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Best Price* ₹ 137.39 MRP ₹ 152.65
(Inclusive of all taxes) * Mkt: Macleods Pharmaceuticals Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

ACUCLAV IV 1.2GM INJECTION contains Amoxicillin and Clavulanic acid, which belong to the group of medicines called Penicillins and Beta-Lactamase Inhibitors. It is used in the treatment of various bacterial infections such as respiratory tract infections (pneumonia, acute exacerbation of chronic bronchitis), urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), tonsillitis, sinusitis, skin and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females.

ACUCLAV IV 1.2GM INJECTION is also used as prophylaxis against various bacterial infections associated with major surgeries of the heart, joints, kidney, head and neck, stomach, biliary tract, intestine and pelvic region. Along with treatment with ACUCLAV IV 1.2GM INJECTION your doctor might order bacterial culture tests to enhance the outcomes of the treatment.

ACUCLAV IV 1.2GM INJECTION is not recommended for use in patients with severe kidney impairment, who had a history of liver problems or jaundice after taking penicillin antibiotics. Consult your doctor before receiving it. ACUCLAV IV 1.2GM INJECTION should be used with caution in patients suffering from glandular fever (a viral infection causing sore throat, high fever, swelling of salivary glands etc.), liver disease, kidney disease, who are not passing urine daily, convulsions (fits) or large intestine inflammation.

ACUCLAV IV 1.2GM INJECTION is not recommended for use in pregnant women unless necessary. ACUCLAV IV 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breast milk. ACUCLAV IV 1.2GM INJECTION should be used with caution in children as it may require dose modification. Consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION. The most common side effects after receiving ACUCLAV IV 1.2GM INJECTION are diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately if any of your symptoms get worse or persist.

USES OF ACUCLAV IV 1.2GM INJECTION

  • Treatment and prophylaxis management of various bacterial infections

HOW ACUCLAV IV 1.2GM INJECTION WORKS

ACUCLAV IV 1.2GM INJECTION helps in treating bacterial infection where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall) leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases and hence enhances the antibacterial activity of amoxicillin.

DIRECTIONS FOR USE

ACUCLAV IV 1.2GM INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or intravenous injection. Your doctor will decide the exact dose and duration of treatment for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF ACUCLAV IV 1.2GM INJECTION

COMMON

  • diarrhoea
  • thrush (candida fungal infection)

UNCOMMON

  • rashes, itching, hives (raised itch rashes)
  • urticaria
  • nausea and vomiting
  • dizziness, headache
  • indigestion
  • abnormal liver enzymes

RARE

  • erythema multiforme (skin rashes, blisters, small target rashes)
  • low number of platelets (cells that helps in clotting)
  • decreased white blood cells
  • swelling and inflammation at site of injection

Stop receiving ACUCLAV IV 1.2GM INJECTION and consult your doctor immediately in case you experience:

  • severe allergic reaction which includes rashes, collapsing or fainting, swelling of the face, throat which may cause difficulty in breathing, fever, joint pain, swollen lymph nodes of neck, armpits, groin, red or purple raised spots on skin due to inflammation of blood vessels
  • Swelling and tenderness of vein which is very painful on touching
  • Watery diarrhoea with blood or mucus, fever and abdominal pain which occurs due to inflammation of the large intestine
  • inflammation of the liver (hepatitis), jaundice (yellowing of white part of eyes, nails, skin paleness)
  • inflammation of kidney tubes
  • delayed blood clotting 
  • convulsions (fits) most commonly experienced by patients suffering from kidney disease
  • severe skin reactions such as widespread rashes with blisters and peeling skin, around the mouth, nose, eyes and genitals (stevens-johnson syndrome, toxic epidermal necrolysis), widespread red skin rash with small pus-containing blisters (bullous exfoliative dermatitis), a red, scaly rash with bumps under the skin and blisters (exanthemous pustulosis)
  • flu-like symptoms with a rash, fever, swollen glands, an increased number of white blood cells and abnormal liver enzymes (Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

HOW TO MANAGE SIDE EFFECTS

Nausea, vomiting:

Receive the medicine, before meals. Stick to simple meals. Avoid eating oily or spicy food however, contact your doctor if nausea or vomiting gets worse or persists.

Itchy skin:

Avoid hot showers because hot water can irritate the skin and do not scratch the affected area. Apply moisturizing cream, Sunscreen and use protective clothing. Contact your doctor in case the itching gets worse or persists.

Diarrhoea:

Drink plenty of water or fruit juices to keep you hydrated. Don’t take any medicine on your own for treating diarrhoea however contact your doctor if diarrhoea gets worse or persists.

Headache:

Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol however, contact your doctor if your headache gets worse or persists.

WARNING & PRECAUTIONS

PREGNANCY

ACUCLAV IV 1.2GM INJECTION is not recommended for use in pregnant women unless necessary. Consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION.

BREASTFEEDING

ACUCLAV IV 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breast milk. Consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION.

DRIVING AND USING MACHINES

Do not drive or operate machinery after receiving ACUCLAV IV 1.2GM INJECTION.

KIDNEY

ACUCLAV IV 1.2GM INJECTION is not recommended for use in patients with severe kidney impairment. Consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION.

ACUCLAV IV 1.2GM INJECTION should be used with caution in patients suffering from kidney problems. Consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION.

LIVER

ACUCLAV IV 1.2GM INJECTION is not recommended for use in patients who had a history of liver problems or jaundice after taking penicillin antibiotics. Consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION.

