BIMODE M TABLET 10'S

INTRODUCTION

BIMODE M is a combination of Glipizide and Metformin which belongs to the group of medicines called Antidiabetic agents. It is used in adults to treat type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate sugar control.

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.

Before taking BIMODE M, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution.

BIMODE M is strictly not recommended for use in patients with type I diabetes mellitus, severe heart failure or lactic acidosis. It is also not suitable for use in pregnant or breastfeeding women.

Along with the treatment, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking BIMODE M as it may aggravate your existing condition.

The most common side effects of taking BIMODE M are low blood sugar levels, nausea, vomiting, diarrhea, stomach upset and changes in taste. Consult your doctor if any of these side effect worsens.

USES OF BIMODE M

• Treats Type II diabetes mellitus

HOW BIMODE M WORKS

BIMODE M stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the amount of glucose produced by the liver and reduces its absoprtion in the body.

DIRECTIONS FOR USE

Take BIMODE M preferably 30 minutes before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Do not stop taking BIMODE M unless your doctor advice you to stop.

SIDE EFFECTS OF BIMODE M

HOW TO MANAGE SIDE EFFECTS

Hypoglycemia:

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or a drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.

Diarrhoea:

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Nausea:

Take BIMODE M with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.

WARNING & PRECAUTIONS

PREGNANCY

BIMODE M is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

BREASTFEEDING

BIMODE M is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if your ability is affected by BIMODE M.

ALCOHOL

Avoid consumption of alcohol while taking BIMODE M as it may increase the risk of unwanted side effects.

KIDNEY

BIMODE M is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.

LIVER

BIMODE M is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take BIMODE M if you are allergic to Glipizide, Metformin or to any other sulfonylureas (Ex. glyburide, glimepiride) or sulphonamides (Ex. sulfasalazine).

LUNGS

BIMODE M is not recommended for use in patients with breathing problems (such as asthma or COPD) or lung infections. Therefore, consult your doctor before taking it.

HEART DISEASE

BIMODE M is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking BIMODE M, inform your doctor if you are taking any of the following medicines:

• other medicines used to treat diabetes (Ex. teneligliptin, rosiglitazone, pioglitazone, glimepiride)
• diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
• medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
• medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
• medicines used to treat asthma (Ex. salbutamol or terbutaline)
• corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
• verapamil (a medicine used to treat heart problems)
• rifampicin (a medicine used to treat tuberculosis)
• cimetidine (a medicine used to treat stomach ulcer)
• dolutegravir (a medicine used to treat HIV infection)
• ranolazine (a medicine used to treat chest pain)
• trimethoprim (a medicine used to treat bacterial infection)
• vandetanib, crizotinib and olaparib (medicines used to treat cancer)
• antifungal medicines (used to treat fungal infections) such as miconazole, isavuconazole or fluconazole
• antibiotics (used to treat bacterial infections) such as fluorquinolones (Ex. ciprofloxacin, moxifloxacin), clarithromycin, co-trimoxazole, rifampicin, chlormaphenicol, tetracyclines or sulphonamides (Ex. sulphasalazine)
• medicines used to treat stomach ulcers such as ranitidine, famotidine, cimetidine
• medicines used to treat depression (such as moclobemide, isocarboxazid, phenelzine and tranylcypromine)
• medicines used for pain relief (Ex. aspirin, phenylbutazone, ibuprofen, phenylbutazone, azapropazone)
• medicines to treat mental illness (such as chlorpromazine, prochlorperazine, lithium)
• danazol (a medicine used to treat breast disorders, heavy menstrual bleeding and endometriosis)
• medicines used for blood thinning (Ex. warfarin)
• oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
• sulfinpyrazone, probenecid (medicines used to treat gout)
• thyroid hormones such as thyroxine (used to treat thyroid deficiency)
• phenytoin (a medicine used to treat epilepsy)
• clofibrate, nicotinic acid (medicines used to treat high blood cholesterol levels)
• isoniazid (a medicine used to treat tuberculosis)

Overdosage:

If you or anyone else accidentally took more BIMODE M, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

SYNOPSIS

MORE INFORMATION

• Keep BIMODE M out of reach of children
• Store BIMODE M at room temperature

FAQs ABOUT BIMODE M

Q: What is BIMODE M used for?

