ABIRATRED 500mg Tablet 60's

Cancer/Oncology Rx required
OUT OF STOCK

Best Price* ₹ 31,600.00 MRP ₹ 39,500.00
(Inclusive of all taxes) *60 Tablet(s) in a Bottle * Mkt: Dr Reddy'S Laboratories Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

ABIRATRED 500MG contains Abiraterone which belongs to a group of medicines called Androgen biosynthesis inhibitors. ABIRATRED 500MG is used in adult men with prednisone or prednisolone (medicines used to lower high blood pressure or reduce fluid retention in body) to treat newly diagnosed high risk metastatic hormone sensitive prostate cancer in combination with androgen deprivation therapy. It is also used in the treatment of metastatic castration resistant prostate cancer (mCRPC) who remain asymptomatic or mildly symptomatic after the failure of androgen deprivation therapy to whom chemotherapy is not clinically indicated. ABIRATRED 500MG is also used in the treatment of mCRPC in adult men whose disease has progressed on or after receiving a docetaxel-based chemotherapy regimen. Prostate cancer is a type of cancer that occurs in the prostate gland characterized by troubled urination, blood in urine, blood in semen, bone pain, losing weight without trying, and erectile dysfunction.

Abiraterone is an androgen biosynthesis inhibitor which works by inhibiting the production of 17α-hydroxylase (CYP17) enzyme needed for the production of testosterone (male sex hormone) which enables the growth of cancer cells in the prostate gland. Since ABIRATRED 500MG suppresses the production of testosterone, the cancer cells in the prostate gland won't be able to grow thus preventing its effects on the gland. Prior to the treatment, your doctor may want you to take liver function test to understand the functioning of the liver and may advise you to take several blood tests periodically to understand the effects on your liver. Also, along with this treatment, your doctor might advise you to take another medicine called prednisone or prednisolone which is a medicine given to lower your chances of getting high blood pressure or having too much water in your body (fluid retention) or having reduced levels of potassium in your blood.

Before taking ABIRATRED 500MG, inform your doctor if you are allergic to Abiraterone or have heart, liver, pituitary or any other medical conditions. ABIRATRED 500MG is not recommended for use in pregnant and childbearing potential women. ABIRATRED 500MG is also not recommended for use in children and adolescents (less than 18 years of age). ABIRATRED 500MG must not be taken along with the food as it may cause unwanted side effects. Consult your doctor before taking the medication. The most common side effects of taking ABIRATRED 500MG are fluid in your legs or feet, high blood pressure, urinary tract infection, diarrhea, chest pain, irregular heartbeat, heart failure, rapid heart rate, sepsis (severe infection), bone fractures, indigestion, blood in urine, and rash. Contact your doctor if any of the symptoms worsen.

USES OF ABIRATRED 500MG

It is used in adult men with prednisone or prednisolone:

  • To treat newly diagnosed high risk metastatic hormone sensitive prostate cancer in combination with androgen deprivation therapy.
  • To treat metastatic castration resistant prostate cancer (mCRPC) (who remain asymptomatic or mildly symptomatic after the failure of androgen deprivation therapy to whom chemotherapy is not clinically indicated)
  • To treat of metastatic castration resistant prostate cancer (mCRPC) (whose disease has progressed on or after receiving a docetaxel-based chemotherapy regimen)

HOW ABIRATRED 500MG WORKS

ABIRATRED 500MG is an androgen biosynthesis inhibitor which works by inhibiting the production of 17α-hydroxylase (CYP17) enzyme needed to produce testosterone (male sex hormone) which enables the growth of cancer cells in the prostate gland. Since ABIRATRED 500MG suppresses the production of testosterone, the cancer cells in the prostate gland won't be able to grow thus preventing its effects on the gland.

DIRECTIONS FOR USE

Take ABIRATRED 500MG as advised by your physician. Swallow ABIRATRED 500MG with a glass of water and do not chew or crush the medicine. Do not take ABIRATRED 500MG along with food. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ABIRATRED 500MG

COMMON

  • sepsis (a condition that occurs due to life-threatening complication of an infection)
  • high fat levels in blood (hypertriglyceridemia)
  • signs of heart failure (such as tiredness, breathing difficulty, fluid retention, irregular heartbeat, chest pain)   
  • atrial fibrillation (irregular heartbeat)  
  • tachycardia (rapid heartbeat)
  • indigestion
  • allergic reactions like rash
  • blood in urine
  • fractures (osteoporosis (a condition in which bone becomes weak and brittle)
  • oedema peripheral (swelling in lower hands or legs)
  • signs of urinary tract infection (burning sensation during urination, frequent urination, urinary urgency)
  • high blood pressure
  • diarrhoea

