INTRODUCTION

ADVENT 150MG INJECTION contains Amoxicillin and Clavulanic acid, which belong to the group of medicines called Penicillins and Beta-Lactamase Inhibitors. It is used in children for the treatment and prophylaxis of various bacterial infections (such as respiratory tract infections, which include pneumonia), acute exacerbation of chronic bronchitis, urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), tonsillitis, sinusitis, skin and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females.

Along with treatment with ADVENT 150MG INJECTION your doctor might order bacterial culture tests to enhance the outcomes of the treatment and in cases of prolong treatment with ADVENT 150MG INJECTION your doctor might conduct complete blood count, liver or kidney function test.

ADVENT 150MG INJECTION is not recommended for use in patients with severe kidney impairment, a history of liver problems or jaundice after taking penicillin antibiotics. ADVENT 150MG INJECTION should be used with caution in patients suffering from glandular fever (viral infection causing sore throat, high fever, swelling of salivary glands etc), liver disease, kidney disease, who are not passing urine daily, convulsions (fits) or large intestine inflammation.

ADVENT 150MG INJECTION is not recommended for use in pregnant women unless clearly necessary. ADVENT 150MG INJECTION should be used with caution in breastfeeding women as it may pass through breastmilk. ADVENT 150MG INJECTION should be used with caution in neonates, infants (less than 12 weeks of age). Consult your doctor before receiving ADVENT 150MG INJECTION. The most common side effects after receiving ADVENT 150MG INJECTION are diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately in case any of side effects worsens.

USES OF ADVENT 150MG INJECTION

• Treatment and prophylactic management of various bacterial infection

HOW ADVENT 150MG INJECTION WORKS

ADVENT 150MG INJECTION help in treating bacterial infection where Amoxicillin works by inhibiting penicillin binding proteins (which are involved in the synthesis of bacterial cell wall) leading to activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta lactamases and hence enhancing the antibacterial activity of amoxicillin.

DIRECTIONS FOR USE

ADVENT 150MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or intravenous injection. Your doctor will decide the exact dose and duration of treatment for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ADVENT 150MG INJECTION

HOW TO MANAGE SIDE EFFECTS

Nausea, vomiting:

Receive the medicine, before meals. Stick to simple meals. Avoid eating oily or spicy food. Consult your doctor if your symptoms get worse or persist.

Itchy skin:

Avoid hot showers because hot water can irritate the skin and do not scratch the affected area. Apply moisturizing cream, Sunscreen and use protective clothing. Consult your doctor if your symptoms get worse or persist.

Diarrhoea:

Drink plenty of water or fruit juices to keep you hydrated. Don’t take any medicine on your own to treat diarrhoea. Consult your doctor if your symptoms get worse or persist.

Headache:

Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if required. Consult your doctor if your symptoms get worse or persist.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before receiving ADVENT 150MG INJECTION, inform your doctor if you are taking any of the following medicine:

• medicines used to treat gout (Ex. allopurinol, probenecid)
• medicines used to treat blood clots (Ex. warfarin)
• methotrexate (used for the treatment of cancer, severe psoriasis)
• medicine used to prevent organ transplant rejection (Ex. Mycophenolate mofetil)
• medicines used for prevention of pregnancy (oral contraceptives)

Overdosage:

ADVENT 150MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms. Symptoms of overdose of ADVENT 150MG INJECTION are nausea, diarrhoea, fits, upset stomach.

SYNOPSIS

MORE INFORMATION

• Keep ADVENT 150MG INJECTION out of reach from children
• Store ADVENT 150MG INJECTION below 25 degrees

FAQs ABOUT ADVENT 150MG INJECTION

What are uses of ADVENT 150MG INJECTION?

ADVENT 150MG INJECTION is used in adults and children for treatment of various bacterial infections such as respiratory tract infections which includes pneumonia, Acute exacerbation of chronic Bronchitis, urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), Tonsillitis, sinusitis, skin and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females. ADVENT 150MG INJECTION is also used as prophylaxis against various bacterial infection associated with major surgeries of heart, joints, kidney, head and neck, stomach, biliary tract, intestine and pelvic region.

What are side effects of ADVENT 150MG INJECTION?

The most common side effects after receiving ADVENT 150MG INJECTION are vomiting, diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately in case any of side effects worsens.

How ADVENT 150MG INJECTION works?

ADVENT 150MG INJECTION help in treating bacterial infection where Amoxicillin works by inhibiting penicillin binding proteins (which are involved in the synthesis of bacterial cell wall) leading to activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta lactamases and hence enhancing the antibacterial activity of amoxicillin.

Is ADVENT 150MG INJECTION safe for use in pregnant and breast-feeding women?

No, ADVENT 150MG INJECTION is not recommended for use in pregnant women unless clearly necessary and ADVENT 150MG INJECTION should be used with caution in breast feeding women as it may pass through breastmilk. Consult your doctor before receiving ADVENT 150MG INJECTION.

Is ADVENT 150MG INJECTION safe for use in children?

Yes, ADVENT 150MG INJECTION is safe for use in children but it should be used with caution in children less than 3 months of age. Consult your doctor for advice.

REFERENCES

1. KD Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology, 7th edition. 2013. Page-723, 724.

2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. National Centre for Biotechnology. NLM. National Institute of Health. Statpearls. December 2021. [Accessed on 22nd October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/#article-17475.s5

3. GlaxoSmithKline Pharmaceuticals Limited. Amoxicillin + Clavulanic acid. [Revised in July 2022] [Accessed on 22nd October 2022] https://india-pharma.gsk.com/media/6337/augmentin-i-v.pdf

4. Cipla Limited. Amoxicillin + Clavulanic acid. [Revised in September 2019] [Accessed on 22nd October 2022] https://www.ciplamed.com/content/advent-iv-injection https://www.ciplamed.com/print-product-pdf/24188

5. Augpen Injection (Amoxicillin + Clavulanic acid). Zuventus Healthcare Limited. [Accessed on 22nd October 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=65

USEFUL DIAGNOSTIC TESTS

• bacterial culture tests
• complete blood count
• liver and kidney function test