Agoprex 25mg Tablet 10'S

Depression Rx required

Best Price* ₹ 119.20 MRP ₹ 149.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Sun Pharmaceutical Industries Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

AGOPREX 25MG contains Agomelatine which belongs to the group of medicines called Antidepressants. AGOPREX 25MG is used in adults to treat depression and reduce and gradually remove the symptoms related to depression. Depression is a continuing disturbance of mood that causes interference with everyday life, which is characterized by symptoms such as deep sadness, feeling worthless, loss of interest, sleep disturbances, feeling of being low, feeling anxious and changes in weight.

Agomelatine is an antidepressant which works in two ways, by stimulating certain receptors ( MT1,  MT2, responsible for sleep-wake cycle in brain) and by blocking the 5-HT2C receptors (a protein that regulates mood, anxiety, feeding, and reproductive behavior) in the brain that leads to the increase in the levels of the neurotransmitters (chemicals that allow nerve cells in the brain to communicate with each other) mainly dopamine and noradrenaline. As dopamine and noradrenaline are involved in the control of mood, their increase between nerve cells in the brain due to Agomelatine is believed to help relieve the symptoms of depression which also help to normalize sleep patterns. Prior to the treatment, your doctor may want you to take a liver function test to understand the functioning of the liver and may advise you for a follow-up liver function test to decide whether you should receive or continue taking AGOPREX 25MG.

Before taking AGOPREX 25MG, inform your doctor if you are overweight, diabetic, and/or  have bipolar disorder with manic symptoms such as emotional highs and depression (including thoughts of killing or harming yourself) and suffering from dementia (a state of loss of thinking, remembering and thinking).  AGOPREX 25MG is not recommended for use if you are allergic to Agomelatine and or have serious liver problems that affect proper functioning of your liver. Pregnant women or women with childbearing potential are not recommended to take AGOPREX 25MG as a precautionary measure and are advised to consult their doctor before use if there is a need to take the medicine. AGOPREX 25MG is not recommended for use in breastfeeding women and also children and adolescents (less than 18 years of age). The most common side effects of taking AGOPREX 25MG are headache, dizziness, sleepiness, increase in weight, difficulty in sleeping, nausea, diarrhea, constipation, abdominal pain, back pain, tiredness, anxiety, abnormal dreams, and vomiting. Consult your doctor if any of these symptoms gets worse.

USES OF AGOPREX 25MG

  • Treat depression and also reduce and gradually remove the symptoms related to depression in adult patients

HOW AGOPREX 25MG WORKS

AGOPREX 25MG is an antidepressant which works in two ways, by stimulating the MT1,  MT2 receptors (a protein that binds melatonin (a hormone responsible for sleep-wake cycle) in brain)  and by blocking the 5-HT2C receptors (a protein that regulates mood, anxiety, feeding, and reproductive behavior) in the brain that leads to an increase in the levels of the neurotransmitters (chemicals that allow nerve cells in the brain to communicate with each other) mainly dopamine and noradrenaline. As dopamine and noradrenaline are involved in the control of mood, their increase between nerve cells in the brain due to Agomelatine is believed to help relieve the symptoms of depression which also help to normalize sleep patterns.

DIRECTIONS FOR USE

Take AGOPREX 25MG as advised by your physician. Swallow AGOPREX 25MG with a glass of water and do not chew or crush the medicine. AGOPREX 25MG can be taken with or without food. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking your medicine without the advice of your doctor even if you feel better.

SIDE EFFECTS OF AGOPREX 25MG

COMMON

  • headache
  • dizziness, sleepiness
  • difficulty in sleeping
  • nausea
  • diarrhea
  • constipation
  • abdominal pain
  • back pain
  • tiredness
  • anxiety
  • abnormal dreams
  • vomiting
  • increase in weight

UNCOMMON

  • migraine
  • an abnormal tingling and pricking sensation in fingers and toes
  • blurred vision
  • restless legs syndrome (a disorder characterized by an uncontrollable urge to move the legs)
  • ringing in the ears
  • excessive sweating
  • signs of allergic skin reactions (such as red and itchy skin)
  • signs of bipolar disorder or manic depression (such as agitation, irritability, restlessness, aggressive behavior, and nightmare)
  • suicidal thoughts or behavior, confusion,
  • decrease in weight
  • muscle pain

RARE

  • erythematous rash (serious skin disorder that occurs due to injured blood vessel)
  • signs of allergic reactions (such as swelling of the skin, face, lips, tongue and/or throat that may cause difficulty in breathing or swallowing),
  • signs of liver disease (such as yellow colouration of the skin or the whites of the eyes, hepatitis (swelling of liver), and liver damage)
  • hallucinations, inability to stand still (due to physical and mental unrest)
  • inability to completely empty the bladder

Stop taking AGOPREX 25MG and contact your doctor if you experience any of the following side effects:      

  • suicidal thoughts of harming or killing yourself at any time
  • signs and symptoms that your liver might not be working properly such as unusual darkening of the urine, light-colored stools, yellow skin/eyes, pain in the upper right belly, unusual fatigue

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Nausea and vomiting:

Try to take AGOPREX 25MG with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.

WARNING & PRECAUTIONS

PREGNANCY

AGOPREX 25MG is not recommended for use in pregnant women and in women who think they might get pregnant. If there is a need to take this medicine, consult your doctor before taking AGOPREX 25MG.

BREASTFEEDING

AGOPREX 25MG is not recommended for use in breastfeeding women. Consult your doctor before taking AGOPREX 25MG.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizziness or sleepiness after taking AGOPREX 25MG.

ALCOHOL

Avoid consumption of alcohol while taking AGOPREX 25MG.