UNCOMMON

  • adrenal insufficiency (disorder in which the adrenal glands won't be able to produce enough hormones)
  • other types of arrhythmias (irregular heartbeat)
  • myopathy (muscular disease that affects the voluntary movement of the muscle), rhabdomyolysis (abnormal muscle breakdown)

RARE

  • lung irritation (allergic alveolitis)
  • signs of acute liver failure (stomach pain, nausea, vomiting, yellowing of the skin or white of the eyes)

Stop taking ABIRATRED 500MG and contact your doctor if you experience any of the following side effects:

  • signs of low potassium levels in the blood (such as muscle weakness, muscle twitches or palpitation

HOW TO MANAGE SIDE EFFECTS

Diarrhea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.

Dyspepsia (indigestion):

Try to reduce consumption of tea, coffee, cola or alcohol and lose weight if you are obsese. Avoid smoking and do not eat three to four hours before going to bed. Consult your doctor if the symptom gets worse.

Rashes:

Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

PREGNANCY

ABIRATRED 500MG is not recommended for use in pregnant women and in women who think might get pregnant since it might cause harm to the unborn child. Always it is necessary to follow effective contraceptive method (such as condom) during sexual activity with a pregnant women or women of childbearing potential to protect the unborn child. Consult your doctor before taking.

BREASTFEEDING

ABIRATRED 500MG is generally not used in women and is indicated only for male individuals.

DRIVING AND USING MACHINES

ABIRATRED 500MG does not affect your ability to drive or use machines. Consult your doctor before taking ABIRATRED 500MG.

ALCOHOL

Avoid consumption of alcohol while taking ABIRATRED 500MG.

KIDNEY

ABIRATRED 500MG should be used with caution in patients with severe kidney impairment. Consult your doctor for advice before taking ABIRATRED 500MG.

LIVER

ABIRATRED 500MG is not recommended for use in patients with severe liver disease or severe liver impairment and should be used with caution in patients with liver problems or moderate liver impairment. Consult your doctor for advice before taking ABIRATRED 500MG.

ALLERGY

ABIRATRED 500MG is not recommended for use if you are allergic to abiraterone.

LUNGS

ABIRATRED 500MG should be taken with caution if you have shortness of breath. Consult your doctor before taking this medicine.

HEART DISEASE

ABIRATRED 500MG should be used with caution in patients with heart problems such as heart failure, irregular heart rate (due to low level potassium), rapid heart rate. Consult your doctor before taking ABIRATRED 500MG.

OTHERS

Before taking ABIRATRED 500MG, inform your doctor if you:

  • have high blood pressure
  • have any blood vessel problems such as blood pressure, stroke
  • have gained weight rapidly
  • have swelling in the feet, ankles, or legs (edema)
  • have possible side effects on your bone
  • have diabetes
  • are intolerant to sodium and some sugars like lactose (sugar found in milk and cheese)
  • have reduced sex drive (libido)
  • have muscle weakness or pain
  • have anemia (reduced red blood cells)

Use in Pediatrics:

ABIRATRED 500MG is generally not recommended for use in children and adolescents (below 18 years). Consult your doctor before taking ABIRATRED 500MG.

Use in Geriatrics:

ABIRATRED 500MG should be used with caution in elderly patients (aged 75 years or above). Consult your doctor before taking ABIRATRED 500MG.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking ABIRATRED 500MG, inform your doctor, if you are taking any of the following medicine:

  • tranquillizers (medicines used to treat fear, agitation, anxiety, tension and related states of mental disturbance) Ex. diazepam, lorazepam, chlordiazepoxide 
  • medicines used to treat diabetes such as metformin, insulin, pramlintide
  • herbal medications Ex. St John’s wort (medicine used to treat depression)
  • ketoconazole (medicine used to treat skin infections such as athlete's foot, jock itch, ringworm, and certain kinds of dandruff)
  • ra-223 (radioactive drug used to treat prostate cancer)
  • quinidine, procainamide, amiodarone and sotalol (medicines used to treat irregular heartbeat)
  • medicines used in androgen deprivation treatment to treat prostate cancer (Ex. leuprolide, goserelin, triptorelin, histrelin)
  • methadone (medicine used for pain relief and part of drug deaddiction therapy)
  • moxifloxacin (antibiotic used to treat bacterial infections)
  • antipsychotics (used for serious mental illnesses) Ex. aripiprazole, asenapine, cariprazine

B. Drug-Food Interactions:

ABIRATRED 500MG should not be taken with grapefruit juice since it may increase the risks of side effects.

