearls. NIH National Library of Medicine. National Center for Biotechnology Information. October 2021. [Accessed on 8th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK430908/
3. Taccone, F.S., Laterre, PF., Spapen, H. et al. Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock. Biomed Central. BMC. April 2010. [Accessed on 8th October 2022] https://ccforum.biomedcentral.com/articles/10.1186/cc8945
4. Maria S. Ramirez, Marcelo E. Tolmasky. Amikacin: Uses, Resistance, and Prospects for Inhibition. Molecules. NIH National Library of Medicine. National Center for Biotechnology Information. December 2017. [Accessed on 8th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889950/
5. Hospira UK Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 8th October 2022] https://www.medicines.org.uk/emc/files/pil.3784.pdf
6. MIAS Pharma Limited. Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 8th October 2022] https://www.medicines.org.uk/emc/files/pil.11189.pdf
7. Fresenius Kabi Manufacturing SA (Pty) Ltd. Amikacin. [Revised in April 2019] [Accessed on 8th October 2022] https://www.sahpra.org.za/wp-content/uploads/2020/02/Amikacin-Fresenius_PIL_Fresenius-Kabi_MCC-format-02-March-2012.pdf
8. Square Pharmaceuticals Ltd. Amikacin. [Accessed on 8th October 2022] https://www.squarepharma.com.bd/downloads/1636429189_pdoc_Akicin%20DS.pdf
9. Heritage Pharmaceuticals. Amikacin Sulfate. Dailymed. [Revised in November 2021] [Accessed on 8th October 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a43188fa-f228-4acd-8a5d-9a3462034f4b
10. Bosch Pharmaceuticals. Amkay Injection (Amikacin). [Accessed on 8th October 2022] https://bosch-pharma.com/product/amkay-25mg-injections/#description
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Peripheral Smear Examination
- Kidney Function Test
- Hearing Function Test
AUTHOR DETAILS
Written By Dr. Priyanka Goel, BDS
Last updated on 12 Oct 2022 | 01:19 PM(IST)
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