A: BIMODE M is an antidiabetic medicine used to treat Type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate response.

Q: How and when to take BIMODE M?

A: Take BIMODE M preferably 30 minutes before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take BIMODE M?

A: You need to take BIMODE M as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take BIMODE M?

A: BIMODE M must be taken just before meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of BIMODE M?

A: If you forgot to take a dose of BIMODE M, take it as soon as you remember. However, if it is time for the next dose of BIMODE M, skip the missed dose and take the next one regularly. Do not take a double dose of BIMODE M to compensate the missed ones.

Q: Can I stop taking BIMODE M without consulting your doctor?

A: No. You should not stop taking BIMODE M without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using BIMODE M, consult your doctor for advice.

Q: Will taking a higher dose of BIMODE M be more effective?

A: No, taking a higher dose of BIMODE M will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: Can I take medication for high blood pressure along with BIMODE M?

A: It is not advisable to take medicines to control blood pressure while taking BIMODE M without consulting your doctor, as they have known interactions with BIMODE M.

Q: How to manage the side effects of BIMODE M?

A: Low blood sugar is a common side effect of taking BIMODE M. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar levels once again. If your condition did not improve, consult your doctor immediately.

Q: Can BIMODE M be taken with insulin?

A: Co-administration of BIMODE M with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.

Q: Can BIMODE M be used in pregnant women?

A: BIMODE M is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.

Q: What are the side effects of taking BIMODE M?

A: The most common side effects of taking BIMODE M are low blood sugar levels, nausea, vomiting, diarrhea, stomach upset and changes in taste. Consult your doctor if any of these side effect worsens.

Q: Can BIMODE M cause dizziness?

A: Yes. Dizziness is a common side effect of using BIMODE M. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking BIMODE M.

Q: What precautions do I need to follow while taking BIMODE M?

A: Before taking BIMODE M inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking BIMODE M if you are pregnant or breastfeeding.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270 & 275.

2. Ricardo Correa; Bryan S. Quintanilla Rodriguez; Thomas M. Nappe. Glipizide. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 17th January 2023] https://www.ncbi.nlm.nih.gov/books/NBK459177/

3. Jie Hong, Yifei Zhang, Shenghan Lai, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui, Dajin Zou, Dawang Wang, Hong Li, Chao Liu, Guoting Wu, Jie Shen, Dalong Zhu, Weiqing Wang, Weifeng Shen, Guang Ning and on behalf of the SPREAD-DIMCAD Investigators. Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. April 2013. [Accessed on 17th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631843/

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 17th January 2023] https://www.medicines.org.uk/emc/files/pil.594.pdf

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 17th January 2023] https://www.medicines.org.uk/emc/files/pil.11951.pdf

6. Pharmacia Italia S.p.a., Ascoli Piceno Plant. MinodiabÒ 5 mg Tablets Glipizide. Electronic Medicines Compendium (EMC). [Revised in February 2018] [Accessed on 17th January 2023] https://www.medicines.org.uk/emc/files/pil.1687.pdf

7. Actavis Pharma, Inc. GLIPIZIDE ER- glipizide tablet, film coated, extended release. Dailymed.com. [Revised in December 2020]. [Accessed on 17th January 2023] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a430577c-f233-40a7-bfd8-3d2bc6f98aa2

8. Central Drugs Standard Control Organization. Glipizide 2.5mg/5mg +Metformin 250mg/500mg tablet. March 1998. [Accessed on 17th January 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Haemoglobin

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 18 Jan 2023 | 06:00 PM(IST)