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INTRODUCTION
AJADUO 25MG TABLET is a combination of Empagliflozin and Linagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to manage type II diabetes mellitus among adult patients when diet, exercise and management with other conventional medicines does not result in adequate sugar control. It is used as an adjunct therapy along with proper diet and exercise to achieve better results.
AJADUO 25MG TABLET can also be used in the management of heart complications among patients having both diabetes and heart problems. Follow proper hygiene and regular foot care as instructed by your doctor while taking AJADUO 25MG TABLET. Regularly monitor your blood glucose levels as instructed by your doctor.
Before taking AJADUO 25MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you are severely dehydrated due to excessive vomiting or diarrhea recently as a precaution.
AJADUO 25MG TABLET is not recommended for use in patients with Type I diabetes. It is also not suitable for use in patients with alcoholism and in patients with diabetic ketoacidosis.
Consult your doctor before taking AJADUO 25MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking AJADUO 25MG TABLET are vaginal infection, sore throat or nose, cough, passing more urine than normal, thirst and constipation. Consult your doctor if any of these side effects trouble you.
USES OF AJADUO 25MG TABLET
It is used to manage:
- type II diabetes mellitus in adults along with proper diet and exercise
- heart problems among patients having both diabetes and heart problems
HOW AJADUO 25MG TABLET WORKS
AJADUO 25MG TABLET is an antidiabetic medicine. It contains two medicines namely Empagliflozin and Linagliptin. Empagliflozin eliminates the excess sugars from the body via urine. Whereas linagliptin makes the pancreas to secrete more insulin (a hormone that digests glucose in the body). Collectively, these actions controls blood sugar levels and improve glycemic control in patients with type II diabetes.
DIRECTIONS FOR USE
Take AJADUO 25MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. AJADUO 25MG TABLET can be taken with or without meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking AJADUO 25MG TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF AJADUO 25MG TABLET
COMMON
- vaginal infection (such as vaginal thrush)
- sore throat or nose, cough
- passing more urine than normal
- increased urge to pass urine
- skin rash or itching
- increased amylase/lipase levels in blood
- thirst
- constipation
UNCOMMON
- pain or strain while passing urine
- changes in blood fat levels
- increase in the amount of red blood cells
- kidney problems
RARE
- sore mouth
Stop taking AJADUO 25MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- signs of severe decrease in blood sugar levels (such as increased sweating, feeling shaky, anxiety, blurred vision, increased hunger, headache, mood changes or confusion)
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- severe skin rashes with redness and blistering of the skin
- inflammation of the pancreas causing severe persistent stomach pain which radiates towards your back along with nausea and vomiting
- signs of diabetic ketoacidosis (such as nausea, vomiting, sudden weight loss, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, metallic taste, smelly urine or sweat)
- infection of kidneys or urinary tract with fever (such as burning sensation while passing urine, mid-back pain or pelvic pain, cloudy urine, urge to pee)
- signs of Fournier’s gangrene (such as pain, tenderness, redness, or swelling of the genitals or the area between the genitals and/or anus combined with fever or general weakness)
- signs of dehydration (such as excessive thirst, dizziness upon standing, fainting)
HOW TO MANAGE SIDE EFFECTS
Constipation
Taking AJADUO 25MG TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
WARNING & PRECAUTIONS
PREGNANCY
Consult your doctorIt is not known whether the use of AJADUO 25MG TABLET could affect the unborn baby. Therefore, it should not be used during pregnancy unless recommended by your doctor.
BREASTFEEDING
Consult your doctorIt is not known whether the use of AJADUO 25MG TABLET could pass through the breast milk. Therefore, it should not be used in breastfeeding unless considered necessary by the physician.
DRIVING AND USING MACHINES
Use with CautionAJADUO 25MG TABLET has no influence on your ability to drive or handle heavy tools or machines. However, do not drive or operate any machines if your ability is affected by AJADUO 25MG TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking AJADUO 25MG TABLET as it may increase the risk of unwanted side effects.
KIDNEY
Use with CautionAJADUO 25MG TABLET should be used with caution in in patients with serious kidney problems. Therefore, consult your doctor before taking it.
LIVER
ContraindicatedAJADUO 25MG TABLET is not recommended for use in patients with severe liver problems. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take AJADUO 25MG TABLET if you are allergic to Empagliflozin or Linagliptin.
USE IN PEDIATRICS
ContraindicatedAJADUO 25MG TABLET is not generally recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
USE IN GERIATRICS
Use with CautionAJADUO 25MG TABLET should be used with caution among the elderly patients (aged 75 years or above). Therefore, consult your doctor before taking it.