KIDNEY

AGOPREX 25MG should be used with caution in patients with severe or moderate kidney impairment. Consult your doctor before taking AGOPREX 25MG.

LIVER

AGOPREX 25MG is not recommended for use in patients with liver impairment (such as cirrhosis or active liver disease) and it should be used with caution in patients with increased levels of liver enzymes (before treatment). Consult your doctor for advice before taking AGOPREX 25MG.

ALLERGY

Do not take AGOPREX 25MG if you are allergic to Agomelatine or any of the other ingredients of this medicine.

OTHERS

Before taking AGOPREX 25MG, inform your doctor if you:       

  • are obese or overweight        
  • are diabetic          
  • have bipolar disorder and have experienced or developed manic symptoms (a period of abnormally high excitability and emotions)   
  • are suffering from dementia (a state of loss of thinking, remembering and thinking)

Use in Pediatrics:

AGOPREX 25MG is generally not recommended for use in children and adolescents (below 18 years).Consult your doctor before taking AGOPREX 25MG.

Use in Geriatrics:

AGOPREX 25MG is not recommended for use in elderly patients (aged 75 years or above). Consult your doctor before taking AGOPREX 25MG.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking AGOPREX 25MG, inform your doctor, if you are taking any of the following medicine:

  • fluvoxamine (used to treat depression)
  • ciprofloxacin, enoxacin (used to treat bacterial infections)
  • propranolol (used to treat high blood pressure)

Overdosage:

If you or anyone else accidentally takes too much of AGOPREX 25MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are pain in the upper part of the stomach, sleepiness, fatigue, agitation, anxiety, tension, dizziness, cyanosis (abnormal blue discoloration of the skin) or malaise (state of discomfort, illness, or uneasiness).

SYNOPSIS

Drug :  

Agomelatine

Pharmacological Category :  

Melatonin receptor agonist

Therapeutic Indication :  

Depression

Dosage Forms :   Tablet

MORE INFORMATION

  • Keep AGOPREX 25MG out of reach in children
  • Store AGOPREX 25MG at room temperature

FAQs ABOUT AGOPREX 25MG

What AGOPREX 25MG is used for?

AGOPREX 25MG is used in adults to treat depression and reduce and gradually remove the symptoms related to depression which is characterized by symptoms such as deep sadness, feeling worthless, loss of interest, sleep disturbances, feeling of being low, feeling anxious and changes in weight.

How AGOPREX 25MG works in your body?

AGOPREX 25MG works in two ways, by stimulating the MT1,  MT2 receptors (a protein that binds melatonin (a hormone responsible for sleep-wake cycle) in brain)  and by blocking the 5-HT2C receptors (a protein that regulates mood, anxiety, feeding, and reproductive behavior) in the brain that leads to an increase in the levels of the neurotransmitters (chemicals that allow nerve cells in the brain to communicate with each other) mainly dopamine and noradrenaline. As dopamine and noradrenaline are involved in the control of mood, their increase between nerve cells in the brain due to Agomelatine is believed to help relieve the symptoms of depression which also help to normalize sleep patterns.

What side effects are seen with AGOPREX 25MG?

The most common side effects of taking AGOPREX 25MG are  as deep sadness, feeling worthless, loss of interest, sleep disturbances, feeling of being low, feeling anxious and changes in weight. Consult your doctor if any of these symptoms gets worse.

Is AGOPREX 25MG safe to use in children?

No. AGOPREX 25MG is not recommended for use in children and adolescents (less than 18 years of age). If AGOPREX 25MG is accidentally ingested by a child or adolescent, go to the hospital immediately and consult the doctor for further management.

Can AGOPREX 25MG be taken by a diabetes patient?

AGOPREX 25MG should be used with caution in patients with high blood sugar. Consult your doctor before taking AGOPREX 25MG who may advise you to check your blood sugar level before AGOPREX 25MG is advised to be taken.

Can AGOPREX 25MG be taken by pregnant or breastfeeding women?

AGOPREX 25MG is not recommended for use as a precautionary measure in pregnant women and in women who think they might get pregnant. If there is a need to take this medicine, consult your doctor before taking AGOPREX 25MG. GBNKEYWORD] is not recommended for use in breastfeeding women who should consult a doctor before taking AGOPREX 25MG.

REFERENCES

1. Paul Harrison, Philip Cowen, Tom Burns, Mina Fazel. The acute treatment of depression. Shorter Oxford Textbook Of Psychiatry. Seventh edition. 2018. Page – 219.

2. Novartis.Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2020]  [Accessed on 25th April 2022] https://clinicaltrials.gov/ct2/show/NCT00411099

3. B Guardiola-Lemaitre, C De Bodinat, P Delagrange, M J Millan, C Munoz, and E Mocaër.Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties. NIH National Library of Medicine, National center for biotechnology information. PMC Pubmed Central. [Revised in July 2014] [Accessed on 25th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128060/ 

4. Les Laboratoires Servier. European Medicines Agency (EMA). [Revised in December 2018] [Accessed on 25th April 2022] https://www.ema.europa.eu/en/documents/product-information/valdoxan-epar-product-information_en.pdf

5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC) [Revised in February 2021] [Accessed on 25th April 2022]          https://www.medicines.org.uk/emc/files/pil.9887.pdf

USEFUL DIAGNOSTIC TESTS

  • Liver function test

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    AGOMELATINE 25MG
    Hsn Code
    30049099
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Agoprex 25mg Tablet 10'S

Agoprex 25mg Tablet 10'S Mkt: Sun Pharmaceutical Industries Ltd

M.R.P.: Rs.149.00
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