ACUCLAV IV 1.2GM INJECTION should be used with caution in patients suffering from, liver disease. consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION.

ALLERGY

Do not receive ACUCLAV IV 1.2GM INJECTION if you are allergic to Amoxicillin, Clavulanic acid or any other ingredients in this medicine.

OTHERS

Before receiving ACUCLAV IV 1.2GM INJECTION inform your doctor if you have:

  • glandular fever (viral infection causing sore throat, high fever, swelling of salivary glands etc)
  • not been urinating regularly
  • convulsions (fits)
  • large intestine inflammation
  • urine and blood tests

Use in paediatrics:

ACUCLAV IV 1.2GM INJECTION should be used with caution children as it may requires dose modification. Consult your doctor before administration of ACUCLAV IV 1.2GM INJECTION to your child.

Use in geriatrics:

ACUCLAV IV 1.2GM INJECTION should be used with caution in the elderly. Consult your doctor for advice.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving ACUCLAV IV 1.2GM INJECTION, inform your doctor if you are taking any of the following medicine:

  • medicines used to treat gout (Ex. allopurinol, probenecid)
  • medicines used to treat blood clots (Ex. warfarin)
  • methotrexate (used for the treatment of cancer, severe psoriasis)
  • medicine used to prevent organ transplant rejection (Ex. Mycophenolate mofetil)
  • medicines used for prevention of pregnancy (oral contraceptives)

Overdosage:

ACUCLAV IV 1.2GM INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms. Symptoms of overdose of ACUCLAV IV 1.2GM INJECTION are nausea, diarrhoea, fits, upset stomach.

SYNOPSIS

Drug :   Amoxicillin + Clavulanic acid
Pharmacological Category :   Penicillins and Beta-Lactamase Inhibitors
Therapeutic Indication :   Bacterial Infections
Dosage Forms :   Tablets, Syrup, Oral Drops, Eye Drops, Ear Drops, Oral Suspension, Injection, Dispersible Tablet, Dry Suspension, Dry Syrup, Sachet

MORE INFORMATION

  • Keep ACUCLAV IV 1.2GM INJECTION out of reach from children
  • Store ACUCLAV IV 1.2GM INJECTION below 25 degrees

FAQs ABOUT ACUCLAV IV 1.2GM INJECTION

What are the uses of ACUCLAV IV 1.2GM INJECTION?

ACUCLAV IV 1.2GM INJECTION is used in adults and children for the treatment of various bacterial infections such as respiratory tract infections which includes pneumonia, acute exacerbation of chronic bronchitis, urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), tonsillitis, sinusitis, skin and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females. ACUCLAV IV 1.2GM INJECTION is also used as prophylaxis against various bacterial infections associated with major surgeries of the heart, joints, kidney, head and neck, stomach, biliary tract, intestine and pelvic region.

What are the side effects of ACUCLAV IV 1.2GM INJECTION?

The most common side effects after receiving ACUCLAV IV 1.2GM INJECTION are vomiting, diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately in case any of the side effects worsen.

How does ACUCLAV IV 1.2GM INJECTION work?

ACUCLAV IV 1.2GM INJECTION helps in treating bacterial infection where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall), leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases, hence enhancing the antibacterial activity of amoxicillin.

Is ACUCLAV IV 1.2GM INJECTION safe for use in pregnant and breastfeeding women?

No, ACUCLAV IV 1.2GM INJECTION is not recommended for use in pregnant women unless necessary and ACUCLAV IV 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breastmilk. Consult your doctor before receiving ACUCLAV IV 1.2GM INJECTION.

REFERENCES

1. KD Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 7th edition. 2013. Page-723, 724.

2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. National Centre for Biotechnology. NLM. National Institute of Health. Statpearls. December 2021. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/#article-17475.s5

3. Pharmachemie B.V. Human Products and Regulatory Authority (HPRA). [Revised in October 2021] [Accessed on 21st October 2022] https://www.hpra.ie/img/uploaded/swedocuments/8b431234-1c37-4f42-b962-f92da83d33ef.pdf

4. Antibiotice SA. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 21st October 2022] https://www.medicines.org.uk/emc/files/pil.11108.pdf

5. Fresensius Kabi Limited. Human Products and Regulatory Authority (HPRA). [Revised in March 2022] [Accessed on 21st October 2022] https://www.hpra.ie/img/uploaded/swedocuments/71865a06-c147-4ab6-8563-5db6ce566a30.pdf

6. GlaxoSmithKline Pharmaceuticals Limited. Amoxicillin + Clavulanic acid. [Revised in July 2022] [Accessed on 21st October 2022] https://india-pharma.gsk.com/media/6337/augmentin-i-v.pdf

7. Medreich Limited. Amoxicillin + Clavulanic acid. [Revised in June 2015] [Accessed on 21st October 2022] http://www.paradigmpharma.com/CMS/IMAGES/pdfuploads/1503656556_Fleming%20(Co-Amoxiclav).pdf

8. Cipla Limited. Amoxicillin + Clavulanic acid. [Revised in September 2019] [Accessed on 21st October 2022] https://www.ciplamed.com/content/advent-iv-injection

9. Augpen Injection (Amoxicillin + Clavulanic acid). Zuventus Healthcare Limited. [Accessed on 21st October 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=65

USEFUL DIAGNOSTIC TESTS

  • bacterial culture tests

PRODUCT DETAILS

    Country Of Origin
    India
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