OTHERS
AJADUO 25MG TABLET is not recommended for use if you:
- have type I diabetes mellitus
- have diabetic ketoacidosis (buildup of ketones in the body)
- are an alcoholic
Before taking AJADUO 25MG TABLET, inform your doctor if you:
- are on fasting
- suddenly increase or decrease the dose of insulin
- have or previously had any problems in pancreas
- have dehydration or at risk of becoming dehydrated (such as due to excessive vomiting, diarrhea, fever, or if you are not able to eat or drink)
- have high RBC in blood
INTERACTIONS
A. Drug - Drug interactions:
Before taking AJADUO 25MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage diabetes (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone, insulin)
- medicines used to manage epilepsy (Ex. carbamazepine, phenytoin)
- diuretics (used to reduce edema and to manage hypertension) Ex. furosemide, hydrochlorothiazide
- lithium (a medicine used to manage mental illness)
- rifampicin (a medicine used to manage tuberculosis)
Overdosage:
If you or anyone else accidentally took more AJADUO 25MG TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Empagliflozin, Linagliptin |
| Pharmacological Category | : | SGLT2 inhibitors, DPP-4 Inhibitors |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep AJADUO 25MG TABLET out of the sight and reach of children
- Store AJADUO 25MG TABLET below 30°C
FAQs ABOUT AJADUO 25MG TABLET
Q: What is AJADUO 25MG TABLET used for?
A: AJADUO 25MG TABLET is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with type II diabetes mellitus.
Q: How and when to take AJADUO 25MG TABLET?
A: Take AJADUO 25MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. It can be taken with or without meals. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How long should I take AJADUO 25MG TABLET?
A: You need to take AJADUO 25MG TABLET as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
Q: What is the best time to take AJADUO 25MG TABLET?
A: AJADUO 25MG TABLET can be taken with or without meals and at any time of the day. However, try to take this medicine at the same time each day.
Q: What to do if I forgot to take a dose of AJADUO 25MG TABLET?
A: If you forgot to take a dose of AJADUO 25MG TABLET, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and take the next one regularly. Do not take a double dose of AJADUO 25MG TABLET to compensate the missed ones.
Q: What are the most common side effects of taking AJADUO 25MG TABLET?
A: The most common side effects of taking AJADUO 25MG TABLET are vaginal infection, sore throat or nose, cough, passing more urine than normal, thirst and constipation. Consult your doctor if any of these side effects trouble you.
Q: Can I stop taking AJADUO 25MG TABLET without consulting your doctor?
A: No. You should not stop taking AJADUO 25MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using AJADUO 25MG TABLET, consult your doctor for advice.
Q: Will taking a higher dose of AJADUO 25MG TABLET be more effective?
A: No, taking a higher dose of AJADUO 25MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with AJADUO 25MG TABLET?
A: It is not advisable to take medicines to control blood pressure while taking AJADUO 25MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with AJADUO 25MG TABLET as they have known interactions with AJADUO 25MG TABLET.
Q: What should I do if I experience low blood sugar after taking AJADUO 25MG TABLET?
A: Low blood sugar is a common side effect of taking AJADUO 25MG TABLET. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.
Q: Can AJADUO 25MG TABLET be taken with insulin?
A: Co-administration of AJADUO 25MG TABLET with insulin is considered risky as they increase the chance of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.
Q: Can AJADUO 25MG TABLET be used in pregnant women?
A: AJADUO 25MG TABLET should not be used in pregnant women unless recommended by the physician. Therefore, consult your doctor for advice.
Q: How much AJADUO 25MG TABLET should I take?
A: AJADUO 25MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Q: Can AJADUO 25MG TABLET cause constipation?
A: Yes. Constipation is a common side effect of using AJADUO 25MG TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly while taking this medicine. Contact your doctor if this side effect bothers you.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.
2. V. Woo. Empagliflozin/linagliptin single-tablet combination: first-in-class treatment option. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2015. [Accessed on 27th November 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049636/
3. Rottendorf Pharma GmbH. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 27th November 2023]. https://www.medicines.org.uk/emc/files/pil.10317.pdf
4. Boehringer Ingelheim Pharmaceuticals, Inc. GLYXAMBI- empagliflozin and linagliptin tablet, film coated. Dailymed.com. [Revised in July 2022] [Accessed on 27th November 2023] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ddbab689-f76c-488c-9613-4168d41dd730
5. Cipla Ltd. TIPTENGIO ® Tablets (FDC of Empagliflozin and Linagliptin). Ciplamed.com. [Revised in July 2021] [Accessed on 27th November 2023] file:///C:/Users/50062978/Downloads/TIPTENGIO%20%C2%AE%20Tablets.pdf
6. Central Drugs Standard Control Organization. Each film coated tablet contains: Empagliflozin 10mg/ 25mg Linagliptin 5mg / 5 mg. October 2017. [Accessed on 27th November 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
USEFUL DIAGNOSTIC TESTS
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin Glucose - Postprandial Blood
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (Rbs)
- Post Prandial Blood Sugar (PPBS)
- Advance Diabetes Care
- Diabetes Screening
- Diabetic Profile – Basic
- Diabetes Care Package - Essential
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 28 Nov 2023 | 05:51 PM(IST)
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