Availability & Expiry
INTRODUCTION
ALEVO 25MG INJECTION contains Levosulpiride which belongs to the group of medicines called Dopamine Antagonists. It is used to treat nausea, vomiting, indigestion and diabetic gastroparesis (diabetes that causes a delay in emptying the stomach contents into the intestines).
It can also be used to treat depression and schizophrenia (disorder of thoughts and behavior) in adults.
ALEVO 25MG INJECTION should be used only under medical supervision. It is highly recommended by doctors only when oral therapy is not feasible.
Before receiving ALEVO 25MG INJECTION inform your doctor if you have any kidney or heart problems. You must also inform your doctor if you have epilepsy, mania or any other mental illness as a precaution.
ALEVO 25MG INJECTION is not recommended for use in patients having bleeding or any blockage or tear in the gut. It is also not suitable for use in patients having cancer or tumours in the body. Inform your doctor before receiving ALEVO 25MG INJECTION if you are pregnant or breastfeeding.
The most common side effects of receiving ALEVO 25MG INJECTION are headache, drowsiness, tiredness, breast enlargement and discharge and decrease in sex drive. Consult your doctor if any of these side effect bothers you.
USES OF ALEVO 25MG INJECTION
It is used to treat:
- nausea and vomiting
- indigestion
- diabetic gastroparesis (causing sensation of fullness or lack of appetite)
- depression
- schizophrenia
HOW ALEVO 25MG INJECTION WORKS
ALEVO 25MG INJECTION is an antipsychotic medicine with anti-emetic and anti-dyspeptic properties. It acts by blocking the actions of certain chemical messengers (dopamine and serotonin) in the brain that controls the mood, behaviour and movement of stomach muscles.
As a result, it improves muscle movement in the stomach (gastric motility) and reduces the unpleasant symptoms of GI tract (such as nausea, vomiting, indigestion, sensation of fullness and lack of appetite). It can also stabilize your mood, reduces the signs of depression and control abnormal thoughts and behaviours.
DIRECTIONS FOR USE
ALEVO 25MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously) or into the muscles (intramuscularly).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ALEVO 25MG INJECTION
COMMON
- headache
- drowsiness, sedation
- tiredness
- weight gain
- lack of sleep
- increased salivation, tremor
- breast enlargement and discharge
- decrease in sex drive, problems in erection
- stomach pain, constipation, dry mouth, diarrhea
- menstrual changes
- hot flushes
RARE
Contact your doctor immediately if you experience any of the following side effects after receiving ALEVO 25MG INJECTION:
- signs of Neuroleptic malignant syndrome (such as high fever, rigid muscles, mood swings, fast or irregular heartbeat, changes in blood pressure, increased sweating)
- feeling dizzy or faint while standing up
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Drowsiness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling drowsy. Do not consume excessive alcohol, as it could aggravate your drowsiness. Consult your doctor if your drowsiness worsens.
WARNING & PRECAUTIONS
PREGNANCY
ALEVO 25MG INJECTION is not recommended for use in pregnant women as it may harm the growing baby. Therefore, consult your doctor before receiving it.
BREASTFEEDING
ALEVO 25MG INJECTION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you feel drowsy after receiving ALEVO 25MG INJECTION.
ALCOHOL
Avoid consumption of alcohol while receiving ALEVO 25MG INJECTION, as it could make you feel drowsier.
KIDNEY
ALEVO 25MG INJECTION should be used with caution in patients with kidney problems. Therefore, consult with your doctor before receiving it.
ALLERGY
Do not receive ALEVO 25MG INJECTION if you are allergic to Levosulpiride.
HEART DISEASE
ALEVO 25MG INJECTION should be used with caution in patients with heart problems (such as cardiac insufficiency, prolong QT interval). Therefore, consult with your doctor before receiving it.
OTHERS
ALEVO 25MG INJECTION is not recommended for use if you:
- have pheochromocytoma (tumours of the adrenal gland)
- have epilepsy (fits)
- have prolactinoma (a non-cancerous tumour of pituitary gland)
- have breast cancer
- have mania (elevated mood)
- have manic depression (alternative episodes of excitement and sadness)
- have bloody stools or bleeding in the gut
- have blockage or tear in the intestines
Before receiving ALEVO 25MG INJECTION, inform your doctor if you:
- have or had a previous history of stroke or problems in blood circulation
- have porphyria (an inherited blood disorder)
Use in pediatrics:
ALEVO 25MG INJECTION is not recommended for use in children and adolescents (aged below 18 years) unless prescribed by the physician. Therefore, consult your doctor for advice.