Overdosage:

If you or anyone else accidentally takes too much of ABIRATRED 500MG, contact your doctor immediately or go to a hospital straight away.

SYNOPSIS

Drug :   Abiraterone acetate
Pharmacological Category :   Androgen biosynthesis inhibitors
Therapeutic Indication :   Metastatic prostate cancer
Dosage Forms :   Tablet, Injection

MORE INFORMATION

  • Keep ABIRATRED 500MG out of reach in children
  • Store ABIRATRED 500MG at room temperature

FAQs ABOUT ABIRATRED 500MG

What ABIRATRED 500MG is used for?

ABIRATRED 500MG is used to treat prostate cancer in adult men that has spread to other parts of the body. Abiraterone stops your body from making testosterone (male sex hormone) which slows the growth of prostate cancer.

Can ABIRATRED 500MG be taken along with food?

No. ABIRATRED 500MG should not be taken along with food since it may increase the absorption of this medicine and can increase the risk of side effects. Take this medicine one hour before or after two hours of eating the food. Consult your doctor before taking ABIRATRED 500MG and maintain caution.

What side effects are seen with ABIRATRED 500MG?

The most common side effects of taking ABIRATRED 500MG are swelling in legs (edema), chest pain, indigestion, blood in urine (hematuria), rash, high blood pressure, diarrhea. Consult your doctor for advice if your symptoms get worsen over the time.

Is ABIRATRED 500MG safe to use in children?

No. ABIRATRED 500MG is not recommended for use in children and adolescents (less than 18 years). If ABIRATRED 500MG is accidentally ingested by a child or adolescent, go to the hospital immediately and consult the doctor for further management.

Can ABIRATRED 500MG be taken by a diabetes pateint?

ABIRATRED 500MG should be used with caution in patients with high blood sugar. Consult your doctor before taking ABIRATRED 500MG who may advise you to check your blood sugar level before ABIRATRED 500MG is advised to be taken.

Can ABIRATRED 500MG be taken by pregnant or breastfeeding women?

ABIRATRED 500MG is not recommended for use in pregnant women and in women who think might get pregnant and in breastfeeding women since it might cause harm to the unborn child. Always it is necessary to follow effective contraceptive method (such as condom) during sexual activity with a pregnant women or women of childbearing potential to protect the unborn child. Consult your doctor before taking ABIRATRED 500MG.

REFERENCES

1. Beverly Moy, Richard J. Lee and Mathew Smith. Natural products in cancer chemotherapy: Hormones and related drugs. Goodman & Gilman’s: The pharmacological basics of therapeutics. 12th Edition. New York MC Graw Hill Medical 2011. Page – 1767.

2. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1525.

3. Cougar Biotechnology, Inc. Abiraterone Acetate in Castration-Resistant Prostate Cancer Previously Treated with Docetaxel-Based Chemotherapy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2014] [Accessed on 26th April 2022] https://clinicaltrials.gov/ct2/show/NCT00638690

4. Yasser Rehman, Jonathan E Rosenberg. Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 2012 [Accessed on 26th April 2022] https://pubmed.ncbi.nlm.nih.gov/22291466/

5. Janssen-Cilag SpA European Medicines Agency (EMA). [Revised in May 2016] [Accessed on 26th April 2022] https://www.ema.europa.eu/en/documents/product-information/zytiga-epar-product-information_en.pdf

6. Remedica Ltd. Health Products Regulatory Authority (HPRA). [Revised in April 2021] [Accessed on 26th April 2022] https://www.hpra.ie/img/uploaded/swedocuments/0bed35be-6003-4eae-9b93-99e457533333.pdf

7. Biocon Biologics India Limited. ABSTET. [Revised in July 2019] [Accessed on 26th April 2022] https://www.biocon.com/docs/domestic-market-pi/onco/ABSTET%20PI.pdf

USEFUL DIAGNOSTIC TESTS

  • Prostate Specific Antigen (Free) PSA
  • Prostate Specific Antigen (Total) PSA

PRODUCT DETAILS

    Net Qty
    1 N
    Ingredient
    ABIRATERONE ACETATE 500 mg
    Hsn Code
    30049049
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