INTRODUCTION

ADAPNIL GEL contains Adapalene which belongs to the group of medicines called Retinoids. It is used to treat acne vulgaris. Acne vulgaris is a common skin condition which occurs when hair follicles get blocked with oil and dead skin cells.

ADAPNIL GEL has an anti-inflammatory effect reducing soreness and irritation when used on the face, chest or back for acne, blackheads, spots and pimples. During the treatment, your doctor might ask you to avoid exposure to sunlight and artificial UV light.

Avoid using ADAPNIL GEL if you have eczema (inflammatory skin condition), cuts or scrapes, and on sensitive areas such as the eyes, mouth and nostrils. ADAPNIL GEL is not recommended for use in pregnant women. ADAPNIL GEL should be used with caution in breastfeeding women.

ADAPNIL GEL is not recommended for use in children (below 12 years of age). The most common side effects of using ADAPNIL GEL include dryness, irritation, redness and burning sensation of skin. Call your doctor if any of the symptoms worsen over time.

USES OF ADAPNIL GEL

• Treats Acne vulgaris

HOW ADAPNIL GEL WORKS

ADAPNIL GEL is believed to work by modifying the action of skin cells to produce fewer pimples or acne.

DIRECTIONS FOR USE

Apply ADAPNIL GEL as advised by your physician. It is for external use only. Wash the areas to be treated with water, keep it clean and dry before applying this medicine. Apply a thin layer of this medicine with your fingertips to the affected areas and rub gently.

Avoid contact of ADAPNIL GEL with the eyes, mouth or nose and sensitive areas of your body. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ADAPNIL GEL

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before using ADAPNIL GEL, inform your doctor if you are taking any of the following medicines:

• other medicines used for acne (Ex. benzoyl peroxide, erythromycin, clindamycin)
• cosmetics which may cause blackheads or dry skin
• harsh cleansers, strong drying agents, or irritant products
• medicines containing sulfur, resorcinol, or salicylic acid

Overdosage:

If you or anyone else accidentally use or swallow too much of ADAPNIL GEL, consult your doctor immediately. Symptoms of overdose are irritation, redness, peeling or discomfort of skin.

SYNOPSIS

MORE INFORMATION

• Keep ADAPNIL GEL out of reach of children
• Do not store above 25°C

FAQs ABOUT ADAPNIL GEL

Can ADAPNIL GEL be used in the morning?

Apply ADAPNIL GEL as advised by your physician. It is best when applied at night and washed off in the morning since it is sensitive to sunlight and may not yield good results. Consult your doctor for further queries.

Can ADAPNIL GEL cause irritation?

Yes ADAPNIL GEL can cause slight sensation of warmth and stinging after applying it for the initial 2-4 weeks but will reduce with continued usage.  Consult your doctor if any of these bother you over time.

Can ADAPNIL GEL be used daily?

No. ADAPNIL GEL should be used according to the doctor’s advice. Using it daily won’t make the treatment faster instead the side effects might worsen. Make sure you use the same quantity at the same time each day for better effects of the medicine.

Can ADAPNIL GEL make skin darker?

No. ADAPNIL GEL doesn’t make skin darker. Instead, it can slightly make the skin lighter by healing acne, pimples, blackheads and spots. Consult your doctor for further queries.

Can I go outside after applying ADAPNIL GEL?

No, avoid going out after applying ADAPNIL GEL especially when its windy or raining since it can cause local irritation and skin discomfort. It is best used at night. Consult the doctor for further assistance.

REFERENCES

1. KD. Tripathi. Drugs acting on skin and mucous membranes. Essentials of medical pharmacology. Eighth edition. 2019. Page – 953, 954.

2. Leila Tolaymat; Heidi Dearborn; Patrick M. Zito. Adapalene. NIH National Library of Medicine, National center for biotechnology information. StatPearls [Internet]. August 2022. [Accessed on 28th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK482509/

3. Galderma R&D. Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1%. NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in February 2021] [Accessed on 28th November 2022] https://clinicaltrials.gov/ct2/show/NCT00598832

4. Piskin S, Uzunali E. A review of the use of adapalene for the treatment of acne vulgaris. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 2007. [Accessed on 28th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374937/

5. Laboratoires Galderma. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 28th November 2022] https://www.medicines.org.uk/emc/files/pil.921.pdf

6. Galderma Canada Inc. Adapalene. [Revised in December 2018] [Accessed on 28th November 2022] https://pdf.hres.ca/dpd_pm/00048625.PDF

7. Central Drugs Standard Control Organization (CDSCO). [Accessed on 28th November 2022] https://cdscoonline.gov.in/CDSCO/Drugs