Use in geriatrics:
ALEVO 25MG INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
INTERACTIONS
A. Drug – Drug Interactions:
Before receiving ALEVO 25MG INJECTION inform your doctor if you are taking any of the following medicines such as:
- levodopa, ropinirole (medicines used to treat Parkinsonism)
- medicines used to treat high blood pressure (such as propranolol, atenolol, amlodipine, diltiazem, clonidine, methyldopa, ramipril, azilsartan)
- medicines used to treat severe tics (such as pimozide)
- medicine used to treat mental illness or depression (such as haloperidol, lithium, imipramine, thioridazine, sulpiride)
- methadone (a medicine used to treat drug addiction)
- other medicines used to treat stomach disorders (such as cisapride, aluminium hydroxide, sucralfate)
- medicines used to treat anxiety (such as diazepam, clonazepam, pentobarbital, phenobarbital)
- narcotic analgesics (used for pain relief) Ex. morphine, fentanyl, pethidine
- medicines used to treat allergic reactions (Ex. cetirizine, levocetirizine)
- analgesics (used for pain relief) Ex. codeine, oxycodone
- anticholinergic medicines (used to reduce muscle movements) Ex. atropine
Overdosage:
ALEVO 25MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms such as extrapyramidal disturbances (such as involuntary muscle contraction, tremors, muscles stiffness, involuntary facial movements and inability to sit still) and sleep disorders.
SYNOPSIS
| Drug | : | Levosulpiride |
| Pharmacological Category | : | Dopamine (D2) Receptor Antagonists |
| Therapeutic Indication | : | Indigestion, Nausea, Vomiting, Diabetic Gastroparesis, depression, Schizophrenia |
| Dosage Forms | : | Tablets, Capsule, Injection |
MORE INFORMATION
- Keep ALEVO 25MG INJECTION out of the sight and reach of children
- Store ALEVO 25MG INJECTION at room temperature
FAQs ABOUT ALEVO 25MG INJECTION
What is ALEVO 25MG INJECTION used for?
ALEVO 25MG INJECTION is used to treat nausea, vomiting, indigestion, diabetic gastroparesis, depression and schizophrenia when oral therapy is not feasible.
How ALEVO 25MG INJECTION is administered?
ALEVO 25MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously) or into the muscles (intramuscularly).
How long should I take ALEVO 25MG INJECTION?
You need to take ALEVO 25MG INJECTION for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
What are the most common side effects of receiving ALEVO 25MG INJECTION?
The most common side effects of receiving ALEVO 25MG INJECTION are headache, drowsiness, tiredness, breast enlargement and discharge and decrease in sex drive. Consult your doctor if any of these side effect bothers you.
Can I stop receiving ALEVO 25MG INJECTION without consulting your doctor?
No. You should not stop receiving therapy with ALEVO 25MG INJECTION without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using ALEVO 25MG INJECTION, consult your doctor for advice.
What precautions do I need to follow while receiving ALEVO 25MG INJECTION?
Before receiving ALEVO 25MG INJECTION inform your doctor if you have any kidney or heart problems. You must also inform your doctor if you have epilepsy, mania or any other mental illness as a precaution. ALEVO 25MG INJECTION is not recommended for use in patients having bleeding or any blockage or tear in the gut. It is also not suitable for use in patients having cancer or tumours in the body. Do not take ALEVO 25MG INJECTION without consulting your doctor if you are pregnant or breastfeeding.
Can I take medication for high blood pressure along with ALEVO 25MG INJECTION?
It is not advisable to take medicines to control blood pressure along with ALEVO 25MG INJECTION without consulting your doctor as they may further reduce your blood pressure and make you feel dizzier.
Can ALEVO 25MG INJECTION be used in pregnant women?
ALEVO 25MG INJECTION is not recommended for use in pregnant women as it may harm the growing fetus. Therefore, consult your doctor before receiving it.
Can ALEVO 25MG INJECTION make me feel drowsy?
Yes. Drowsiness is one of the common side effects of receiving ALEVO 25MG INJECTION. Avoid driving or operating any tools or machines completely while you are feeling drowsy. Do not consume excessive alcohol, as it could aggravate your drowsiness. Consult your doctor if your drowsiness worsens.
Can the use of ALEVO 25MG INJECTION affect my sexual life?
ALEVO 25MG INJECTION may cause decrease in sex drive and problems in erection in some individuals, although not everybody gets them. These side effects are usually temporary and disappears once the therapy is stopped. However, consult your doctor if it bothers you.
REFERENCES
1. Laurence Brunton, John Lazo, Keith Parker. Drugs Affecting Gastrointestinal Function. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. Eleventh Edition. 2005. Page – 986.
2. Renuka Sharma, Pradeep Goyal, Manish Wadhwa, Money Gupta, Vishal Mandial, K S Jaswal. Efficacy of Levosulpride in minimizing Post-operative Nausea and Vomiting after Laparoscopic Cholecystectomy. International Journal of Contemporary Medical Research. May 2019. [Accessed on 8th November 2022] https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_2518.pdf
3. Torrent Pharmaceuticals Ltd. Levazeo Injection. [Accessed on 8th November 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2499.pdf
4. Central Drugs Standard Control Organization. Levosulpiride Inj. 25mg/ml, 2ml. September 2008. [Accessed on 8th November 2022] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS
- Abdomen - Ultrasound
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